Ingrid Hook
Adjunct Associate Professor, School Office - Pharmacy & Pharmceut Sci

Publications and Further Research Outputs

Peer-Reviewed Publications

Hook, Ingrid L. I., Danggui to Angelica sinensis root: Lost in translation? Are potential benefits of a TCM lost to European women? A review, Journal of Ethnopharmacology, 2014 Journal Article, 2014 TARA - Full Text

Sheridan H, Nestor C, O'Driscoll L, Hook I., Isolation, structure elucidation, and cytotoxic evaluation of furanonaphthoquinones from in vitro plantlets and cultures of Streptocarpus dunnii., J Nat Prod., 71, (1), 2011, p82 - 85 Journal Article, 2011 DOI TARA - Full Text URL

H Sheridan, I Hook, J Coppins, C Nestor, C Ehrhardt, N Frankish, Inhibition of LFA-1 mediated T-cell motility by naphthoquinones, Planta Med, 74, (11), 2008, p1383-1387 Journal Article, 2008 DOI

Carolan J, Hook I, Chase M, Kadereit J, Hodkinson T, Phylogenetics of Papaver and related genera based on DNA sequences from ITS nuclear ribosomal DNA and plastid trnL Intron and trn-L -F intergenetic spacers, Annals of Botany, 98, (1), 2006, p141-155 Journal Article, 2006 DOI

Carolan, J.C., Hook, I.L.I., Chase, M.W., Kadereit, J.W., Hodkinson, T.R, Phylogenetics of Papaver and Related Genera Based on DNA Sequences from ITS Nuclear Ribosomal DNA and Plastid trnL Intron and trnL-F Intergenic Spacers, Annals of Botany, 98, (1), 2006, p141 - 155 Journal Article, 2006 DOI

Paclitaxel content of Yews in Ireland in, Medicinal and Aromatic Plants, Industrial Profiles - Taxus, London, Taylor & Francis,, 2003, [Hook I, Dempsey D.] Book Chapter, 2003

Hook I, Dempsey D, O'Flaherty K. , Taxus species - morphological and chemical variations in needles and seed, Proc. of 4th Intl. Conifer Conference, 4th Intl. Conifer Conference, Wye College, Univ. of London, Wye, Kent, International Society for Horticultural Science, 2003, pp223-231 Conference Paper, 2003 URL

Hook I, Ryan S, Sheridan H. , Biotransformation of aliphatic and aromatic ketones, including several monoterpenoid ketones and their derivatives by five species of marine microalgae, Phytochemistry, 63, (1), 2003, p31 - 36 Journal Article, 2003 DOI

Carolan ,J.C., Hook, I.L.I., Walsh, J.J., Hodkinson, T.R., Using AFLP markers for species differentiation and assessment of genetic variability of in vitro cultured Papaver bracteatum (Section Oxytona'), Vitro Cellular and Developmental Biology - Plant, 38, (3), 2002, p300-307 Journal Article, 2002 DOI

Using AFLP markers for species differentiation and assessment of genetic variability of in vitro cultured Papaver bracteatum (Section Oxytona) in, Vitro Cellular and Developmental Biology - Plant, 2002, pp300-307 , [Carolan J, Hook I, Walsh JJ, Hodkinson T.] Book Chapter, 2002 DOI

Hook, I., Naphthoquinone contents of in vitro cultured plants and cell suspensions of Dionaea muscipula and Drosera species, Plant Cell, Tissue and Organ Culture, 67, (3), 2001, p281-285 Journal Article, 2001 DOI

Transgenic Leontopodium (Edelweiss) in, Y.P.S. Bajaj , Biotechnology in Agriculture and Forestry, Berlin, Heidelberg, Springer-Verlag, 2001, pp221-236. , [Hook I, Sheridan H.] Book Chapter, 2001

Poupat C, Ahond A, Hook I, et al., Neutral and basic taxoid contents in needles of Taxus species, Planta Medica, 66, (6), 2000, p580-584 Journal Article, 2000 DOI

Comer, N., Grey, A.I., Hook, I.L., James, P., Sheridan, H., Erratum: Sesquiterpenes from Leontopodium alpinum (Phytochemistry (1999) 50 (1057-1060) PII: S0031942298006256) , 2000, - 551 Miscellaneous, 2000

Dempsey D, Hook I., Yew (Taxus) species - chemical and morphological variations, Pharmaceutical Biology, 38, (4), 2000, p274-280 Journal Article, 2000 DOI

Comey N, Grey A, Hook I, James P, Sheridan H. , Sesquiterpenes from Leontopodium alpinum., Phytochemistry, 50, (6), 1999, p1057 - 1060 Journal Article, 1999 DOI

Hook I, Ryan S, Sheridan H. , Biotransformation of aromatic aldehydes by five species of marine microalgae, Phytochemistry, 51, (5), 1999, p621 - 627 Journal Article, 1999 DOI

Hook I, Poupat C, Ahond A, et al., Seasonal variation of neutral and basic taxoids in shoots of european yew (Taxus baccata), Phytochemistry, 52, (6), 1999, p1041-1045 Journal Article, 1999 DOI

I Hook., D Dempsey & C Poupat, A Ahond, et al , ICSN/CNRS, Gif-sur-Yvette Cedex, , Seasonal variation of neutral and basics taxoids in shoots of Taxus baccata var fastigiata growing in Ireland, Phytochemical Society of Europe & French Pharmacognosy Association, International Symposium on Antitumour Products from Higher Plants, Paris, France, 1998 Conference Paper, 1998

Hook, I. Reininger, Naphthoquinone production by Drosera capensis cell cultures, Gesellschaft fur Arzneipflanzeforschung, , Regensburg., 1997 Conference Paper, 1997

Comey N, Hook I, Sheridan H, Walsh J. , Isolation of (S)-(-)-2,3-dihydro-2,6-dimethyl - 4H-benzopyran-4-one from roots of Leontopodium alpinum, Journal Of Natural Products (Lloydia) , 60, (2), 1997, p148-149 Journal Article, 1997 DOI

Comey N, Sheridan H, Hook I, Influence of inulin, culture medium and light on the growth and essential oil content of Edelweiss hairy roots., Proceedings of the 27th ISEO Meeting, 27th ISEO Meeting, Vienna, Allured Publishing Corporation, 1997, pp116-119 Conference Paper, 1997

Hook I, Walsh J, Kavanagh P, Reininger R., Naphthoquinone production by cultures of Cape Sundew (Drosera capensis), Pharmaceutical and Pharmacological Letters , 7, (2-3), 1997, p93-95 Journal Article, 1997

Griffin J., Hook I. , Taxol content of irish yews, Planta Medica, 62, (4), 1996, p370 - 372 Journal Article, 1996 DOI

The microscopic structure of Leontopodium alpinum (Edelweiss) in, editor(s)PDS Caligari & DJN Hind , Compositae: Biology & Utilization, 1996, pp383-392 , [Hook I, Reid C.] Book Chapter, 1996

Papaver bracteatum Lindley (Giant Scarlet Poppy): In vitro production of benzophenanthridine alkaloids in, editor(s)Y.P.S. Bajaj , Biotechnology in Agriculture and Forestry, Berl, Springer-Verlag, 1994, [Hook I. ] Book Chapter, 1994

Taraxacum officinale Weber (Dandelion): In vitro culture, micropropagation and production of volatile metabolites in, Y.P.S. Bajaj , Biotechnology in Agriculture and Forestry, Berlin, Heidelberg, Springer-Verlag , 1994, pp357 - 369 , [Hook I. ] Book Chapter, 1994

Hook, I., & Comey, N. & Sheridan, H., Essential oil of Edelweiss, Leontopodium alpinum, 25th International Symposium on Essential Oils, Grasse., 1994 Conference Paper, 1994

Hook I. , Secondary metabolites in "hairy" roots cultures of Leontopodium alpinum Cass. (Edelweiss)., Plant Cell, Tissue and Organ Culture , 38, (2-3), 1994, p321-326 Journal Article, 1994 DOI

Hook, I. & Griffin, J., Variation of taxol content in Taxus species growing in Ireland, VIIe Colloque Internationale consacre aux Plantes Medicinales et Substances d'origine Naturelle, , Angers, 1993 Conference Paper, 1993

Hook I, McGee A, Henman M. , Evaluation of Dandelion for diuretic activity and variation in potassium content, International Journal of Pharmacognosy, 31, (1), 1993, p29 - 34 Journal Article, 1993 DOI

Leontopodium alpinum Cass: In vitro culture, micropropagation and the production of secondary metabolites in, editor(s)Y.P.S. Bajaj , Biotechnology in Agriculture and Forestry, Berlin, Heidelberg, Springer-Verlag, 1993, pp217-232 , [Hook I.] Book Chapter, 1993

Hook I, Reid C. , Effect of adrenochrome on the root hair formation of P. somniferum L., Proceedings of the Royal Microscopical Society, 17, (6), Royal Microscopical Society, 1992, pp18-19 Conference Paper, 1992

Lecky R, Hook I, Sheridan H., Enhancement of dihydrosanguinarine production in suspension cultures of Papaver bracteatum, I Medium modifications, Journal Of Natural Products (Lloydia) , 55, (10), 1992, p1513 - 1517 Journal Article, 1992

Canning A-M, Hook I, Sheridan H. , Bisradicinin: a novel dimmer elicited in cultures of Alternaria chrysanthemi, Journal Of Natural Products (Lloydia) , 55, (4), 1992, p487 - 490. Journal Article, 1992

Mockler, U., Hook, I., Rogers, D., Lectins from marine microalgae, Planta Medica, 58, ((7 SUPPL.)), 1992, pA657 Journal Article, 1992

Comey, N., Hook, I., Sheridan, H., Enhancement of anthocyanin production in cell cultures and hairy roots of Leontopodium alpinum , Planta Medica , 58, ((7 SUPPL.)), 1992, A605-A606 Journal Article, 1992

Hook I, Sheridan H, Wilson G., Volatile metabolites from suspension cultures of Taraxacum officinale, Phytochemistry , 30, (12), 1991, p3977 - 3979 Journal Article, 1991 DOI

Hook I., Pharmaceuticals from Plant Tissue Cultures , Journal of Biomedical Science, 1, (4), 1991, p193 - 203 Journal Article, 1991

Hook I, Lecky R, McKenna B, Sheridan H., Biotransformation of linalyl acetate by suspension cultures of Papaver bracteatum, Phytochemistry, 29, (7), 1990, p2143 - 2144 Journal Article, 1990 DOI

Hook, I., Sheridan, H., Wilson, G., Volatile metabolites with 'apple' odour from suspension cultures of Taraxacum officinale , Planta Medica, 56, (6), 1990, p627-628 Journal Article, 1990 DOI

Hennessy D, Hook I, Sheridan H, McGee A., Hydroxycinnamic acid esters from cell suspension cultures and plants of Leontopodium alpinum, Phytochemistry , 28, (2), 1989, p489 -490 Journal Article, 1989 DOI

Hook I, Sheridan H, Wilson G., Alkaloids of cell cultures derived from strains of Papaver bracteatum, Phytochemistry, 27, (7), 1988, p2137 - 2141 Journal Article, 1988 DOI

Hook, I., Hennessy, D. & Sheridan, H., Tissue culture of L. alpinum, Gesellschaft fur Arzneipflanzeforschung,, Leiden, 1987 Conference Paper, 1987

Hook I. , Administration sets for intravenous fluids used in the Republic of Ireland, International Journal of Pharmaceutics, 1, 1978, p105 - 120 Journal Article, 1978

Hook, I., Some effects of chlorocholine chloride on Mentha piperita, Planta Med., 24, (3), 1973, 249 -260 Journal Article, 1973

Non-Peer-Reviewed Publications

Hook, I. & Visdal-Johnsen, L., Free radical-scavenging activity of flavonoids from Taxus cell cultures, Phytochemical Society of Europe (Young Scientists), Gargnano. , 2004 Conference Paper, 2004

Hook, I. & Nestor, C., Effect of nitrogen and copper concentrations on plumbagin production in Dionaea muscipula cell cultures, Phytochemical Society of Europe (Young Scientists), Gargnano, 2004 Conference Paper, 2004

Hook, I, Nestor, C., Drosera and Dionaea cell cultures as biotransformants of exogenous substrates, Gargnano, Phytochemical Society of Europe (Young Scientists), 2002 Conference Paper, 2002

Hook, I., Visdal-Johnsen, L. & Hodkinson, T., Diversity of morphological and chemical characteristics of yew species, Phytochemical Society of Europe (Young Scientists), Gargnano., 2002 Conference Paper, 2002

Hook, I., Carolan, J. & Hodkinson, T., Systematics and phytochemical analysis of the genus Papaver Section Oxytona (=Macrantha), World Conference on Medicinal and Aromatic Plants, Budapest, 2001 Conference Paper, 2001

Hook, I., Comey, N. & Sheridan, H., Phytochemical evaluation of roots from cultivated L alpinum, Irish Botanists Meeting, University College Dublin, 2001 Conference Paper, 2001

Hook, I., Kilmartin, L. & Hodkinson, T., Molecular systematics and chemical characterization of Taxus and related genera, World Conference on Medicinal and Aromatic Plants, Budapest, 2001 Conference Paper, 2001

Hook, I. & Dempsey, D., Factors affecting paclitaxel yields in rooted Taxus cuttings, International Congress and 49th Annual; Meeting of the Society for Medicinal Plant Research (Gesellschaft fur Arzneipflanzeforschung), Erlangen, 2001 Conference Paper, 2001

Hook, I. & Chiu, P., Antitussive activity of extracts of in vitro cultured Drosera species, Gesellschaft fur Arzneipflanzeforschung, Zurich, 2000 Conference Paper, 2000

I Hook, J Carolan, T Hodkinson, In vitro culture of Papaver bracteatum: Systematics of the Section Oxytona, Irish Botanists Meeting , UCC, 2000 Conference Paper, 2000

Hook, I. & Bristow, S., Extra strong mints-is there a risk, National Scientific Medical Meeting , Royal College of Physicians, Dublin, 2000 Conference Paper, 2000

Hook, I., Kilmartin, L. & Hodkinson, T., Molecular systematics and chemical characterization of Taxus and related genera, Irish Botanists Meeting , UCC, 2000 Conference Paper, 2000

Hook, I. & Dempsey, D., Morphological and chemical variations in Taxus species, Gesellschaft fur Arzneipflanzeforschung, Vienna., 1998 Conference Paper, 1998

Hook, I., Don't tan your hide-use sunscreens, Irish Pharmacy Journal , 76, (5), 1998, p124 - 126 Journal Article, 1998

Hook, I., O'Flahert K. & Dempsey, D., Taxus species - variation in morphology and chemical constituents, 4th International Conifer Conference, Wye College, University of London, Wye, Kent, 1998 Conference Paper, 1998

I Hook, J Walsh, P Kavanagh, & R Reininger, Naphthoquinone production by cultures of Drosera capensis and Drosera rotundifolia, Royal Society of Chemistry (TCD Meeting) Drugs from Natural Products., Trinity College Dublin, 1998 Conference Paper, 1998

Hook, I., O'Shea, S., O'Shea, D.G. & Kieran, P., Characterization of suspension cultures of Drosera capensis, 2nd European Symposium on Biochemical Engineering Science, Porto, 1998 Conference Paper, 1998

I Hook, D Dempsey, C Poupat, A Ahond, et al ICSN/CNRS, Gif-sur-Yvette Cedex, Variation of neutral and basic taxoids in Taxus (Yew), Royal Society of Chemistry (TCD Meeting) Drugs from Natural Products. , Trinity College Dublin, 1998 Conference Paper, 1998

Hook, I., & Paper, D., Evaluation for antiangiogenic activity of the mucin separated from Drosera capensis suspension cultures, Bioassay Methods in Natural Product Research and Drug Development, Uppsala, 1997 Conference Paper, 1997

Hook, I. & paper, D., Sugar composition of the mucin produced by Drosera capensis cell cultures, Gesellschaft fur Arzneipflanzeforschung, University of Regensburg, Prague., University of Regensburg, 1996 Conference Paper, 1996

Hook, I., Modern Wound Dressings, Irish Pharmacy Journal, 74, (1), 1996, p17 - 20 Journal Article, 1996

Hook, I., Comey, N. & Sheridan, H., Effect of inulin as carbon source on growth and essential oil content of Edelweiss hairy roots, 27th International Symposium on Essential Oils, Vienna, Austria, 1996 Conference Paper, 1996

Hook, I. & Paper, D., Mucin Production by suspension cultures of Drosera capensis, Herba Drosera - Botanik Analytik Workshop, University of Regensburg, Inhalstoffe, Vienna, 1995 Conference Paper, 1995

Hook, I., Comey, N., James, P. & Sheridan, H., A 2,3- dihydrochromone from the essential oil of edelweiss, Royal Society of Chemistry (TCD Meeting) Drugs from Natural Products. , Trinity College Dublin, 1994 Conference Paper, 1994

Hook, I., Secondary metabolites from "hairy" roots of Leontopodium alpinum, 3rd Workshop on Primary and Secondary Metabolism of plants and plant cell cultures, Leiden, 1993 Conference Paper, 1993

Hook, I., Secondary metabolites from hairy roots of L. alpinum, Plant Biotechnology-Dublin Group meeting , Trinity College Dublin, 1993 Conference Paper, 1993

Hook, I., Essential oil from transformed (hairy) roots of Edelweiss, 12th International Congress of Flavours, Fragrances and Essential Oils, Vienna, 1992 Conference Paper, 1992

Hook, I. & Ryan, S., Bioconversion of organic substrates by marine microalgae, Plant Biotechnology - Dublin Group meeting , University College Dublin, 1992 Conference Paper, 1992

Hook, I., Comey, N. & Sheridan, H., Essential oil from roots of Edelweiss, Leontopodium alpinum, 23rd International Symposium on Essential Oils, Ayr, Scotland, 1992 Conference Paper, 1992

Hook, I. Ryan, S. & Sheridan, H., Biotransformation of exogenous organic substrates by marine microalgae, European Marine Biology Symposium, Trinity College Dublin, 1992 Conference Paper, 1992

Hook, I. & U Mockler, Effect of alpha-radiation on marine microalgae, European Marine Biology Symposium, TCD, Dublin., 1992 Conference Paper, 1992

Hook, I., Sheridan, H. & Waldren, S., Preliminary phytochemical evaluation of Nesocodon mauritianus, Irish Botanists Meeting, University College Dublin, 1991 Conference Paper, 1991

Hook, I. & Sheridan, H., Tissue culture and micropropagation of the fern Onychium japonicum, Plant Biotechnology-Dublin Group meeting , Maynooth, Ireland, 1991 Conference Paper, 1991

Hook, I. & McCullagh, H., Preliminary investigations of tissue cultures from Vinca major, Plant Biotechnology-Dublin Group meeting , Maynooth, Ireland, 1990 Conference Paper, 1990

Hook, I., & Kinsealy, AFT., Biotechnological potential of marine microalgae, Plant Biotechnology-Dublin Group meeting, 1990 Conference Paper, 1990

Hook, I., Sheridan, H. & Wilson, G., Production of volatile metabolites by tissue cultures of Taraxacum officinale, Gesellschaft fur Arzneipflanzeforschung, Bonn, 1990 Conference Paper, 1990

Hook, I., Lecky, R. & Sheridan, H., Biotransformation of exogenously applied terpenes by cell suspension culture of P bracteatum, Irish Botanists Meeting , Trinity College Dublin, 1989 Conference Paper, 1989

Hook, I. & Falvey, G., Inhibition of growth by Papaver somniferum by catecholamaines, morphine & verapamil, International Congress of Pharmaceutical Sciences (F.I.P.), Vienna., 1989 Conference Paper, 1989

Hook, I., Lecky, R. & Sheridan, H., Biotransformation of exogenously applied substrates by cell suspension cultures of P bracteatum, SEB International Symposium, King's College London, Phytochemical Society of Europe, 1988 Conference Paper, 1988

Hook, I., Lecky, R. & Sheridan, H., Biotransformation of substrates by plant cell cultures, Plant Biotechnology - Dublin Group meeting , Trinity College Dublin, 1988 Conference Paper, 1988

Hook, I. & Hennessy, D., Tissue culture of L. alpinum, Plant Biotechnology - Dublin Group meeting, University College Dublin, 1987 Conference Paper, 1987

Hook, I. & Kinsealy, AFT, Enhancement of alkaloid production by tissue cultures of P. bracteatum, Plant Biotechnology - Dublin Group meeting, 1987 Conference Paper, 1987

Hook, I., Problems associated with tissue cultures of P. bracteatum, Plant Biotechnology-Dublin Group meeting , Maynooth, Ireland, 1985 Conference Paper, 1985

Hook, I., McGee, A. & Henman, M., Taraxacum officinale-its tissue culture and diuretic activity, Gesellschaft fur Arzneipflanzeforschung, Regensburg, 1985 Conference Paper, 1985

Hook, I., Quality control of Disposable Incontinence Products available in Ireland - I, Journal of the Irish Pharmaceutical Union , 8, (2), 1983, p64,66,67,69,71. Journal Article, 1983

Hook, I., Protecting the skin from sunlight., Irish Pharmacy Journal, 61, (5), 1983, p162-4,166-9,171. Journal Article, 1983

Hook, I., Essential polyunsaturated fatty acids, Irish Pharmacy Journal , 61, (2), 1983, p44-6,48,51,54. Journal Article, 1983

Hook, I. & Reid, C., Effect of calcium antagonists on plant growth and structure, Phytochemical Society of Europe, Toulouse, 1983 Conference Paper, 1983

Hook, I., Quality control of Disposable Incontinence Products available in Ireland - II, Journal of the Irish Pharmaceutical Union , 8, (2), 1983, p71,72,74. Journal Article, 1983

Hook, I., Sunscreens and their side effects, 1981, - 161 Miscellaneous, 1981

Hook, I., Psoralens and Tanning Aids, Journal of the Irish Pharmaceutical Union, 5, (4), 1980, p132-136 Journal Article, 1980

Hook, I., Possible cancer hazard associated with 5-MOP in suntan preparations, 1980, - 1537 Miscellaneous, 1980

Hook, I., Ginseng - A Review, Irish Pharmacy Journal , 57, (12), 1979, p4321-4,5,7 Journal Article, 1979

Hook, I. & Reid, C., Effects of vincristine and vinblastine on seedling root tips, Irish Pharmacy Congress, 1977 Conference Paper, 1977

Hook, I. & Reid, C., Effects of vincristine and vinblastine on seedling root tips, Irish Pharmacy Congress, 1977 Conference Paper, 1977

Hook, I., New problems replace old in intravenous fluid administration, Hospital Formulary (USA), 240, 1975, p343-347 Journal Article, 1975

Research Expertise

Description

Main Research interests
  • Culture and biotechnological aspects of medicinal plants, including Mentha, Papaver, Leontopodium, Taraxacum, Drosera, Dionaea, Ajuga, Taxus, Streptocarpus. This work has focused on the production of secondary metabolites by these plant cell cultures, the optimisation of culture conditions for secondary metabolite production.
  • Micropropagation of dicotyledonous plants, including Agrobacterium rhizogenes-mediated rooting, inducing the production of 'hairy' roots.
Areas of Research Focus
  • Biotechnological development of novel plant cell cultures.
  • Optimisation of secondary metabolite production in plant cell cultures.
  • Metabolic transformation of active natural products in cell culture systems.
  • Induction of de novo metabolite synthesis in plant cell cultures.
Research collaborators and awards
  • Enterprise Ireland (EI)-Industry project
  • EI- Basic research project.
  • EU funding for Taxus research - a multi-centre project.
  • EI-British Council Travel Awards for collection of samples
  • EOLAS Cooperative research award to establish collaboration with CNRS Gif-sur-Yvette Cedex.
Collaborations with:
  • CNRS Gif-sur-Yvette Cedex, France;
  • Dept. of Pharmaceutical Biology, University of Regensburg, Germany;
  • Dept. of Pharmacognosy, University of Vienna, Austria.

Recognition

Awards and Honours

MA (Jure Officii), University of Dublin 1981

Manchester Pharmaceutical Association Prize for Distinction in 4th year BSc (Hons) course 1965

Awarded Membership of Royal Pharmaceutical Society of Great Britain 1965