Emily Hams
Research Fellow, Clinical Medicine

Publications and Further Research Outputs

Peer-Reviewed Publications

Cooke G, Kamal I, Strengert M, Hams E, Mawhinney L, Tynan A, O' Reilly C, O' Dwyer DN, Kunkel SL, Knaus UG, Shields DC, Moller DR, Bowie AG, Fallon PG, Hogaboam CM, Armstrong ME, Donnelly SC., Toll-like receptor 3 L412F polymorphism promotes a persistent clinical phenotype in pulmonary sarcoidosis., QJM, 2018, p217-224 Journal Article, 2018 URL

Mills, E.L. and Ryan, D.G. and Prag, H.A. and Dikovskaya, D. and Menon, D. and Zaslona, Z. and Jedrychowski, M.P. and Costa, A.S.H. and Higgins, M. and Hams, E. and Szpyt, J. and Runtsch, M.C. and King, M.S. and McGouran, J.F. and Fischer, R. and Kessler, B.M. and McGettrick, A.F. and Hughes, M.M. and Carroll, R.G. and Booty, L.M. and Knatko, E.V. and Meakin, P.J. and Ashford, M.L.J. and Modis, L.K. and Brunori, G. and Sévin, D.C. and Fallon, P.G. and Caldwell, S.T. and Kunji, E.R.S. and Chouchani, E.T. and Frezza, C. and Dinkova-Kostova, A.T. and Hartley, R.C. and Murphy, M.P. and O'Neill, L.A., Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1, Nature, 556, (7699), 2018, p113-117 Journal Article, 2018 DOI

Schwartz, C., Hams, E., Fallon, P.G. , Helminth Modulation of Lung Inflammation, Trends in Parasitology, 2018 Journal Article, 2018 TARA - Full Text DOI

Oleszycka E, McCluskey S, Sharp FA, Muñoz-Wolf N, Hams E, Gorman AL, Fallon PG, Lavelle EC., The vaccine adjuvant alum promotes IL-10 production that suppresses Th1 responses., Eur J Immunol., 2018, 705-715 Journal Article, 2018 DOI

Schwartz C, Khan AR, Floudas A, Saunders SP, Hams E, Rodewald HR, McKenzie ANJ, Fallon PG., ILC2s regulate adaptive Th2 cell functions via PD-L1 checkpoint control., The Journal of experimental medicine, 214, (9), 2017, p2507-2521 Journal Article, 2017 DOI

Floudas A, Saunders SP, Moran T, Schwartz C, Hams E, Fitzgerald DC, Johnston JA, Ogg GS, McKenzie AN, Walsh PT, Fallon PG., IL-17 Receptor A Maintains and Protects the Skin Barrier To Prevent Allergic Skin Inflammation., Journal of immunology (Baltimore, Md. : 1950), 199, (2), 2017, p707-717 Journal Article, 2017 DOI

Yang Y, Andersson P, Hosaka K, Zhang Y, Cao R, Iwamoto H, Yang X, Nakamura M, Wang J, Zhuang R, Morikawa H, Xue Y, Braun H, Beyaert R, Samani N, Nakae S, Hams E, Dissing S, Fallon PG, Langer R, Cao Y., The PDGF-BB-SOX7 axis-modulated IL-33 in pericytes and stromal cells promotes metastasis through tumour-associated macrophages., Nature communications, 7, 2016, p11385 Journal Article, 2016 TARA - Full Text DOI

Hams E, Bermingham R, Wurlod FA, Hogan AE, O'Shea D, Preston RJ, Rodewald HR, McKenzie AN, Fallon PG., The helminth T2 RNase "1 promotes metabolic homeostasis in an IL-33- and group 2 innate lymphoid cell-dependent mechanism., FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 30, (2), 2016, p824-835 Journal Article, 2016 DOI

de Kleer IM, Kool M, de Bruijn MJ, Willart M, van Moorleghem J, Schuijs MJ, Plantinga M, Beyaert R, Hams E, Fallon PG, Hammad H, Hendriks RW, Lambrecht BN., Perinatal Activation of the Interleukin-33 Pathway Promotes Type 2 Immunity in the Developing Lung., Immunity, 45, (6), 2016, p1285-1298 Journal Article, 2016 TARA - Full Text DOI

Spence S, Greene MK, Fay F, Hams E, Saunders SP, Hamid U, Fitzgerald M, Beck J, Bains BK, Smyth P, Themistou E, Small DM, Schmid D, O'Kane CM, Fitzgerald DC, Abdelghany SM, Johnston JA, Fallon PG, Burrows JF, McAuley DF, Kissenpfennig A, Scott CJ., Targeting Siglecs with a sialic acid-decorated nanoparticle abrogates inflammation., Science translational medicine, 7, (303), 2015, p303ra140 Journal Article, 2015 DOI

Khan AR, Amu S, Saunders SP, Hams E, Blackshields G, Leonard MO, Weaver CT, Sparwasser T, Sheils O, Fallon PG., Ligation of TLR7 on CD19(+) CD1d(hi) B cells suppresses allergic lung inflammation via regulatory T cells., European Journal of Immunology, 2015 Journal Article, 2015 DOI TARA - Full Text

Hams E, Bermingham R, Fallon PG., Macrophage and Innate Lymphoid Cell Interplay in the Genesis of Fibrosis., Frontiers in immunology, 6, 2015, p597 Journal Article, 2015 TARA - Full Text DOI

Khan AR, Hams E, Floudas A, Sparwasser T, Weaver CT, Fallon PG, PD-L1(hi) B cells are critical regulators of humoral immunity., Nature communications, 6, 2015, p5997 Journal Article, 2015 DOI TARA - Full Text

Barr MP, Gray SG, Gately K, Hams E, Fallon PG, Davies AM, Richard DJ, Pidgeon GP, O'Byrne KJ., Vascular endothelial growth factor is an autocrine growth factor, signaling through neuropilin-1 in non-small cell lung cancer., Molecular Cancer, 14, 2015, p45- Journal Article, 2015

Saunders SP, Moran T, Floudas A, Wurlod F, Kaszlikowska A, Salimi M, Quinn EM, Oliphant CJ, Núñez G, McManus R, Hams E, Irvine AD, McKenzie AN, Ogg GS, Fallon PG, Spontaneous atopic dermatitis is mediated by innate immunity, with the secondary lung inflammation of the atopic march requiring adaptive immunity., Journal of Allergy and Clinical Immunology, 137, (2), 2015, 482-491 Journal Article, 2015 TARA - Full Text DOI

Hams E, Armstrong ME, Barlow JL, Saunders SP, Schwartz C, Cooke G, Fahy RJ, Crotty TB, Hirani N, Flynn RJ, Voehringer D, McKenzie AN, Donnelly SC, Fallon PG, IL-25 and type 2 innate lymphoid cells induce pulmonary fibrosis., Proceedings of the National Academy of Sciences of the United States of America, 111, (1), 2014, p367-72 Journal Article, 2014 DOI TARA - Full Text

Fielding CA, Jones GW, McLoughlin RM, McLeod L, Hammond VJ, Uceda J, Williams AS, Lambie M, Foster TL, Liao CT, Rice CM, Greenhill CJ, Colmont CS, Hams E, Coles B, Kift-Morgan A, Newton Z, Craig KJ, Williams JD, Williams GT, Davies SJ, Humphreys IR, O'Donnell VB, Taylor PR, Jenkins BJ, Topley N, Jones SA, Interleukin-6 signaling drives fibrosis in unresolved inflammation., Immunity, 40, (1), 2014, p40-50 Journal Article, 2014 DOI

Ní Gabhann J, Hams E, Smith S, Wynne C, Byrne JC, Brennan K, Spence S, Kissenpfennig A, Johnston JA, Fallon PG, Jefferies CA., Btk regulates macrophage polarization in response to lipopolysaccharide., PloS One, 21, 2014, pe85834. Journal Article, 2014 TARA - Full Text DOI

Spence, S. and Fitzsimons, A. and Boyd, C.R. and Kessler, J. and Fitzgerald, D. and Elliott, J. and Gabhann, J.N. and Smith, S. and Sica, A. and Hams, E. and Saunders, S.P. and Jefferies, C.A. and Fallon, P.G. and McAuley, D.F. and Kissenpfennig, A. and Johnston, J.A., Retraction Notice to: Suppressors of Cytokine Signaling 2 and 3 Diametrically Control Macrophage Polarization, Immunity, 40, (6), 2014, p1002 Journal Article, 2014 DOI

Oliphant CJ, Hwang YY, Walker JA, Salimi M, Wong SH, Brewer JM, Englezakis A, Barlow JL, Hams E, Scanlon ST, Ogg GS, Fallon PG, McKenzie AN., MHCII-Mediated Dialog between Group 2 Innate Lymphoid Cells and CD4(+) T Cells Potentiates Type 2 Immunity and Promotes Parasitic Helminth Expulsion., Immunity, 41, 2014, p283 - 295 Journal Article, 2014 Other TARA - Full Text

Gleeson, E.M. and O'Donnell, J.S. and Hams, E. and à inle, F.N. and Kenny, B.-A. and Fallon, P.G. and Preston, R.J.S., Activated factor x signaling via protease-activated receptor 2 suppresses pro-inflammatory cytokine production from lipopolysaccharide-stimulated myeloid cells, Haematologica, 99, (1), 2014, p185-193 Journal Article, 2014 DOI

Doyle, SL, Ozaki, E, Brennan, K, Humphries, MM, Mulfaul, K, Keaney, J, Kenna, PF, Maminishkis, A, Kiang, AS, Saunders, SP, Hams, E, Lavelle, EC, Gardiner, C, Fallon, PG, Adamson, P, Humphries, P, Campbell, M, IL-18 Attenuates Experimental Choroidal Neovascularization as a Potential Therapy for Wet Age-Related Macular Degeneration, SCIENCE TRANSLATIONAL MEDICINE, 6, 2014, p230- Journal Article, 2014 TARA - Full Text DOI

Hams, E. and Aviello, G. and Fallon, P.G., The Schistosoma granuloma: Friend or foe?, Frontiers in Immunology, 4, (APR), 2013 Journal Article, 2013 DOI

Hams E, Locksley RM, McKenzie AN, Fallon PG., Cutting edge: IL-25 elicits innate lymphoid type 2 and type II NKT cells that regulate obesity in mice., Journal of Immunology, 191, 2013, p5349 - 5353 Journal Article, 2013 DOI TARA - Full Text

Spence, S. and Fitzsimons, A. and Boyd, C. and Kessler, J. and Fitzgerald, D. and Elliott, J. and Gabhann, J. and Smith, S. and Sica, A. and Hams, E. and Saunders, S. and Jefferies, C. and Fallon, P. and McAuley, D. and Kissenpfennig, A. and Johnston, J., Suppressors of Cytokine Signaling 2 and 3 Diametrically Control Macrophage Polarization, Immunity, 39, (1), 2013, p196-197 Journal Article, 2013 DOI

Scholz CC, Cavadas MA, Tambuwala MM, Hams E, Rodríguez J, von Kriegsheim A, Cotter P, Bruning U, Fallon PG, Cheong A, Cummins EP, Taylor CT, Regulation of IL-1ß-induced NF-"B by hydroxylases links key hypoxic and inflammatory signaling pathways., Proceedings of the National Academy of Sciences of the United States of America, 110, (46), 2013, p18490-5 Journal Article, 2013 DOI TARA - Full Text

Spence, S. and Fitzsimons, A. and Boyd, C.R. and Kessler, J. and Fitzgerald, D. and Elliott, J. and Gabhann, J.N. and Smith, S. and Sica, A. and Hams, E. and Saunders, S.P. and Jefferies, C.A. and Fallon, P.G. and McAuley, D.F. and Kissenpfennig, A. and Johnston, J.A., Suppressors of Cytokine Signaling 2 and 3 Diametrically Control Macrophage Polarization, Immunity, 38, (1), 2013, p66-78 Journal Article, 2013 DOI

Hams E, Fallon PG., Innate type 2 cells and asthma. , Curr. Opin. Pharmacol., 12, 2012, p503 - 509 Review Article, 2012 DOI

Mellett M, Atzei P, Horgan A, Hams E, Floss T, Wurst W, Fallon PG, Moynagh PN., Orphan receptor IL-17RD tunes IL-17A signalling and is required for neutrophilia., Nat Commun, 3, 2012, p1119 Journal Article, 2012 DOI

Young A, Linehan E, Hams E, O'Hara Hall AC, McClurg A, Johnston JA, Hunter CA, Fallon PG, Fitzgerald DC., Cutting edge: suppression of GM-CSF expression in murine and human T cells by IL-27., J. Immunol., 186, 2012, p2079 - 2083 Journal Article, 2012 DOI

Wong SH, Walker JA, Jolin HE, Drynan LF, Hams E, Camelo A, Barlow JL, Neill DR, Panova V, Koch U, Radtke F, Hardman CS, Hwang YY, Fallon PG, McKenzie AN., Transcription factor RORα is critical for nuocyte development., Nature Immunology, 13, 2012, p229 - 236 Journal Article, 2012 DOI

Hams, E. and Saunders, S.P. and Cummins, E.P. and O'Connor, A. and Tambuwala, M.T. and Gallagher, W.M. and Byrne, A. and Campos-Torres, A. and Moynagh, P.M. and Jobin, C. and Taylor, C.T. and Fallon, P.G., The hydroxylase inhibitor dimethyloxallyl glycine attenuates endotoxic shock via alternative activation of macrophages and IL-10 production by B1 cells, Shock, 36, (3), 2011, p295-302 Journal Article, 2011 DOI

Nel HJ, Hams E, Saunders SP, Mangan NE, Smith P, Atzberger A, Flavell RA, Akira S, McKenzie AN, Fallon PG. , Impaired basophil induction leads to an age-dependent innate defect in type 2 immunity during helminth infection in mice. , Journal of Immunology, 186, (8), 2011, p4631-4639 Journal Article, 2011 URL TARA - Full Text

Hams E, Saunders SP, Cummins EP, O'Connor A, Tambuwala MT, Gallagher WM, Byrne AT, Campos-Torres A, Moynagh PM, Jobin C, Taylor CT, Fallon PG ., The hydroxylase inhibitor DMOG attenuates endotoxic shock via alternative activation of macrophages and IL-10 production by B-1 cells., Shock, 36, (3), 2011, p295-302 Journal Article, 2011 TARA - Full Text

Emily Hams, Mark J. McCarron, Sylvie Amu, Hideo Yagita, Miyuki Azuma, Lieping Chen and Padraic G. Fallon, Blockade of B7-H1 (Programmed Death Ligand 1) Enhances Humoral Immunity by Positively Regulating the Generation of T Follicular Helper Cells , The Journal of Immunology, 186, (10), 2011, p5648-5655 Journal Article, 2011 URL TARA - Full Text

Alexander Ludwig, Grant P. Otto, Kirsi Riento, Emily Hams, Padraic G. Fallon, and Ben J. Nichols, Flotillin microdomains interact with the cortical cytoskeleton to control uropod formation and neutrophil recruitment, Journal of Cell Biology, 191, (4), 2010, p771-781 Journal Article, 2010 TARA - Full Text

Hams, E. and Colmont, C.S. and Dioszeghy, V. and Hammond, V.J. and Fielding, C.A. and Williams, A.S. and Tanaka, M. and Miyajima, A. and Taylor, P.R. and Topley, N. and Jones, S.A., Oncostatin M receptor-β signaling limits monocytic cell recruitment in acute inflammation, Journal of Immunology, 181, (3), 2008, p2174-2180 Journal Article, 2008