Keith Tipton
Fellow Emeritus, Biochemistry

Publications and Further Research Outputs

Peer-Reviewed Publications

McDonald, A.G, Tipton, K.F. and Davey, G.P. , A knowledge-based system for display and prediction of O-glycosylation network behaviour in response to enzyme knockouts, PLOS Computational Biology, 12, (4), 2016, pe1004844- Journal Article, 2016 URL

Kelly JA, Boyle NT, Cole N, Slator GR, Colivicchi MA, Stefanini C, Gobbo OL, Scalabrino GA, Ryan SM, Elamin M, Walsh C, Vajda A, Goggin MM, Campbell M, Mash DC, O'Mara SM, Brayden DJ, Callanan JJ, Tipton KF, Della Corte L, Hunter J, O'Boyle KM, Williams CH, Hardiman O, First-in-class thyrotropin-releasing hormone (TRH)-based compound binds to a pharmacologically distinct TRH receptor subtype in human brain and is effective in neurodegenerative models., Neuropharmacology, 89C, 2015, p193-203 Journal Article, 2015 TARA - Full Text DOI

Andrew G. McDonald and Keith F. Tipton, The effects of tyramine and 4-aminophenol on the oscillating peroxidase-oxidase reaction, The Journal of Physical Chemistry B, 118, (1), 2014, p18 - 25 Journal Article, 2014 DOI

McDonald, A.G., Hayes, J.M., Bezak, T., Głuchowska, S.A., Cosgrave, E.F.J., Struwe, W.B., Stroop, C.J.M., Kok, H., van den Lar, T., Rudd, P.M., Tipton, K.F. and Davey, G.P., Galactosyltransferase 4 is a major control point for glycan branching in N-linked glycosylation, Journal of Cell Science, 127, 2014, p5014 - 5026 Journal Article, 2014 DOI TARA - Full Text

Andrew G. McDonald and Keith F. Tipton, Fifty-five years of Enzyme classification: advances and difficulties, FEBS Journal, 2013 Journal Article, 2013 DOI

Monitoring extracellular amino acid neurotransmitters and hROS by in vivo microdialysis in rats: a practical approach. in, G Giovanni & V. Di Matteo , Microdialysis Techniques in Neuroscience, Neuromethods, New York, USA, Humana Press, 2013, pp225-248 , [M.A. Colivicchi, C. Stefanini, W. Freinbichler, C. Ballini, L. Bianchi, K.F. Tipton and L. Della Corte.] Book Chapter, 2013

Olivieri A, Tipton K, O'Sullivan J, Characterization of the in vitro binding and inhibition kinetics of primary amine oxidase/vascular adhesion protein-1 by glucosamine., Biochimica et biophysica acta, 1820, (4), 2012, p482-487 Journal Article, 2012 DOI

Enzymes: Irreversible Inhibition. in, A.G. McDonald and K.F. Tipton, Keith F. , Encyclopedia of the Life Sciences (eLS)., Chichester., John Wiley & Sons, Ltd, 2012, [A.G. McDonald and K.F. Tipton.] Book Chapter, 2012

Roberta J Ward, Frederic Lallemand, Philippe de Witte, Robert R Crichton, Jacques Piette, Keith Tipton, Karl Hemmings, Arnaud Pitard, Mike Page, Laura Della Corte, Deanna Taylor, David Dexter, Anti-inflammatory actions of a taurine analogue; ethane β-sultam; in phagocytic cells; in vivo and in vitro, Biochemical Pharmacology, 81, 2011, p743 - 751 Journal Article, 2011 TARA - Full Text

Robert A. Alberty, Athel Cornish Bowden, Robert N. Goldberg, Gordon G. Hammes, Keith Tipton, Hans V. Westerhoff, Recommendations for terminology and databases for biochemical thermodynamics, Biophysical Chemistry, 155, (2-3), 2011, p89-103 Journal Article, 2011 TARA - Full Text

Freinbichler W, Colivicchi MA, Stefanini C, Bianchi L, Ballini C, Misini B, Weinberger P, Linert W, Vare"lija D, Tipton KF, Della Corte L, Highly reactive oxygen species: detection, formation, and possible functions., Cellular and molecular life sciences : CMLS, 68, (12), 2011, p2067-2079 Journal Article, 2011 DOI

Olivieri, A., Tipton. K., Inhibition of bovine plasma semicarbazide-sensitive amine oxidase by caffeine. , Journal of Biochemical and Molecular Toxicology, 25, 2011, p26 - 27 Journal Article, 2011 DOI

Olivieri A, Rico D, Khiari Z, Henehan G, O'Sullivan J, Tipton K, From caffeine to fish waste: amine compounds present in food and drugs and their interactions with primary amine oxidase., Journal of neural transmission (Vienna, Austria : 1996), 118, (7), 2011, p1079-1089 Journal Article, 2011 DOI

Tipton KF, Davey GP, McDonald AG, Kinetic behavior and reversible inhibition of monoamine oxidases--enzymes that many want dead., International review of neurobiology, 100, 2011, p43-64 Journal Article, 2011 DOI

McDonald, A.G., Tipton, K.F., Stroop, C.J., Davey G.P., GlycoForm and Glycologue: two software applications for the rapid construction and display of N-glycans from mammalian sources., BMC Research Notes, 18, (3), 2010, p1-7 Journal Article, 2010 TARA - Full Text

Olivieri A, O'Sullivan J, Fortuny LR, Vives IL, Tipton KF, Interaction of L-lysine and soluble elastin with the semicarbazide-sensitive amine oxidase in the context of its vascular-adhesion and tissue maturation functions., Biochimica et biophysica acta, 1804, 2010, p941 - 947 Journal Article, 2010 DOI

Aldo Olivieri, Jeff O'Sullivan, Luis Raimon Alvarez Fortuny, Itziar Larrauri Vives, Keith F. Tipton, Interaction of l-lysine and soluble elastin with the semicarbazide-sensitive amine oxidase in the context of its vascular-adhesion and tissue maturation functions, BBA - Proteins and Proteomics, 1804, (4), 2010, p941-947 Journal Article, 2010 TARA - Full Text

Apweiler, R. Armstrong, R., Bairoch, A., Cornish-Bowden, A., Halling, P.J. Hofmeyr, J.H., Kettner, C... Leyh, T.S., Rohwer J., D. Schomburg, D. Steinbeck C., K. Tipton K., A large-scale protein-function database., Nature Chemical Biology, 6, 2010, p785 - 785 Journal Article, 2010

McDonald AG, Tipton KF, Computer-controlled system for the study of oxidase reactions: application to the peroxidase-oxidase oscillator., The Journal of Physical Chemistry. B, 114, (49), 2010, p16244-52 Journal Article, 2010 DOI

Black WJ, Stagos D, Marchitti SA, Nebert DW, Tipton KF, Bairoch A and Vasilio V., Human aldehyde dehydrogenase genes: alternatively spliced transcriptional variants and their suggested nomenclature., Pharmocogenetics and Genomica, 2009 Journal Article, 2009

Boobis A, Watelet JB, Whomsley R, Benedetti MS, Demoly P and Tipton KF., Drug interactions, Drug Metabolism Reviews, 41, (3), 2009, p486 - 527 Journal Article, 2009

Nomenclature and potential functions of copper amine oxidases. in, editor(s)G. Floris & B. Mondovi , Copper Amine Oxidases, Boca Raton, FL, USA , CRC Press, 2009, pp5 - 17, [S. Boyce, K.F. Tipton, M.I. O'Sullivan, G.P. Davey. M. Motherway Gildea, A.G. McDonald, A. Olivieri, and J. O'Sullivan] Book Chapter, 2009

McDonald, A., Boyce, S., and Tipton, K.F. , ExplorEnz: the primary source of the IUBMB enzyme list, Nucleic Acids Research, 37, (Database Issue), 2009, pD593 - D597 Journal Article, 2009

McDonald AG, Tipton KF and Davey GP, Mathematical modelling of metabolism, The Biochemist, 31, 2009, p24 - 27 Journal Article, 2009

McDonald, Andrew G., Tipton, Keith F. and Boyce, Sinéad, Tracing metabolic pathways from enzyme data , BBA - Proteins & Proteomics, 1794, (9), 2009, p1364-1371 Journal Article, 2009 TARA - Full Text DOI

Freinbichler, W., Tipton, K.F., Della Corte, L. and Linert, W. , Mechanistic aspects of the Fenton reaction under conditions approximated to the extracellular fluid. , Journal of Inorganic Biochemistry, 103, (1), 2009, p28 - 34 Journal Article, 2009

Effects of pH on enzymes in, editor(s)D.L Purich , Enzyme Kinetics and Mechanism, New York, USA, Academic Pres, 2009, pp124 - 178, [Tipton, K.F., McDonald, A.G., Dixon, H.B.F.] Book Chapter, 2009

Kotera, M., McDonald, A.G., Boyce, S. and Tipton, K.F. , Functional Group and Substructure Searching as a Tool in Metabolomics, PLoS ONE , 3, (2, e1537), 2008, p1-8 Journal Article, 2008 TARA - Full Text DOI URL

Freinbichler, W., Bianchi, L., Colivicchi, M.A., Ballini, C., Tipton, K.F., Linert, W. and Della Corte, L. , The detection of hydroxyl radicals in vivo, Journal of Inorganic Biochemistry, 102, (5-6), 2008, p1329 - 1333 Journal Article, 2008

Kilbride, S.M., Telford, J.E., Tipton, K.F. and Davey, G.P., Partial inhibition of complex I activity increases Ca2+-independent glutamate release rates from depolarized synaptosomesPartial inhibition of complex I activity increases Ca2+-independent glutamate release rates from depolarized synaptosomes, Journal of Neurochemistry, 106, (2), 2008, p826 - 834 Journal Article, 2008

Cornally, D., Mee, B., MacDonaill, C., Tipton, K.F., Kelleher, D., Windle, H.J. and Henehan, G.T.M., Aldo-keto reductase from Helicobacter pylori - role in adaptation to growth at acid pH, FEBS Journal, 275, (12), 2008, p3041 - 3050 Journal Article, 2008

Freinbichler, W., Colivicchi, M.A., Fattori, M., Ballini, C., Tipton, K.F., Linert, W. and Della Corte, L., Validation of a robust and sensitive method for detecting hydroxyl radical formation together with evoked neurotransmitter release in brain microdialysis, Journal of Neurochemistry, 105, (3), 2008, p738 - 749 Journal Article, 2008

From the enzyme list to pathways and back again in, editor(s)M.G. Hicks & C. Kettner , Proceedings of the 3rd International Beilstein Workshop on Experimental Standard Conditions of Enzyme Characterizations, Frankfurt, Germany, Beilstein Institut, 2008, pp109 - 122, [McDonald, A.G., Tipton, K.F. and Boyce, S. ] Book Chapter, 2008

Ballini, C., Della Corte, L., Pazzagli, M., M.A, Colivicchi, M.A., Pepeu, G.. Tipton, K.F. and Giovannini, M.G. , Extracellular levels of brain aspartate, glutamate and GABA during an inhibitory avoidance response in the rat, Journal of Neurochemistry, 106, (3), 2008, p1035 - 1043 Journal Article, 2008

Taylor, C.F., Field, D., Sansone, S.A., Aerts, J., Apweiler, R., Ashburner, M., Ball, C.A., Binz, P.A., Bogue, M., Booth, T., Brazma, A., Brinkman, R.R., Clark, M.A., Deutsch, E.W., Fiehn, O., Fostel, J., Ghazal, P., Gibson, F., Gray, T., Grimes, G., Hancock, J.M., Hardy, N.W., Hermjakob, H., Julian, R.K. Kane, M., Kettner, C., Kinsinger, C., Kolker, E., Kuiper, M., Novère N.L., Leebens-Mack, J., Lewis, S.E., Lord, P., Mallon, A.M., Marthandan, N., Masuya, H., McNally, R., Mehrle, A., Morrison, N., Orchard, S., Quackenbush, J., Reecy, J.M., Robertson, D.G., Rocca-Serra, P., Rodriguez, H., Rosenfelder, H., Santoyo-Lopez, J., Scheuermann, R.H., Schober, D., Smith, B., Snape, J., Stoeckert, C.J., Tipton, K.F., Sterk, P., Untergasser, A., Vandesompele, J. and Wiemann, S. , Promoting coherent minimum reporting requirements for biological and biomedical investigations: The MIBBI project, Nature Biotechnology, 26, (8), 2008, p889 - 896 Journal Article, 2008

Sanz, E., Quintana, A., Battaglia, V., Toninello, A., Hidalgo, J., Ambrosio, S., Valoti, M., Marco, J.L., Tipton, K.F., Unzeta, M.. ., Anti-apoptotic effect of Mao-B inhibitor PF9601N [N-(2-propynyl)-2-(5-benzyloxy-indolyl) methylamine] is mediated by p53 pathway inhibition in MPP(+)-treated SH-SY5Y human dopaminergic cells, Journal of Neurochemistry, 105, (6), 2008, p2404 - 2417 Journal Article, 2008

Kotera, M., McDonald, A.G., Boyce, S. and Tipton, K.F. , Eliciting possible reaction equations and metabolic pathways involving orphan metabolites. , Journal of Chemical Information and Modeling. , 48, (12), 2008, p2335 - 2349 Journal Article, 2008

Scalabrino, G.A., Hogan, N., O'Boyle, K.M., Slator, G.R., Gregg, D.J., Fitchett, C.M., Draper, S.M., Bennett, G.W., Hinkle, P.M., Bauer, K., Williams, C.H., Tipton, K.F. and Kelly, J.A., Discovery of a dual action first-in-class peptide that mimics and enhances CNS-mediated actions of thyrotropin-releasing hormone. , Neuropharmacology, 52, (7), 2007, p1472 - 1481 Journal Article, 2007

Strolin Benedetti, M., Tipton, K.F., Whomsley, R. and Baltes, E., Factors affecting the relative importance of amine oxidases and monooxygenases in the in vivo metabolism of xenobiotic amines in humans. , Journal of Neural Transmission, 114, (6), 2007, p787 - 791 Journal Article, 2007

McDonald, A.G., Boyce, S., Moss, G.P., Dixon, H.B.F. and Tipton, K.F. , ExplorEnz: a MySQL database of the IUBMB enzyme nomenclature, BMC Biochemistry, 27, (8:14), 2007, p1-7 Journal Article, 2007

Ben Ramadan, Z., Wrang, M.L. and Tipton, K.F. , Species Differences in the Selective Inhibition of Monoamine Oxidase (1-methyl-2-phenylethyl)hydrazine and its Potentiation by Cyanide., Neurochemical Research, 32, (10), 2007, p1783 - 1790 Journal Article, 2007

Strolin Benedetti, M., Tipton, K.F. and Whomsley., R. , Amine oxidases and monooxygenases in the in vivo metabolism of xenobiotic amines in humans: has the involvement of amine oxidases been neglected?, Fundamamental and Clinical Pharmacology, 21, (5), 2007, p467 - 480 Journal Article, 2007

Boomsma, F. and Tipton, K.F. , Renalase, a catecholamine-metabolising enzyme? , Journal of Neural Transmission, 114, (6), 2007, p775 - 775 Journal Article, 2007

G. A. Scalabrino, N. Hogan, K.M.O'Boyle, G.R. Slator, D.J.Gregg, C.M.Fitchett, S.M.Draper, G.W. Bennet, P.M.Hinkle, K.Bauer, Discovery of a Dual Action, First-in-class Peptide that mimics and enhances CNS-mediated actions of Thyrotropin-releasing Hormone , Neuropharmacology, 52, (7), 2007, p1472 - 1481 Journal Article, 2007 DOI

McDonald, AG., Tipton, K.F., O'Sullivan, J., Olivieri, A., Davey, G. P., Coonan, A.M. and Fu, W., , Modelling the roles of MAO and SSAO in glucose transport., Journal of Neural Transmission, 114, (6), 2007, p783 - 786 Journal Article, 2007

Hernandez-Guillamon, M., Bolea, I., Sole, M., Boada, M., Tipton, K.F. and Unzeta, M., Sodium bicarbonate enhances membrane-bound and soluble human semicarbazide-sensitive amine oxidase activity in vitro. , Journal of Biochemistry (Tokyo), 142, (5), 2007, p571 - 576 Journal Article, 2007

Olivieri, A., Tipton, K. and O'Sullivan, J., L-lysine as a recognition molecule for the VAP-1 function of SSAO., Journal of Neural Transmission, 114, (6), 2007, p747 - 749 Journal Article, 2007

Healy, J. and Tipton, K.F., Ceruloplasmin and what it might do., Journal of Neural Transmission, 114, (6), 2007, p777 - 781 Journal Article, 2007

O'Sullivan, J., Davey, G.P., O'Sullivan, M. I. and Tipton, K.F, Hydrogen peroxide derived from amine oxidation mediates the interaction between aminosugars and semicarbazide-sensitive amine oxidase., Journal of Neural Transmission, 114, (6), 2007, p751 - 756 Journal Article, 2007

O'Sullivan, J., O'Sullivan, M. I., Tipton, K.F. and Davey, G, P., Inhibition of amine oxidases by the histamine-1 receptor antagonist hydroxyzine., Journal of Neural Transmission (suppl.), 71, 2006, p105 - 112 Journal Article, 2006

Youdim, M.B.H., Edmondson, D. and Tipton, K.F., The therapeutic potential of monoamine oxidase inhibitors., Nature Reviews in Neuroscience, 7, (4), 2006, p295 - 309 Journal Article, 2006 URL

Mee, B., Kelleher, D., Frias, J., Malone, R., Tipton, K.F., Henehan ,G.T. and Windle,H.J., Characterization of cinnamyl alcohol dehydrogenase of Helicobacter pylori., FEBS JOURNAL, 272, (5), 2005, p1255 - 1264 Journal Article, 2005

J.A. Kelly, G.A. Scalabrino, G.R. Slator, A.A. Cullen, J.F. Gilmer, D.G. Lloyd, G.W. Bennett, K. Bauer, K.F. Tipton and C.H. Williams., Structure-activity studies with high affinity inhibitors of pyroglutamyl-peptidase II., Biochemical Journal, 389, 2005, p569 - 576 Journal Article, 2005

B Mee, D Kelleher, J Frias, R Malone, KF Tipton, GT Henehan, HJ Windle, Characterization of cinnamyl alcohol dehydrogenase of Helicobacter pylori. An aldehyde dismutating enzyme, FEBS J, 272, (5), 2005, p1255 - 1264 Journal Article, 2005 DOI TARA - Full Text

Amine Oxidases and Drug Metabolism. in, editor(s)F. Oesch , Proc 15th Int Symp Microsomes and Drug Oxidations, Mainz Germany. , Bologna, Italy , Merimond S.r.l., 2005, pp47 - 54, [K.F. Tipton and M. Strolin Benedetti] Book Chapter, 2005

Enzyme Classification and Nomenclature , Encyclopedia of the Life Sciences, Chichester, John Wiley & Sons, Ltd,, 2005, pp14 pp , [Tipton, K. F. and Boyce, S.] Item in dictionary or encyclopaedia, etc, 2005

Apweiler, R., Cornish-Bowden, A., Hofmeyr, J.H., Kettner, C., Leyh, T.S., Schomburg, D. and Tipton, K.F. , The importance of uniformity in reporting protein-function data. , Trends in Biochemical Sciences, 30, 2005, p11 - 12 Journal Article, 2005

O'Sullivan, J., Unzeta, M., Healy, J., O'Sullivan, M. I., Davey, G., and Tipton, K. F.,, Semicarbazide-Sensitive Amine Oxidases: Enzymes with Quite a Lot to Do, Neurotoxicology, 25, 2004, p303 - 315 Journal Article, 2004

The effects of two salsolinol derivatives on mitochondrial respiration and the likely nature of any endogenous parkinsonism-inducing toxin. in, editor(s)T.L..Török & I. Klebovich , Design of Monoamine oxidase Inhibitors and their role in neurotransmission (drug development). , Budapest, Medicina Publishing House Co, 2004, pp55 - 77, [Farmer, M.K., Tipton, K.F. and Davey, G.P.] Book Chapter, 2004

Irwin, J. A. and Tipton, K. F., Affinity precipitation methods, Methods Mol Biol, 244, 2004, p205 - 224 Journal Article, 2004

Monoamine oxidases (MAO): Functions in the nervous system. in, editor(s)G. Adelman and B. Smith , Encyclopedia of Neuroscience, 3rd Edition, Amsterdam, Elsevier Science BV, 2004, pp1-17 , [Tipton, K.F., O'Sullivan, J. and Youdim, M.B.H.] Book Chapter, 2004

Bridge, M.H., Williams, E., Lyons, M.E., Tipton, K.F. and Linert. W., Electrochemical investigation into the redox activity of Fe(II)/Fe(III) in the presence of nicotine and possible relations to neurodegenerative diseases., BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 1690, (1), 2004, p77 - 84 Journal Article, 2004

Colivicchi, M.A., Raimondi, L., Bianchi, L., Tipton, K.F., Pirisino, R. and Della Corte, L., Taurine prevents streptozotocin impairment of hormone-stimulated glucose uptake in rat adipocytes. , EUROPEAN JOURNAL OF PHARMACOLOGY, 495, (2-3), 2004, p209 - 215 Journal Article, 2004

Fleischmann, A., Darsow, M., Degtyarenko, K., Fleischmann, W., Boyce, S., Axelsen, K. B., Bairoch, A., Schomburg, D., Tipton, K. F. and Apweiler, R., IntEnz, the integrated relational enzyme database, Nucleic Acids Res, 32, 2004, pD434 - 477 Journal Article, 2004

Bianchi, L., De Micheli, E., Bricolo, A., Ballini, C., Fattori, M., Venturi, C., Pedata, F., Tipton, K. F. and Della Corte, L., Extracellular levels of amino acids and choline in human high grade gliomas: an intraoperative microdialysis study, NEUROCHEMICAL RESEARCH, 29, (1), 2004, p325 - 334 Journal Article, 2004

Tipton, K.F., Boyce, S., O'Sullivan, J., Davey, G.P. and Healy, J., Monoamine oxidases: certainties and uncertainties , Current Medicinal Chemistry , 11, 2004, p1965 - 1982 Journal Article, 2004

Boyce, S., Tipton, K.F. and McDonald, A.G., Extending enzyme classification with metabolic and kinetic data: Some difficulties to be resolved. , 1st International Beilstein Workshop on Experimental Standard Conditions of Enzyme Characterizations. , Beilstein Institut, Frankfurt, Germany , 5-8 October 2003, edited by M.G. Hicks and C. Kettner , 2004, pp17 - 43 Conference Paper, 2004

Joyce, O. J. P., Farmer, M. K., Tipton, K. F. and Porter, R. K., Oxidative phosphorylation by in situ synaptosomal mitochondria from whole brain of young and old rats, JOURNAL OF NEUROCHEMISTRY, 86, (4), 2003, p1032 - 1041 Journal Article, 2003

Seymour, C. B., Mothersill, C., Mooney, R., Moriarty, M. and Tipton, K. F., Monoamine oxidase inhibitors l-deprenyl and clorgyline protect nonmalignant human cells from ionising radiation and chemotherapy toxicity, BRITISH JOURNAL OF CANCER, 89, (10), 2003, p1979 - 1986 Journal Article, 2003

Kinetics of Catalyzed Reactions ' Biological in, editor(s)I.T. Horváth , Encyclopedia of Catalysis , John Wiley & Sons, Inc, 2003, pp395 - 471 , [McDonald, A. G. and Tipton, K. F.] Book Chapter, 2003

O'Sullivan, M., MacDougall, M. B., Unzeta, M., Lizcano J. M. and Tipton K. F., Semicarbazide-sensitive amine oxidases in pig dental pulp, BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS, 1647, (1-2), 2003, p333 - 336 Journal Article, 2003

Dalfo, E., Hernandez, M., Lizcano, J. M., Tipton, K. F. and Unzeta, M., Activation of human lung semicarbazide sensitive amine oxidase by a low molecular weight component present in human plasma. , BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 1638, (3), 2003, p278 - 286 Journal Article, 2003

Tipton, K. F., O'Sullivan, M. P., Davey, G. P. and O'Sullivan, J. , It can be a complicated life being an enzyme, Biochem. Soc. Trans, 31, 2003, p711 - 715 Journal Article, 2003

O'Sullivan, J., O'Sullivan, M., Tipton, K. F., Unzeta, M., Del Mar Hernandez, M. and Davey, G. P., The inhibition of semicarbazide-sensitive amine oxidase by aminohexoses, BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS, 1647, (1-2), 2003, p367 - 371 Journal Article, 2003

O'Sullivan, M., Tipton, K. F. and McDevitt, W. E. , Immunolocalization of semicarbazide-sensitive amine oxidase in human dental pulp and its activity towards serotonin, Oral Biol, 47, 2002, p399 - 406 Journal Article, 2002

Youdim, M. B. H. and Tipton, K. F., Rat striatal monoamine oxidase-B inhibition by l-deprenyl and rasagiline: its relationship to 2-phenylethylamine-induced stereotypy and Parkinson's disease. , Parkinsonism Relat. Disord, 8, 2002, p247 - 253 Journal Article, 2002

Hayes, J. P. and Tipton, K. F., Interactions of the neurotoxin 6-hydroxydopamine with glyceraldehyde-3-phosphate dehydrogenase, Toxicology Letters , 128, 2002, p197-206 Journal Article, 2002

Della Corte, L., Crichton, R. R., Duburs, G., Nolan, K., Tipton, K. F., Tirzitis, G. and R.J, The use of taurine analogues to investigate taurine functions and their potential therapeutic applications, Amino Acids , 23, 2002, p367 - 379 Journal Article, 2002

Quinlan, C. A., Zisterer, D. M., Tipton, K. F. and O'Sullivan, M. I., A study of the in vitro cytotoxicity of a composite resin and compomer , Int. Endod. J., 35, 2002, p47 - 55 Journal Article, 2002

Principles of enzyme assay and kinetic studies in, editor(s)R, Eisenthal and M.J. Danson , Enzyme Assays: A Practical Approach , Oxford University Press , 2002, pp1 - 47, [K.F. Tipton] Book Chapter, 2002

Principles of enzyme assay and kinetic studies in, editor(s)R, Eisenthal and M.J. Danson , Enzyme Assays: A Practical Approach , Oxford University Press , 2002, pp1 - 47, [K.F. Tipton] Book Chapter, 2002

Youdim, M. B. H. and K.F. Tipton, K. F., Rat striatal monoamine oxidase-B inhibition by l-deprenyl and rasagiline: its relationship to 2-phenylethylamine-induced stereotypy and Parkinson's disease. , Parkinsonism Relat. Disord, 8, 2002, p247 - 253 Journal Article, 2002

Fitzgerald, D. H. and K. F. Tipton, K. F., Inhibition of monoamine oxidase modulates the behaviour of semicarbazide-sensitive amine oxidase (SSAO). , J. Neural Transm, 109, 2002, p251-265 Journal Article, 2002

Quinlan, C.A., O'Sullivan, M.I., Zisterer, D.M. & Tipton, K.F., In vitro cytotoxicity of a composite resin and compomer., International Endodontic Journal, 35, (1), 2002, p47 - 55 Journal Article, 2002 URL DOI

O'Byrne, M. B. and Tipton, K. F. , Inhibition of the neuronal isoform of nitric oxide synthase significantly attenuates 1-methyl-4-phenylpyridinium (MPP+) toxicity in vitro, J. Neural Transm, 109, 2002, p585 - 596 Journal Article, 2002

Biogenic amines. diet and the properties of amine oxidases in, editor(s)D. M. L. Morgan, T. Hirvi, G. Dandrifosse, P. Deloyer and A. White , Biogenically Active Amines in Food, Brussels, Belgium , European Communities Publication Office, , 2002, pp117 - 121, [Tipton, K. F.] Book Chapter, 2002

Cunningham, C. and Strolin Benedetti, M. , Oxidative stress and radical detection, Food Antioxidants and Human Health (EC FAIR Conference)., Siena, Italy , edited by G. Sgaragli and M. Valoti , Casa Editrice I Mori, 2001, pp47 - 56 Conference Paper, 2001

Hayes, J., Tipton, K. F., Bianchi, L. and Della Corte, L., Complexities in the neurotoxic actions of 6-hydroxydopamine in relation to thecytoprotective properties of taurine, Brain Research Bulletin, 55, 2001, p239-245 Journal Article, 2001

Amine Oxidases and the metabolism of xenobiotics in, editor(s)C. Ioannides , Enzyme Systems that Metabolise Drugs and Other Xenobiotics, Chichester, UK , John Wiley & Sons, Ltd, 2001, pp95 -146 , [Tipton, K. F. and Strolin Benedetti, M.] Book Chapter, 2001

Alcohol and Alcoholism , (2001), Tipton, K. F., [Chief ed.], 1996-2001 Journal, 2001

McDonald, A. G., Boyce, S., Connolly, J., Kazic, T., Wise, W. and Tipton, K. F., Metabolic systems and the behaviour of neuronal systems, Proceedings of the First World Congress of Neuroinfomatics, Vienna, Austria, edited by F. Rattay , Argesima/ASIM Verlag, 2001, pp308 - 316 Conference Paper, 2001

M. Marangolo, M. M. McGee, K. F. Tipton, D. C. Williams and D. M. Zisterer, Oxidative stress induces apoptosis in C6 glioma cells: involvement of mitogen-activated protein kinases and nuclear factor kappa B, Neurotox Research, 3, (4), 2001, p397-409 Journal Article, 2001 URL URL DOI

Marangolo, M., Tipton, K. F., McGee, M. M., Williams D. C. and Zisterer, D. M., Oxidative stress induces apoptosis in C6 glioma cells: involvement of mitogen-activated protein kinase and nuclear factor kappa B, Neurotoxicity Res, 3, 2001, p397 - 409 Journal Article, 2001

Monoamine oxidase assays. in, editor(s)S.J. Enna, M. Willias , J. W. Ferkany, T, Kenakin, R. E. Porsolt and J.P. Sullivan , Current Protocols in Pharmacology, New York , John Wiley , 2000, pp3.6.1 - 3.6.42 , [Tipton, K. F., Davey, G. and Motherway, M.] Book Chapter, 2000

O'Byrne, M. B., Bolam, J. P., Hanley, J. J. and Tipton, K. F. , Tyrosine-hydroxylase immuno-reactive cells in the rat striatum following treatment with MPP+. , Advances in Experimental Medicine and Biology, 483, 2000, p369 - 374 Journal Article, 2000

Palmi, M., Youmbi, G., Sgaragli, G. P., Meini, A., Benocci, A., Fusi, F., Frosini, M., Della Corte, L., Davey, L. and K.F. Tipton, K. F., The mitochondrial permeability transition and taurine, Advances in Experimental Medicine and Biology, 483, 2000, p87 - 96 Journal Article, 2000

O'Byrne, M. B. and Tipton, K. F., Taurine-induced attenuation of MPP+ neurotoxicity in vitro: a possible role for the GABA(A) subclass of GABA receptors, J. Neurochem, 74, 2000, p2087 - 2093 Journal Article, 2000

Cunningham, C. M. and Tipton, K. F., Metabolism of taurine to sulphoacetaldehyde during oxidative stress, Advances in Experimental Medicine and Biology, 483, 2000, p383 - 388 Journal Article, 2000

Enzyme Classification and Nomenclature in, Encyclopedia of Life Sciences, UK, Macmillan Reference Co, 2000, ppArticle 710, 13 pp , [Tipton, K. F. and Boyce, S.] Book Chapter, 2000

Kelly, J. A., Slator, G. R., Tipton, K. F., Williams, C. H. and Bauer, K., Kinetic Investigation of the Specificity of Porcine Brain Thyrotropin-releasing Hormone-degrading Ectoenzyme for Thyrotropin-releasing Hormone-like Peptides, J. Biol. Chem, 275, 2000, p16746 - 16751 Journal Article, 2000

Capodarca, S., Cunningham, C. M., Bartolini, P., Tipton, K. F., Della Corte, L., Bianchi, L., Ward, R. J., Dachour, A., Quertemont, E., Lallemand, F. and De Witte, P., Effects of ethanol and glutamate agonist infusion on the outflow of sulphoacetaldehyde: Microdialysis studies, Advances in Experimental Medicine and Biology, 483, 2000, p397 - 304 Journal Article, 2000

Taurine 4: Taurine and Excitable Tissues in, editor(s)L. Della Corte, R. J. Huxtable, G.P. Sgaragli and K. F. Tipton , Advances in Experimental Medicine and Biology, Dordrecht, The Netherlands , Kluwer Academic/Plenum Publishers, 2000, pp1 - 664, [ ] Book Chapter, 2000

Boyce, S. and Tipton, K. F., History of the enzyme nomenclature system, Bioinformatics, 16, 2000, p34 - 40 Journal Article, 2000

Valoti, M., Fusi, F., Frosini, M., Pessina, F., Tipton, K. F. and Sgaragli, G. P., Cytochrome P450-dependent N-dealkylation of L-deprenyl in C57BL mouse liver microsomes: effects of in vivo pretreatment with ethanol, phenobarbital, beta-naphthoflavone and L-deprenyl. , Eur. J. Pharmacol, 391, 2000, p199 - 206 Journal Article, 2000

Inhibitors of monoamine oxidase and the pressor response to dietary amines in, editor(s)K. Magyar and E.S. Vizi , Milestones in Monoamine Oxidase Research: Discovery of (-)-Deprenyl, Budapest, Hungary, Medicina Publishing House, 2000, pp19 - 32, [Tipton, K. F. ] Book Chapter, 2000

Lizcano, J. M., Unzeta. M. and Tipton, K. F., Time-dependent activation of the semicarbazide-sensitive amine oxidase (SSAO) from ox lung microsomes, 351, 2000, p789 - 794 Journal Article, 2000

Davey, G. P. and Tipton, K. F., Mitochondria, cell death and DNA damage. , Radiation Research , 2, 2000, p390 - 394 Journal Article, 2000

Lizcano, J. M., Unzeta, M. and Tipton, K. F., A spectrophotometric method for determining the oxidative deamination of methylamine by the amine oxidases, Analyt. Biochem, 286, 2000, p75 - 79 Journal Article, 2000

Bartolini B, Tipton KF, Bianchi L, Stephenson D, Cunningham C, Della Corte L., Determination of monoamine oxidase activity by HPLC with fluorimetric detection, Neurobiology (Bp), 79, ((2)), 1999, p109-21 Journal Article, 1999

McDonald, A. G. and Tipton, K. F., Kinetics for the numerically challenged, The Biochemist , 21, 1999, p18 - 23 Journal Article, 1999

Bartolini, P., Tipton, K. F., Bianchi, L., Stephenson, D., Cunningham, C., and Della Corte, L., Determination of monoamine oxidase activity by hplc with fluorimetric detection. , Neurobiology, 7, 1999, p159 - 174 Journal Article, 1999

Kelly, J. A., Slator, G. R., Tipton, K. F., Williams, C. H. and Bauer, K., Development of a continuous, fluorometric coupled enzyme assay for thyrotropin-releasing hormone-degrading ectoenzyme, Anal. Biochem, 274, 1999, p195 - 202 Journal Article, 1999

M .Palmi, G.T. Youmbi, F. Fusi , G.P. Sgaragli, H.B.F.Dixon, M. Frosini and K.F. Tipton, Potentiation of mitochondrial Ca2+ sequestration by taurine, Biochem. Pharmacol. , 58, 1999, p1123 - 31 Journal Article, 1999

Vasilou, V., Bairoch, A., Tipton, K. F. and Nebert, D. W., Eukaryotic aldehyde dehydrogenase (ALDDH) genes: human polymorphisms and recommended nomenclature based on divergent evolution and chromosome mapping. , Pharmacogenetics , 9, 1999, p421 - 434 Journal Article, 1999

Farren, C. K. and Tipton, K. F., Trait markers for alcoholism: clinical utility. , Alc. Alcoholism , 34, 1999, p649 - 665 Journal Article, 1999

Strolin Benedetti, M. and Tipton, K. F., nvolvement of monooxygenases and amine oxidases in hydroxyl radical generation in vivo, Neurobiology , 7, 1999, p123 - 134 Journal Article, 1999

Monoamine oxidases (MAO): Functions in the nervous system in, editor(s)G. Adelman and B. Smith , Encyclopedia of Neuroscience, Amsterdam, Elsevier Science BV, 1999, [Tipton, K. F., O'Brien, E. M. and Youdim, M. B. H.] Book Chapter, 1999

Ben Ramadan, Z., Dostert, P. and Tipton, K. F., Some Peculiar aspects of monoamine oxidase inhibition, Neurobiology, 7, 1999, p123 - 134 Journal Article, 1999

Porter, R. K., Joyce, O. J. P., Farmer, M. K., Heneghan, R., Tipton, K. F., Andrews, J. F., McBennet, A. M., Lund, M. D., Jensen, C. H. and Melia, H. P., Indirect measurement of mitochondrial proton leak and its application. , Int. J. Obesity , 23, 1999, p1 - 7 Journal Article, 1999

Bianchi, L., Della Corte, L. and Tipton, K. F., Simultaneous determination of basal and evoked output levels of aspartate, glutamate, taurine and GABA during microdialysis and from superfused brain slice.s, J. Chromatogr. B, 723, 1999, p47 - 59 Journal Article, 1999

Monoamine oxidases (MAO): Functions in the nervous system in, editor(s)G. Adelman and B. Smith , Encyclopedia of Neuroscience, Amsterdam, Elsevier Science BV, 1999, [Tipton, K. F., O'Brien, E. M. and Youdim, M. B. H.] Book Chapter, 1999

Farren, C. K., Clare, A. W., K.F. Tipton and T.G. Dinan, Platelet MAO activity in subtypes of alcoholics and controls in a homogenous, J. Psychiatr. Res. , 32, 1998, p49 - 54 Journal Article, 1998

J.P.M. Finberg, M.B.H. Youdim, P. Riederer and K.F.Tipton (Eds), MAO ' The Mother of all Amine Oxidases, Vienna, Austria , Springer-Verlag, 1998, xix plus 355pp Book, 1998

Strolin Benedetti, M., Sanson, M., Bona, G., Gallina, M., Persiani S. and Tipton, K. F. , The oxidation of dopamine and epinine by the two forms of monoamine oxidase from rat liver., J. Neural Transm. (Suppl.), 52, 1998, p233 - 238 Journal Article, 1998

Antagonism by taurine of the ruthenium red-induced and 6-hydroxydopamine plus 1-methyl-4-phenylpyridinium-induced Ca2+ release from rat liver mitochondria in, editor(s)S. Schaffer, J.B. Lombardini and R.J. Huxtable , Taurine 3: cellular and regulatory mechanisms, New York, Plenum Press, 1998, pp91 - 98 , [Palmi, M., Youmbi, G., Fusi, F., Frosini, M., Sgaragli, G. P., Della Corte, L. and Tipton, K. F. ] Book Chapter, 1998

Farren, C. K., Clare, A. W., Tipton, K. F., and Dinan, T. G., Platelet MAO activity in subtypes of alcoholics and controls in a homogenous, J. Psychiatr. Res. , 32, 1998, p49 - 54 Journal Article, 1998

Colm Cunningham, Keith F. Tipton and Henry B.F. Dixon, Conversion of taurine into N-chlorotaurine (taurine chloramine) and sulphoacetaldehyde in response to oxidative stress, Biochemical Journal, 330, 1998, p939-945. Journal Article, 1998

Analysis of salsolinols, endogenous neurotoxins, in human materials in, editor(s)G.A. Qureshi, H. Parvez, P. Caudy and S. Parvez , Neurochemical markers of degenerative nervous diseases and drug addiction., The Netherlands, VSP,, 1998, pp423 - 460 , [Naoi, M., Maruyama, W., Matsubara, K., Tipton, K. F., Strolin Benedetti, M. and Parvez, H.] Book Chapter, 1998

Strolin Benedetti. M. and Tipton. K. F. , Monoamine oxidases and related amine oxidases as phase I enzymes in the metabolism of xenobiotics, J. Neural Transm. (Suppl.) , 52, 1998, p149 - 171 Journal Article, 1998

Cunningham, C., Tipton, K. F. and Dixon, H. B. F. , Conversion of taurine into N-chlorotaurine (taurine chloramine) and sulphoacetaldehyde in response to oxidative stress, Biochem. J. , 330, 1998, p933 - 937 Journal Article, 1998

Strolin Benedetti, M., Sanson, M., Bona, G., Gallina, M., Persiani, S. and K.F. Tipton, K. F. , The oxidation of dopamine and epinine by the two forms of monoamine oxidase from rat liver, Neural Transm. (Suppl.), 52, 1998, p251 - 257 Journal Article, 1998

Fitzgerald, D., Tipton, K. F. and Lyles, G. A., Studies on the behaviour of semicarbazide-sensitive amine oxidases in Sprague-Dawley rats treated with the monoamine oxidase inhibitor tranylcypromine. , J. Neural Transm. (Suppl.) , 52, 1998, p259 - 264 Journal Article, 1998

Lizcano, J. M., Tipton, K. F. and Unzeta, M., Purification and characterization of membrane-bound semicarbazide-sensitive amine oxidase (SSAO) from bovine lung, Biochem. J. , 331, 1998, p69 - 78 Journal Article, 1998

Glinka, Y., Tipton, K. F. and Youdim, M. B. H. , Mechanism of inhibition of mitochondrial respiratory complex I by 6-hydroxydopamine and its prevention by desferrioxamine, Eur. J. Pharmacol, 351, 1998, p121 - 129 Journal Article, 1998

Ward, R. J., McCrodden, J., Tipton, K., Sherwood, R., Keating, J., Peters, T.J. and de Witte. P., Biochemical and genetic studies on Caucasian subjectswith ethanol-induced flushing reaction, Addiction Biology , 3, 1998, p465 - 472 Journal Article, 1998

Essays in Biochemistry, (1995), Tipton, K. F., [Chief ed.], 1985-95 Journal, 1995

Journal of Neurochemistry , (1991), Tipton, K. F., [Chief ed.], 1983-91 Journal, 1991

Journal of Enzyme Inhibition; Journal of Neural Transmission , , 1990 Editorial Board, 1990

Biochimica et Biophysica Acta , , 1985 Editorial Board, 1985

Non-Peer-Reviewed Publications

Biochemical Pharmacology [1970-2004], , [eds.] Editorial Board,

Biochemical Journal , London, The Biochemical Society - Portland Press, [Editorial Board], 1981 -2004 Editorial Board,

Research Expertise

Description

Enzymology: regulation, kinetics, inhibition, isolation, applications. Enzyme bioinformatics: metabolic analysis and simulation. Systems biology. Neurochemistry: depression, degenerative diseases and 'neuroprotection'. Biochemical Pharmacology: drug design, ethanol.

Keywords

Biochemistry; Biochemistry, metabolism; Bioinformatics; Biosystematics; DEGENERATION; Depression; Design and synthesis of drugs; Drug Metabolism; ENZYME INHIBITION; ENZYME KINETICS; Enzymology; ETHANOL; Neurodegenerative Diseases/Disorders; Neurophysiology; NEUROPROTECTION

Recognition

Representations

Molecular Enzymology Group (Chairman), (Biochemical Society) 1995-1997

Neurochemical Group (Chairman) (Biochemical Society) 1998-1990

Publications Board, (Biochemical Society) 1982-89

Institute of Biology of Ireland (Chairman) 1985-87

Institute of Biology of Ireland (President) 1988-90

Biochemical Society (Committee) 1982-1986

International Society for Neurochemistry (Publications Committee) 1985-1992

International Union of Biochemistry & Molecular Biology: Special Interest Group on Enzymology (Chairman ) 1991-

Irish Society for Toxicology (Vice-president) 2001

Irish Society for Toxicology (President) 2002-3

Beilstein International Committee on Standards for Reporting of Enzymology Data 2004-

IUBMB-IUPAC Joint Committee on Biochemical Nomenclature (responsible for Enzyme Nomenclature, Classification & Bioinformatics) 1985-

Medical Research Council (U.K.) Neurosciences Grants Committee 1992-1997

Multiple Sclerosis Society of Ireland: Research Committee 1988- 1999

Member of the International Advisory Committee to the HUGO Gene Nomenclature Committee 1999-

European Society for Neurochemistry (Council) 1989-1994

Health Research Board (Neurosciences & Mental Health Committee) 1994-2002

Awards and Honours

M.R.I.A. Royal Irish Academy 1984

RIA Biochemistry Medal, Royal Irish Academy 1989

Memberships

International Union of Biochemistry and Molecular Biology (IUBMB)

Irish Neurosciences Discussion Group

Hungarian Pharmacological Society (Honorary Member)