John Walsh
Associate Professor, Pharmacy

Publications and Further Research Outputs

Peer-Reviewed Publications

Zhang T, Finn D.F, Barlow J.W, Walsh J.J, Mast cell stabilisers, European Journal of Pharmacology, 778, 2016, p158 - 168 Journal Article, 2016 DOI URL

Egan M, Connors E.M, Anwar Z, Walsh J.J, Nature's Treatment for Irritable Bowel Syndrome: Studies on the Isolation of (-)-Menthol from Peppermint Oil and Its Conversion to (-)-Menthyl Acetate, Journal of Chemical Education, 92, (10), 2015, p1736 - 1740 Journal Article, 2015 URL DOI

Bopha Chrea, Juliette A. O'Connell, Orlando Silkstone-Carter, John O'Brien, and John J. Walsh, Nature's Antidepressant for Mild to Moderate Depression: Isolation and Spectral Characterization of Hyperforin from a Standardized Extract of St. John's Wort (Hypericum perforatum), Journal of Chemical Education, 91, (3), 2014, p440 - 442 Journal Article, 2014 URL

Linker technologies and release mechanisms for antibody-drug conjugates in, editor(s)Professor Norbert Sewald , Optimizing antibody-drug conjugates for targeted delivery of therapeutics, Future press, 2014, pp1 - 15, [John J. Walsh and Gary D. Stack [Accepted 22-01-2014] Book Chapter, 2014

Paul Matthew O'Byrne, Robert Williams, John J. Walsh, John Gilmer, Part Two: Evaluation of N-methylbupropion as a Potential Bupropion Prodrug, Pharmaceuticals, 7, (6), 2014, p676 - 694 Journal Article, 2014

Paul Matthew O'Byrne, Robert Williams, John J. Walsh, John Gilmer, Synthesis, screening and pharmacokinetic evaluation of potential prodrugs of bupropion, Pharmaceuticals, 7, (5), 2014, p595 - 620 Journal Article, 2014

Finn, D.F., Walsh, J.J., Twenty-first century mast cell stabilizers, British Journal of Pharmacology, 170, (1), 2013, p23-37 Journal Article, 2013 DOI TARA - Full Text

Prokopiou, E.M., Ryder, S.A., Walsh, J.J., Tumour vasculature targeting agents in hybrid/conjugate drugs, Angiogenesis, 16, (3), 2013, p503-524 Journal Article, 2013 DOI

Carroll, A.-M., Kavanagh, D.J., McGovern, F.P., Reilly, J.W., Walsh, J.J., Natures chiral catalyst and anti-malarial agent: Isolation and structure elucidation of cinchonine and quinine from cinchona calisaya, Journal of Chemical Education, 89, (12), 2012, p1578-1581 Journal Article, 2012 DOI

Anne-Marie Carroll, David J. Kavanagh, Fiona P. McGovern, Joe W. Reilly, and John J. Walsh, Nature's Chiral Catalyst and Anti-Malarial Agent: Isolation and Structure Elucidation of Cinchonine and Quinine from Cinchona calisaya, Journal of Chemical Education, 89, 2012, p1578 - 1581 Journal Article, 2012 URL

Emma L. Walsh, Siobhan Ashe, and John J. Walsh, Nature's Migraine Treatment: Isolation and Structure Elucidation of Parthenolide from Tanacetum parthenium, Journal of Chemical Education, 89, 2012, p134 - 137 Journal Article, 2012 URL

Gary D. Stack and John J. Walsh, Optimising the Delivery of Tubulin Targeting Agents through Antibody Conjugation., Pharmaceutical Research, 29, (11), 2012, p2972 - 2984 Journal Article, 2012 URL

Maisarah Mohd Nazri, Farah D. Samat, Pierce V. Kavanagh, and John J. Walsh, Nature's Cholesterol-Lowering Drug: Isolation and Structure Elucidation of Lovastatin from Red Yeast Rice-Containing Dietary Supplements, Journal of Chemical Education, 89, 2012, p138 - 140 Journal Article, 2012 URL

James W. Barlow, Aengus P. McHugh, Orla Woods, John J. Walsh, Synthesis of novel mast cell-stabilising and anti-allergic 1,2,3,4-tetrahydro-1-naphthalenols and related compounds, European Journal of Medicinal Chemistry, 46, (5), 2011, p1545-1554 Journal Article, 2011 TARA - Full Text

Adam J. Byrne, James W. Barlow, John J. Walsh, Synthesis and pharmacological evaluation of the individual stereoisomers of 3- [methyl(1,2,3,4-tetrahydro-2-naphthalenyl)amino]-1-indanone, a potent mast cell stabilising agent, Bioorganic & Medicinal Chemistry Letters, 21, (4), 2011, p1191-1194 Journal Article, 2011 TARA - Full Text

O'Byrne PM, Williams R, Walsh JJ, Gilmer JF., The aqueous stability of bupropion, Journal of Pharmaceutical and Biomedical Analysis, 53, (3), 2010, p376 - 381 Journal Article, 2010 URL

Breen EC and Walsh JJ, Tubulin-targeting agents in hybrid drugs., Current Medicinal Chemistry, 17, (7), 2010, p609 - 639 Journal Article, 2010 URL

Barlow JW, Walsh JJ., Synthesis and evaluation of dimeric 1,2,3,4-tetrahydro-naphthalenylamine and indan-1-ylamine derivatives with mast cell-stabilising and anti-allergic activity., European Journal of Medicinal Chemistry, 45, (1), 2010, p25 - 37 Journal Article, 2010 URL

Catherine M. Halpin, Ciara Reilly, and John J. Walsh, Nature's Anti-Alzheimer's Drug: Isolation and Structure Elucidation of Galantamine from Leucojum aestivum, Journal of Chemical Education, 87 , (11), 2010, p1242 - 1243 Journal Article, 2010 URL

Walsh JJ and Bell A, Hybrid Drugs for Malaria, Current Pharmaceutical Design, 15(25), 2009, p2970-85 Journal Article, 2009 URL

Sheridan H, Walsh JJ, Jordan M, Cogan C, Frankish N., A series of 1, 2-coupled indane dimers with mast cell stabilisation and smooth muscle relaxation properties., European Journal of Medicinal Chemistry, 44, (12), 2009, p5018 - 5022 Journal Article, 2009 URL

Sheridan H, Walsh JJ, Cogan C, Jordan M, McCabe T, Passante E, Frankish NH, Diastereoisomers of 2-Benzyl-2, 3-dihydro-2-(1H-inden-2-yl)-1H-inden-1-ol: Potent anti-inflammatory agents, Bioorganic & Medicinal Chemistry Letters, 19, 2009, p5927 - 5930 Journal Article, 2009 DOI

Sheridan H, Butterly S, Walsh JJ, Cogan C, Jordan M, Nolan O, Frankish N, Synthesis and pharmacological activity of aminoindanone dimers and related compounds, Bioorganic and Medicinal Chemistry, 16, (1), 2008, p248 - 254 Journal Article, 2008 URL

Barlow JW, Walsh JJ, Synthesis and evaluation of 4-amino-3,4-dihydro-2H-naphthalen-1-one derivatives as mast cell stabilising and anti-inflammatory compounds, European Journal of Medicinal Chemistry, 43, (12), 2008, p2891 - 2900 Journal Article, 2008 URL

Douglas RH, Muldowney CA, Mohamed R, Keohane F, Shanahan C, Kavanagh PV, Walsh JJ, Detection and quantification of valerenic acid in commercially available valerian products, Journal of Chemical Education, 84, (5), 2007, p829 - 831 Journal Article, 2007 URL

Walsh JJ, Coughlan D, Heneghan N, Gaynor C, Bell A, A novel artemisinin-quinine hybrid with potent antimalarial activity, Bioorganic and Medicinal Chemistry Letters, 17, (13), 2007, p3599 - 3602 Journal Article, 2007 URL

Walsh JJ, Coughlan D, Heneghan N, Gaynor C, Bell A., A novel artemisinin-quinine hybrid with antimalarial activity., 11th International Congress of Parasitology, Glasgow, Aug, 2006 Meeting Abstract, 2006

Kavanagh PV, McCarthy S, Walsh JJ, Identification and quantitation of lovastatin in red yeast rice, 12th International symposium on separation sciences, Lipica, Slovenia, Sept 27-29, 2006, pp335- Meeting Abstract, 2006

Walsh JJ, Treacy S, Dunne A, Kavanagh PV, A Simple Method For The Identification of Common Herbal/Alternative health products by Gas Chromatography/Mass Spectrometry, 12th International symposium on separation sciences, Lipica, Slovenia, Sept 27-29, 2006, pp334- Meeting Abstract, 2006

White M, Walsh JJ., Sodium Azide: A mild and selective deprotecting reagent for use in the synthesis of novel inhibitors of endothelial cell proliferation, Fifth interdisciplinary euroconference on angiogenesis, Sitges, Spain , May 27-30, 2005, pp114- Meeting Abstract, 2005

Byrne A, Walsh JJ, Studies on the Mast cell stabilising properties of plant extracts with reputed anti-inflammatory activity, 34th meeting of the European histamine research society, Bled, Slovenia, 2005 May 11-14, 2005, pp7- Meeting Abstract, 2005

Mills C, Cleary BJ, Gilmer JF, Walsh JJ, Inhibition of acetylcholinesterase by Tea Tree oil, Journal Of Pharmacy and Pharmacology, 56, (3), 2004, p375 - 379 Journal Article, 2004 URL

Byrne A, Donnelly C, Mills C, Walsh JJ, A study on the mast cell stabilising properties of Sargentodoxa cuneata, 33rd annual meeting of theEuropean histamine research society, Düsseldorf / Köln, Germany, Apr 28-May2, 2004, pp29- Meeting Abstract, 2004

Walsh JJ, McCormack EM, Shah R, Endothelium as a target in the design of novel tumour vasculature targeting agents, Anticancer Research: Special edition, 24, 2004, p527 - 528 Journal Article, 2004

Doyle AM, Reilly J, Murphy N, Kavanagh PV, O'Brien JE, Walsh MS, Walsh JJ, Nature's sedative: Isolation and structural elucidation of valtrate from Centranthus ruber, Journal Of Chemical Education, 81, (10), 2004, p1486 - 1487 Journal Article, 2004 URL

Screening for aminopeptidase inhibitors using silica gel thin layer chromatography, Hudson GJ, Ryan EP, Walsh JJ, British Microcirculation Society, 41st Scientific meeting and symposium: Tumour microcirculation: Development and Therapeutic targets, Sheffield, Apr 5-6, 2004, pp37- Meeting Abstract, 2004

Simplício AL, Gilmer JF, Frankish N, Sheridan H, Walsh JJ, Clancy JM., Ionisation characteristics and elimination rates of some aminoindanones determined by capillary electrophoresis, Journal of Chromatography A, 1045, (1/2), 2004, p233 - 238 Journal Article, 2004 URL

Cunningham D, Grayson DH, McArdle P, Walsh JJ, The bromination of (-)-camphorquinone, Tetrahedron-Asymmetry, 14, (9), 2003, p1197 - 1200 Journal Article, 2003 URL

Carolan JC, Hook ILI, Walsh JJ, Hodkinson TR, Using AFLP markers for species differentiation and assessment of genetic variability of in vitro-cultured Papaver bracteatum (section Oxytona), In Vitro Cellular & Developmental Biology-Plant, 38, (3), 2002, p300 - 307 Journal Article, 2002 URL

Walsh JJ, Frankish NF, Sheridan H, Byrne W, Jordan M, Indane compounds and their pharmaceutical use, 2002, US6433021 Patent, 2002

Walsh JJ, Frankish NF, Sheridan H, Byrne W, Indane dimer compounds with smooth muscle relaxing and/or mast cell stabilising and/or anti-inflammatory activity, 2002, US6423752 Patent, 2002

Walsh JJ, Frankish NF, Sheridan H, Byrne W. Farrell R, Indane dimer compounds and their pharmaceutical use, 2001, US6300376 Patent, 2001

Walsh JJ, Frankish NF, Sheridan H, Byrne W, Indane compounds with smooth muscle relaxing and/or mast cell stabilising and/or anti-inflammatory activity, 2001, US6297399 Patent, 2001

Walsh JJ, Walsh MS, Ni Bhrangain S, Kavanagh PV and Feely J, Red Valerian-Nature's Sedative, Irish Journal of Medical Science, 168, (141), 1999, p143- Journal Article, 1999

Comey N, Hook I, Sheridan H, Walsh J, James P., Isolation of (S)-(-)-2,3-dihydro-2,6-dimethyl-4H-benzopyran-4-one from roots of Leontopodium alpinum, Journal of Natural Products., 60, (2), 1997, p148 - 148-149 Journal Article, 1997 URL

Walsh JJ, Hook I, Kavanagh P, Reininger R., Naphthoquinone production by cultures of cape sundew (Drosera capensis), Pharmacy/Pharmacoloy Letters, 7, 1997, p93 - 95 Journal Article, 1997

Davis AP, Menzer S, Walsh JJ. , Steroid-based receptors with tunable cavities; A series of polyhydroxylated macrocycles of varying size and flexibility, Chemical Communications , 1996, p453 - 456 Journal Article, 1996 URL

Davis AP, Walsh JJ., Steroid-based receptors with tunable cavities; Stepwise and direct syntheses of a C-3-symmetrical prototype, Chemical Communications, 1996, p449 - 451 Journal Article, 1996 URL

Davis AP, Walsh JJ, Amide bond formation via pentafluorothiophenyl active esters, Tetrahedron Letters, 35, (27), 1994, p4865 - 4868 Journal Article, 1994 URL

Non-Peer-Reviewed Publications

C Ehrhardt, S Nickel, MA Selo, CG Clerkin, JJ Salomon, B Talbot, JJ Walsh, OCTN1-mediated ergothioneine uptake protects lung epithelial cells from tobacco smoke-induced damage, FASEB J, Experimental Biology Meeting 2015, Boston, MA, 28/03-01/04/2015, 29, 2015, pp970.7 Meeting Abstract, 2015

Research Expertise

Description

Drug discovery, Assay development, Tumour Angiogenesis, Tumour Vasculature, Endothelial cells, Tubulin, Proteases, Integrins, Vascular Endothelial Growth Factor, Allergies, Mast cells, Basophils, Histamine, Malaria, Natural Products, Herbal Medicinal Products. Research students supervised: PhD graduates: Dr James Barlow (Jan 2003); Dr Emmet McCormack (Apr 2003); Dr Richard Shah (Apr 2003); Dr Adam Byrne (Jun 2007); Dr Gillian Hudson (Jun 2007); Dr Martina White (Sept 2008); Dr Tao Zhang (February 2010); Dr Orla Woods, (December 2010); Dr Paul O'Byrne (Conjoint with JG), (December 2010); Dr Deirdre Finn, (October 2011), Dr Elaine Breen (December 2012), Dr Ekatherine Prokopiou (Conjoint with SR) (January 2013), Dr Gary Stack (July 2013), Dr Adrian Coogan (August 2013). MSc students supervised: Sharon Butterly Jun 1998 (Conjoint with NF); Aengus McHugh (Apr 2007); William Casey, (November 2010); Miriam Holohan (October 2011).

Projects

  • Title
    • Development of Dual Inhibitors of Tumour Angiogenesis/Vasculature
  • Funding Agency
    • Enterprise Ireland
  • Date From
    • Oct 2008
  • Date To
    • Sept 2011
  • Title
    • Pre-clinical Development of Novel Anti-allergic Compounds
  • Funding Agency
    • Enterprise Ireland
  • Date From
    • Oct 2004
  • Date To
    • Mar 2009
  • Title
    • Design of Tumour Homing Vasculature Targeting Agents
  • Funding Agency
    • Irish Research Council for Science Engineering and Technology
  • Date From
    • 01-10-2008
  • Date To
    • 30-09-2011
  • Title
    • Design of Hybrid-based Tumour Homing Anti-angiogenesis Agents
  • Funding Agency
    • Irish Research Council for Science Engineering and Technology
  • Date From
    • 01-10-2008
  • Date To
    • 30-09-2011
  • Title
    • Studies on Novel Mast Cell Stabilising Compounds
  • Funding Agency
    • Irish Research Council For Science Engineering and Technology
  • Date From
    • 01-10-2008
  • Date To
    • 30-09-2009
  • Title
    • Synthesis and evaluation of tunable cyclolactams for antimalarial therapy
  • Summary
    • In collaboration with Dr Aongus Bell, Department of Microbiology, TCD: PC/2003/013: Proof of Concept
  • Funding Agency
    • Enterprise Ireland
  • Date From
    • Jan. 2004
  • Date To
    • Apr. 2005
  • Title
    • Endothelium as a Target in the Design of Novel Anti-cancer agents
  • Summary
    • T05009
  • Funding Agency
    • Cancer Research Ireland
  • Date From
    • Oct. 2003
  • Date To
    • Sept. 2006
  • Title
    • Pre-clinical Development of Novel Anti-allergic Compounds
  • Summary
    • Allergy Research: IF/2001/014: Research Innovation Fund.
  • Funding Agency
    • Enterprise Ireland
  • Date From
    • Dec 2001
  • Date To
    • Apr. 2004
  • Title
    • Discovery of Novel Anti-cancer compounds
  • Summary
    • HE/98/249: Applied Research Grant
  • Funding Agency
    • Enterprise Ireland
  • Date From
    • Oct. 1998
  • Date To
    • Mar. 2001

Keywords

ALLERGY; ASSAY; BASOPHILS; DRUG DISCOVERY; ENDOTHELIAL CELLS; HISTAMINE; MALARIA; MAST-CELLS; NATURAL PRODUCT SYNTHESIS; PROTEASES; VASCULAR ENDOTHELIAL GROWTH FACTOR (VEGF)

Recognition

Awards and Honours

Henkel Award (Organic Chemistry)

Memberships

Phytochemical Society of Europe 1998 – to date

European Histamine Research Society 2002 – to date