Clive Williams
Fellow Emeritus, Fellows Emeritii

Publications and Further Research Outputs

Peer-Reviewed Publications

Kinsella P, Greene LM, Bright SA, Pollock JK, Butini S, Campiani G, Bauer S, Williams DC, Zisterer DM, The novel pyrrolo-1,5-benzoxazepine, PBOX-15, synergistically enhances the apoptotic efficacy of imatinib in gastrointestinal stromal tumours; suggested mechanism of action of PBOX-15., Investigational new drugs, 34, (2), 2016, 159-167 Journal Article, 2016 DOI

Kelly PM, Bright SA, Fayne D, Pollock JK, Zisterer DM, Williams DC, Meegan MJ, Synthesis, antiproliferative and pro-apoptotic activity of 2-phenylindoles., Bioorganic & medicinal chemistry, 24, (18), 2016, p4075-99 Journal Article, 2016 DOI

Nathwani SM, Greene LM, Butini S, Campiani G, Williams DC, Samali A, Szegezdi E, Zisterer DM, The pyrrolo-1,5-benzoxazepine, PBOX-15, enhances TRAIL"induced apoptosis by upregulation of DR5 and downregulation of core cell survival proteins in acute lymphoblastic leukaemia cells., International journal of oncology, 49, (1), 2016, p74-88 Journal Article, 2016 DOI

Lennon JC, Butini S, Campiani G, O'Meara A, Williams DC, Zisterer DM, Involvement of AMP-activated protein kinase in mediating pyrrolo-1,5-benzoxazepine-induced apoptosis in neuroblastoma cells., Investigational new drugs, 34, (5), 2016, p663-76 Journal Article, 2016 DOI

Fiore D, Proto MC, Pisanti S, Picardi P, Pagano Zottola AC, Butini S, Gemma S, Casagni A, Laezza C, Vitale M, Ligresti A, Di Marzo V, Zisterer DM, Nathwani S, Williams DC, Campiani G, Gazzerro P, Bifulco M, Antitumor effect of pyrrolo-1,5-benzoxazepine-15 and its synergistic effect with Oxaliplatin and 5-FU in colorectal cancer cells., Cancer biology & therapy, 17, (8), 2016, p849 - 858 Journal Article, 2016 DOI

Martínez-Calvo M, Orange KN, Elmes RB, la Cour Poulsen B, Williams DC, Gunnlaugsson T, Ru(ii)-polypyridyl surface functionalised gold nanoparticles as DNA targeting supramolecular structures and luminescent cellular imaging agents., Nanoscale, 8, (1), 2015, p563-74 Journal Article, 2015 DOI

Thorfinnur Gunnlaugsson, Miguel Martínez-Calvo, Kim Orange, Robert B. P. Elmes, Bjørn la Cour Poulsen and D. Clive Williams , Ru(II)-polypyridyl surface functionalised gold nano-particles as DNA targeting supramolecular structures and luminescent cellular imaging agents, Nanoscale, 2015 Journal Article, 2015 URL

Cloonan SM, Elmes RB, Erby M, Bright SA, Poynton FE, Nolan DE, Quinn SJ, Gunnlaugsson T, Williams DC, Detailed Biological Profiling of a Photoactivated and Apoptosis Inducing pdppz Ruthenium(II) Polypyridyl Complex in Cancer Cells., Journal of medicinal chemistry, 58, (11), 2015, p4494-505 Journal Article, 2015 DOI

Spallarossa A, Caneva C, Caviglia M, Alfei S, Butini S, Campiani G, Gemma S, Brindisi M, Zisterer DM, Bright SA, Williams CD, Crespan E, Maga G, Sanna G, Delogu I, Collu G, Loddo R, Unconventional Knoevenagel-type indoles: Synthesis and cell-based studies for the identification of pro-apoptotic agents., European journal of medicinal chemistry, 102, 2015, p648-60 Journal Article, 2015

Ryan GJ, Poynton FE, Elmes RB, Erby M, Williams DC, Quinn SJ, Gunnlaugsson T, Unexpected DNA binding properties with correlated downstream biological applications in mono vs. bis-1,8-naphthalimide Ru(ii)-polypyridyl conjugates., Dalton transactions (Cambridge, England : 2003), 44, (37), 2015, p16332-44 Journal Article, 2015

O'Callaghan K, Palagano E, Butini S, Campiani G, Williams DC, Zisterer DM, O'Sullivan J, Induction of apoptosis in oral squamous carcinoma cells by pyrrolo-1,5-benzoxazepines., Molecular medicine reports, 12, (3), 2015, p3748-54 Journal Article, 2015 DOI

Murphy S, Bright SA, Poynton FE, McCabe T, Kitchen JA, Veale EB, Williams DC, Gunnlaugsson T, Synthesis, photophysical and cytotoxicity evaluations of DNA targeting agents based on 3-amino-1,8-naphthalimide derived Tröger's bases., Organic & biomolecular chemistry, 12, (34), 2014, p6610-23 Journal Article, 2014

Banerjee S, Bright SA, Smith JA, Burgeat J, Martinez-Calvo M, Williams DC, Kelly JM, Gunnlaugsson T, Supramolecular approach to enantioselective DNA recognition using enantiomerically resolved cationic 4-amino-1,8-naphthalimide-based Tröger's bases., The Journal of organic chemistry, 79, (19), 2014, p9272-83 Journal Article, 2014

McNamara YM, Bright SA, Byrne AJ, Cloonan SM, McCabe T, Williams DC, Meegan MJ, Synthesis and antiproliferative action of a novel series of maprotiline analogues., European journal of medicinal chemistry, 71, 2014, p333-53 Journal Article, 2014

Lennon JC, Bright SA, Carroll E, Butini S, Campiani G, O'Meara A, Williams DC, Zisterer DM, The novel pyrrolo-1,5-benzoxazepine, PBOX-6, synergistically enhances the apoptotic effects of carboplatin in drug sensitive and multidrug resistant neuroblastoma cells., Biochemical pharmacology, 87, (4), 2014, p611-24 Journal Article, 2014

Greene LM, Nolan DP, Regan-Komito D, Campiani G, Williams DC, Zisterer DM, Inhibition of late-stage autophagy synergistically enhances pyrrolo-1,5-benzoxazepine-6-induced apoptotic cell death in human colon cancer cells., International journal of oncology, 2013 Journal Article, 2013

Gangemi G, Gazzerro P, Fiore D, Proto MC, Butini S, Gemma S, Casagni A, Laezza C, Vitale M, Ligresti A, Di Marzo V, Zisterer DM, Nathwani S, Clive Williams D, Campiani G, Bifulco M, PBOX-15 induces apoptosis and improves the efficacy of oxaliplatin in human colorectal cancer cell lines., European journal of pharmacology, 2013 Journal Article, 2013

Banerjee S, Kitchen JA, Bright SA, O'Brien JE, Williams DC, Kelly JM, Gunnlaugsson T, Synthesis, spectroscopic and biological studies of a fluorescent Pt(ii) (terpy) based 1,8-naphthalimide conjugate as a DNA targeting agent., Chemical communications (Cambridge, England), 49, (76), 2013, p8522-8524 Journal Article, 2013 DOI TARA - Full Text

Bright SA, Brinkø A, Larsen MT, Sinning S, Williams DC, and Jensen HH. , . Basic N-interlinked imipramines show apoptotic activity against malignant cells including Burkitt's lymphoma, Bioorg Med Chem Lett. , 23, 2013, p1220 - 1224 Journal Article, 2013 DOI

Lysaght J, Verma NK, Maginn EN, Ryan JM, Campiani G, Zisterer DM, Williams DC, Browne PV, Lawler MP, McElligott AM, The microtubule targeting agent PBOX-15 inhibits integrin-mediated cell adhesion and induces apoptosis in acute lymphoblastic leukaemia cells., International journal of oncology, 42, (1), 2013, p239-46 Journal Article, 2013 DOI

Breen, JM, Clerac R, Zhang L, Cloonan SM, Kennedy E, Feeney M, McCabe T, Williams DC, and Schmitt, W., Self-assembly of hybrid organic-inorganic polyoxovanadates: functionalised mixed-valent clusters and molecular cages, Dalton Transactions, 41, (10), 2012, p2918 - 2926 Journal Article, 2012

Elmes RB, Erby M, Bright SA, Williams DC, Gunnlaugsson T, Photophysical and biological investigation of novel luminescent Ru(ii)-polypyridyl-1,8-naphthalimide Tröger's bases as cellular imaging agents., Chemical communications (Cambridge, England), 48, (20), 2012, p2588-90 Journal Article, 2012

Caboni L, Kinsella GK, Blanco F, Fayne D, Jagoe WN, Carr M, Williams DC, Meegan MJ, Lloyd DG, 'True' antiandrogens - selective non ligand-binding pocket disruptors of androgen receptor-coactivator interactions: Novel Tools for Prostate Cancer., Journal of Medicinal Chemistry, 55, (4), 2012, p1635 - 1644 Journal Article, 2012 DOI

Elmes RB, Kitchen JA, Williams DC, Gunnlaugsson T, Pushing the limit: synthesis, photophysical and DNA binding studies of a NIR-emitting Ru(II)-polypyridyl probe with 'light switch' behaviour., Dalton transactions (Cambridge, England : 2003), 41, (22), 2012, p6607-10 Journal Article, 2012 DOI

Yvonne M. McNamara, Suzanne M. Cloonan, Andrew J.S. Knox, John J. Keating, Stephen G. Butler, Günther H. Peters, Mary J. Meegan and D. Clive Williams, Synthesis and serotonin transporter activity of 1,3-bis(aryl)-2-nitro-1-propenes as a new class of anticancer agents, Bioorganic & Medicinal Chemistry, 19, (3), 2011, p1328 - 1348 Journal Article, 2011 TARA - Full Text

Elmes RB, Orange KN, Cloonan SM, Williams DC, Gunnlaugsson T, Luminescent ruthenium(II) polypyridyl functionalized gold nanoparticles; their DNA binding abilities and application as cellular imaging agents., Journal of the American Chemical Society, 133, (40), 2011, p15862 - 15865 Journal Article, 2011 DOI

Forde JC, Maginn EN, McNamara G, Martin LM, Campiani G, Williams DC, Zisterer D, McElligott AM, Lawler M, Lynch TH, Hollywood D, Marignol L, Microtubule-targeting-compound PBOX-15 radiosensitizes cancer cells in vitro., Cancer biology & therapy, 11, (4), 2011, p421-8 Journal Article, 2011

Forde JC., Maginn EN., McNamara G., Martin LM., Campiani GC. , Williams DC, Zisterer D.M, McElligott AM., Lawler M, , Lynch TH, Hollywood D., Marignol L, Microtubule-Targeting-Compound PBOX-15 Radiosensitizes Cancer Cells In Vitro , Cancer Biology and Therapy, 11, (4), 2011, p6 - 13 Journal Article, 2011

O'Boyle, N.M., Knox, A.J.S., Price, T.P., Williams, D.C., Zisterer, D.M., Lloyd, D.G., Meegan, M.J.,, Lead identification of beta-lactam and related imine inhibitors of the molecular chaperone heat shock protein 90, Bioorganic & Medicinal Chemistry, 19, (20), 2011, p6055-6068 Journal Article, 2011 DOI TARA - Full Text

Cloonan, S.M. and Williams, D.C. , The antidepressants maprotiline and fluoxetine induce Type-II autophagic cell death in drug resistant Burkitt's lymphoma, International Journal of Cancer, 128, 2011, p1712 - 1723 Journal Article, 2011

Maginn EN, Browne PV, Hayden P, Vandenberghe E, McDonagh B, Evans P, Goodyer M, Tewari P, Campiani G, Butini S, Williams DC, Zisterer DM, Lawler MP, McElligott AM., PBOX-15, a novel microtubule targeting agent, induces apoptosis, upregulates death receptors, and potentiates TRAIL-mediated apoptosis in multiple myeloma cells., British Journal of Cancer, 104, (2), 2011, p281 - 289 Journal Article, 2011 DOI

Robert B. P. Elmes, Marialuisa Erby, Suzanne M. Cloonan, Susan J. Quinn, D. Clive Williams and Thorfinnur Gunnlaugsson, Quaternarized pdppz: Synthesis, DNA-binding and biological studies of a novel dppz derivative that causes cellular death upon light irradiation, Chemical Communications, 47, 2011, p686 - 688 Journal Article, 2011 TARA - Full Text DOI

Suzanne M. Cloonan, John J. Keating, John E. O'Brien, Desmond Corrigan, Pierce V Kavanagh, D. Clive Williams and Mary J. Meegan, Synthesis and in vitro toxicity of 4-MTA, its characteristic clandestine synthesis byproducts and related sulphur substituted á-alkylthioamphetamines, Bioorganic and Medicinal Chemistry, 18, 2010, p4009 - 4031 Journal Article, 2010 TARA - Full Text

Cloonan SM, Dr0zgowska A, Fayne D and Williams DC, The antidepressants maprotiline and fluoxetine have potent antiproliferative effects against Burkitt's lymphoma independently of the norepinephrine and serotonin transporters, Leukemia and Lymphoma, 51, (3), 2010, p523 - 539 Journal Article, 2010 DOI

Yang Y, Carta G, Peters MB, Price T, O'Boyle N, Knox AJ, Fayne D, Williams DC, Meegan MJ, Lloyd DG , 'tieredScreen' - Layered Virtual Screening Tool for the Identification of Novel Estrogen Receptor Alpha, Molecular Informatics, 29, 2010, p421 - 430 Journal Article, 2010 DOI

Onnis, Valeria; Kinsella, Gemma; Carta, Giorgio; Jagoe, William; Price, Trevor; Williams, Clive; Fayne, Darren; Lloyd, David, Virtual Screening for the identification of novel non-steroidal Glucocorticoid Modulators, Journal of Medicinal Chemistry, 53, 2010, p3065 - 3074 Journal Article, 2010 DOI

S A Bright, A M McElligott, J W O'Connell, L O'Connor, P Carroll, G Campiani, M W Deininger, E Conneally, M Lawler, D C Williams, and D.M Zisterer, Novel pyrrolo-1,5-benzoxazepine compounds display significant activity against resistant chronic myeloid leukaemia cells in vitro, in ex vivo patient samples and in vivo , British Journal of Cancer, 102, 2010, p1474 - 1482 Journal Article, 2010 TARA - Full Text

Sandra A. Bright, Giuseppe Campiani, Michael W. Deininger, Mark Lawler, D. Clive Williams and Daniela M. Zisterer, Sequential treatment with flavopiridol synergistically enhances pyrrolo-1,5-benzoxazepine-induced apoptosis in human chronic myeloid leukaemia cells including those resistant to imatinib treatment , Biochemical Pharmacology, 80, 2010, p31 - 38 Journal Article, 2010 DOI

Seema-Maria Nathwani , Suzanne M. Cloonan, Maeve Stronach, Giuseppe Campiani, Mark Lawler, D. Clive Williams and Daniela M. Zisterer, Novel microtubule-targeting agents, pyrrolo-1,5-benzoxazepines, induce cell cycle arrest and apoptosis in prostate cancer cells. , Oncology Reports, 24, 2010, p1499 - 1507 Journal Article, 2010 DOI

Nathwani, S-M., Butler, S., Meegan, M.J., Campiani, G., Lawler, M., Williams, D.C. & Zisterer, D.M., Dual targeting of tumour cells and host endothelial cells by novel microtubule-targeting agents, pyrrolo-1,5-benzoxazepines., Cancer Chemotherapy and Pharmacology, 65, (2), 2010, p289-300 Journal Article, 2010 TARA - Full Text

Nathwani,SM, Butler, S, Fayne,D, McGovern,NN, Sarkardi,B, Meegan,MJ, Lloyd,DG, Campiani,G, Lawler,M, Williams,DC, and Zisterer, DM, Novel Microtubule targetting agents, pyrrolo-1,5,benzoxazepines induce apoptosis in multi-drug-resistant cancer cells, CANCER CHEMOTHERAPY AND PHARMACOLOGY, 66, (3), 2010, p585 - 596 Journal Article, 2010 TARA - Full Text

Bane, F.T., Pennington, S.R., Campiani, G., Williams, D.C., Zisterer, D.M. & Mc Gee, M.M. , The microtubule-targeting agents, PBOX-6 [pyrrolobenzoxazepine 7-[(dimethylcarbamoyl)oxy]-6-(2-naphthyl)pyrrolo-[2,1-d] (1,5)-benzoxazepine] and paclitaxel, induce nucleocytoplasmic redistribution of the peptidyl-prolyl isomerases, cyclophilin A and pin1, in malignant hematopoietic cells., Journal of Pharmacology and Experimental Therapeutics, 329, 2009, p38-47 Journal Article, 2009 URL DOI

Knox AJ, Price T, Pawlak M, Golfis G, Flood CT, Fayne D, Williams DC, Meegan MJ, Lloyd DG, Integration of ligand and structure-based virtual screening for the identification of the first dual targeting agent for heat shock protein 90 (Hsp90) and tubulin., Journal of medicinal chemistry, 52, (8), 2009, p2177-80 Journal Article, 2009 DOI

Bright S.A., Greene, L.M., Greene, T.F., Campiani, G., Buitini, S., Brindisi, M., Lawler, M., Meegan, M.J., Williams, D.C. and Zisterer, D.M. , The novel pyrrolo-1,5-benzoxazepine, PBOX-21, potentiates the apoptotic efficacy of STI571 (imatinib mesylate) in human chronic myeloid leukaemia cells, Biochemical Pharmacology, 77, (3), 2009, p310-321 Journal Article, 2009 URL DOI

McElligott, AM, Maginn, EN, Greene, LM, McGuckin, S, Hayat, A, Browne, PV, Butini, S, Campiani, G, Catherwood, MA, Vandenberghe, E, Williams, DC, Zisterer, DM, Lawler, M, The Novel Tubulin-Targeting Agent Pyrrolo-1,5-Benzoxazepine-15 Induces Apoptosis in Poor Prognostic Subgroups of Chronic Lymphocytic Leukemia., Cancer Research, 69, (21), 2009, p8366 - 8375 Journal Article, 2009 DOI

Cloonan, SM, Keating, JJ, Butler, SG, Knox, AJ, Jørgensen, AM, Peters, GH, Rai, D, Corrigan, D, Lloyd, DG, Williams, DC, Meegan, MJ, Synthesis and serotonin transporter activity of sulphur-substituted alpha-alkyl phenethylamines as a new class of anticancer agents., European Journal of Medicinal Chemistry, 44, 2009, p4862 - 4888 Journal Article, 2009 DOI

Greene, LM, Campiani, GC, Lawler, M, Williams, DC and Zisterer, DM, BubR1 is Required for a Sustained Mitotic Spindle checkpoint arrest in Human Cancer cells treated with a tubulin-targetting pyrrolo-1,5-benzoxazepine, Molecular Pharmacology, 73, (2), 2008, p419 - 430 Journal Article, 2008 URL DOI

Verma NK, Dempsey E, Conroy J, Olwell P, Mcelligott AM, Davies AM, Kelleher D, Butini S, Campiani G, Williams DC, Zisterer DM, Lawler M, Volkov Y., A new microtubule-targeting compound PBOX-15 inhibits T-cell migration via post-translational modifications of tubulin., Journal of Molecular Medicine, 86, (4), 2008, p457-469 Journal Article, 2008 DOI

Greene LM, Kelly L, Onnis V, Campiani G, Lawler M, Williams DC, Zisterer DM., STI-571 (imatinib mesylate) enhances the apoptotic efficacy of pyrrolo-1,5-benzoxazepine-6, a novel microtubule-targeting agent, in both STI-571-sensitive and -resistant Bcr-Abl-positive human chronic myeloid leukemia cells., Journal of Pharmacology and Experimental Therapeutics, 321, (1), 2007, p288-297 Journal Article, 2007 DOI

Knox AJ, Meegan MJ, Sobolev V, Frost D, Zisterer DM, Williams DC, Lloyd DG., Target specific virtual screening: optimization of an estrogen receptor screening platform., Journal of Medicinal Chemistry, 50, (22), 2007, p5301-5310 Journal Article, 2007 DOI URL

Mulligan JM, Greene LM, Cloonan S, Mc Gee MM, Onnis V, Campiani G, Fattorusso C, Lawler MP, Williams C, Zisterer DM., Identification of tubulin as the molecular target of pro-apoptotic pyrrolo-1,5-benzoxazepines., Molecular Pharmacology, 70, (1), 2006, p60-70 Journal Article, 2006 DOI

McGrath, LB, Onnis, V, Campiani, G, Williams, DC, Zisterer, DM and McGee, MM, Caspase-activated DNase (CAD)-independent oligonucleosomal DNA fragmentation in chronic myeloid leukaemia cells; a requirement for serine protease and Mn(2+)-dependent acidic endonuclease activity., Apoptosis, 11, (9), 2006, p1473 - 1487 Journal Article, 2006 URL DOI

Greene, L.M., Fleeton, M., Mulligan, J., Chikana, G., Sheahan, B.J., Atkins, G.J., Campiani, G., Nacci, V., Lawler, M., Williams, D.C. and Zisterer, D.M., The pyrrolo-1,5-benzoxazepine, PBOX-6, inhibits the growth of breast cancer cells in vitro independent of estrogen receptor status, and inhibits breast tumour growth in vivo, Oncology Reports, 14, 2005, p1357 - 1363 Journal Article, 2005

McGee, MM, Gemma, S, Rammunno, A, Zisterer,DM, Fatterusso, C, Catalanotti, B, Butini, S, Fiorini,I, Pisano, C, Cucco, C, Novellino, E, Nacci, V, Williams, DC and Campiani, G, Pyrolo [1,5] benzoxathiazepines as a new class of potent apoptotic agents. Biological studies and identification of an intracellular location of their drug target., Journal of Medicinal Chemistry, 48, (13), 2005, p4367 - 4377 Journal Article, 2005 DOI URL

Lloyd DG, Hughes RB, Zisterer DM, Williams DC, Fattorusso C, Catalanotti B, Campiani G, Meegan MJ., Benzoxepin-derived estrogen receptor modulators: a novel molecular scaffold for the estrogen receptor, Journal of Medicinal Chemistry, 47, (23), 2004, p5612 - 5615 Journal Article, 2004 URL DOI

Rogers, A, Schmuck, G, Scholz, G, and Williams D.C., c-fos mRNA expression in rat cortical neurons during glutamate-mediated excitotoxicity, Toxicol. Sci., 82, 2004, p562 - 569 Journal Article, 2004

Lloyd, D.G., Hughes, R.B., Zisterer, D.M., Williams, D.C., Fattorusso, C., Catalanotti, B. Campiani, G.C., and Meegan, M.J., Benzoxepin-derived estrogen receptor modulators - a novel molecular scaffold for the estrogen receptor, J Med Chem, 47, 2004, p5612 - 5615 Journal Article, 2004

M. M. Mc Gee, L. M. Greene, S. Ledwidge, G. Campiani, V. Nacci, M. Lawler, D. C. Williams and D. M. Zisterer, Selective induction of apoptosis by the pyrrolo-1,5-benzoxazepine 7-[[dimethylcarbamoyl]oxy]-6-(2-naphthyl)pyrrolo-[2,1-d] (1,5)-benzoxazepine (PBOX-6) in Leukemia cells occurs via the c-Jun NH2-terminal kinase-dependent phosphorylation and inactivation of Bcl-2 and Bcl-XL, The Journal of pharmacology and experimental therapeutics, 310, (3), 2004, p1084-1095 Journal Article, 2004 URL URL DOI

Magnani F, Tate CG, Wynne S, Williams DC , and Haase,J., Partitioning of the serotonin transporter into lipid microdomains modulates transport of serotonin, J. Biol.Chem., 279, 2004, p38770 - 38778 Journal Article, 2004

Tate, C.G., Haase, J., Baker, C.M., Boorsma, M., Magnani, F., Vallis, Y., and Williams, D.C., Comparison of seven different protein expression systems for the production of the serotonin transporter, Biochim. Biophys. Acta., 1610, 2003, p141 - 153 Journal Article, 2003

Campiani, G., Ramuno, A., Fiorini, I., Nacci, V., Morelli, E., Novellino, E., Menninni, T., Zisterer, D.M., Williams, D.C. , Synthesis of new molecular probes for investigation of steroid biosynthesis induced by selective interaction with peripheral-type benzodiazepine receptors (PBR)., Journal Medicinal Chemistry, 45, (19), 2002, p4276 - 4281 Journal Article, 2002 DOI URL

M. M. Mc Gee, G. Campiani, A. Ramunno, V. Nacci, M. Lawler, D. C. Williams and D. M. Zisterer, Activation of the c-Jun N-terminal kinase (JNK) signaling pathway is essential during PBOX-6-induced apoptosis in chronic myelogenous leukemia (CML) cells, The Journal of Biological Chemistry, 277, (21), 2002, p18383-18389 Journal Article, 2002 DOI URL URL

M. Marangolo, M. M. McGee, K. F. Tipton, D. C. Williams and D. M. Zisterer, Oxidative stress induces apoptosis in C6 glioma cells: involvement of mitogen-activated protein kinases and nuclear factor kappa B, Neurotox Research, 3, (4), 2001, p397-409 Journal Article, 2001 DOI URL URL

D. M. Zisterer, M. M. McGee, G. Campiani, A. Ramunno, C. Fattorusso, V. Nacci, M. Lawler and D. C. Williams, Pyrrolo-1,5-benzoxazepines: a new class of apoptotic agents, Biochemical Society transactions, 29, (6), 2001, p704-706 Journal Article, 2001 URL URL

MC GEE, MM, CAMPIANI, G, RAMUNNO, A, FATTORUSSO, C, NACCI, V, LAWLER, M, WILLIAMS, DC, ZISTERER, DM, PYRROLO-1,5-BENZOXAZEPINES INDUCE APOPTOSIS IN CHRONIC MYELOGENOUS LEUKEMIA (CML) CELLS BY BYPASSING THE APOPTOTIC SUPPRESSOR BCR-ABL, JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 296, 2001, p31 - 40 Journal Article, 2001

Williams. D.C., and Haase, J. ( eds), Neurotransmitter Transporters: Molecular mechanism and regulation, Biochem. Soc. Trans., 29, 2001, 707 - 750 Journal Article, 2001

SCANLON, SM, WILLIAMS, DC, SCHLOSS, P, MEMBRANE CHOLESTEROL MODULATES SEROTONIN TRANSPORTER ACTIVITY, BIOCHEMISTRY, 40, 2001, p10507 - 10513 Journal Article, 2001

MEEGAN, MJ, HUGHES, RB, LLOYD, DG, WILLIAMS, DC, ZISTERER, DM, FLEXIBLE ESTROGEN RECEPTOR MODULATORS: DESIGN, SYNTHESIS, AND ANTAGONISTIC EFFECTS IN HUMAN MCF-7 BREAST CANCER CELLS, JOURNAL OF MEDICINAL CHEMISTRY, 44, 2001, p1072 - 1084 Journal Article, 2001

HAASE, J, KILLIAN, AM, MAGNANI, F, WILLIAMS, C, REGULATION OF THE SEROTONIN TRANSPORTER BY INTERACTING PROTEINS, BIOCHEMICAL SOCIETY TRANSACTIONS, 29, 2001, p722 - 728 Journal Article, 2001

MEEGAN, MJ, HUGHES, RB, LLOYD, DG, WILLIAMS, DC, ZISTERER, DM, ETHYL SIDE-CHAIN MODIFICATIONS IN NOVEL FLEXIBLE ANTIESTROGENS - DESIGN, SYNTHESIS AND BIOLOGICAL EFFICACY IN ASSAY AGAINST THE MCF-7 BREAST TUMOR CELL LINE, ANTI-CANCER DRUG DESIGN, 16, 2001, p57 - 69 Journal Article, 2001

ZISTERER, DM, MCGEE, MM, CAMPIANI, G, RAMUNNO, A, FATTORUSSO, C, NACCI, V, LAWLER, M, WILLIAMS, DC, PYRROLO-1,5-BENZOXAZEPINES: A NEW CLASS OF APOPTOTIC AGENTS, BIOCHEMICAL SOCIETY TRANSACTIONS, 29, 2001, p704 - 706 Journal Article, 2001

Meegan, M., Hughes, R., Lloyd, D.G., Zisterer, D.M. & Williams, D.C. , Flexible estrogen receptor modulators: design, synthesis and antagonistic effects in human MCF-7 breast cancer cells. , Journal Medicinal Chemistry, 44, (7), 2001, p1072 - 1084 Journal Article, 2001 URL DOI

M. M. Mc Gee, G. Campiani, A. Ramunno, C. Fattorusso, V. Nacci, M. Lawler, D. C. Williams and D. M. Zisterer, Pyrrolo-1,5-benzoxazepines induce apoptosis in chronic myelogenous leukemia (CML) cells by bypassing the apoptotic suppressor bcr-abl, The Journal of Pharmacology and Experimental Therapeutics, 296, (1), 2001, p31-40 Journal Article, 2001 URL URL

Zisterer, D.M., Campiani., Nacci, V. & Williams, D.C. , Pyrrolobenzoxazepines induce apoptosis in HL-60, Jurkat and Hut-78 cells: A new class of apoptotic agents., Journal Pharmacology and Experimental Therapeutics, 293, (1), 2000, p48 - 59 Journal Article, 2000 URL

ZISTERER, DM, CAMPIANI, G, NACCI, V, WILLIAMS, DC, PYRROLO-1,5-BENZOXAZEPINES INDUCE APOPTOSIS IN HL-60, JURKAT, AND HUT-78 CELLS: A NEW CLASS OF APOPTOTIC AGENTS, JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 293, 2000, p48 - 59 Journal Article, 2000

ZISTERER, DM, HANCE, N, CAMPIANI, G, GAROFALO, A, NACCI, V, WILLIAMS, DC, ANTIPROLIFERATIVE ACTION OF PYRROLOBENZOXAZEPINE DERIVATIVES IN CULTURED CELLS: ABSENCE OF CORRELATION WITH BINDING TO THE PERIPHERAL-TYPE BENZODIAZEPINE BINDING SITE, BIOCHEMICAL PHARMACOLOGY, 55, 1998, p397 - 403 Journal Article, 1998

Zisterer D.M., Campiani, G., Garafalo, A., Nacci, V. and Williams, D.C. , Antiproliferative action of pyrrolobenzoxazepine derivatives in cultured cells: Absence of correlation with binding to the peripheral-type benzodiazepine binding site, Biochemical Pharmacology, 55, (4), 1998, p397 - 403 Journal Article, 1998 DOI URL

SCHLOSS, P, WILLIAMS, DC, THE SEROTONIN TRANSPORTER: A PRIMARY TARGET FOR ANTIDEPRESSANT DRUGS, JOURNAL OF PSYCHOPHARMACOLOGY, 12, 1998, p115 - 121 Journal Article, 1998

ZISTERER, DM, WILLIAMS, DC, CALMIDAZOLIUM AND OTHER IMIDAZOLE COMPOUNDS AFFECT STEROIDOGENESIS IN Y1 CELLS: LACK OF INVOLVEMENT OF THE PERIPHERAL-TYPE BENZODIAZEPINE RECEPTOR, JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 60, 1997, p189 - 195 Journal Article, 1997

WOODS, MJ, ZISTERER, DM, WILLIAMS, DC, TWO CELLULAR AND SUBCELLULAR LOCATIONS FOR THE PERIPHERAL-TYPE BENZODIAZEPINE RECEPTOR IN RAT LIVER, BIOCHEMICAL PHARMACOLOGY, 51, 1997, p1283 - 1292 Journal Article, 1997

ZISTERER, DM, MOYNAGH, PN, WILLIAMS, DC, HEXACHLOROCYCLOHEXANES INHIBIT STEROIDOGENESIS IN Y1 CELLS - ABSENCE OF CORRELATION WITH BINDING TO THE PERIPHERAL-TYPE BENZODIAZEPINE BINDING SITE, BIOCHEMICAL PHARMACOLOGY, 51, 1997, p1303 - 1308 Journal Article, 1997

Zisterer, D.M. and Williams, D.C., Peripheral-type benzodiazepine receptors, General Pharmacology, 29, (3), 1997, p305 - 314 Journal Article, 1997 URL DOI

Campiani G, Nacci V, Fiorini I, De Filippis MP, Garofalo A, Ciani SM, Greco G, Novellino E, Williams DC, Zisterer DM, Woods MJ, Mihai C, Manzoni C, Mennini T. , Synthesis, biological activity, and SARs of pyrrolobenzoxazepine derivatives, a new class of specific "peripheral-type" benzodiazepine receptor ligands., Journal of Medicinal Chemistry, 39, (18), 1996, p3435 - 3450 Journal Article, 1996 URL DOI

DUNICAN, DJ, GRIFFITHS, R, WILLIAMS, DC, ONEILL, LAJ, ENDOTHELIN-1 INCREASES ARACHIDONIC ACID RELEASE IN C6 GLIOMA CELLS THROUGH A POTASSIUM-MODULATED INFLUX OF CALCIUM, JOURNAL OF NEUROCHEMISTRY, 67, 1996, p830 - 837 Journal Article, 1996

D. M. Zisterer, P. N. Moynagh and D. C. Williams, Hexachlorocyclohexanes inhibit steroidogenesis in Y1 cells. Absence of correlation with binding to the peripheral-type benzodiazepine binding site, Biochemical Pharmacology, 51, (10), 1996, p1303-1308 Journal Article, 1996 DOI URL URL

CAMPIANI, G, NACCI, V, FIORINI, I, DEFILIPPIS, MP, GAROFALO, A, CIANI, SM, GRECO, G, NOVELLINO, E, WILLIAMS, DC, ZISTERER, DM, WOODS, MJ, MIHAI, C, MANZONI, C, MENNINI, T, SYNTHESIS, BIOLOGICAL ACTIVITY, AND SARS OF PYRROLOBENZOXAZEPINE DERIVATIVES, A NEW CLASS OF SPECIFIC ''PERIPHERAL-TYPE'' BENZODIAZEPINE RECEPTOR LIGANDS, JOURNAL OF MEDICINAL CHEMISTRY, 39, 1996, p3435 - 3450 Journal Article, 1996

Woods MJ, Zisterer DM, Williams DC. , Two cellular and subcellular locations for the peripheral-type benzodiazepine receptor in rat liver. , Biochemical Pharmacology, 51, (10), 1996, p1283 - 1292 Journal Article, 1996 URL DOI

WOODS, MJ, WILLIAMS, DC, MULTIPLE FORMS AND LOCATIONS FOR THE PERIPHERAL-TYPE BENZODIAZEPINE RECEPTOR, BIOCHEMICAL PHARMACOLOGY, 52, 1996, p1805 - 1814 Journal Article, 1996

TARRANT, HM, WILLIAMS, DC, RECONSTITUTION OF THE RAT-BRAIN SEROTONIN TRANSPORTER, BIOCHEMICAL SOCIETY TRANSACTIONS, 23, 1995, pS40 - S40 Journal Article, 1995

TARRANT, HM, WILLIAMS, DC, DITHIOTHREITHOL PROMOTES A HIGHER AFFINITY STATE OF THE SEROTONIN TRANSPORTER FOR THE TRICYCLIC ANTIDEPRESSANT, IMIPRAMINE, BIOCHEMICAL SOCIETY TRANSACTIONS, 23, 1995, pS41 - S41 Journal Article, 1995

DUNICAN, DJ, GRIFFITHS, R, ONEILL, LAJ, WILLIAMS, DC, DEPOLARIZING LEVELS OF KCI INHIBIT ENDOTHELIN-1-MEDIATED RELEASE OF ARACHIDONIC-ACID IN RAT C6 GLIOMA-CELLS, BIOCHEMICAL SOCIETY TRANSACTIONS, 23, 1995, pS285 - S285 Journal Article, 1995

ZISTERER, DM, SUNOL, C, MOYNAGH, PN, WILLIAMS, DC, RODRIGUEZFARRE, E, PK-11195 REDUCES THE BRAIN AVAILABILITY OF LINDANE IN RATS AND THE CONVULSIONS INDUCED BY THIS NEUROTOXIC AGENT, LIFE SCIENCES, 57, 1995, p2359 - 2364 Journal Article, 1995

D. M. Zisterer, C. Sunol, P. N. Moynagh, D. C. Williams and E. Rodriguez-Farre, PK 11195 reduces the brain availability of lindane in rats and the convulsions induced by this neurotoxic agent, Life Sciences, 57, (25), 1995, p2359-2364 Journal Article, 1995 URL DOI URL

ZISTERER, DM, WILLIAMS, DC, IDENTIFICATION BF NOVEL LIGANDS FOR THE PERIPHERAL-TYPE BENZODIAZEPINE RECEPTOR, BIOCHEMICAL SOCIETY TRANSACTIONS, 23, 1995, pS371 - S371 Journal Article, 1995

WORRALL, DM, SODIUM ION-DEPENDENT TRANSPORTERS FOR NEUROTRANSMITTERS - A REVIEW OF RECENT DEVELOPMENTS, by WILLIAMS, DC , BIOCHEMICAL JOURNAL, 297, 1994, p425 - 436 Review, 1994

MOYNAGH, PN, SCHOUSBOE, A, WILLIAMS, DC, THE PERIPHERAL-TYPE BENZODIAZEPINE RECEPTOR IS PRESENT IN ASTROCYTES BUT IS NOT A PRIMARY SITE OF ACTION FOR CONVULSANTS/ANTICONVULSANTS, JOURNAL OF NEUROCHEMISTRY, 62, 1994, p673 - 679 Journal Article, 1994

ATTERWILL, CK, BRUININK, A, DREJER, J, DUARTE, E, ABDULLA, EM, MEREDITH, C, NICOTERA, P, REGAN, C, RODRIGUEZFARRE, E, SIMPSON, MG, SMITH, R, VERONESI, B, VIJVERBERG, H, WALUM, E, WILLIAMS, DC, IN-VITRO NEUROTOXICITY TESTING - THE REPORT AND RECOMMENDATIONS OF ECVAM WORKSHOP-3, ATLA-ALTERNATIVES TO LABORATORY ANIMALS, 22, 1994, p350 - 362 Journal Article, 1994

MOYNAGH, PN, WILLIAMS, DC, ONEILL, LAJ, ACTIVATION OF NF-KAPPA-B AND INDUCTION OF VASCULAR CELL-ADHESION MOLECULE-1 AND INTRACELLULAR ADHESION MOLECULE-1 EXPRESSION IN HUMAN GLIAL-CELLS BY IL-1 - MODULATION BY ANTIOXIDANTS, JOURNAL OF IMMUNOLOGY, 153, 1994, p2681 - 2690 Journal Article, 1994

MOYNAGH, PN, INTERLEUKIN-1 ACTIVATES TRANSCRIPTION FACTOR NF-KAPPA-B IN GLIAL-CELLS, 1993, - Miscellaneous, 1993

MOYNAGH, PN, ONEILL, LAJ, WILLIAMS, DC, INTERLEUKIN-1 AND PHORBOL-MYRISTATE ACETATE MODULATE THE PERIPHERAL-TYPE BENZODIAZEPINE RECEPTOR IN LYMPHOCYTES AND GLIAL-CELLS, BIOCHEMICAL PHARMACOLOGY, 46, 1993, p821 - 827 Journal Article, 1993

MOYNAGH, PN, WILLIAMS, DC, STABILIZATION OF THE PERIPHERAL-TYPE BENZODIAZEPINE ACCEPTOR BY SPECIFIC PHOSPHOLIPIDS, BIOCHEMICAL PHARMACOLOGY, 43, 1992, p1939 - 1945 Journal Article, 1992

Zisterer DM, Gorman AM, Williams DC, Murphy MP. , The effects of the peripheral-type benzodiazepine acceptor ligands, Ro5-4864 and PK 11195, on mitochondrial respiration. , Methods and Findings in Experimental and Clinical Pharmacology, 14, (2), 1992, p85 - 90 Journal Article, 1992 URL

REGAN, CM, LARSSON, OM, MARTIN, ML, SCHOUSBOE, A, WILLIAMS, DC, INVITRO SCREENING FOR ANTICONVULSANT-INDUCED TERATOGENESIS - STRUCTURE-ACTIVITY-RELATIONSHIPS IN THE BARBITURATE AND BRANCHED-CHAIN CARBOXYLIC-ACID CLASSES, TOXICOLOGY IN VITRO, 5, 1991, p77 - 82 Journal Article, 1991

MOYNAGH, PN, BAILEY, CJ, BOYCE, SJ, WILLIAMS, DC, IMMUNOLOGICAL STUDIES ON THE RAT PERIPHERAL-TYPE BENZODIAZEPINE ACCEPTOR, BIOCHEMICAL JOURNAL, 275, 1991, p419 - 425 Journal Article, 1991

WILLIAMS, DC, PHILLIPS, OM, PROBING THE PLATELET PLASMA-MEMBRANE 5-HYDROXYTRYPTAMINE TRANSPORTER, BIOCHEMICAL SOCIETY TRANSACTIONS, 19, 1991, p112 - 115 Journal Article, 1991

RONAYNE, L, MCINERNEY, M, PHILLIPS, OM, REGAN, CM, WILLIAMS, DC, A MONOCLONAL ANTI-IMIPRAMINE ANTIBODY WITH ANTIDEPRESSANT BINDING-PROPERTIES SIMILAR TO THE MUSCARINIC RECEPTOR, BIOCHEMICAL PHARMACOLOGY, 39, 1990, p507 - 511 Journal Article, 1990

BARRY, S, PHILLIPS, OM, WILLIAMS, DC, DINAN, TG, PLATELET 5-HT UPTAKE IN POSTSTROKE DEPRESSION, ACTA PSYCHIATRICA SCANDINAVICA, 82, 1990, 88 - 89 Miscellaneous, 1990

REGAN, CM, GORMAN, AMC, LARSSON, OM, MAGUIRE, C, MARTIN, ML, SCHOUSBOE, A, WILLIAMS, DC, INVITRO SCREENING FOR ANTICONVULSANT-INDUCED TERATOGENESIS IN NEURAL PRIMARY CULTURES AND CELL-LINES, INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE, 8, 1990, p143 - 150 Journal Article, 1990

OBEIRNE, GB, WOODS, MJ, WILLIAMS, DC, 2 SUBCELLULAR LOCATIONS FOR PERIPHERAL-TYPE BENZODIAZEPINE ACCEPTORS IN RAT-LIVER, EUROPEAN JOURNAL OF BIOCHEMISTRY, 188, 1990, p131 - 138 Journal Article, 1990

ORIORDAN, C, PHILLIPS, OM, WILLIAMS, DC, 2 AFFINITY STATES FOR [H-3] IMIPRAMINE BINDING TO THE HUMAN PLATELET 5-HYDROXYTRYPTAMINE CARRIER - AN EXPLANATION FOR THE ALLOSTERIC INTERACTION BETWEEN 5-HYDROXYTRYPTAMINE AND IMIPRAMINE, JOURNAL OF NEUROCHEMISTRY, 54, 1990, p1275 - 1280 Journal Article, 1990

GORMAN, AMC, OBEIRNE, GB, REGAN, CM, WILLIAMS, DC, ANTIPROLIFERATIVE ACTION OF BENZODIAZEPINES IN CULTURED BRAIN-CELLS IS NOT MEDIATED THROUGH THE PERIPHERAL-TYPE BENZODIAZEPINE ACCEPTOR, JOURNAL OF NEUROCHEMISTRY, 53, 1989, p849 - 855 Journal Article, 1989

PHILLIPS, OM, WOOD, KM, WILLIAMS, DC, KINETICS OF THE INTERACTION OF SERTRALINE WITH THE HUMAN-PLATELET PLASMA-MEMBRANE 5-HYDROXYTRYPTAMINE CARRIER, EUROPEAN JOURNAL OF PHARMACOLOGY, 146, 1988, p299 - 306 Journal Article, 1988

ONEILL, C, WILLIAMS, DC, THE EFFECT OF TRITON X-100 ON BOVINE BRAIN SYNAPTIC-MEMBRANES, NEUROCHEMICAL RESEARCH, 13, 1988, p871 - 877 Journal Article, 1988

SMYTHE, E, WILLIAMS, DC, A SIMPLE RAPID PURIFICATION SCHEME FOR HYDROXYMETHYLBILANE SYNTHASE FROM HUMAN-ERYTHROCYTES, BIOCHEMICAL JOURNAL, 251, 1988, p237 - 241 Journal Article, 1988

SMYTHE, E, WILLIAMS, DC, RAT-LIVER UROPORPHYRINOGEN-III SYNTHASE HAS SIMILAR PROPERTIES TO THE ENZYME FROM EUGLENA-GRACILIS, INCLUDING ABSENCE OF A REQUIREMENT FOR A REVERSIBLY BOUND COFACTOR FOR ACTIVITY, BIOCHEMICAL JOURNAL, 253, 1988, p275 - 279 Journal Article, 1988

OBEIRNE, GB, WILLIAMS, DC, THE SUBCELLULAR LOCATION IN RAT-KIDNEY OF THE PERIPHERAL BENZODIAZEPINE ACCEPTOR, EUROPEAN JOURNAL OF BIOCHEMISTRY, 175, 1988, p413 - 421 Journal Article, 1988

WILLIAMS, DC, OBEIRNE, GB, HIGH-AFFINITY PERIPHERAL-TYPE BENZODIAZEPINE-BINDING SITES, BIOCHEMICAL SOCIETY TRANSACTIONS, 15, 1987, p220 - 220 Journal Article, 1987

OCALLAGHAN, AM, PHILLIPS, OM, WILLIAMS, DC, ANTISERA RAISED AGAINST THE DRUG IMIPRAMINE, JOURNAL OF NEUROCHEMISTRY, 49, 1987, p1091 - 1095 Journal Article, 1987

WILLIAMS, DC, POSSIBLE ARTIFACTS IN IMPIRAMINE BINDING ASSAYS - RESPONSE, 1985, - Miscellaneous, 1985

OBEIRNE, GB, BINDING OF BENZODIAZEPINES TO BLOOD-PLATELETS FROM VARIOUS SPECIES, 1984, - Miscellaneous, 1984

PHILLIPS, OM, WILLIAMS, DC, MULTIPLE AFFINITY STATES FOR [H-3]IMIPRAMINE BINDING-SITES ON HUMAN-PLATELET MEMBRANES, EUROPEAN JOURNAL OF PHARMACOLOGY, 100, 1984, 247 - 248 Miscellaneous, 1984

WILLIAMS, DC, CHARACTERIZATION OF THE MULTIPLE FORMS OF HYDROXYMETHYLBILANE SYNTHASE FROM RAT SPLEEN, BIOCHEMICAL JOURNAL, 217, 1984, p675 - 683 Journal Article, 1984

Phillips, O.M., Wood, K.M. & Williams, D.C., Binding of [3H]-Imipramine to Human Platelet Membranes with Compensation for Saturable Binding to Filters and the Implication for Binding Studies with Brain Membranes, J. Neurochem., 43, 1984, p479 - 485 Journal Article, 1984

GRIFFITHS, R, WILLIAMS, DC, ONEILL, C, DEWHURST, IC, EKUWEM, CE, SINCLAIR, CD, SYNERGISTIC INHIBITION OF [H-3]MUSCIMOL BINDING TO CALF-BRAIN SYNAPTIC-MEMBRANES IN THE PRESENCE OF L-HOMOCYSTEINE AND PYRIDOXAL 5'-PHOSPHATE - A POSSIBLE MECHANISM FOR HOMOCYSTEINE-INDUCED SEIZURES, EUROPEAN JOURNAL OF BIOCHEMISTRY, 137, 1984, p467 - 478 Journal Article, 1984

Phillips, O.M. & Williams, D.C., Multiple Affinity States for [3H]-Imipramine Binding Sites on Human Platelet Membranes, Eur. J. Pharmacol., 100, 1984, p247 - 248 Journal Article, 1984

O'Beirne, G. B. & Williams D.C., Binding of Benzodiazepines to Blood Platelets from Various Species, Biochem. Pharmacol., 33, 1984, p1563 - 1571 Journal Article, 1984

Williams, D.C., Characterisation of the Multiple Forms of Hydroxymethylbilane Synthase From Rat Spleen, Biochem. J., 217, 1984, p675 - 683 Journal Article, 1984

PHILLIPS, OM, WOOD, KM, WILLIAMS, DC, BINDING OF [H-3]IMIPRAMINE TO HUMAN-PLATELET MEMBRANES WITH COMPENSATION FOR SATURABLE BINDING TO FILTERS AND ITS IMPLICATION FOR BINDING-STUDIES WITH BRAIN MEMBRANES, JOURNAL OF NEUROCHEMISTRY, 43, 1984, p479 - 486 Journal Article, 1984

Griffiths, R., Williams, D.C., O'Neill, C., Dewhurst, I.C., Ekuwem, C.E. & Sinclair, C.D., Synergistic Inhibition of [3H]Muscimol Binding to Calf Brain Synaptic Membranes in the Presence of L-Homocysteine and Pyridoxal 5'-Phosphate. A Possible Mechanism for Homocysteine-Induced Seizures, Eur. J. Biochem., 1983, p467 - 478 Journal Article, 1983

Williams, D.C., Morgan, G.S., McDonald, E. & Battersby, A.R., Purification of Porphobilinogen Deaminase from Euglena Gracilis and Studies of its Kinetics, Biochem. J., 193, 1981, p301 - 310 Journal Article, 1981

Battersby, A.R., Buckley, D.G., Johnson, D.W., Mander, L.N., McDonald, E. & Williams, D.C., Biosynthesis of Porphyrins and Related Macrocycles. Part 15. Chemical and Enzymic Formation of Uroporphyrinogen Isomers From Unrearranged Aminoethylpyrromethane : Separation of Isomeric Coproporphyrin Esters, J. Chem. Soc. Perkin I., 1981, p2279 - 2785 Journal Article, 1981

Ahrens, E.H., Williams, D.C. & Battersby, A.R., Biosynthesis of Porphyrins and Related Macrocycles. Part 11. Studies of Biosynthesis of the Phytyl Chain of Chlorophyll A Using Carbon-13, J. Chem. Soc. Chem. Perkin I., 1977, p2540 - 2545 Journal Article, 1977

Battersby, A.R., McDonald, E., Morris, H.R., Thompson, M., Williams, D.C., Bykhovsky, V.Y., Zaitseva, N.I. & Bukin, V. N., Biosynthesis of Vitamin B-12. Structural Studies On the Corriphyrins from Propionibacterium Shermanii and Link with Sirodihydrochlorin, Tetrahedron Letters, 25, 1977, p2217 - 2220 Journal Article, 1977

Battersby, A.R., Johnson, D.W., McDonald, E. & Williams, D.C., Mechanistic Study of the Enzymic Incorporation of Unrearranged AP.AP Pyrromethane into Uroporphyrinogen III, J. Chem. Soc. Chem. Commun., 1977, p117 - 118 Journal Article, 1977

Battersby, A.R., Buckley, D.G., McDonald, E. & Williams, D.C., Enzymic Formation of the Type III Porphyrin Macrocycle from Unrearranged AP.AP Pyrromethane, J. Chem. Soc. Chem. Commun., 1977, p115 - 117 Journal Article, 1977

Battersby, A.R., McDonald, E., Hollenstein, R., Ihara, M., Satoh, F. & Williams D.C., Biosynthesis of Porphyrinogens and Related Macrocycles.Vitamin B-12. Biochemical Derivation of Cobyrinic Acid From Uroporphyrinogen III. Studies With The Corresponding Ring-C-Methyl Heptacarboxylic Porphyrinogen and Proof of Seven Intact Methyl Transfers, J. Chem. Soc. Chem. Perkin I., 1977, p166 - 178 Journal Article, 1977

Battersby, A.R., McDonald, E., Williams, D.C. & Wurziger, H.K.W., Biosynthesis of the Natural (Type III) Porphyrins. Proof that Rearrangement Occurs after Head-to-tail Bilane Formation, J. Chem. Soc. Chem. Commun., 1977, p113 - 115 Journal Article, 1977

Williams, D.C. & Jones, J.G., Dissociation and Catalysis in Yeast Hexokinase A, Biochem. J., 155, 1976, p661 - 667 Journal Article, 1976

Battersby, A.R., Sheldrake, P.W., Staunton, J. & Williams, D.C., Studies on Enzyme-mediated Reactions Part VII : Stereo Specific Syntheses of Tritium Labelled (2R)- and (2S)- Dopamine. Stereochemical Course of Hydroxylation of Dopamine by Dopamine-Beta-Hydroxylase, J. Chem. Soc. Perkin I., 1976, p1056 - 1062 Journal Article, 1976

Battersby, A.R., Hollenstein, R., McDonald, E. & Williams, D.C., Biosynthesis of Vitamin B-12. Evidence from Double-labelling Studies (13-CD3) for the Intact Incorporation of Seven Methyl Groups, J. Chem. Soc. Chem. Commun., 1976, p543 - 544 Journal Article, 1976

Bryce, C.F.A., Williams, D.C., John, R.A. & Fasella, P., Anomalous Kinetics of Coupled Aspartate Aminotransferase and Malate Dehydrogenase Evidence for Compartmentation of Oxaloacetate, Biochem. J, 1976, p571 - 577 Journal Article, 1976

Battersby, A.R., Ihara, M., McDonald, E., Satoh, F. & Williams, D.C., Biosynthesis of Vitamin B-12: Derivation of Cobyrinic Acid From Uroporphyrinogen III, J. Chem. Soc. Chem. Commun., 1975, p436 - 437 Journal Article, 1975

Battersby, A.R., Sheldrake, P.W., Staunton, J. & Williams, D.C., Stereochemical Course of Hydroxylation of Dopamine by Dopamine-Beta-Hydroxylase, J. Chem. Soc. Chem. Commun., 1974, p566 - 567 Journal Article, 1974

Non-Peer-Reviewed Publications

Zisterer, D.M., McGee, M.M., Campiani.G.C., Ramunno, A., Fattorusso, C., Nacci, V., Lawler,M., and Williams, D.C., Pyrrolo-1,5, benzoxazepines: a new class of apoptotic agents, Biochem. Soc. Trans., 29, 2001, 704 - 706 Journal Article, 2001

Haase, J., Killian, A-M., Magnani, F., and Williams, D.C., Regulation of the serotonin transporter by interacting proteins, Biochem. Soc. Trans., 29, 2001, p722 - 728 Journal Article, 2001

Meegan, M.J., Hughes, R.B., Lloyd, D.G., Williams, D.C., Zisterer, D.M., Campiani, G.C., Fattorusso, C., and Catalanotti, B., Novel conformationally restrained estrogen receptor modulators - design, synthesis, and antagonistic effects in human breast cancer cells, Proceedings of the Molecular Graphics and Modelling Society Symposium on Structure-Based Drug Design, St. Catherine's College, University of Oxford, 2000 Conference Paper, 2000

Meegan, M.J., Hughes, R.B., Lloyd, D.G., Williams, D.C., and Zisterer, D.M., Novel antiestrogens - synthesis, computational modelling and biological inhibition of MCF-7 cells, Proceedings of the 23rd Annual Pharmacy Joint Research Seminar, Trinity College Dublin, 2000 Conference Paper, 2000

Elliott, G., Campiani, G., Drejer, J., Griffiths, R., Hildebrand, H., Meredith, C., Schousboe, A., Schmuck, G. and Williams, D.C., Demonstration of an in vitro test for excitotoxicity based on early response gene measurement, Alternatives to Laboratory Animals (ATLA), 27, 1999, p289 Journal Article, 1999

Haase, J., Schloss, P., and Williams, D.C., Regulation of the serotonin transporter: Identification of interacting proteins using a yeast two-hybrid system, J.Neurochem., 73, 1999, pS98D Journal Article, 1999

Griffiths, R., Grieve, A., Scollon, J., Scott, M., Williams., D.C. and Meredith, C., Preliminary validation of an in vitro test for assessment of excitotoxicity by measurement of early c-fos mRNA levels, J. Neurochem., 73, 1999, pS146A Journal Article, 1999

Hughes, R.B., Meegan, M.J., Lloyd, D.G., Williams, D.C. and Zisterer, D.M., Investigation of diaryl benzoxepines as novel antiestrogens and selective estrogen receptor modulators (SERMs), Proceedings of the 22nd Annual Pharmacy Joint Research Seminar, Queens University Belfast, 1999, 1999 Conference Paper, 1999

Meegan, M.J., Hughes, R.B., Lloyd, D.G., Williams, D.C., and Zisterer, D.M., Novel antiestrogens - synthesis, computational modelling and biological inhibition of MCF-7 cells, Proceedings of the 10th International RSC-SCI Medicinal Chemistry Symposium, Cambridge, UK, 1999 Conference Paper, 1999

Baker, C.R., Williams, D.C., Titgemeyer, F. & Robillard, G.T., Towards overexpression of the serotonin transporter in bacteria and yeast, J. Neurochem., 66, (suppl. 2), 1996, pS43C Journal Article, 1996

Marangolo, M., Zisterer, D., Williams, D.C., Tipton, K., Dixon, H. and Della Corte, L., Different specificities for taurine analogues and their target sites, J. Neurochem., 66, (suppl. 2), 1996, pS102D Journal Article, 1996

Zisterer, D.M. & Williams, D.C., Hexachlorocyclohexanes inhibits steroidogenesis in Y1 cells: Absence of correlation with binding to the peripheral-type benzodiazepine receptor, J. Neurochem., 66, (suppl. 2), 1996, pS87C Journal Article, 1996

Tarrant, H.M. & Williams, D.C., Dithiothreitol promotes a higher affinity state of the serotonin transporter for the tricyclic antidepressant imipramine, Biochem. Soc. Trans., 23, 1995, p41S Journal Article, 1995

Tarrant, H.M. & Williams, D.C., Reconstitution of the rat brain serotonin transporter, Biochem. Soc. Trans., 23, 1995, p40S Journal Article, 1995

Dunican, D.J., Griffiths, R., O'Neill, L.A.J., & Williams, D.C., Depolarizing levels of KCl inhibit endothelin-1-mediated release of arachidonic acid in rat C6 glioma cells, Biochem. Soc. Trans., 23, 1994, p285S Journal Article, 1994

Moynagh, P.N., Williams, D.C., Gearing, A.J.H. & O'Neill, L.A.J., Induction of VCAM-1 and ICAM-1 in human glioma cells by IL-1, Lymphokine and Cytokine Research, 12, 1993, p224 Journal Article, 1993

Williams, D.C., Abstracts of 9th General Meeting of the European Neurochemical Society, Neurochem. Int. (suppl), 21, 1992 Meeting Abstract, 1992

Moynagh, P.N., O'Neill, L.A.J. & Williams, D.C., Modulation of the peripheral-type benzodiazepine acceptor by IL-1 and PMA, Neurochem. Int., 21, 1992, pC63 Journal Article, 1992

Worrall, D.M., Tarrant, H.M., Mabjeesh, N.J., Williams, D.C. & Kanner, B.I., Partial purification of the human platelet 5-HT transporter and cross-reactivity with antibodies to the rat brain GABA transporter, Proceedings of the 21st FEBS Meeting, Dublin, 1992, ppTh77 Conference Paper, 1992

Williams, D.C.(ed.), CEC Biotechnology Programme In-vitro Pharmacotoxicology Sectoral Meeting, Dublin, 1992 Proceedings of a Conference, 1992

Moynagh, P.N. & Williams, D.C., Molecular studies on the peripheral-type benzodiazepine acceptor, Biochem. Soc. Trans., 20, 1992, p267S Journal Article, 1992

Moynagh, P.N., Williams, D.C. & O'Neill, L.A.J., Activation of NFB by IL-1 in glial cells, Neurochem. Int., 21, 1992, pC62 Journal Article, 1992

Moynagh, P.N., Bailey, C.J. & Williams, D.C., Purification and Immunological Studies on the Peripheral-type Benzodiazepine Acceptor, Biochem. Soc. Trans., 19, 1991, p115 Journal Article, 1991

Williams, D.C., Strategies for Studying Membrane Proteins of the Nervous System, Biochem. Soc. Trans., Joint Membrane Group, Neurochem. Group, Pharmacological Biochemical Group Colloquium, Biochemical Society Meeting No. 636, Trinity College, Dublin, September, 19, 1991, pp79 - 151 Conference Paper, 1991

Maher, W.J., Phillips, O.M. & Williams D.C., The Design of photo-affinity labels for the characterisation of the 5-hydroxytryptamine transporter on human platelet membranes, Biochem. Soc. Trans., 19, 1991, p105 Journal Article, 1991

Williams, D.C. & Phillips, O.M., Probing the platelet plasma-membrane 5-hydroxytryptamine transporter, Biochem. Soc. Trans., 19, 1991, p112 - 114 Journal Article, 1991

Regan, C.M., Rodriguez-Farré, E., Schousboe, A. & Williams, D.C., CEC Biotechnology Action Programme, Final Report 1990 In-vitro sreening for Anticonvulsant-induced Teratogenesis in Neural Primary Cultures and Cell Lines, 1990 Report, 1990

Regan, C.M., Schousboe, A. & Williams, D.C., CEC Biotechnology Action Programme, Progress Report 1989. In-vitro sreening for Anticonvulsant-induced Teratogenesis in Neural Primary Cultures and Cell Lines, 1989 Report, 1989

Phillips, O.M., Wood, K.M. & Williams, D.C., Kinetics of the Interaction of Sertraline with the Human Platelet Plasma Membrane 5-Hydroxytryptamine Carrier, Neuropsychopharmacology, 96, 1989, p269 Journal Article, 1989

Regan, C.M., Schousboe, A. & Williams, D.C., CEC Biotechnology Action Programme, Progress Report 1988, In-vitro screening for Anticonvulsant-induced Teratogenesis in Neural Primary Cultures and Cell Lines, 1988 Report, 1988

O'Callaghan, A.M., Phillips, O.M. & Williams, D.C., Production of Rabbit Anti-imipramine Antibodies, Biochem. Soc. Trans., 15, 1987, p274 - 275 Journal Article, 1987

McInerney, M. & Williams, D.C., Purification and properties of calmodulin-activated phosphodiesterase from bovine brain, Biochem. Soc. Trans., 15, 1987, p275 - 276 Journal Article, 1987

O'Riordan, C., Phillips, O.M. & Williams, D.C., Solubilisation of Human Platelet Plasma Membrane 5-Hydroxytryptamine Carrier with Retention of Native Properties, Biochem. Soc. Trans., 14, 1986, p596 - 597 Journal Article, 1986

O'Beirne, G.B. & Williams, D.C., Enrichment of rat liver and kidney 'peripheral-type' benzodiazepine-binding sites in plasma membrane-derived fractions, Biochem. Soc. Trans., 14, 1986, p594 - 595 Journal Article, 1986

Williams, D.C., Gorman, A.M.C., O'Beirne, G.B. & Regan, C.M., Inhibition of brain cell proliferation by benzodiazepines, Biochem. Soc. Trans., 14, 1986, p595 - 596 Journal Article, 1986

Williams, D.C., O'Riordan, C., Beattie, R.E. & O'Neill, C.M., Multiple Forms of Calmodulin on SDS-Polyacrylamide-gel Electrophoresis, Biochem. Soc. Trans., 12, 1984, p472 - 474 Journal Article, 1984

Griffiths, R., Williams, D.C., O'Neill, C., Dewhurst, I.C. & Ekuwem, C.E., Synergistic Inhibition of [3H]-Muscimol Binding to Calf Brain Synaptic Membranes by L-Homocysteine and Pyridoxal Phosphate, J Neurochem (Abstr), 41 (Suppl), 1983, p526 Journal Article, 1983

Summers, M.C. & Williams, D.C., Enzyme Chemistry, Ann. Reports Chem. Soc., B, (Chapter 14 (IV)), 1978, p432 - 446 Journal Article, 1978

John, R.A., Bryce, C.F.A., Williams D.C. & Fasella, P., Anomalous Kinetics of Coupled Aspartate Aminotransferase and Malic Dehydrogenase, Proc. 10th FEBS Meeting, Paris, 1975 Conference Paper, 1975

Research Expertise

Description

Current Research Interests and Projects

Keywords

5-HYDROXYTRYPTAMINE UPTAKE; ANTIDEPRESSANT DRUGS; ANTIPROLIFERATIVE ACTION; APOPTOSIS; BCR-ABL; BENZODIAZEPINE BINDING-SITES; BENZODIAZEPINES; CANCER; CASPASES; CELL CYCLE; CELL PROLIFERATION; CHOLESTEROL; Computational Biology; DIFFERENTIATION; ESTROGEN-RECEPTOR; GABA TRANSPORTER; Immunology, Immunotherapy; In Vitro Testing, Trial Methods; INSECTICIDES; L-GLUTAMATE TRANSPORTER; LIGAND; MITOCHONDRIA; Molecular Biology; PERIPHERAL-TYPE BENZODIAZEPINE BINDING SITE; PYRROLO-1,5-BENZOXAZEPINES; PYRROLO-1,5-BENZOXAZEPINES INDUCE APOPTOSIS; RECEPTOR LIGANDS; RECEPTORS; SEROTONIN TRANSPORTER; Structural Biology, Determination, Function

Recognition

Representations

Member and sometime Chair of The National Committee for Biochemistry 1993-96,00-03

Secretary and Member of The Neurochemical Group Committee of The Biochemical Society 1990-95

Member of HRB Mental Health and Neurology, and Post-doctoral Fellowship Research Grants Committees 1991-2

Trustee of The Irish Area Section of The Biochemical Society FEBS Fund for Graduate students 1987-92

External examiner for research degrees in St Andrews, Leeds, Cardiff, Galway, Cork, Aarhus, etc

Chairman Organising committee for EU TMR Euroconference on Neuronal Transporters Dublin 1998 1998

Member Organising Committees for 636 and 648th Biochemical Society Meeting - Dublin 1990, 2002, 21st FEBS Meeting -Dublin 1992, INSERM Phillipe Laudet Conference on Neuronal transporters - Strasbourg, 1993

NUI Phelan Scholarship Evaluation Panel 2003-

Chair of Local Organising Committee, and Member of International Programme Committee for the 9th General Meeting of the European Society for Neurochemistry, Dublin 1992 1992

Awards and Honours

Elected Fellow of Trinity College 1987

Elected To Membership of Royal Irish Academy 1995

Memberships

Member of the Society for Neuroscience 2000

Member and Council Member of European Society for Neurochemistry 1990

Member of The International Society for Neurochemistry 1990

Royal Irish Academy 1995

The Biochemical Society 1970