Gavin Davey
Associate Professor, Biochemistry
Associate Professor, Trinity Inst. of Neurosciences (TCIN)

Biography

My research interests are in the areas of Neuroscience and Glycobiology, with specific focus on enzymology, metabolic flux, glycosylation, computational & systems biology. My group researches the molecular and cellular mechanisms that underlie neurodegeneration in the brain, in particular, the role that energy metabolism and bioenergetics play in controlling neuronal function and dysfunction. A major goal is to understand how abnormal mitochondrial dynamics control cell loss in Parkinson's disease and other common brain disorders. My group also has interests in drug development and application of our technologies to the development of next-generation biotherapeutics, including bio- and glyco-engineering of recombinant proteins and therapeutic antibodies.

Publications and Further Research Outputs

Peer-Reviewed Publications

Hayes J.M, Wormald M.R, Rudd P.M, Davey G.P, Fc gamma receptors: Glycobiology and therapeutic prospects, Journal of Inflammation Research, 9, 2016, p209 - 219 Journal Article, 2016 DOI URL TARA - Full Text

McDonald AG, Hayes JM, Davey GP, Metabolic flux control in glycosylation., Current opinion in structural biology, 40, 2016, p97-103 Journal Article, 2016 DOI

McDonald AG, Tipton KF, Davey GP, A Knowledge-Based System for Display and Prediction of O-Glycosylation Network Behaviour in Response to Enzyme Knockouts., PLoS computational biology, 12, (4), 2016, pe1004844 Journal Article, 2016 TARA - Full Text DOI

Harte NP, Klyubin I, McCarthy EK, Min S, Garrahy SA, Xie Y, Davey GP, Boland JJ, Rowan MJ, Mok KH, Amyloid Oligomers and Mature Fibrils Prepared from an Innocuous Protein Cause Diverging Cellular Death Mechanisms., The Journal of biological chemistry, 290, (47), 2015, p28343 - 28352 Journal Article, 2015 TARA - Full Text DOI

Hayes JM, Cosgrave EF, Struwe WB, Wormald M, Davey GP, Jefferis R, Rudd PM, Glycosylation and Fc receptors., Current topics in microbiology and immunology, 382, 2014, p165-99 Journal Article, 2014 DOI

McDonald, A.G., Hayes, J.M., Bezak, T., Głuchowska, S.A., Cosgrave, E.F.J., Struwe, W.B., Stroop, C.J.M., Kok, H., van den Lar, T., Rudd, P.M., Tipton, K.F. and Davey, G.P., Galactosyltransferase 4 is a major control point for glycan branching in N-linked glycosylation, Journal of Cell Science, 127, 2014, p5014 - 5026 Journal Article, 2014 TARA - Full Text DOI

Hayes JM, Frostell A, Cosgrave EF, Struwe WB, Potter O, Davey GP, Karlsson R, Anneren C and Rudd PM , Fc gamma receptor glycosylation modulates the binding of IgG Glycoforms - a requirement for stable antibody interactions. , Journal of Proteome Research , (13), 2014, p5471 - 5485 Journal Article, 2014

Davey, G.P., Bolaños, J.P., Peroxiredoxin 5 links mitochondrial redox signalling with calcium dynamics: Impact on Parkinson's disease, Journal of Neurochemistry, 125, (3), 2013, p332-333 Journal Article, 2013 DOI TARA - Full Text

Artemenko, N.V., McDonald, A.G., Davey, G.P., Rudd, P.M., Databases and tools in glycobiology, Methods in Molecular Biology, 899, 2012, p325-350 Journal Article, 2012 DOI

Min S, Meehan J, Sullivan LM, Harte NP, Xie Y, Davey GP, Svanborg C, Brodkorb A, Mok KH, Alternatively folded proteins with unexpected beneficial functions., Biochemical Society transactions, 40, (4), 2012, p746-51 Journal Article, 2012 DOI TARA - Full Text

Burleigh SC, van de Laar T, Stroop CJ, van Grunsven WM, O'Donoghue N, Rudd PM, Davey GP, Synergizing metabolic flux analysis and nucleotide sugar metabolism to understand the control of glycosylation of recombinant protein in CHO cells., BMC biotechnology, 11, 2011, p95 Journal Article, 2011 TARA - Full Text DOI

Tipton KF, Davey GP, McDonald AG, Kinetic behavior and reversible inhibition of monoamine oxidases--enzymes that many want dead., International review of neurobiology, 100, 2011, p43-64 Journal Article, 2011 DOI

Simon J.R. Heales, Adrian Menzes, Gavin P. Davey, Depletion of glutathione does not affect electron transport chain complex activities in brain mitochondria: Implications for Parkinsons's disease and postmortem studies, Free Radical Biology and Medicine, 50, (7), 2011, p899-902 Journal Article, 2011 TARA - Full Text

Seán M Kilbride, Sonia A Gluchowska, Jayne E Telford, Catherine O'Sullivan and Gavin P Davey, High-level inhibition of mitochondrial complexes III and IV is required to increase glutamate release from the nerve terminal, Molecular Neurodegeneration , 6, (53), 2011 Journal Article, 2011 TARA - Full Text

McDonald, A.G., Tipton, K.F., Stroop, C.J., Davey G.P., GlycoForm and Glycologue: two software applications for the rapid construction and display of N-glycans from mammalian sources., BMC Research Notes, 18, (3), 2010, p1-7 Journal Article, 2010 TARA - Full Text

Telford, J.E., Kilbride, S.M., Davey, G.P., Decylubiquinone increases mitochondrial function in synaptosomes, Journal of Biological Chemistry, 285, (12), 2010, p8639-8645 Journal Article, 2010 DOI TARA - Full Text

Nomenclature and Potential Functions of Copper Amine Oxidases in, editor(s)Giovanni Floris and Bruno Mondovi , Copper Amine Oxidases: Structures, Catalytic Mechanisms and Role in Pathophysiology, CRC Press, 2009, [S. Boyce, K. F. Tipton, M. I. O'Sullivan, G. P. Davey, M. Motherway Gildea, A. G. McDonald, A. Olivieri, and J. O'Sullivan] Book Chapter, 2009

Telford, JE, Kilbride SM and Davey GP, Complex I is rate limiting for oxygen consumption in the nerve terminal. , Journal Biological Chemistry, 284, 2009, p9109 - 9114 Journal Article, 2009 TARA - Full Text

Kilbride SM, Telford, JE, Tipton, KF and Davey GP, Partial inhibition of complex I activity increases Ca2+-independent glutamate release rates from synaptosomes. , Journal of Neurochemistry, 106, 2008, p826 - 834 Journal Article, 2008

Upadhyay R and Davey GP , Complex I and energy thresholds in the brain, Biochim Biophys Acta Bioenergetics, 1777, 2008, p777 - 782 Journal Article, 2008 TARA - Full Text

Kilbride SM, Telford JE, Davey GP, Age-related changes in H2O2 production and bioenergetics in rat brain synaptosomes, Biochim Biophys Acta Bioenergetics, 1777, 2008, p783 - 788 Journal Article, 2008 TARA - Full Text

McDonald A, Tipton K, O'Sullivan J, Olivieri A, Davey GP, Coonan AM, Fu W, Modelling the roles of MAO and SSAO in glucose transport, Journal of Neural Transmission, 114, 2007, p783 - 786 Journal Article, 2007

J O'Sullivan, G Davey, M O'Sullivan, KF Tipton, Hydrogen peroxide derived from amine oxidation mediates the interaction between aminosugars and semicarbazide-sensitive amine oxidase, J Neural Transm, 2007 Journal Article, 2007

Keith F Tipton, Gavin Davey, Martha Motherway, Monoamine oxidase assays, Current Protocols in Toxicology, 2006, p4.21.1 - 4.21.42 Journal Article, 2006

O'Sullivan J., Hernandez M., Unzeta M., Tipton K.F. and Davey G.P, Inhibition of semicarbazide sensitive sensitive amine oxidase and adhesion function. , Journal of Neural Transmission, 75, 2006, p105 - 112 Journal Article, 2006

Taurine, taurine analogues, and mitochondrial function and dysfuntion in, Taurine 6, 2006, pp469 - 479, [M Palmi, G Davey, KF Tipton, A Meini] Book Chapter, 2006

O'Sullivan J., O'Sullivan M.I., Tipton K.F. and Davey G.P. , Inhibition of amine oxidases by the histamine-1 receptor antagonist hydroxyzine, Journal of Neural Transmission, 71, 2006, p105 - 112 Journal Article, 2006

O'Sullivan J, Unzeta M, Healy J, O'Sullivan MI, Davey G, Tipton KF, Semicarbazide-sensitive amine oxidases: enzymes with quite a lot to do, Neurotoxicology, 25, 2004, p303 - 315 Journal Article, 2004

Tipton KF, Boyce S, O'Sullivan J., Davey G.P. and Healy J., Monoamine Oxidases: Certainties and Uncertanties, Current Med. Chemistry , 11, 2004, p1965 - 1982 Journal Article, 2004

Farmer MK, Tipton KF and Davey GP, The effects of two salsolinol derivatives on mitochondrial respiration and the likely nature of any endogenous parkinsonism-inducing toxin. In Monoamine Oxidase inhibitors and their role in neurotransmission, In Monoamine Oxidase inhibitors and their role in neurotransmission, 2004, p42 - 55 Journal Article, 2004

Tipton KF, O'Sullivan MI, Davey GP, O'Sullivan J, It can be a complicated life being an enzyme., Biochem Soc Trans, 31, 2003, p711 - 715 Journal Article, 2003

O'Sullivan J, O'Sullivan M, Tipton KF, Unzeta M, Del Mar Hernandez M, Davey GP, The inhibition of semicarbazide-sensitive amine oxidase by aminohexoses, Biochim Biophys Acta., 1647, (1-2), 2003, p367 - 371 Journal Article, 2003

Davey G.P. and Tipton K.F. , Mitochondria, Cell Death and DNA Damage, Radiation Research , (2), 2000, p390 - 394 Journal Article, 2000

Palmi M., Youmbi G., Sgaragli G.P., Meini A., Benocci A., Fusi F., Frosini M., Della Corte L., Davey G. P. and Tipton K.F., Advances in Experimental Medicine and Biology, 483, 2000, p87 - 96 Journal Article, 2000

Tipton K.F., Davey G.P. and Motherway M., Monoamine oxidase assays, Current Protocols in Pharmacology , (2), 1999, p3.61 - 3.6.42 Journal Article, 1999

Davey G.P., Peuchen S. and Clark J.B., Energy thresholds in brain mitochondria: potential involvement in neurodegeneration, Journal of Biological Chemistry , (273), 1998, p12753 - 12757 Journal Article, 1998

Davey G.P., Canevari L and Clark J.B. , Threshold effects in synaptosomal and nonsynaptic mitochondria from hippocampal CA1 and paramedian neocortex brain regions, Journal of Neurochemistry , (69), 1997, p2564 - 2570 Journal Article, 1997

Davey G.P. and Tipton K.F, Chronic ethanol consumption and mitochondrial sensitivity to 1-methyl-4-phenylpyridinium ion (MPP+) inhibition , Biogenic Amine, (12), 1996, p103 - 115 Journal Article, 1996

Bates TE, Strangward M, Keelan J, Davey GP, Munro PM, Clark JB., Inhibition of N-acetylaspartate production: implications for 1H MRS studies in vivo, Neuroreport, 7, (8), 1996, p1397 - 400 Journal Article, 1996

Davey G.P. and Clark J.B, Control of oxidative phosphorylation in non-synaptic rat brain mitochondria. , Journal of Neurochemistry , (66), 1996, p1617 - 1624 Journal Article, 1996

Almeida A, Brooks KJ, Sammut I, Keelan J, Davey GP, Clark JB, Bates TE., Postnatal development of the complexes of the electron transport chain in synaptic mitochondria from rat brain, Dev Neurosci, 17, (4), 1995, p212 - 218 Journal Article, 1995

Davey G.P., Tipton K.F. and Murphy M.P. , Uptake and accumulation of 1-methyl-4-phenylpyridinium by rat liver mitochondria measured using an ion-selective electrode, Biochemical Journal , (288), 1992, p439 - 443 Journal Article, 1992

Davey G.P., Tipton K.F. and Murphy M.P. , Use of an electrode selective for 1-methyl-4-phenylpyridinium (MPP+) to measure its uptake and accumulation by mitochondria , Journal of Neural Transmission Suppl, (40), 1992, p47 - 45 Journal Article, 1992

Non-Peer-Reviewed Publications

Reprogramming human dermal fibroblasts for the generation of pluripotent stem cells. in, editor(s)Freshney, R.I. , Culture of Animal Cells, a Manual of Basic Technique and Specialized Applications, John Wiley & Sons , 2010, [Sullivan S, Davey GP ] Book Chapter, 2010

McDonald AG, Tipton KF and Davey GP, Mathematical modelling of metabolism., The Biochemist, 2009 Journal Article, 2009

Research Expertise

Description

. Metabolism, Systems Biology & Enzymology: Flux control analysis; mathematical models of cellular metabolic networks and N- and O-linked glycosylation networks in cancer cells, immune cells and neurons; NMR metabolomics. . Glycosylation and Bioprocessing: Glycosyltransferases; CHO cells & recombinant biotherapeutics; metabolism and CHO cell performance; controlling N- and O-linked glycosylation in CHO cells; glycosylation & Fc- FcγR interactions. . Mitochondrial dysfunction: Mitochondrial dysfunction in ageing brain; supercomplex structures; ETC post-translational modifications; neurodegeneration models. . Neuroprotection and Neuroregeneration: Neuronal cell surface glycome; Fc-FcγR interactions in the brain; control of mitochondrial dynamics & Parkinson's disease; stem cell regeneration; drug development; biomarker discovery. . In silico drug design: Computational modelling of cell transporters & and drug design.

Projects

  • Title
    • Advanced Biopharmaceutical Technologies
  • Summary
    • Effect of extractables & leachables on CHO cell metabolism during single use bioprocessing.
  • Funding Agency
    • Science Foundation Ireland
  • Date From
    • 2014
  • Date To
    • 2017
  • Title
    • Training in neurodegeneration, therapeutics intervention and neurorepair
  • Summary
    • Research training of 12 PhD students
  • Funding Agency
    • EU Marie Curie
  • Date From
    • 2013
  • Date To
    • 2017
  • Title
    • Glycoengineering Fc/FcγR interactions
  • Summary
    • Investigation of cell surface glycosylation and glycan interactions that influence immune responses.
  • Funding Agency
    • Saudi Education Ministry
  • Date From
    • 2016
  • Date To
    • 2020
  • Title
    • What is the role for ACAD9 as a neurotherapeutic?
  • Summary
    • A PhD project investigation the role of ACAD9 on nerve terminal mitochondria function in the context of neurodegeneration.
  • Funding Agency
    • Irish Research Council
  • Date From
    • 2013
  • Date To
    • 2017
  • Title
    • Japan - Ireland International Strategic Cooperation Award
  • Summary
    • SFI funded student/academic exchange program with Japanese research institutions.
  • Funding Agency
    • Science Foundation Ireland
  • Date From
    • 2014
  • Date To
    • 2016
  • Title
    • Characterisation of Mitochondrial Proteins in Brain
  • Summary
    • Establishment of mitochondrial proteomics centre in the School of Biochemistry and Immunology.
  • Funding Agency
    • European Union
  • Date From
    • 2006
  • Date To
    • 2010
  • Title
    • Understanding glycosylation systems in the brain
  • Summary
    • An investigation of the dopamine cell surface glycome and regulation of bioenergetics in the context of Parkinson's disease
  • Funding Agency
    • Parkinson's Association of Ireland
  • Date From
    • 2010
  • Date To
    • 2011
  • Title
    • Glycan profiling in rheumatoid arthritis patients and biomarker development for MTX and anti-TNF non-responders
  • Summary
    • 2 PhD research projects investigating the metabolomics, bioenergetics and glycosylation status in PBMCs from RA patients.
  • Funding Agency
    • Croom Arthritis Research Charity
  • Date From
    • 2012
  • Date To
    • 2016
  • Title
    • Mitochondrial fusion dynamics in cancer cells and neurons
  • Summary
    • A PhD research project focussing on confocal imaging of mitochondrial dynamics in cancer cells and neurons
  • Funding Agency
    • Irish Research Council
  • Date From
    • 2007
  • Date To
    • 2010
  • Title
    • Computational Analysis of the Nerve Terminal
  • Summary
    • Systems Biology analysis of the nerve terminal in collaboration with Keith Tipton
  • Funding Agency
    • Science Foundation Ireland
  • Date From
    • 2002
  • Date To
    • 2006
  • Title
    • MITOTOX - Mitochondria and Toxicology
  • Summary
    • In vitro toxicology testing
  • Funding Agency
    • Enterprise Ireland
  • Date From
    • 2001
  • Date To
    • 2003
  • Title
    • Health Research Board Equipment Grant
  • Funding Agency
    • Health Research Board
  • Date From
    • 2000

Keywords

Ageing, stroke, dementia; Alzheimer's disease; Anticancer therapies; Apoptosis, molecular control; Biocomputing; Biomarkers of disease; Bioprocesses; Bioreactors; Brain; CANCER; CANCER CELL-LINE; Catecholamine; Cell reprogramming; Computational Biology; Depression; Enzymology and catalysis; GLYCOBIOLOGY; GLYCOSAMINOGLYCANS; In vitro testing, trial methods; Induced pluripotent stem cells; Mathematical modelling; Metabolism and metabolic diseases; MITOCHONDRIAL COMPLEX I; Mitochondrial fission & fusion mechanisms; MITOCHONDRIAL MONOAMINE-OXIDASE; MITOCHONDRIAL-MEMBRANE POTENTIAL; MITOCHONDRION; Molecular Biology; Multiple Sclerosis; Neurochemistry and neuropharmacology; Neurodegeneration; Neuroimmunology; Neuroinformatics; Neuropharmacology; Neuroscience; Neurotoxicity; Oligosaccharide and polysaccharide biochemistry; OXYGEN FREE-RADICALS; PARKINSONS DISEASE; Stem cells; SYNAPSE; SYNAPTOSOMES

Recognition

Representations

Member of University Council, Trinity College Dublin 2012-2014

Editor EBEC 2008 BBA Bioenergetics 2008

Scientific Advisory Board NIBRT 2013

Awards and Honours

International Conference of Radiation Research conference lecture 1999

European Union Marie Curie Return Grant 1997

European Union Human Capital and Mobility Fellowship 1994-1996

Memberships

The Biochemical Society, The International Society for Neurochemistry, The Irish Society of Toxicology, The European Society for Neurochemistry, The American Society for Neurochemistry, Neuroscience Ireland, The Irish Network of Neural Stem Cell Investigators (INNSI)