Thomas Frodl
Adjunct Professor, Psychiatry

Biography

Positions and Employment 1992-1998 Study of Medicine at Free University of Berlin and University of Munich 1998-2003 Registrar and Senior Registrar in Psychiatry, Dept. Of Psychiatry and Psychotherapy, University Munich, Germany 2003-2004 Senior Registrar in Neurology, Dept. of Neurology, University of Munich 2005-2008 Consultant in General Psychiatry, Dept. of Psychiatry, University of Munich 2004-2008 Senior Lecturer / Assistant Professor, Dept. of Psychiatry, University of Munich 2008- Professor & Chair of Integrated Neuroimaging, Psychiatry, Trinity College, University of Dublin

Publications and Further Research Outputs

Peer-Reviewed Publications

Leonardo Tozzi, Angela Carballedo, Friedrich Wetterling, Hazel McCarthy, Veronica O'Keane, Michael Gill, Derrek Morris, Ciara Fahey, James Meaney, Thomas Frodl, Single Nucleotide Polymorphism of the FKBP5 Gene and Childhood Maltreatment as Predictors of Structural Changes in Brain Areas Involved in Emotional Processing in Depression., Neuropsychopharmacology, 41, 2016, p487-497 Journal Article, 2016 DOI

Mothersill O, Tangney N, Morris D.W, McCarthy H, Frodl T, Gill M, Corvin A, Donohoe G, Further evidence of alerted default network connectivity and association with theory of mind ability in schizophrenia, Schizophrenia Research, 2016 Journal Article, 2016 URL DOI TARA - Full Text

Booij L, Szyf M, Carballedo A, Frey E.-M, Morris D, Dymov S, Vaisheva F, Ly V, Fahey C, Meaney J, Gill M, Frodl T, DNA methylation of the serotonin transporter gene in peripheral cells and stress-related changes in hippocampal volume: A study in depressed patients and healthy controls, PLoS ONE, 10, (3), 2015, p011906- Journal Article, 2015 URL DOI TARA - Full Text

Frodl, T, Gene x Environment Interaction in depression, NIAS, The Netherlands Institute of Advanced Sicence , Utrecht, Januar, 2014, NIAS Invited Talk, 2014

Frodl, T, Gene x Environment Interaction in Depression, Bunnik Symposium, Utrecht, January, 2014, Lundbeck Invited Talk, 2014

Ugwu ID, Amico F, Carballedo A, Fagan AJ, Frodl T, Childhood adversity, depression, age and gender effects on white matter microstructure: a DTI study., Brain structure & function, 2014 Journal Article, 2014

Frodl T, Skokauskas N, Frey EM, Morris D, Gill M, Carballedo A, BDNF Val66Met genotype interacts with childhood adversity and influences the formation of hippocampal subfields., Human brain mapping, 35, (12), 2014, p5776-83 Journal Article, 2014 TARA - Full Text DOI

Frodl T, Skokauskas N, Neuroimaging of externalizing behaviors and borderline traits., Biological psychiatry, 75, (1), 2014, p7-8 Journal Article, 2014

Thompson PM, Stein JL, Medland SE, Hibar DP, Vasquez AA, Renteria ME, Toro R, Jahanshad N, Schumann G, Franke B, Wright MJ, Martin NG, Agartz I, Alda M, Alhusaini S, Almasy L, Almeida J, Alpert K, Andreasen NC, Andreassen OA, Apostolova LG, Appel K, Armstrong NJ, Aribisala B, Bastin ME, Bauer M, Bearden CE, Bergmann O, Binder EB, Blangero J, Bockholt HJ, Bøen E, Bois C, Boomsma DI, Booth T, Bowman IJ, Bralten J, Brouwer RM, Brunner HG, Brohawn DG, Buckner RL, Buitelaar J, Bulayeva K, Bustillo JR, Calhoun VD, Cannon DM, Cantor RM, Carless MA, Caseras X, Cavalleri GL, Chakravarty MM, Chang KD, Ching CR, Christoforou A, Cichon S, Clark VP, Conrod P, Coppola G, Crespo-Facorro B, Curran JE, Czisch M, Deary IJ, de Geus EJ, den Braber A, Delvecchio G, Depondt C, de Haan L, de Zubicaray GI, Dima D, Dimitrova R, Djurovic S, Dong H, Donohoe G, Duggirala R, Dyer TD, Ehrlich S, Ekman CJ, Elvsåshagen T, Emsell L, Erk S, Espeseth T, Fagerness J, Fears S, Fedko I, Fernández G, Fisher SE, Foroud T, Fox PT, Francks C, Frangou S, Frey EM, Frodl T, Frouin V, Garavan H, Giddaluru S, Glahn DC, Godlewska B, Goldstein RZ, Gollub RL, Grabe HJ, Grimm O, Gruber O, Guadalupe T, Gur RE, Gur RC, Göring HH, Hagenaars S, Hajek T, Hall GB, Hall J, Hardy J, Hartman CA, Hass J, Hatton SN, Haukvik UK, Hegenscheid K, Heinz A, Hickie IB, Ho BC, Hoehn D, Hoekstra PJ, Hollinshead M, Holmes AJ, Homuth G, Hoogman M, Hong LE, Hosten N, Hottenga JJ, Hulshoff Pol HE, Hwang KS, Jack CR, Jenkinson M, Johnston C, Jönsson EG, Kahn RS, Kasperaviciute D, Kelly S, Kim S, Kochunov P, Koenders L, Krämer B, Kwok JB, Lagopoulos J, Laje G, Landen M, Landman BA, Lauriello J, Lawrie SM, Lee PH, Le Hellard S, Lemaître H, Leonardo CD, Li CS, Liberg B, Liewald DC, Liu X, Lopez LM, Loth E, Lourdusamy A, Luciano M, Macciardi F, Machielsen MW, Macqueen GM, Malt UF, Mandl R, Manoach DS, Martinot JL, Matarin M, Mather KA, Mattheisen M, Mattingsdal M, Meyer-Lindenberg A, McDonald C, McIntosh AM, McMahon FJ, McMahon KL, Meisenzahl E, Melle I, Milaneschi Y, Mohnke S, Montgomery GW, Morris DW, Moses EK, Mueller BA, Muñoz Maniega S, Mühleisen TW, Müller-Myhsok B, Mwangi B, Nauck M, Nho K, Nichols TE, Nilsson LG, Nugent AC, Nyberg L, Olvera RL, Oosterlaan J, Ophoff RA, Pandolfo M, Papalampropoulou-Tsiridou M, Papmeyer M, Paus T, Pausova Z, Pearlson GD, Penninx BW, Peterson CP, Pfennig A, Phillips M, Pike GB, Poline JB, Potkin SG, Pütz B, Ramasamy A, Rasmussen J, Rietschel M, Rijpkema M, Risacher SL, Roffman JL, Roiz-Santiañez R, Romanczuk-Seiferth N, Rose EJ, Royle NA, Rujescu D, Ryten M, Sachdev PS, Salami A, Satterthwaite TD, Savitz J, Saykin AJ, Scanlon C, Schmaal L, Schnack HG, Schork AJ, Schulz SC, Schür R, Seidman L, Shen L, Shoemaker JM, Simmons A, Sisodiya SM, Smith C, Smoller JW, Soares JC, Sponheim SR, Sprooten E, Starr JM, Steen VM, Strakowski S, Strike L, Sussmann J, Sämann PG, Teumer A, Toga AW, Tordesillas-Gutierrez D, Trabzuni D, Trost S, Turner J, Van den Heuvel M, van der Wee NJ, van Eijk K, van Erp TG, van Haren NE, van 't Ent D, van Tol MJ, Valdés Hernández MC, Veltman DJ, Versace A, Völzke H, Walker R, Walter H, Wang L, Wardlaw JM, Weale ME, Weiner MW, Wen W, Westlye LT, Whalley HC, Whelan CD, White T, Winkler AM, Wittfeld K, Woldehawariat G, Wolf C, Zilles D, Zwiers MP, Thalamuthu A, Schofield PR, Freimer NB, Lawrence NS, Drevets W, The ENIGMA Consortium: large-scale collaborative analyses of neuroimaging and genetic data., Brain imaging and behavior, 8, (2), 2014, p153-82 Journal Article, 2014 TARA - Full Text DOI

McCarthy H, Skokauskas N, Frodl T, Identifying a consistent pattern of neural function in attention deficit hyperactivity disorder: a meta-analysis., Psychological medicine, 44, (4), 2014, p869-80 Journal Article, 2014

Chaney A, Carballedo A, Amico F, Fagan A, Skokauskas N, Meaney J, Frodl T, Effect of childhood maltreatment on brain structure in adult patients with major depressive disorder and healthy participants., Journal of psychiatry & neuroscience : JPN, 39, (1), 2014, p50 - 59 Journal Article, 2014 TARA - Full Text DOI

Frodl, T, Gene x Environment Interaction on brain structure and function, Calgary Symposium, Calgary, Canada, June, 2013, University of Calgary Invited Talk, 2013

Lisiecka DM, Carballedo A, Fagan AJ, Ferguson Y, Meaney J, Frodl T, Recruitment of the left hemispheric emotional attention neural network in risk for and protection from depression., Journal of psychiatry & neuroscience : JPN, 38, (2), 2013, p117-28 Journal Article, 2013 TARA - Full Text DOI

Frodl T, O'Keane V, How does the brain deal with cumulative stress? A review with focus on developmental stress, HPA axis function and hippocampal structure in humans., Neurobiology of disease, 52, 2013, p24-37 Journal Article, 2013

Koutsouleris N, Davatzikos C, Borgwardt S, Gaser C, Bottlender R, Frodl T, Falkai P, Riecher-Rössler A, Möller HJ, Reiser M, Pantelis C, Meisenzahl E, Accelerated Brain Aging in Schizophrenia and Beyond: A Neuroanatomical Marker of Psychiatric Disorders., Schizophrenia bulletin, 2013 Journal Article, 2013

McCarthy H, Skokauskas N, Mulligan A, Donohoe G, Mullins D, Kelly J, Johnson K, Fagan A, Gill M, Meaney J, Frodl T, Attention network hypoconnectivity with default and affective network hyperconnectivity in adults diagnosed with attention-deficit/hyperactivity disorder in childhood., JAMA psychiatry, 70, (12), 2013, p1329-37 Journal Article, 2013 DOI

Frodl T, Amico F, Is there an association between peripheral immune markers and structural/functional neuroimaging findings?, Progress in neuro-psychopharmacology & biological psychiatry, 2013 Journal Article, 2013

Skokauskas N, Hitoshi K, Shuji H, Frodl T, Neuroimaging markers for the prediction of treatment response to Methylphenidate in ADHD., European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society, 17, (6), 2013, p543-51 Journal Article, 2013

O'Neill A, D'Souza A, Carballedo A, Joseph S, Kerskens C, Frodl T, Magnetic resonance imaging in patients with borderline personality disorder: a study of volumetric abnormalities., Psychiatry research, 213, (1), 2013, p1-10 Journal Article, 2013

Frodl, T, Neuroimaging in Depression, Seminar, Edinburgh, May, 2013 Invited Talk, 2013

Carballedo A, Morris D, Zill P, Fahey C, Reinhold E, Meisenzahl E, Bondy B, Gill M, Möller HJ, Frodl T, Brain-derived neurotrophic factor Val66Met polymorphism and early life adversity affect hippocampal volume., American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, 162, (2), 2013, p183-90 Journal Article, 2013

Bermingham R, Carballedo A, Lisiecka D, Fagan A, Morris D, Fahey C, Donohoe G, Meaney J, Gill M, Frodl T, Effect of genetic variant in BICC1 on functional and structural brain changes in depression., Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 37, (13), 2012, p2855-62 Journal Article, 2012

O'Keane V, Frodl T, Dinan TG, A review of Atypical depression in relation to the course of depression and changes in HPA axis organization., Psychoneuroendocrinology, 37, (10), 2012, p1589-99 Journal Article, 2012

Emma J. Rose, Ciara Greene, Sinead Kelly, Derek W. Morris, Ian H. Robertson, Ciara Fahey, Sarah Jacobson, John O'Doherty, Fiona N. Newell, Jane McGrath, Arun Bodke, Hugh Garavan, Thomas Frodl, Michael Gill, Aiden P. Corvin, Gary Donohoe, The NOS1 variant rs6490121 is associated with variation in prefrontal function and gray matter density in healthy individuals, NeuroImage, 60, (1), 2012, p614-622 Journal Article, 2012 TARA - Full Text

Rose EJ, Greene C, Kelly S, Morris DW, Robertson IH, Fahey C, Jacobson S, O'Doherty J, Newell FN, McGrath J, Bokde A, Garavan H, Frodl T, Gill M, Corvin AP, Donohoe G, The NOS1 variant rs6490121 is associated with variation in prefrontal function and grey matter density in healthy individuals., NeuroImage, 60, (1), 2012, p614-22 Journal Article, 2012

Murphy ML, Carballedo A, Fagan AJ, Morris D, Fahey C, Meaney J, Frodl T, Neurotrophic tyrosine kinase polymorphism impacts white matter connections in patients with major depressive disorder., Biological Psychiatry, 72, (8), 2012, p663-70 Journal Article, 2012

Skokauskas N, Gallagher L, Frodl T, Gill M. , Assessing Problem based learning in Child and Adolescent Psychiatry at the Trinity College Dublin Ireland, Oman Medical Journal, 27, (2), 2012, p168 - 169 Journal Article, 2012 TARA - Full Text

Amico F, Carballedo A, Lisiecka D, Fagan AJ, Boyle G, Frodl T, Functional anomalies in healthy individuals with a first degree family history of major depressive disorder., Biology of mood & anxiety disorders, 2, (1), 2012, p1 Journal Article, 2012

Thomas Frodl, Veronica O'Keane, How does the brain deal with cumulative stress? A review with focus on developmental stress, HPA axis function and hippocampal structure in humans, Neurobiology of Disease, 52, 2012, p24 - 37 Journal Article, 2012 TARA - Full Text

Everaerd D, Gerritsen L, Rijpkema M, Frodl T, van Oostrom I, Franke B, Fernández G, Tendolkar I, Sex modulates the interactive effect of the serotonin transporter gene polymorphism and childhood adversity on hippocampal volume., Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 37, (8), 2012, p1848-55 Journal Article, 2012

Carballedo A, Lisiecka D, Fagan A, Saleh K, Ferguson Y, Connolly G, Meaney J, Frodl T, Early life adversity is associated with brain changes in subjects at family risk for depression., The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry, 13, (8), 2012, p569-78 Journal Article, 2012

Skokauskas N, Gallagher L, Frodl T, Gill M, Assessing problem based learning in child and adolescent psychiatry at the trinity college dublin, ireland., Oman medical journal, 27, (2), 2012, p168-9 Journal Article, 2012

Carballedo A, Amico F, Ugwu I, Fagan AJ, Fahey C, Morris D, Meaney JF, Leemans A, Frodl T, Reduced fractional anisotropy in the uncinate fasciculus in patients with major depression carrying the met-allele of the Val66Met brain-derived neurotrophic factor genotype., American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, 159B, (5), 2012, p537-48 Journal Article, 2012

Bermingham R, Carballedo A, Lisiecka D, Fagan A, Morris D, Fahey C, Donohoe G, Meaney J, Gill M, Frodl T, Effect of genetic variant in BICCI on functional and structural brain changes in depression, Neuropsychopharmacology, 37, (13), 2012, p2855-2862 Journal Article, 2012 DOI TARA - Full Text

O'Neill A, Frodl T, Brain structure and function in borderline personality disorder., Brain structure & function, 2012 Journal Article, 2012

F. Amico, A. Carballedo, D. Lisiecka, A.J. Fagan, G. Boyle, T. Frodl, Functional Anomalies in Healthy Individuals with 1st Degree Family History of Major Depressive Disorder, Biology of mood and anxiety Disorders, 2:1, 2012 Journal Article, 2012

Lisiecka DM, Carballedo A, Fagan AJ, Connolly G, Meaney J, Frodl T, Altered inhibition of negative emotions in subjects at family risk of major depressive disorder., Journal of psychiatric research, 46, (2), 2012, p181-8 Journal Article, 2012

Frodl T, Skokauskas N, Meta-analysis of structural MRI studies in children and adults with attention deficit hyperactivity disorder indicates treatment effects., Acta psychiatrica Scandinavica, 125, (2), 2012, p114-26 Journal Article, 2012

Hughes MM, Carballedo A, McLoughlin DM, Amico F, Harkin A, Frodl T, Connor TJ, Tryptophan depletion in depressed patients occurs independent of kynurenine pathway activation., Brain, behavior, and immunity, 26, (6), 2012, p979-987 Journal Article, 2012 DOI

Saleh K, Carballedo A, Lisiecka D, Fagan AJ, Connolly G, Boyle G, Frodl T, Impact of family history and depression on amygdala volume., Psychiatry research, 203, (1), 2012, p24-30 Journal Article, 2012

Frodl T, Carballedo A, Fagan AJ, Lisiecka D, Ferguson Y, Meaney JF, Effects of early-life adversity on white matter diffusivity changes in patients at risk for major depression., Journal of psychiatry & neuroscience : JPN, 37, (1), 2012, p37-45 Journal Article, 2012

Biology of Mood and Anxiety Disorders, BioMed Central, [eds.], until present, 2012 Editorial Board, 2012

Frodl T, Carballedo A, Hughes MM, Saleh K, Fagan A, Skokauskas N, McLoughlin DM, Meaney J, O'Keane V, Connor TJ, Reduced expression of glucocorticoid-inducible genes GILZ and SGK-1: high IL-6 levels are associated with reduced hippocampal volumes in major depressive disorder., Translational psychiatry, 2, 2012, pe88 Journal Article, 2012 DOI

Finke K, Schwarzkopf W, Müller U, Frodl T, Müller HJ, Schneider WX, Engel RR, Riedel M, Möller HJ, Hennig-Fast K, Disentangling the adult attention-deficit hyperactivity disorder endophenotype: parametric measurement of attention., Journal of abnormal psychology, 120, (4), 2011, p890-901 Journal Article, 2011 DOI

Frodl, T, Neuroimaging in ADHD, Irish National ADHD Conference, Dublin, November, 2011 Invited Talk, 2011

Skokauskas N, McNicholas F, Masaud T, Frodl T, Complementary medicine for children and young people who have attention deficit hyperactivity disorder., Current opinion in psychiatry, 24, (4), 2011, p291-300 Journal Article, 2011 DOI

Lisiecka D, Meisenzahl E, Scheuerecker J, Schoepf V, Whitty P, Chaney A, Moeller HJ, Wiesmann M, Frodl T, Neural correlates of treatment outcome in major depression., The International Journal of Neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP), 14, (4), 2011, p1-14 Journal Article, 2011 TARA - Full Text DOI

Frodl T, Scheuerecker J, Schoepf V, Linn J, Koutsouleris N, Bokde AL, Hampel H, Möller HJ, Brückmann H, Wiesmann M, Meisenzahl E., Different effects of mirtazapine and venlafaxine on brain activation: an open randomized controlled fMRI study, Journal of Clinical Psychiatry, 72, (4), 2011, p448-57 Journal Article, 2011 DOI

Carballedo A, Scheuerecker J, Meisenzahl E, Schoepf V, Bokde A, Möller HJ, Doyle M, Wiesmann M, Frodl T, Functional connectivity of emotional processing in depression., Journal of affective disorders, 134, (1-3), 2011, p272-9 Journal Article, 2011 DOI

Schmitt GJ, Dresel S, Frodl T, la Fougère C, Boerner R, Hahn K, Möller HJ, Meisenzahl EM, Dual-isotope SPECT imaging of striatal dopamine: a comparative study between never-treated and haloperidol-treated first-episode schizophrenic patients., European archives of psychiatry and clinical neuroscience, 2011 Journal Article, 2011

Samson AC, Meisenzahl E, Scheuerecker J, Rose E, Schoepf V, Wiesmann M, Frodl T, Brain activation predicts treatment improvement in patients with major depressive disorder., Journal of psychiatric research, 45, (9), 2011, p1214-22 Journal Article, 2011 DOI

Murphy ML, Frodl T, Meta-analysis of diffusion tensor imaging studies shows altered fractional anisotropy occurring in distinct brain areas in association with depression., Biology of mood & anxiety disorders, 1, (1), 2011, p3 Journal Article, 2011

Frodl, T, Neuroimaging in Depression, Cambridge Lucan Conference, Cambridge, September, 2011, University of Cambridge Invited Talk, 2011

Amico F, Stauber J, Koutsouleris N, Frodl T, Anterior cingulate cortex gray matter abnormalities in adults with attention deficit hyperactivity disorder: a voxel-based morphometry study., Psychiatry research, 191, (1), 2011, p31-5 Journal Article, 2011 DOI

Frodl T, Stauber J, Schaaff N, Koutsouleris N, Scheuerecker J, Ewers M, Omerovic M, Opgen-Rhein M, Hampel H, Reiser M, Möller HJ, Meisenzahl E, Amygdala reduction in patients with ADHD compared with major depression and healthy volunteers., Acta psychiatrica Scandinavica, 121, (2), 2010, p111-8 Journal Article, 2010 DOI

Frodl T, Scheuerecker J, Schoepf V, Linn J, Koutsouleris N, Bokde AL, Hampel H, Möller HJ, Brückmann H, Wiesmann M, Meisenzahl E, Different effects of mirtazapine and venlafaxine on brain activation: an open randomized controlled fMRI study., The Journal of clinical psychiatry, 2010 Journal Article, 2010 DOI

Donohoe G, Frodl T, Morris D, Spoletini I, Cannon DM, Cherubini A, Caltagirone C, Bossù P, McDonald C, Gill M, Corvin AP, Spalletta G, Reduced occipital and prefrontal brain volumes in dysbindin-associated schizophrenia., Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 35, (2), 2010, p368-73 Journal Article, 2010 DOI

Preuss UW, Zetzsche T, Pogarell O, Mulert C, Frodl T, Müller D, Schmidt G, Born C, Reiser M, Möller HJ, Hegerl U, Meisenzahl EM, Anterior cingulum volumetry, auditory P300 in schizophrenia with negative symptoms., Psychiatry research, 183, (2), 2010, p133-9 Journal Article, 2010 DOI

Frodl T, Comorbidity of ADHD and Substance Use Disorder (SUD): A Neuroimaging Perspective., Journal of attention disorders, 2010 Journal Article, 2010 DOI

Juckel G, Mergl R, Brüne M, Villeneuve I, Frodl T, Schmitt G, Zetzsche T, Born C, Hahn K, Reiser M, Möller HJ, Bär KJ, Hegerl U, Meisenzahl EM, Is evaluation of humorous stimuli associated with frontal cortex morphology? A pilot study using facial micro-movement analysis and MRI., Cortex; a journal devoted to the study of the nervous system and behavior, 2010 Journal Article, 2010 DOI

Frodl T, Bokde AL, Scheuerecker J, Lisiecka D, Schoepf V, Hampel H, Möller HJ, Brückmann H, Wiesmann M, Meisenzahl E, Functional connectivity bias of the orbitofrontal cortex in drug-free patients with major depression., Biological psychiatry, 67, (2), 2010, p161-7 Journal Article, 2010 DOI

Amico F, Meisenzahl E, Koutsouleris N, Reiser M, Möller HJ, Frodl T, Structural MRI correlates for vulnerability and resilience to major depressive disorder., Journal of psychiatry & neuroscience : JPN, 2010 Journal Article, 2010 DOI

Frodl T, Reinhold E, Koutsouleris N, Reiser M, Meisenzahl EM, Interaction of childhood stress with hippocampus and prefrontal cortex volume reduction in major depression., Journal of psychiatric research, 2010 Journal Article, 2010 DOI

Bokde AL, Karmann M, Born C, Teipel SJ, Omerovic M, Ewers M, Frodl T, Meisenzahl E, Reiser M, Möller HJ, Hampel H, Altered Brain Activation During a Verbal Working Memory Task in Subjects with Amnestic Mild Cognitive Impairment., Journal of Alzheimer's disease : JAD, 2010 Journal Article, 2010 DOI

Frodl T, Reinhold E, Koutsouleris N, Donohoe G, Bondy B, Reiser M, Möller HJ, Meisenzahl EM, Childhood stress, serotonin transporter gene and brain structures in major depression., Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 35, (6), 2010, p1383-90 Journal Article, 2010 DOI

Donohoe G, Rose E, Frodl T, Morris D, Spoletini I, Adriano F, Bernardini S, Caltagirone C, Bossù P, Gill M, Corvin AP, Spalletta G, ZNF804A risk allele is associated with relatively intact gray matter volume in patients with schizophrenia., NeuroImage, 2010 Journal Article, 2010 DOI

Meisenzahl EM, Seifert D, Bottlender R, Teipel S, Zetzsche T, Jäger M, Koutsouleris N, Schmitt G, Scheuerecker J, Burgermeister B, Hampel H, Rupprecht T, Born C, Reiser M, Möller HJ, Frodl T, Differences in hippocampal volume between major depression and schizophrenia: a comparative neuroimaging study., European archives of psychiatry and clinical neuroscience, 260, (2), 2010, p127-37 Journal Article, 2010 DOI

Scheuerecker J, Meisenzahl EM, Koutsouleris N, Roesner M, Schöpf V, Linn J, Wiesmann M, Brückmann H, Möller HJ, Frodl T, Orbitofrontal volume reductions during emotion recognition in patients with major depression., Journal of psychiatry & neuroscience : JPN, 35, (5), 2010, p311-20 Journal Article, 2010 DOI

Gary Donohoe, Emma Rose, Thomas Frodl, Derek Morris, Ilaria Spoletini, Fulvia Adriano, Sergio Bernardini, CarloCaltagirone, Paola Bossù, Michael Gill, Aiden P. Corvin and Gianfranco Spalletta, ZNF804A risk allele is associated with relatively intact gray matter volume in patients with schizophrenia, NeuroImage, 54, (3), 2010, p2132-2137 Journal Article, 2010 TARA - Full Text

Schmitt GJ, Meisenzahl EM, Frodl T, La Fougère C, Hahn K, Möller HJ, Dresel S, Increase of striatal dopamine transmission in first episode drug-naive schizophrenic patients as demonstrated by [(123)I]IBZM SPECT., Psychiatry research, 173, (3), 2009, p183-9 Journal Article, 2009 DOI

Koutsouleris N, Meisenzahl EM, Davatzikos C, Bottlender R, Frodl T, Scheuerecker J, Schmitt G, Zetzsche T, Decker P, Reiser M, Möller HJ, Gaser C, Use of neuroanatomical pattern classification to identify subjects in at-risk mental states of psychosis and predict disease transition., Archives of general psychiatry, 66, (7), 2009, p700-12 Journal Article, 2009 DOI

Meisenzahl, EM, Schmitt, G, Gründer, G, Dresel, S, Frodl, T, la Fougère, C, Scheuerecker, J, Schwarz, M, Boerner, R, Stauss, J, Hahn, K, Möller, HJ, Striatal D2/D3 receptor occupancy, clinical response and side effects with amisulpride: an iodine-123-iodobenzamide SPET study., Pharmacopsychiatry, 41, (5), 2008, p169-175 Journal Article, 2008 DOI URL

Meisenzahl, EM, Koutsouleris, N, Bottlender, R, Scheuerecker, J, Jäger, M, Teipel, SJ, Holzinger, S, Frodl, T, Preuss, U, Schmitt, G, Burgermeister, B, Reiser, M, Born, C, Möller, HJ, Structural brain alterations at different stages of schizophrenia: A voxel-based morphometric study., Schizophrenia research, 104, (1-3), 2008, p44-60 Journal Article, 2008 URL DOI

Juckel, G, Gudlowski, Y, Müller, D, Ozgürdal, S, Brüne, M, Gallinat, J, Frodl, T, Witthaus, H, Uhl, I, Wutzler, A, Pogarell, O, Mulert, C, Hegerl, U, Meisenzahl, EM, Loudness dependence of the auditory evoked N1/P2 component as an indicator of serotonergic dysfunction in patients with schizophrenia--a replication study., Psychiatry research, 158, (1), 2008, p79-82 Journal Article, 2008 URL DOI

Frodl, T., Attention deficit/hyperactivity disorder in adults: Behavior therapy | [Aufmerksamkeitsdefizits-/hyperaktivitätsstörung (ADHS) im erwachsenenalter: Verhaltenstherapie], Journal fur Neurologie, Neurochirurgie und Psychiatrie, 9, (4), 2008, p60-64 Journal Article, 2008 URL

Frodl, T, Zill, P, Baghai, T, Schüle, C, Rupprecht, R, Zetzsche, T, Bondy, B, Reiser, M, Möller, HJ, Meisenzahl, EM, Reduced hippocampal volumes associated with the long variant of the tri- and diallelic serotonin transporter polymorphism in major depression., American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, 147B, (7), 2008, p1003 - 1007 Journal Article, 2008 URL DOI

Frodl T, Aufmerksamkeitsdefizits-/Hyperaktivitätsstörung (ADHS) im Erwachsenenalter: Verhaltenstherapie, Journal fuer Neurologie, Neurochirurgie und Psychiatrie, 9, (4), 2008, p60 - 65 Journal Article, 2008

Frodl T, Jäger M, Born C, Ritter S, Kraft E, Zetzsche T, Bottlender R, Leinsinger G, Reiser M, Möller HJ, Meisenzahl E. , Anterior cingulate cortex does not differ between patients with major depression and healthy controls, but relatively large anterior cingulate cortex predicts a good clinical course , Psychiatry Research - Neuroimaging , 163, (1), 2008, p76-83 Journal Article, 2008 URL DOI

Zetzsche, T., Preuss, U.W., Frodl, T., Leinsinger, G., Born, C., Reiser, M., Hegerl, U., Möller, H.-J Meisenzahl, E.M., White matter alterations in schizophrenic patients with pronounced negative symptomatology and with positive family history for schizophrenia , European Archives of Psychiatry and Clinical Neuroscience, 285, (5), 2008, p278-284 Journal Article, 2008 DOI URL

Schmitt, GJ, la Fougère, C, Dresel, S, Frodl, T, Hahn, K, Möller, HJ, Meisenzahl, EM, Dual-isotope SPECT imaging of striatal dopamine: first episode, drug naïve schizophrenic patients., Schizophrenia research, 101, (1-3), 2008, p133-141 Journal Article, 2008 DOI URL

Frodl, T, Jäger, M, Smajstrlova, I, Born, C, Bottlender, R, Palladino, T, Reiser, M, Möller, HJ, Meisenzahl, EM, Effect of hippocampal and amygdala volumes on clinical outcomes in major depression: a 3-year prospective magnetic resonance imaging study., Journal of psychiatry & neuroscience : JPN, 33, (5), 2008, p423-430 Journal Article, 2008 URL URL

Frodl, T , Guest editorial, 2008, - 29 Miscellaneous, 2008 URL

Frodl, T, Möller, HJ, Meisenzahl, E, Neuroimaging genetics: new perspectives in research on major depression?, Acta psychiatrica Scandinavica, 118, (5), 2008, p363-372 Journal Article, 2008 URL DOI

Frodl, TS, Koutsouleris, N, Bottlender, R, Born, C, Jäger, M, Scupin, I, Reiser, M, Möller, HJ, Meisenzahl, EM, Depression-related variation in brain morphology over 3 years: effects of stress?, Archives of general psychiatry, 65, (10), 2008, p1156-1165 Journal Article, 2008 DOI URL

Juckel, G., Clotz, F., Frodl, T., Kawohl, W., Hampel, H., Pogarell, O., Hegerl, U., Diagnostic usefulness of cognitive auditory event-related P300 subcomponents in patients with Alzheimers disease? , Journal of Clinical Neurophysiology, 25, (3), 2008, p147-152 Journal Article, 2008 URL DOI

Frodl T, Neurobiology of attention deficit hyperactivity disorder (ADHD): signs and symptoms in adults, Psychotherapie, (2), 2008 Journal Article, 2008

Scheuerecker, J, Ufer, S, Zipse, M, Frodl, T, Koutsouleris, N, Zetzsche, T, Wiesmann, M, Albrecht, J, Brückmann, H, Schmitt, G, Möller, HJ, Meisenzahl, EM, Cerebral changes and cognitive dysfunctions in medication-free schizophrenia - an fMRI study., Journal of psychiatric research, 42, (6), 2008, p469-476 Journal Article, 2008 URL DOI

Frodl, T, Koutsouleris, N, Bottlender, R, Born, C, Jäger, M, Mörgenthaler, M, Scheuerecker, J, Zill, P, Baghai, T, Schüle, C, Rupprecht, R, Bondy, B, Reiser, M, Möller, HJ, Meisenzahl, EM, Reduced gray matter brain volumes are associated with variants of the serotonin transporter gene in major depression., Molecular psychiatry, 13, (12), 2008, p1093-1101 Journal Article, 2008 URL DOI

Hennig-Fast, K, Meister, F, Frodl, T, Beraldi, A, Padberg, F, Engel, RR, Reiser, M, Möller, HJ, Meindl, T, A case of persistent retrograde amnesia following a dissociative fugue: neuropsychological and neurofunctional underpinnings of loss of autobiographical memory and self-awareness., Neuropsychologia, 46, (12), 2008, p2993-3005 Journal Article, 2008 URL DOI

Zetzsche, T, Preuss, UW, Bondy, B, Frodl, T, Zill, P, Schmitt, G, Koutsouleris, N, Rujescu, D, Born, C, Reiser, M, Möller, HJ, Meisenzahl, EM, 5-HT1A receptor gene C -1019 G polymorphism and amygdala volume in borderline personality disorder., Genes, brain, and behavior, 7, (3), 2008, p306-313 Journal Article, 2008 URL DOI

Koutsouleris, N, Gaser, C, Jäger, M, Bottlender, R, Frodl, T, Holzinger, S, Schmitt, GJ, Zetzsche, T, Burgermeister, B, Scheuerecker, J, Born, C, Reiser, M, Möller, HJ, Meisenzahl, EM, Structural correlates of psychopathological symptom dimensions in schizophrenia: a voxel-based morphometric study., NeuroImage, 39, (4), 2008, p1600-1612 Journal Article, 2008 DOI URL

World Journal of Biological Psychiatry, Informa Healthcare, [eds.], until 2014, 2007 Editorial Board, 2007

Zetzsche, T, Preuss, UW, Frodl, T, Schmitt, G, Seifert, D, Münchhausen, E, Tabrizi, S, Leinsinger, G, Born, C, Reiser, M, Möller, HJ, Meisenzahl, EM, Hippocampal volume reduction and history of aggressive behaviour in patients with borderline personality disorder., Psychiatry research, 154, (2), 2007, p157-170 Journal Article, 2007 URL DOI

Zetzsche, T, Preuss, U, Frodl, T, Watz, D, Schmitt, G, Koutsouleris, N, Born, C, Reiser, M, Möller, HJ, Meisenzahl, EM, In-vivo topography of structural alterations of the anterior cingulate in patients with schizophrenia: new findings and comparison with the literature., Schizophrenia research, 96, (1-3), 2007, p34-45 Journal Article, 2007 DOI URL

Mergl, R, Pogarell, O, Juckel, G, Rihl, J, Henkel, V, Frodl, T, Müller-Siecheneder, F, Karner, M, Tigges, P, Schröter, A, Hegerl, U, Hand-motor dysfunction in depression: characteristics and pharmacological effects., Clinical EEG and neuroscience : official journal of the EEG and Clinical Neuroscience Society (ENCS), 38, (2), 2007, p82-88 Journal Article, 2007 URL

Scheuerecker, J, Frodl, T, Koutsouleris, N, Zetzsche, T, Wiesmann, M, Kleemann, AM, Brückmann, H, Schmitt, G, Möller, HJ, Meisenzahl, EM, Cerebral differences in explicit and implicit emotional processing--an fMRI study., Neuropsychobiology, 56, (1), 2007, p32-9 Journal Article, 2007 URL DOI

Juckel, G, Pogarell, O, Augustin, H, Mulert, C, Müller-Siecheneder, F, Frodl, T, Mavrogiorgou, P, Hegerl, U, Differential prediction of first clinical response to serotonergic and noradrenergic antidepressants using the loudness dependence of auditory evoked potentials in patients with major depressive disorder., The Journal of clinical psychiatry, 68, (8), 2007, p1206-12 Journal Article, 2007 URL

Frodl, T, Schüle, C, Schmitt, G, Born, C, Baghai, T, Zill, P, Bottlender, R, Rupprecht, R, Bondy, B, Reiser, M, Möller, HJ, Meisenzahl, EM, Association of the brain-derived neurotrophic factor Val66Met polymorphism with reduced hippocampal volumes in major depression., Archives of general psychiatry, 64, (4), 2007, p410-416 Journal Article, 2007 DOI URL

Schmitt, GJ, Frodl, T, Dresel, S, la Fougère, C, Bottlender, R, Koutsouleris, N, Hahn, K, Möller, HJ, Meisenzahl, EM, Striatal dopamine transporter availability is associated with the productive psychotic state in first episode, drug-naive schizophrenic patients., European archives of psychiatry and clinical neuroscience, 256, (2), 2006, p115-121 Journal Article, 2006 URL DOI

Laakmann, G, Ortner, M, Kamleiter, M, Ufer, S, Frodl, T, Goldstein-Müller, B, Jäger, M, Padberg, F, Rüther, T, Sadowsky, N, Tischinger, M, Stec, I, [Treatment of vitally endangered anorexia nervosa patients based on guardianship laws], Der Nervenarzt, 77, (1), 2006, p35-49 Journal Article, 2006 DOI URL

Meisenzahl, EM, Scheuerecker, J, Zipse, M, Ufer, S, Wiesmann, M, Frodl, T, Koutsouleris, N, Zetzsche, T, Schmitt, G, Riedel, M, Spellmann, I, Dehning, S, Linn, J, Brückmann, H, Möller, HJ, Effects of treatment with the atypical neuroleptic quetiapine on working memory function: a functional MRI follow-up investigation., European archives of psychiatry and clinical neuroscience, 256, (8), 2006, p522-31 Journal Article, 2006 DOI URL

Journal of Psychiatry and Neuroscience, Canadian Medical Association, [eds.], present, 2006 Editorial Board, 2006

Frodl, T, Schaub, A, Banac, S, Charypar, M, Jäger, M, Kümmler, P, Bottlender, R, Zetzsche, T, Born, C, Leinsinger, G, Reiser, M, Möller, HJ, Meisenzahl, EM, Reduced hippocampal volume correlates with executive dysfunctioning in major depression., Journal of Psychiatry & Neuroscience : JPN, 31, (5), 2006, p316-325 Journal Article, 2006 URL

Zetzsche, T, Frodl, T, Preuss, UW, Schmitt, G, Seifert, D, Leinsinger, G, Born, C, Reiser, M, Möller, HJ, Meisenzahl, EM, Amygdala volume and depressive symptoms in patients with borderline personality disorder., Biological psychiatry, 60, (3), 2006, p302-310 Journal Article, 2006 URL DOI

Preuss, UW, Zetzsche, T, Jäger, M, Groll, C, Frodl, T, Bottlender, R, Leinsinger, G, Hegerl, U, Hahn, K, Möller, HJ, Meisenzahl, EM, Thalamic volume in first-episode and chronic schizophrenic subjects: a volumetric MRI study., Schizophrenia research, 73, (1), 2005, p91-101 Journal Article, 2005 URL DOI

Schmitt, GJ, Meisenzahl, EM, Frodl, T, La Fougère, C, Hahn, K, Möller, HJ, Dresel, S, The striatal dopamine transporter in first-episode, drug-naive schizophrenic patients: evaluation by the new SPECT-ligand[99mTc]TRODAT-1., Journal of psychopharmacology (Oxford, England), 19, (5), 2005, p488-493 Journal Article, 2005 URL DOI

la Fougère, C, Meisenzahl, E, Schmitt, G, Stauss, J, Frodl, T, Tatsch, K, Hahn, K, Möller, HJ, Dresel, S, D2 receptor occupancy during high- and low-dose therapy with the atypical antipsychotic amisulpride: a 123I-iodobenzamide SPECT study., Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 46, (6), 2005, p1028-1033 Journal Article, 2005 URL

Frodl, T, Meisenzahl, EM, Zill, P, Baghai, T, Rujescu, D, Leinsinger, G, Bottlender, R, Schüle, C, Zwanzger, P, Engel, RR, Rupprecht, R, Bondy, B, Reiser, M, Möller, HJ, Reduced hippocampal volumes associated with the long variant of the serotonin transporter polymorphism in major depression., Archives of General Psychiatry, 61, (2), 2004, p177-83 Journal Article, 2004 URL DOI

Frodl, T, Meisenzahl, EM, Möller, HJ, [Value of diagnostic imaging in evaluation of electroconvulsive therapy], Der Nervenarzt, 75, (3), 2004, p227-233 Journal Article, 2004 DOI URL

Born, CM, Meisenzahl, EM, Frodl, T, Pfluger, T, Reiser, M, Möller, HJ, Leinsinger, GL, The septum pellucidum and its variants. An MRI study., European archives of psychiatry and clinical neuroscience, 254, (5), 2004, p295-302 Journal Article, 2004 URL DOI

Juckel, G, Mavrogiorgou, P, Bredemeier, S, Gallinat, J, Frodl, T, Schulz, C, Möller, HJ, Hegerl, U, Loudness dependence of primary auditory-cortex-evoked activity as predictor of therapeutic outcome to prophylactic lithium treatment in affective disorders--a retrospective study., Pharmacopsychiatry, 37, (2), 2004, p46-51 Journal Article, 2004 DOI URL

Frodl, T, Meisenzahl, EM, Zetzsche, T, Höhne, T, Banac, S, Schorr, C, Jäger, M, Leinsinger, G, Bottlender, R, Reiser, M, Möller, HJ, Hippocampal and amygdala changes in patients with major depressive disorder and healthy controls during a 1-year follow-up., The Journal of Clinical Psychiatry, 65, (4), 2004, p492-9 Journal Article, 2004 URL

Meisenzahl, EM, Frodl, T, Müller, D, Schmitt, G, Gallinat, J, Zetzsche, T, Marcuse, A, Juckel, G, Leinsinger, G, Hahn, K, Möller, HJ, Hegerl, U, Superior temporal gyrus and P300 in schizophrenia: a combined ERP/structural magnetic resonance imaging investigation., Journal of Psychiatric Research, 38, (2), 2004, p153-162 Journal Article, 2004 DOI URL

Frodl, T, Meisenzahl, EM, Zetzsche, T, Born, C, Jäger, M, Groll, C, Bottlender, R, Leinsinger, G, Möller, HJ, Larger amygdala volumes in first depressive episode as compared to recurrent major depression and healthy control subjects., Biological Psychiatry, 53, (4), 2003, p338-44. Journal Article, 2003 URL DOI

Mavrogiorgou, P, Juckel, G, Frodl, T, Gallinat, J, Hauke, W, Zaudig, M, Dammann, G, Möller, HJ, Hegerl, U, P300 subcomponents in obsessive-compulsive disorder., Journal of Psychiatric Research, 36, (6), 2002, p399-406 Journal Article, 2002 URL DOI

Frodl, T, Hampel, H, Juckel, G, Bürger, K, Padberg, F, Engel, RR, Möller, HJ, Hegerl, U, Value of event-related P300 subcomponents in the clinical diagnosis of mild cognitive impairment and Alzheimer's Disease., Psychophysiology, 39, (2), 2002, p175-181 Journal Article, 2002 URL DOI

Meisenzahl, EM, Zetzsche, T, Preuss, U, Frodl, T, Leinsinger, G, Möller, HJ, Does the definition of borders of the planum temporale influence the results in schizophrenia?, The American Journal of Psychiatry, 159, (7), 2002, p1198-1200 Journal Article, 2002 DOI URL

Zill, P, Engel, R, Baghai, TC, Juckel, G, Frodl, T, Müller-Siecheneder, F, Zwanzger, P, Schüle, C, Minov, C, Behrens, S, Rupprecht, R, Hegerl, U, Möller, HJ, Bondy, B, Identification of a naturally occurring polymorphism in the promoter region of the norepinephrine transporter and analysis in major depression., Neuropsychopharmacology, 26, (4), 2002, p489-493 Journal Article, 2002 URL DOI

Frodl, T, Meisenzahl, E, Zetzsche, T, Bottlender, R, Born, C, Groll, C, Jäger, M, Leinsinger, G, Hahn, K, Möller, HJ, Enlargement of the amygdala in patients with a first episode of major depression., Biological Psychiatry, 51, (9), 2002, p708-714 Journal Article, 2002 URL DOI

Meisenzahl, EM, Frodl, T, Zetzsche, T, Leinsinger, G, Maag, K, Hegerl, U, Hahn, K, Möller, HJ, Investigation of a possible diencephalic pathology in schizophrenia , Psychiatry Research, 115, (3), 2002, p127-135 Journal Article, 2002 DOI URL

Frodl, T, Meisenzahl, EM, Zetzsche, T, Born, C, Groll, C, Jäger, M, Leinsinger, G, Bottlender, R, Hahn, K, Möller, HJ, Hippocampal changes in patients with a first episode of major depression., The American Journal of Psychiatry, 159, (7), 2002, p1112-1118 Journal Article, 2002 DOI URL

Frodl, T, Meisenzahl, EM, Müller, D, Holder, J, Juckel, G, Möller, HJ, Hegerl, U, P300 subcomponents and clinical symptoms in schizophrenia., International Journal of Psychophysiology , 43, (3), 2002, p237-246 Journal Article, 2002 URL DOI

Preuss, UW, Meisenzahl, EM, Frodl, T, Zetzsche, T, Holder, J, Leinsinger, G, Hegerl, U, Hahn, K, Möller, HJ, Handedness and corpus callosum morphology., Psychiatry Research, 116, (1-2), 2002, p33-42 Journal Article, 2002 DOI URL

Schmitt, GJ, Meisenzahl, EM, Dresel, S, Tatsch, K, Rossmüller, B, Frodl, T, Preuss, UW, Hahn, K, Möller, HJ, Striatal dopamine D2 receptor binding of risperidone in schizophrenic patients as assessed by 123I-iodobenzamide SPECT: a comparative study with olanzapine., Journal of Psychopharmacology, 16, (3), 2002, p200-206 Journal Article, 2002 URL DOI

Frodl, T, Meisenzahl, EM, Müller, D, Leinsinger, G, Juckel, G, Hahn, K, Möller, HJ, Hegerl, U, The effect of the skull on event-related P300., Clinical Neurophysiology, 112, (9), 2001, p1773-1776 Journal Article, 2001 DOI URL

Frodl, T, Meisenzahl, EM, Müller, D, Greiner, J, Juckel, G, Leinsinger, G, Hahn, H, Möller, HJ, Hegerl, U, Corpus callosum and P300 in schizophrenia., Schizophrenia Research, 49, (1-2), 2001, p107-119 Journal Article, 2001 DOI URL

Gallinat, J, Riedel, M, Juckel, G, Sokullu, S, Frodl, T, Moukhtieva, R, Mavrogiorgou, P, Nisslé, S, Müller, N, Danker-Hopfe, H, Hegerl, U, P300 and symptom improvement in schizophrenia., Psychopharmacology, 158, (1), 2001, p55-65 Journal Article, 2001 URL DOI

Meisenzahl, EM, Frodl, T, Zetzsche, T, Leinsinger, G, Heiss, D, Maag, K, Hegerl, U, Hahn, K, Möller, HJ, Adhesio interthalamica in male patients with schizophrenia., The American Journal of Psychiatry, 157, (5), 2000, p823-825 Journal Article, 2000 DOI URL

Carrillo-de-la-Peña, MT, Mavrogiorgou, P, Juckel, G, Hauke, W, Gallinat, J, Frodl, T, Zaudig, M, Hegerl, U, Loudness dependence of auditory evoked potentials in obsessive-compulsive disorder: a pilot study., Psychiatry research, 93, (3), 2000, p209-216 Journal Article, 2000 DOI URL

Tigges, P, Mergl, R, Frodl, T, Meisenzahl, EM, Gallinat, J, Schröter, A, Riedel, M, Müller, N, Möller, HJ, Hegerl, U, Digitized analysis of abnormal hand-motor performance in schizophrenic patients., Schizophrenia research, 45, (1-2), 2000, p133-143 Journal Article, 2000 DOI URL

Meisenzahl, EM, Dresel, S, Frodl, T, Schmitt, GJ, Preuss, UW, Rossmüller, B, Tatsch, K, Mager, T, Hahn, K, Möller, HJ, D2 receptor occupancy under recommended and high doses of olanzapine: an iodine-123-iodobenzamide SPECT study., Journal of Psychopharmacology , 14, (4), 2000, p364-70 Journal Article, 2000 URL

Frodl, T, Juckel, G, Gallinat, J, Bottlender, R, Riedel, M, Preuss, U, Möller, HJ, Hegerl, U, Dipole localization of P300 and normal aging., Brain Topography, 13, (1), 2000, p3-9 Journal Article, 2000 URL DOI

Kathmann, N, Frodl-Bauch, T, Hegerl, U, Stability of the mismatch negativity under different stimulus and attention conditions., Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 110, (2), 1999 Journal Article, 1999

Frodl-Bauch, T, Bottlender, R, Hegerl, U, Neurochemical substrates and neuroanatomical generators of the event-related P300., Neuropsychobiology, 40, (2), 1999 Journal Article, 1999 DOI

Meisenzahl, EM, Frodl, T, Greiner, J, Leinsinger, G, Maag, KP, Heiss, D, Hahn, K, Hegerl, U, Möller, HJ, Corpus callosum size in schizophrenia--a magnetic resonance imaging analysis., European Archives of Psychiatry and Clinical Neuroscience, 249, (6), 1999, p305-312 Journal Article, 1999 URL DOI

Frodl-Bauch, T, Gallinat, J, Meisenzahl, EM, Möller, HJ, Hegerl, U, P300 subcomponents reflect different aspects of psychopathology in schizophrenia., Biological psychiatry, 45, (1), 1999 Journal Article, 1999

Preuss, UW, Frodl-Bauch, T, Benda, E, Soyka, M, Möller, H, Hegerl, U, Late auditory evoked potentials (P300) do not discriminate between subgroups of alcohol-dependent patients defined by family history and antisocial personality traits., European journal of medical research, 4, (3), 1999 Journal Article, 1999

Frodl, T, Meisenzahl, EM, Gallinat, J, Hegerl, U, Möller, HJ, Markers from event-related potential subcomponents and reaction time for information processing dysfunction in schizophrenia., European Archives of Psychiatry and Clinical Neuroscience, 248, (6), 1998, p307-318 Journal Article, 1998 DOI URL

Hegerl, U, Frodl-Bauch, T, Dipole source analysis of P300 component of the auditory evoked potential: a methodological advance?, Psychiatry research, 74, (2), 1997 Journal Article, 1997

Frodl-Bauch, T, Kathmann, N, Möller, HJ, Hegerl, U, Dipole localization and test-retest reliability of frequency and duration mismatch negativity generator processes., Brain topography, 10, (1), 1997 Journal Article, 1997

Non-Peer-Reviewed Publications

Frodl, T, Emotion, Empathy and Neuroimaging, Seminar, Innsbruck, May, 2013 Invited Talk, 2013

Thomas Frodl, Yolande Ferguson, Andrew Fagan, Danusia Lisiecka, Angela Carballedo, Ian Daly, James Meaney & Dermot Kelleher, Microstructural Correlates of Resilience against Major Depressive Disorder: Epigenetic Mechanisms?, 2010 Working Paper, 2010 TARA - Full Text URL

Research Expertise

Description

My research focus is within 3 main areas: A. Translational research starting from experimental studies in mice or rats and applying new and established neuroimaging techniques or blood markers (like genetic or functional genetic biomarkers) to clinical populations in order to gain inside into the pathophysiology of disease, vulnerability and resilience. It will be important to explore the effects of stress and of peripheral stress blood markers on brain function and structure and to examine the impact of functional genetics, e.g. epigenetics on brain structure and function. In the past I carried out multi/disciplinary studies in patients with major depression and ADHD. Currently, we are carrying an HRB funded project on biomarkers of adult ADHD patients longitudinally followed from childhood to adulthood. Recently, I received major funding for translational research within the area of stress, neuroplasticity and ageing within the EU-multi-institutional training program - 4.3 MIO in total and about 730.000 Euro personal funding. This network program is prestigious apart for the science also in terms of close working relationships with other universities like Turku (Finland), Lund (Sweden), Nottingham (UK), Brussels (Belgium) and Magdeburg (Germany). 2. Clinical research programs implementing biological methods: Identifying fundamental brain network alterations in psychiatric disorders such as depression, ADHD, schizophrenia and dementia using neuroimaging and neurophysiological methods that further can be applied to clinical research programs in order to examine biological underpinnings of therapy response and finding markers for therapy response and differential diagnosis. An open question is for example to explore the role that gene x environmental interactions play in therapy response and how this information could be used for therapy guidance. Currently, my research group is carrying out trials on exercise in healthy controls and in patients with major depression. I have a written proposal for a clinical program using neuroimaging and blood investigations as primary outcome measures in a sample of patients receiving either psychotherapy or optimized pharmacotherapy. Moreover, I run several clinical trials that included the use of neuroimaging techniques like fMRI and Single Photon Emission Tomography in Munich. 3. Health service research: Still there is strong need to explore which clinical programs within a service deliver enduring quality for the health of a population and thus also have benefits on the longer term for the resources of a service, e.g. by saving money that can be used then for novel developments of clinical programs. For example it is still a matter of debate whether early intervention or home treatment have enduring benefits or whether they just reduce the need for inpatient therapies. Thus I will be very keen to investigate the clinical and wider health outcomes of programs such as early intervention for psychosis, CBT for psychosis, suicide prevention, crisis intervention, home treatment within naturalistic and clinical trials. A broader view is also to compare the efficacy of the modern Dublin mental health service compared to for example a more traditional health service in Germany. At present I have experience in carrying out health service research in the area of learning disability and have experience with measures for quality control and risk assessment as well as prevention of risks for staff and patients within a service.

Projects

  • Title
    • Brain Imaging Return to Health, rebirth
  • Summary
    • European International Training Network on developing markers for neuroplasticity relevant to stress-related psychiatric disorders
  • Funding Agency
    • EU
  • Date From
    • 1/4/2014
  • Date To
    • 31/3/2017
  • Title
    • Clinical and biological outcome of adults with childhood diagnosed Attention Deficit/Hyperactivity Disorder (ADHD)
  • Summary
    • Attention deficit/hyperactivity disorder (ADHD) is one of the most common mental health disorders in children (5-10% prevalence) and persists in 50-80% of cases into adulthood. In adults it significantly impairs activities of daily living, such as academic, social, occupational, and family functioning and results in a high rate of criminal offences and drug abuse. Research in adult ADHD is at the start and knowing more about the clinical, neuropsychological, social and neurobiological outcome related to maintenance of and remission from ADHD symptomatology in adults is important. Neuroimaging and neuropsychological studies have helped better to understand cognitive dysfunctions in ADHD. Our careful literature review has identified that High Angular Resolution Diffusion Imaging (HARDI)-tractography to measure brain fibre bundles, Arterial Spin Labelling (ASL) as well as functional MRI (fMRI) resting state, decision making fMRI and combining these with neuropsychological assessments of attention and working memory would be novel and the most appropriate methods to use in our study. The aim of the present project is to examine the clinical, neuropsychological and social outcome as well as microstructural and functional imaging changes associated with these outcome variables. Specific aims are to investigate whether clinical variables during childhood will predict the outcome and which changes in resting state ASL, decision-making fMRI and HARDI-tractography will be associated with remission or maintenance of ADHD. Altogether clinical, neuropsychological and neuroimaging data will show a good sensitivity and specificity to diagnose ADHD.
  • Funding Agency
    • Health Research Board
  • Date From
    • 1/10/2011
  • Date To
    • 30/09/2014
  • Title
    • Functional as well as structural brain connectivity and epigenetic changes in major depressive disorder associated with remission and persistence of symptoms over a 5 year course
  • Summary
    • In this project we will intimately investigate dynamic structural, diffusion and functional brain changes in tandem with changes in epigenetics of the glucocorticoid and serotonin transporter system during the long-term course of the disease in order to understand the development from depression to remission and to identify causes for treatment failure. Moreover, we will examine the relationship between epigenetics and brain imaging changes. Longitudinal changes during the disease course in hippocampal subfield volumes, diffusion tensor imaging, task-related fMRI and epigenetics together have never been a matter of investigation.
  • Funding Agency
    • Health Research Board
  • Date From
    • 1/10/2014
  • Date To
    • 30/09/2017
  • Title
    • SFI Stokes Professorship
  • Summary
    • Aim of the research program is to identify biomarkers for stress-related psychiatric disorders using integrated research approaches with neuroimaging, proteomics, trasncriptomics and genomics
  • Funding Agency
    • Science Foundation Ireland (SFI)
  • Date From
    • 1/9/2008
  • Date To
    • 31/8/2014
  • Title
    • Neural and stress correlates of resilience in an exercise-cognitive-behavioural programme
  • Summary
    • To investigate the impact of an exercise program that lastet for 16 weeks on brain structure and function. Idea was to identify markers for neuroplasticity and to identify strategies leading to resilience
  • Funding Agency
    • Meath Foundation
  • Date From
    • 1/1/2012
  • Date To
    • 31/12/2013
  • Title
    • Cognitive remediation therapy in schizophrenia
  • Summary
    • To study the effect of cognitive remediation in patients with schizophrenia and its impact on reorganisation of brain structure and function Funding as Co-PI, PI was Professor Donohoe
  • Funding Agency
    • Health Research Board
  • Date From
    • 1/10/2012
  • Date To
    • 30/09/2015
  • Title
    • The Anatomy of Risk: a population based imaging study of adolescents
  • Summary
    • To study a high risk group of children, who might develop schizophrenia clinically and with using neuroimaging techniques like DTI, fMRI, and structural MRI. The aim was to obtain neurobiological correlates of risk and vulnerability in a pre-prodromal cohort of subjects Funding as Co-PI, PI is Professor Cannon, RCSI Dublin
  • Funding Agency
    • Health Research Board
  • Date From
    • 1/10/2012
  • Date To
    • 30/09/2015
  • Title
    • Genetic variation in the muscarinic cholinergic M2 receptor gene and cholinergic neurotransmission in bipolar disorder
  • Summary
    • To study the impact of acetylcholinergic substances on brain function in order to identify potential targets to treat dementia and prevent from dementia
  • Funding Agency
    • Health Research Board
  • Date From
    • 1/10/2013
  • Date To
    • 30/09/2016
  • Title
    • RlpharmfMR
  • Summary
    • Offcial Collaborator, PI Prof. John O'Doherty: Identifying neurochemical underpinnings of the reward system
  • Funding Agency
    • European Union, ERC
  • Date From
    • 6/2009
  • Date To
    • 5/2012
  • Title
    • Neural Correlates of Theory of Mind
  • Summary
    • Defining the functional basis of theory of mind processes in healthy controls and patients with borderline disorders
  • Funding Agency
    • IRCSET, Irish Research Council
  • Date From
    • 6/2010
  • Date To
    • 5/2013
  • Title
    • Serotonergic levels as measured with [I-123]ADAM SPECT influence the structural and functional integrity of the human brain in major depression. Institution
  • Summary
    • Examining the functional correlates of depression using fMRI and BETA CIT Spect
  • Funding Agency
    • Eli Lilly Foundation
  • Date From
    • 2002
  • Date To
    • 2005
  • Title
    • In vivo-Investigation of the serotonin transporter using [I-123] ADAM SPECT in patients with a first depressive episode, in patients with refractory depression and healthy controls
  • Summary
    • Investigating the serotonergic neurotransmission in patients with depression
  • Funding Agency
    • FoeFole, LMU Munich
  • Date From
    • 2001
  • Date To
    • 2003

Keywords

ADHD; Ageing, memory and other cognitive processes; Alzheimer's disease; Anatomy; Antidepressants; Attention Deficit Hyperactivity Disorder (ADHD); Bipolar disorder; Brain theory,brain mapping; Childhood and mental health; Dementia; Depression; Development, prevention and treatment of mental disease or disorder; Developmental and mental disorders; DNA transcription and translation; Emotional, behavioural and cognitive disorders; Exercise and cystic fibrosis; Health informatics; Human genetics; Learning disabilities; Mood and Anxiety Disorders; Neurobiology; Neurodegeneration; Neurodevelopmental Disorders; Neuroendocrine Immunology; Neurogenetics; Neuroimaging; Neurophysiology; Neuroplasticity; Neuropsychology; Personal Therapy; Psychiatric Disorders; Psychiatric genetics; PSYCHIATRIC PATIENTS; PSYCHIATRIC PHENOMENA; PSYCHIATRIC RESEARCH; PSYCHIATRIC SERVICE; PSYCHIATRIC-DISORDER; PSYCHIATRIC-DISORDERS; PSYCHIATRIC-INPATIENTS; PSYCHIATRIC-SYMPTOMS; Psychiatry; Psychotherapy; Rehabilitation; RNA processing, stability and degradation; Schizophrenia

Recognition

Awards and Honours

Hormosan Research Award of the German Society of Psychiatry, Psychotherapy and Neurology 2005

Association of European Psychiatrists Congress Price 2005

Organon Award of the Society of Biological Psychiatry 2006

Memberships

Irish College of Psychiatrists 1/1/2010

Medical Council, Specialist Register 8/2008

Centre for Integrative Psychotherapy (CIP), Munich 1/1/2008

German Society for Neuropsychopharmacology 2003