Derek Doherty
Associate Professor, Head of Immunology, Immunology

Biography

A graduate of Trinity College Dublin, I completed a PhD at King's College London and postdoctoral research in the University of Washington, Seattle and University College Dublin before holding lecturing positions at NUI Maynooth and subsequently Trinity College Dublin.

Publications and Further Research Outputs

Peer-Reviewed Publications

Galvin KC, Conroy MJ, Doyle SL, Dunne MR, Fahey R, Foley E, O'Sullivan KE, Doherty DG, Geoghegan JG, Ravi N, O'Farrelly C, Reynolds JV, Lysaght J, Extratumoral PD-1 blockade does not perpetuate obesity-associated inflammation in esophageal adenocarcinoma, Cancer Letters, 418, 2018, 230 - 238 Journal Article, 2018 URL

Petrasca A, Melo AM, Breen EP, Doherty DG, Human Vδ3+ γδ T cells induce maturation and IgM secretion by B cells, Immunology Letters, 196, 2018, 126-134 Journal Article, 2018 URL DOI

Dockry É, O'Leary S, Gleeson LE, Lyons J, Keane J, Gray SG, Doherty DG, Epigenetic induction of CD1d expression primes lung cancer cells for killing by invariant natural killer T cells, OncoImmunology, 2018, pe1428156- Journal Article, 2018 URL

Fazekas B, Moreno-Olivera A, Kelly Y, O'Hara P, Murray S, Kennedy A, Conlon N, Scott J, Melo AM, Hickey FB, Dooley D, O'Brien EC, Moran S, Doherty DG, Little MA., Alterations in circulating lymphoid cell populations in systemic small vessel vasculitis are non-specific manifestations of renal injury., Clinical & Experimental Immunology, 191, (2), 2018, p180 - 188 Journal Article, 2018 DOI URL

Ghnewa YG, O'Reilly VP, Vandenberghe E, Browne PV, McElligott AM, Doherty DG, Retinoic acid induction of CD1d expression primes chronic lymphocytic leukemia B cells for killing by CD8+ invariant natural killer T cells, Clinical Immunology, 183, 2017, p91 - 98 Journal Article, 2017 URL

Orikiiriza J, Nakawesi J, Kikaire B, Turitwenka D, Schlech W, Kambugu A, Lamorde M, Normark J, Hennessy M, Musiime V, Rujumba J, Ndeezi G, Tumwesigye NM, Doherty DG, Achan J, Unmet needs persist in pediatric HIV programs: lessons from selected case studies in Uganda. , AIDS , 31, 2017, p1196 - 1199 Journal Article, 2017 DOI

Arduini S, Dunne J, Conlon N, Feighery C, Doherty D.G, Mucosal-associated invariant T cells are depleted and functionally altered in patients with common variable immunodeficiency, Clinical Immunology, 176, 2017, p23 - 30 Journal Article, 2017 DOI URL

Leahy T.R, McManus R, Doherty D.G, Grealy R, Carr M.J, Slattery D, Ryan T, Viral Bronchiolitis is Associated with Altered Cytokine Gene Expression and Lymphocyte Activation Status, Pediatric Infectious Disease Journal, 35, (11), 2016, pp e326-e338 Journal Article, 2016 URL DOI

Leahy TR, McManus R, Doherty DG, Grealy R, Coulter T, Smyth P, Blackshields G, Sheils O, Carr MJ, Purandare N, Geary M, Hodemaekers HM, Janssen R, Bont L, Slattery D, Ryan T, Interleukin-15 is associated with disease severity in viral bronchiolitis., The European respiratory journal, 47, (1), 2016, p212-22 Journal Article, 2016 DOI

Brennan K, McSharry BP, Keating S, Petrasca A, O'Reilly VP, Keane J, Doherty DG, Gardiner CM, Human Natural Killer cell expression of ULBP2 is associated with a mature functional phenotype., Human immunology, 77, (10), 2016, p876-885 Journal Article, 2016 DOI

Doherty D.G, Immunity, tolerance and autoimmunity in the liver: A comprehensive review, Journal of Autoimmunity, 66, 2016, p60 - 75 Journal Article, 2016 DOI URL

Conroy M.J, Mac Nicholas R, Taylor M, O'dea S, Mulcahy F, Norris S, Doherty D.G, Increased frequencies of circulating IFN---producing V-1+ and V-2+ -- T cells in patients with asymptomatic persistent Hepatitis B virus infection, Viral Immunology, 28, (4), 2015, p201 - 208 Journal Article, 2015 DOI URL

Conroy MJ, Mac Nicholas R, Grealy R, Taylor M, Otegbayo JA, O'Dea S, Mulcahy F, Ryan T, Norris S, Doherty DG, Circulating CD56dim natural killer cells and CD56+ T cells that produce interferon-" or interleukin-10 are expanded in asymptomatic, E antigen-negative patients with persistent hepatitis B virus infection., Journal of viral hepatitis, 22, (3), 2015, p335-45 Journal Article, 2015 DOI

Maher C.O, Dunne K, Comerford R, O'Dea S, Loy A, Woo J, Rogers T.R, Mulcahy F, Dunne P.J, Doherty D.G, Candida albicans stimulates IL-23 release by human dendritic cells and downstream IL-17 secretion by V-1 T cells, Journal of Immunology, 194, (12), 2015, p5953 - 5960 Journal Article, 2015 URL DOI

Tyler C., Doherty D., Moser B., Eberl M., Human Vγ9Vδ2 T cells: Innate adaptors of the immune system, Cellular Immunology, 296, (1), 2015, p10-21 Journal Article, 2015 TARA - Full Text DOI

Carolan E, Tobin L.M, Mangan B.A, Corrigan M, Gaoatswe G, Byrne G, Geoghegan J, Cody D, O'Connell J, Winter D.C, Doherty D.G, Lynch L, O'Shea D, Hogan A.E, Altered distribution and increased IL-17 production by mucosal-associated invariant T cells in adult and childhood obesity, Journal of Immunology, 194, (12), 2015, p5775 - 5780 Journal Article, 2015 URL DOI

Kennedy, A. Doherty , D.G Petrasca, A. Hennessy, M. Spiers, J.P., HIV-1 Tat clade-specific cytokine induction in monocytes/macrophages is not evidenced in total or Vγ9Vδ2 T lymphocytes, AIDS, 28, 2014, p131 - 133 Journal Article, 2014 DOI

Petrasca A, Doherty DG. , Vδ2 T cells differentially stimulate the production of proinflammatory cytokines by dendritic cells and B cells. , 15th International Congress of Immunology, Milan, Italy, 22-27 August 2013, Medimond, Bologna, Italy , 2014, pp21 - 24 Conference Paper, 2014

Buggy DJ, Borgeat A, Cata J, Doherty DG, Doornebal CW, Forget P, Gottumukkala V, Gottschalk A, Gupta A, Gupta K, Hales TG, Hemmings HC, Hollmann MW, Kurz A, Ma D, Parat MO, Sessler DI, Shorten G, Singleton P., Consensus statement from the BJA Workshop on Cancer and Anaesthesia., British Journal of Anaesthesia, Aug 7, 2014, ppii: aeu26- Journal Article, 2014 DOI

Petrasca, A., Doherty, D.G., Human Vδ2+ γδ T cells differentially induce maturation, cytokine production, and alloreactive T cell stimulation by dendritic cells and B cells, Frontiers in Immunology, 2014, 650- Journal Article, 2014 URL TARA - Full Text DOI

Zeng, SG, Ghnewa, YG, O'Reilly, VP, Lyons, VG, Atzberger, A, Hogan, AE, Exley, MA, Doherty, DG, Human Invariant NKT Cell Subsets Differentially Promote Differentiation, Antibody Production, and T Cell Stimulation by B Cells In Vitro, JOURNAL OF IMMUNOLOGY, 191, (4), 2013, p1666-1676 Journal Article, 2013 DOI

Baird AM, Dockry E, Daly A, Stack E, Doherty DG, O'Byrne KJ, Gray SG, IL-23R is Epigenetically Regulated and Modulated by Chemotherapy in Non-Small Cell Lung Cancer., Frontiers in oncology, 3, 2013, p162- Journal Article, 2013 TARA - Full Text DOI

Mangan BA, Dunne MR, O'Reilly VP, Dunne PJ, Exley MA, O'Shea D, Scotet E, Hogan AE, Doherty DG, Cutting edge: CD1d restriction and Th1/Th2/Th17 cytokine secretion by human V"3 T cells., Journal of immunology (Baltimore, Md. : 1950), 191, (1), 2013, p30-4 Journal Article, 2013 TARA - Full Text DOI

Grealy, R, White, M, Stordeur, P, Kelleher, D, Doherty, DG, McManus, R, Ryan, T, Characterising Cytokine Gene Expression Signatures in Patients with Severe Sepsis, Mediators of Inflammation, 2013, 2013, 164246 Journal Article, 2013 TARA - Full Text DOI

Dunne, MR, Elliott, L, Hussey, S, Mahmud, N, Kelly, J, Doherty, DG, Feighery, CF, Persistent Changes in Circulating and Intestinal gamma delta T Cell Subsets, Invariant Natural Killer T Cells and Mucosal-Associated Invariant T Cells in Children and Adults with Coeliac Disease, PLOS ONE, 8, (10), 2013, p76008 Journal Article, 2013 URL DOI TARA - Full Text

Murphy, N, Petrasca, A, Murphy, NM, Reilly, VO, Evans, P, Doherty, DG, Zhu, XM, Synthesis and immunostimulatory activity of two alpha-S-galactosyl phenyl-capped ceramides, ARKIVOC, 2013, p363-377 Journal Article, 2013 URL

Petrovic D, Dempsey E, Doherty DG, Kelleher D, Long A, Hepatitis C virus - T-cell responses and viral escape mutations., European journal of immunology, 42, (1), 2012, p17-26 Journal Article, 2012 DOI

White M, Mahon V, Grealy R, Doherty DG, Stordeur P, Kelleher DP, McManus R, Ryan T, Post-operative infection and sepsis in humans is associated with deficient gene expression of Yc cytokines and their apoptosis mediators., Critical Care (London, England), 15, (3), 2011, pR158 Journal Article, 2011 TARA - Full Text DOI URL

O'Reilly V, Zeng SG, Bricard G, Atzberger A, Hogan AE, Jackson J, Feighery C, Porcelli SA, Doherty DG, Distinct and Overlapping Effector Functions of Expanded Human CD4, CD8α and CD4CD8α Invariant Natural Killer T Cells, PloS one, 6, (12, e28648), 2011 Journal Article, 2011 TARA - Full Text DOI

White M, Martin-Loeches I, Lawless MW, O'Dwyer MJ, Doherty DG, Young V, Kelleher D, McManus R, Ryan T, Hospital acquired pneumonia after lung resection surgery is associated with characteristic cytokine gene expression, Chest, 139, 2011, p626 - 632 Journal Article, 2011 DOI

Hogan AE, O'Reilly V, Dunne MR, Dere RT, Zeng SG, O'Brien C, Amu S, Fallon PG, Exley MA, O'Farrelly C, Zhu X, Doherty DG, Activation of human invariant natural killer T cells with a thioglycoside analogue of á-galactosylceramide, Clinical Immunology, 140, (2), 2011, p196-207 Journal Article, 2011 TARA - Full Text DOI

Petrovic D, Stamataki Z, Dempsey E, Golden-Mason L, Freeley M, Doherty D, Prichard D, Keogh C, Conroy J, Mitchell S, Volkov Y, McKeating JA, O'Farrelly C, Kelleher D, Long A, Hepatitis C virus targets the T cell secretory machinery as a mechanism of immune evasion, Hepatology, Mar 30, (doi: 10.1002/hep.243), 2011 Journal Article, 2011 DOI

Hogan AE, Corrigan MA, O'Reilly V, Gaoatswe G, O'Connell J, Doherty DG, Lynch L, O'Shea D. , Cigarette smoke alters invariant natural killer T cell function and may inhibit antitumour responses. , Clinical Immunology, 2011 Journal Article, 2011 DOI

Hogan AE, Tobin AM, Ahern T, Corrigan MA, Gaoatswe G, Jackson R, O'Reilly V, Lynch L, Doherty DG, Moynagh PN, Kirby B, O'Connell J, O'Shea D, Glucagon-like peptide-1 (GLP-1) and the regulation of human invariant natural killer T cells: lessons from obesity, diabetes and psoriasis., Diabetologia, 2011 Journal Article, 2011 DOI TARA - Full Text

Dunne MR, Mangan BA, Madrigal-Estebas L, Doherty DG, Preferential Th1 Cytokine Profile of Phosphoantigen-Stimulated Human Vγ9Vδ2 T Cells, Mediators of Inflammation, 2010, (704941), 2010 Journal Article, 2010 TARA - Full Text DOI

Dunne MR, Madrigal-Estebas L, Tobin LM, Doherty DG, (E)-4-hydroxy-3-methyl-but-2 enyl pyrophosphate-stimulated Vã9Vä2 T cells possess T helper type 1-promoting adjuvant activity for human monocyte-derived dendritic cells, Cancer Immunology Immunotherapy , 59, 2010, p1109 - 1120 Journal Article, 2010 TARA - Full Text URL DOI

Oliveira AL, Hayakawa H, Schor D, Leite AC, Espíndola OM, Waters A, Dean J, Doherty DG, Araújo AQ, Hall WW, High frequencies of functionally competent circulating Tax-specific CD8+ T cells in human T lymphotropic virus type 2 infection., Journal of Immunology, 183, 2009, p2957-2965 Journal Article, 2009 DOI

Lynch L, O'Shea D, Winter DC, Geoghegan J, Doherty DG, O'Farrelly C, Invariant NKT cells and CD1d+ cells amass in human omentum and are depleted in patients with cancer and obesity., European Journal of Immunology, 39, (7), 2009, p1893-1901 Journal Article, 2009 DOI

Golden-Mason, L, Madrigal-Estebas, L, McGrath, E, Conroy, MJ, Ryan, EJ, Hegarty, JE, O'Farrelly, C, Doherty, DG, Altered natural killer cell subset distributions in resolved and persistent hepatitis C virus infection following single source exposure., Gut, 57, (8), 2008, p1121-8 Journal Article, 2008 URL DOI

Rosen, HR, Doherty, DG, Madrigal-Estebas, L, O'Farrelly, C, Golden-Mason, L, Pretransplantation CD56(+) innate lymphocyte populations associated with severity of hepatitis C virus recurrence., Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society, 14, (1), 2008, p31 - 40 Journal Article, 2008 URL DOI

Kenna, T, O'Brien, M, Hogan, AE, Exley, MA, Porcelli, SA, Hegarty, JE, O'Farrelly, C, Doherty, DG, CD1 expression and CD1-restricted T cell activity in normal and tumour-bearing human liver., Cancer immunology, immunotherapy : CII, 56, (4), 2007, p563-72 Journal Article, 2007 URL DOI

Arnaiz B, Madrigal-Estebas L, Todryk S, James TC, Doherty DG, Bond U., A Novel method to identify and characterise peptide mimotopes of heat shock protein 70-associated antigens., Journal of Immune Based Therapies and Vaccines, 4, (12), 2006, p1-12 Journal Article, 2006 DOI

Kelly-Rogers J, Madrigal-Estebas L, O'Connor T, Doherty DG. , Activation-induced expression of CD56 by T cells is associated with a reprogramming of cytolytic activity and cytokine secretion profile in vitro. , Human Immunology, 67, 2006, p863-673 Journal Article, 2006 DOI

Dean, J, McCarthy, D, Lawler, M, Doherty, DG, O'Farrelly, C, Golden-Mason, L, Characterization of NKR+ T-cell subsets in human bone marrow: implications for immunosurveillance of neoplasia., Clinical immunology (Orlando, Fla.), 114, (1), 2005, p42-51 Journal Article, 2005 URL DOI

Garland MR, Lavelle E, Doherty D, Golden-Mason L, Fitzpatrick P, Hill A, Walsh N, O'Farrelly C, Cortisol does not mediate the suppressive effects of psychiatric morbidity on natural killer cell activity: a cross-sectional study of patients with early breast cancer, Psychological Medicine , 34, 2004, p481 - 490 Journal Article, 2004 Other

Kelly, AM, Golden-Mason, L, McEntee, G, Traynor, O, Doherty, DG, Hegarty, JE, O'Farrelly, C, Interleukin 12 (IL-12) is increased in tumour bearing human liver and expands CD8(+) and CD56(+) T cells in vitro but not in vivo., Cytokine, 25, (6), 2004, p273-282 Journal Article, 2004 URL DOI

Differential cytokine production by T cells that are positive or negative for CD56. in, Immunology, Bologna, Italy , Medimond, 2004, pp103 - 108, [Kelly Rogers J, Doherty DG.] Book Chapter, 2004

O'Keeffe, J, Doherty, DG, Kenna, T, Sheahan, K, O'Donoghue, DP, Hyland, JM, O'Farrelly, C, Diverse populations of T cells with NK cell receptors accumulate in the human intestine in health and in colorectal cancer., European journal of immunology, 34, (8), 2004, p2110 - 2119 Journal Article, 2004 DOI URL

Kenna, T, Golden-Mason, L, Norris, S, Hegarty, JE, O'Farrelly, C, Doherty, DG, Distinct subpopulations of gamma delta T cells are present in normal and tumor-bearing human liver., Clinical immunology (Orlando, Fla.), 113, (1), 2004, p56-63 Journal Article, 2004 URL DOI

Golden-Mason, L, Kelly, AM, Doherty, DG, Traynor, O, McEntee, G, Kelly, J, Hegarty, JE, O'Farrelly, C, Hepatic interleuklin 15 (IL-15) expression: implications for local NK/NKT cell homeostasis and development., Clinical and experimental immunology, 138, (1), 2004, p94-101 Journal Article, 2004 TARA - Full Text URL DOI

Kenna, T, Golden-Mason, L, Porcelli, SA, Koezuka, Y, Hegarty, JE, O'Farrelly, C, Doherty, DG, Mason, LG, NKT cells from normal and tumor-bearing human livers are phenotypically and functionally distinct from murine NKT cells., Journal of immunology (Baltimore, Md. : 1950), 171, (4), 2003, p1775-1779 Journal Article, 2003 URL

Garland, M, Doherty, D, Golden-Mason, L, Fitzpatrick, P, Walsh, N, O'Farrelly, C, Stress-related hormonal suppression of natural killer activity does not show menstrual cycle variations: implications for timing of surgery for breast cancer., Anticancer research, 23, (3B), 2003, p2531 - 2535 Journal Article, 2003 Other

Norris, S, Doherty, DG, Curry, M, McEntee, G, Traynor, O, Hegarty, JE, O'Farrelly, C, Selective reduction of natural killer cells and T cells expressing inhibitory receptors for MHC class I in the livers of patients with hepatic malignancy., Cancer immunology, immunotherapy : CII, 52, (1), 2003, p53-8 Journal Article, 2003 DOI URL

Curry, MP, Golden-Mason, L, Doherty, DG, Deignan, T, Norris, S, Duffy, M, Nolan, N, Hall, W, Hegarty, JE, O'Farrelly, C, Expansion of innate CD5pos B cells expressing high levels of CD81 in hepatitis C virus infected liver., Journal of Hepatology, 38, (5), 2003, p642-50 Journal Article, 2003 URL DOI

Cookson S, Doherty DG, Todryk S, Gibbs P, Portmann B, O'Grady J, Rela M, Heaton N, Norris S., Hepatic expression of IL-15 mRNA is associated with liver graft acceptance. , Transplantation Immunology, 11, (1), 2003, p39-49 Journal Article, 2003 DOI

Czaja A, Doherty DG, Donaldson PT., The genetic bases of autoimmune hepatitis., Digestive Diseases and Sciences, 47, (10), 2002, p2139-2150 Journal Article, 2002 DOI

Deignan, T, Curry, MP, Doherty, DG, Golden-Mason, L, Volkov, Y, Norris, S, Nolan, N, Traynor, O, McEntee, G, Hegarty, JE, O'Farrelly, C, Decrease in hepatic CD56(+) T cells and V alpha 24(+) natural killer T cells in chronic hepatitis C viral infection., Journal of Hepatology, 37, (1), 2002, p101-8 Journal Article, 2002 DOI URL

Byrne, B, Madrigal-Estebas, L, McEvoy, A, Carton, J, Doherty, DG, Whelan, A, Feighery, C, O'Donoghue, DP, O'Farrelly, C, Human duodenal epithelial cells constitutively express molecular components of antigen presentation but not costimulatory molecules., Human immunology, 63, (11), 2002, p977-86 Journal Article, 2002 URL DOI

Madrigal-Estebas, L, Doherty, DG, O'Donoghue, DP, Feighery, C, O'Farrelly, C, Differential expression and upregulation of interleukin-1alpha, interleukin-1beta and interleukin-6 by freshly isolated human small intestinal epithelial cells., Mediators of inflammation, 11, (5), 2002, p313-319 Journal Article, 2002 TARA - Full Text URL DOI

Doherty, D.G., O'Farrelly, C., Dendritic cells: Regulators of hepatic immunity or tolerance?, Journal of Hepatology, 34, (1), 2001, p156-160 Journal Article, 2001 DOI

Dunne J, Lynch S, O'Farrelly C, Hegarty JE, Feighery C, Doherty DG., Selective expansion and partial activation of human NK cells and NK receptor-positive T cells by IL-2 and IL-15. , Journal of Immunology, 167, (6), 2001, p3129-3138 Journal Article, 2001 URL

Doherty D.G., Presentation of auto-epitopes by major histocompatibility complex molecules in autoimmune hepatitis., Syllabus of the American Association for the Study of Liver Diseases Single Topic Conference on Autoimmune Hepatitis, 2000, pp33-41 Conference Paper, 2000

Doherty, D.G., O'Farrelly, C., Innate and adaptive lymphoid cells in the human liver , Immunological Reviews, 174, (1), 2000, p5-20 Journal Article, 2000 DOI

Curry, MP, Norris, S, Golden-Mason, L, Doherty, DG, Deignan, T, Collins, C, Traynor, O, McEntee, GP, Hegarty, JE, O'Farrelly, C, Isolation of lymphocytes from normal adult human liver suitable for phenotypic and functional characterization., Journal of Immunological Methods, 242, (1-2), 2000, p21-31 Journal Article, 2000 DOI

Doherty, DG, Norris, S, Madrigal-Estebas, L, McEntee, G, Traynor, O, Hegarty, JE, O'Farrelly, C, The human liver contains multiple populations of NK cells, T cells, and CD3+CD56+ natural T cells with distinct cytotoxic activities and Th1, Th2, and Th0 cytokine secretion patterns., Journal of immunology (Baltimore, Md. : 1950), 163, (4), 1999, p2314-21 Journal Article, 1999 URL

Norris, S, Doherty, DG, Collins, C, McEntee, G, Traynor, O, Hegarty, JE, O'Farrelly, C, Natural T cells in the human liver: cytotoxic lymphocytes with dual T cell and natural killer cell phenotype and function are phenotypically heterogenous and include Valpha24-JalphaQ and gammadelta T cell receptor bearing cells., Human immunology, 60, (1), 1999, p20-31 Journal Article, 1999 URL DOI

Devlin J, Doherty D, Thomson L, Wong T, Donaldson P, Portmann B, Williams R. , Defining the outcome of immunosuppression withdrawal after liver transplantation. , Hepatology, 27, (4), 1998, p926-933 Journal Article, 1998 DOI

Doherty DG, Penzotti JE, Koelle DM, Kwok WW, Lybrand TP, Masewicz S, Nepom GT., Structural basis of specificity and degeneracy of T cell recognition: pluriallelic restriction of T cell responses to a peptide antigen involves both specific and promiscuous contacts between the T cell receptor, peptide and HLA-DR. , Journal of Immunology, 161, (7), 1998, p3527-3535 Journal Article, 1998 URL

Norris, S, Collins, C, Doherty, DG, Smith, F, McEntee, G, Traynor, O, Nolan, N, Hegarty, J, O'Farrelly, C, Resident human hepatic lymphocytes are phenotypically different from circulating lymphocytes., Journal of hepatology, 28, (1), 1998, p84 - 90 Journal Article, 1998 Other

Gregorio, G.V., Portmann, B., Reid, F., Donaldson, P.T., Doherty, D.G., McCartney, M., Mowat, A.P., (...), Mieli-Vergani, G., Autoimmune hepatitis in childhood: A 20-year experience , Hepatology , 25, (3), 1997, p541-547 Journal Article, 1997 DOI

Amino acid residues in the alpha-helical portions of HLA-DR molecules can modulate T cell recognition of antigen. in, editor(s)Charron, D , HLA.Genetic Diversity of HLA: Functional and Medical Implication, Paris, France, EDK Medical and Scientific International Publisher, 1997, pp540-542 , [Doherty DG, Koelle DM, Kwok WW, Masewicz S, Domeier ME, Nepom GT.] Book Chapter, 1997

L. Madrigal-Estebas, R. McManus, B. Byrne, S. Lynch, D. G. Doherty, D. Kelleher, D. P. O'Donoghue, C. Feighery and C. O'Farrelly, Human small intestinal epithelial cells secrete interleukin-7 and differentially express two different interleukin-7 mRNA Transcripts: implications for extrathymic T-cell differentiation, Human Immunology, 58, (2), 1997, p83-90 Journal Article, 1997 DOI

Wright, P., Donaldson, P.T., Underhill, J.A., Choudhuri, K., Doherty, D.G., Murray, R.M., Genetic association of the HLA DRB1 gene locus on chromosome 6p21.3 with schizophrenia, American Journal of Psychiatry , 153, (12), 1996, p1530-1533 Journal Article, 1996 URL

Penzotti JE, Doherty DG, Lybrand TP, Nepom GT., A structural model for TCR recognition of the HLA class II shared epitope sequence implicated in susceptibility to rheumatoid arthritis., Journal of Autoimmunity, 9, (2), 1996, p287-293 Journal Article, 1996 DOI

Duthie A, Doherty DG, Donaldson PT, Scott-Jupp R, Tanner MS, Eddleston ALWF, Mowat AP. , The major histocompatibility complex influences the development of chronic liver disease in male children and young adults with cystic fibrosis., Journal of Hepatology, 23, (5), 1995, p532-537 Journal Article, 1995 DOI

Thomson L, Donaldson P, Doherty D, Devlin J, Williams R. , Detection of microchimerism following liver transplantation., 1995, - 769 Miscellaneous, 1995 URL

Underhill JA, Donaldson PT, Doherty DG, Manabe K, Williams R., HLA DPB polymorphism in primary sclerosing cholangitis and primary biliary cirrhosis., Hepatology, 21, (4), 1995, p959-962 Journal Article, 1995 DOI

Doherty DG, Donaldson PT, Underhill PT, Farrant JM, Duthie A, Mieli-Vergani G, McFarlane IG, Johnson PJ, Eddleston ALWF, Mowat AP, Williams R. , Allelic sequence variation in the HLA class II genes and proteins in patients with autoimmune hepatitis. , Hepatology , 19, (3), 1994, p609-615 Journal Article, 1994 DOI

Doherty DG, Underhill JA, Donaldson PT, Manabe K, Mieli-Vergani G, Eddleston ALWF, Vergani D, Demaine AG, Williams R, Polymorphism in the human complement C4 genes and genetic susceptibility to autoimmune hepatitis., Autoimmunity, 18, (4), 1994, p243-249 Journal Article, 1994 DOI

Teh LS, Doherty DG, Williams BD. , HLA-DRB genes and antiribosomal P antibodies in systemic lupus erythematosus., British Journal of Rheumatology, 33, (12), 1994, p1125-1126 Journal Article, 1994 URL

Manabe K, Hibberd ML, Donaldson PT, Underhill JA, Doherty DG, Demaine AG, Mieli-Vergani G, Eddleston ALWF, Williams R. , T-cell receptor constant β germline gene polymorphisms and susceptibility to autoimmune hepatitis , Gastroenterology , 106, (5), 1994, p1321-1325 Journal Article, 1994 URL

Donaldson P, Doherty D, Underhill J, Williams R., The molecular genetics of autoimmune liver disease., Hepatology, 20, 1994, p225-239 Journal Article, 1994 DOI

Donaldson PT, Doherty DG, Underhill JA, Williams R., Immunogenetic influences in primary biliary cirrhosis., Proceedings of the 70th Falk Symposium, 70th Falk Symposium, Basel, Switzerland, 1992, edited by Meyer zum Buschenfelde K-H, Hoofnagle J, Manns M , Kluwer Academic Press, 1993, pp383-396 Conference Paper, 1993

Manabe K, Donaldson PT, Underhill JA, Doherty DG, Mieli-Vergani G, McFarlane IG, Eddleston ALWF, Williams R. , Human leukocyte antigen A1-B8-DR3-DQ2-DPB1*0401 extended haplotype in autoimmune hepatitis. , Hepatology, 18, (6), 1993, p1334-1337 Journal Article, 1993 DOI

Donaldson P, Underhill J, Doherty D, Hayllar K, Calne R, Tan K-C, O'Grady J, Wight D, Portmann B, Williams R. , Influence of human leukocyte matching on liver allograft survival and rejection: the "dualistic effect"., Hepatology, 17, (6), 1993, p1008-1015 Journal Article, 1993 DOI

Duthie A, Doherty DG, Williams C, Scott-Jupp R, Warner JO, Tanner MS, Williamson R, Mowat AP. , Genotype analysis for ΔF508, G551D and R553X mutations in children and young adults with cystic fibrosis with and without chronic liver disease, Hepatology , 15, (4), 1992, p660-664 Journal Article, 1992 DOI

Doherty DG, Ireland R, Demaine AG, Wang F, Veerapan K, Welsh KI, Vergani D., Major histocompatibility complex genes and susceptibility to systemic lupus erythematosus in southern Chinese., Arthritis and Rheumatism, 35, (6), 1992, p641-646 Journal Article, 1992 DOI

Doherty DG, Vaughan RW, Donaldson PT, Mowat AP. , HLA DQA, DQB, and DRB genotyping by oligonucleotide analysis: distribution of alleles and haplotypes in British Caucasoids., Human Immunology , 34, (1), 1992, p53-63 Journal Article, 1992 DOI

Farrant JM, Doherty DG, Donaldson PT, Vaughan RW, Hayllar KM, Welsh KI, Eddleston ALWF, Williams R., Amino acid substitutions at position 38 of the DR beta polypeptide confer susceptibility to and protection from primary sclerosing cholangitis., Hepatology, 16, (2), 1992, p390-395 Journal Article, 1992 DOI

Bidwell JL, Soong TW, Raymond PA, Doherty DG, Hui KM., HLA genotyping of colorectal carcinoma in the Chinese population., Human Immunology, 34, (1), 1992, p19-23 Journal Article, 1992 DOI

Underhill J, Donaldson PT, Bray G, Doherty D, Portmann, Williams R., Susceptibility to primary biliary cirrhosis is associated with the HLA-DR8-DQB1*0402 haplotype. , Hepatology, 16, (6), 1992, p1414-1408 Journal Article, 1992 DOI

Asherson RA, Doherty DG, Vergani D, Khamashta MA, Hughes GRV. , Major histocompatibility complex associations with primary antiphospholipid syndrome., Arthritis and Rheumatism , 35, (6), 1992, p124-125 Journal Article, 1992 DOI

Donaldson PT, Doherty DG, Hayllar KM, McFarlane IG, Johnson PJ, Williams R., Susceptibility to autoimmune chronic hepatitis: human leukocyte antigens DR4 and A1-B8-DR3 are independent risk factors., Hepatology, 13, (4), 1991, p701-706 Journal Article, 1991 DOI

Doherty DG, Donaldson PT. , HLA-DRB and DQB typing by a combination of serology, restriction fragment length polymorphism analysis and oligonucleotyde probing., European Journal of Immunogenetics, 18, (1-2), 1991, p111-124 Journal Article, 1991 DOI

Doherty DG, Donaldson PT, Whitehouse DB, Mieli-Vergani G, Duthie A, Hopkinson DA, Mowat AP. , HLA phenotypes and gene polymorphisms in juvenile liver disease associated with a1-antitrypsin deficiency., Hepatology, 12, (2), 1990, p218-223 Journal Article, 1990 DOI

Russell SEH, Hull JD, Doherty DG, Clarke DK, Hoey EM, Rima BK, Martin SJ. , Molecular cloning of measles and canine distemper viruses., Biochemical Society Transactions, 13, 1985, p478-479 Journal Article, 1985

Non-Peer-Reviewed Publications

Core concepts in immunology. in, editor(s)Gershwin ME, Vierling JM, Manns MP , Liver Immunology: Principles and Practice, New York, Springer Science and Business Media, 2014, pp11 - 26, [O'Farrelly C, Doherty DG] Book Chapter, 2014

Innate immune mechanisms in the liver. in, editor(s)Gershwin ME, Vierling JM, Manns MP , Liver Immunology: Principles and Practices, New Jersey, Humana Press, 2007, pp41-48 , [O'Farrelly C, Doherty DG. ] Book Chapter, 2007

A short primer on fundamental immunology in, editor(s)Gershwin ME, Vierling JM, Manns MP , Liver Immunology: Principles and Practices, New Jersey, Humana Press, 2007, pp15-24 , [O'Farrelly C, Doherty DG. ] Book Chapter, 2007

Basic immunological terms and concepts: a short primer of fundamental immunology in, editor(s)Gershwin ME, Vierling JM, Manns MP , Liver Immunology, Philadelphia, Hanley & Belfus, 2003, pp1 - 13, [O'Farrelly C, Doherty DG] Book Chapter, 2003

Lymphocyte repertoires in healthy liver. in, editor(s)Gershwin ME, Vierling JM, Manns MP , Liver Immunology, Philadelphia, Hanley & Belfus, 2003, pp31-46 , [Doherty DG, O'Farrelly C.] Book Chapter, 2003

The human major histocompatibility complex and disease susceptibility. in, Rimoin DL, Connor JM, Pyeritz RE , Emery and Rimoin's Principles and Practice of Medical Genetics, New York, Churchill Livingstone, 1997, pp497-504 , [Doherty DG, Nepom GT. ] Book Chapter, 1997

Research Expertise

Description

Our research is aimed at finding out how the immune system can protect against or cause disease in humans and how it can be manipulated for the development of novel therapies. We are particularly interested in "innate lymphocytes" (natural killer cells, natural killer T cells and gamma/delta T cells), which appear to be "master regulators" of the immune system and which are defective in many infectious and immune-mediated diseases and cancers. In collaboration with clinical colleagues, we are studying innate lymphocytes in patients with hepatitis B and C, HIV, chronic lymphocytic leukaemia, lung cancer, post-operative infection and sepsis, coeliac disease, antibody deficiencies and neonatal encephalopathy. Our results show that various innate lymphocyte populations can be manipulated to promote the generation of desirable immune responses for the treatment of disease.

Projects

  • Title
    • CD1d binding peptide motifs for the stimulation of NKT cells.
  • Summary
    • To develop novel CD1d-binding peptides as treatments for cancer
  • Funding Agency
    • ImCyse Specific Active Immunotherapeutics
  • Date From
    • 2017
  • Date To
    • 2019
  • Title
    • The role and treatment potential of innate lymphocytes in neonatal brain injury
  • Summary
    • Investigating the roles of innate T cells in inflammation associated with neonatal encephalopathy
  • Funding Agency
    • Libyan Embassy
  • Date From
    • 2016
  • Date To
    • 2019
  • Title
    • Metabolic profiles of innate lymphocytes from patients with sepsis
  • Summary
    • Investigating how changes in energy metabolism in NK cells and gamma/delta T cells may contribute to the development of sepsis
  • Funding Agency
    • Royal Embassy of Saudi Arabia
  • Date From
    • 2016
  • Date To
    • 2019
  • Title
    • The role and treatment potential of natural killer T cells in patients with upper gastrointestinal cancer
  • Summary
    • Investigating the role of type 1 and type 2 NKT cells in oesophageal and gastric cancer
  • Funding Agency
    • Consejo Nacional de Ciencia y Tecnología (CONACyT)
  • Date From
    • 2015
  • Date To
    • 2018
  • Title
    • Delivery of Gene Editing Tools to Primary T cells using Profector Technology
  • Summary
    • Developing novel methods for expressing transgenes in human T cells for cellular therapies
  • Funding Agency
    • Profector Life Sciences
  • Date From
    • 2016
  • Date To
    • 2018
  • Title
    • Nutrition and Treatment Outcome: Development of a Ugandan - Irish HIV / Nutrition Research Cluster
  • Summary
    • To determine the roles of nutrition, food security and education on the outcome of treatment of HIV infection in adults and children in Uganda
  • Funding Agency
    • Irish Aid and the Higher Education Authority
  • Date From
    • 2012
  • Date To
    • 2016
  • Title
    • Translational approaches to enhance Human γδ T lymphocytes targeting of non-small-cell lung cancer
  • Summary
    • Investigating the use of epigenetic modifying agents to augment antitumour immunity by inducing CD1d expression
  • Funding Agency
    • Molecular Medicine Ireland
  • Date From
    • 2012
  • Date To
    • 2015
  • Title
    • The influence of Vγ9Vδ2 T cells on antigen presentation and antibody production
  • Summary
    • Investigating the use of Vγ9Vδ2 T cells to stimuate dendritic cells and B cells for the treatment of cancer
  • Funding Agency
    • Science Foundation Ireland
  • Date From
    • 2011
  • Date To
    • 2015
  • Title
    • The role of natural killer T cells in the control of immune regulation, antigen presentation and antibody production by human B lymphocytes
  • Summary
    • Investigating how iNKT cells promote differentiation, cytokine and antibody production by B cells from healthy donors and patients with chronic lymphocytic leukaemia
  • Funding Agency
    • Irish Research Council
  • Date From
    • 2011
  • Date To
    • 2015
  • Title
    • An investigation of diagnostic and prognostic indicators in paediatric patients with antibody deficiency: role of T lymphocytes (conventional, regulatory and innate) in disease pathogenesis
  • Summary
    • Investigating the role of innate lymphocytes in the pathogenesis of primary antibody deficiency in children
  • Funding Agency
    • National Children's Research Centre
  • Date From
    • 2011
  • Date To
    • 2014
  • Title
    • The role and treatment potential of γδ T cells in human immunodeficiency virus infection
  • Summary
    • Investigating the contribution of γδ T cell subsets to immunodeficiency in patients with HIV infection
  • Funding Agency
    • Health Research Board
  • Date From
    • 2010
  • Date To
    • 2013
  • Title
    • Novel immunoregulatory cells in human omentum.
  • Summary
    • Investigating the presence of γδ T cells in human omental adipose tissue and characterisation of CD1d recognition by Vδ3 T cells
  • Funding Agency
    • Health Research Board
  • Date From
    • 2010
  • Date To
    • 2013
  • Title
    • The role and treatment potential of γδ T cells in human immunodeficiency virus infection
  • Summary
    • Investigating the role of Vδ1 T cells in immunity against Candida albicans, a frequent co-infection in patients with HIV infection
  • Funding Agency
    • Health Research Board
  • Date From
    • 2012
  • Date To
    • 2013
  • Title
    • The anti-tumour roles of distinct subsets of invariant natural killer T cell
  • Summary
    • A functional comparison of CD4+, CD8+ and double negative iNKT cells in healthy donors and patients with chronic lymphocytic leukaemia
  • Funding Agency
    • Health Research Board
  • Date From
    • 2009
  • Date To
    • 2012
  • Title
    • Combating Diseases of Poverty Consortium
  • Summary
    • Training of students from Africa in biomedical laboratory techniques
  • Funding Agency
    • Higher Education Authority and Irish Aid
  • Date From
    • 2008
  • Date To
    • 2008
  • Title
    • The role of natural killer T cells in B cell maturation and antibody responses
  • Summary
    • Investigating the ability of human iNKT cells to promote differentiation and activation of B cells
  • Funding Agency
    • Health Research Board
  • Date From
    • 2007
  • Date To
    • 2011
  • Title
    • Flow cytometric Cell Sorter
  • Summary
    • This grant funded the purchase of a FACSAria Cell Sorter for the Institute of Immunology at Maynooth University. €300,000
  • Funding Agency
    • Science Foundation Ireland
  • Date From
    • 2006
  • Title
    • The role of CD1d-restricted natural killer T cells in dendritic cell maturation and differentiation
  • Summary
    • Investigating the mechanisms by which iNKT cells induce differentiation and activation of dendritic cells. €138,969.
  • Funding Agency
    • Science Foundation Ireland
  • Date From
    • 2005
  • Date To
    • 2008
  • Title
    • Characterisation and manipulation of human T cells with early immunomodulatory function
  • Summary
    • Analysis of rapid-activating lymphocytes of the immune system. €214,745.
  • Funding Agency
    • Science Foundation Ireland
  • Date From
    • 2004
  • Date To
    • 2006
  • Title
    • The influence of glycolipid-specific T lymphocytes on the maturation and function of human dendritic cells
  • Summary
    • This summer project enabled a secondary level science teacher gain immunology laboratory skills. Doherty DG, Carey M. €9,476.
  • Funding Agency
    • Science Foundation Ireland
  • Date From
    • 2008
  • Date To
    • 2008
  • Title
    • Characterisation of hepatitis C induced immunological subversion and its implications for treatment response
  • Summary
    • Determining the roles of immune cells in the liver in the pathogenesis of hepatitis C. €552,000
  • Funding Agency
    • Health Research Board
  • Date From
    • 2003
  • Date To
    • 2006
  • Title
    • The functional significance of diversity in human natural killer cell receptors
  • Summary
    • Determining how killer immunoglobulin receptor (KIR) allotypes affect NK cell functions €154,044.
  • Funding Agency
    • Enterprise Ireland
  • Date From
    • 2002
  • Date To
    • 2004
  • Title
    • Natural killer cells and natural killer receptor-positive T cells in hepatitis C virus infecti
  • Summary
    • Analysing the numbers and functions of NK cells and NK-like T cells in patients who cleared and those who did not clear hepatitis C virus
  • Funding Agency
    • Libyan People's Bureau, London
  • Date From
    • 2002
  • Date To
    • 2003
  • Title
    • The role of intrahepatic gamma delta T cells in immunity against hepatitis C virus
  • Summary
    • Examining the roles of virus specific hepatic CD8 T cells in immunity against hepatitis C virus. IR£129,260
  • Funding Agency
    • Health Research Board
  • Date From
    • 2001
  • Date To
    • 2004
  • Title
    • Microbeta Trilux Scintillation Counter
  • Summary
    • This equipment grant funded the purchase of a scintillation counter for the Institute of Immunology at Maynooth University. €45,980.
  • Funding Agency
    • Health Research Board
  • Date From
    • 2003
  • Title
    • Activation and regulation of human NKT cells. Doherty DG
  • Summary
    • Phenotypic and functional characterisation of novel populations of T cells with NK cell receptors. IR£57,190.
  • Funding Agency
    • Enterprise Ireland
  • Date From
    • 2000
  • Date To
    • 2003
  • Title
    • Characterisation of CD1-restricted T cells in the human liver
  • Summary
    • Identifying and characterising T cells that recognise CD1a, CD1b, CD1c and CD1d in liver biopsies from healthy donors and patients with metastatic liver disease. IR£49,164.
  • Funding Agency
    • Health Research Board
  • Date From
    • 1999
  • Date To
    • 2002
  • Title
    • Virus variants and host immune responses in the resolution and progression of chronic liver disease following hepatitis C infection
  • Summary
    • Determining the viral and host factors that determine whether a patient clears hepatitis C virus or develops chronic viral infection. IR£741,972.
  • Funding Agency
    • Health Research Board
  • Date From
    • 1997
  • Date To
    • 2002
  • Title
    • Characterisation of T cells in human liver
  • Summary
    • Investigating novel T cell populations in liver biopsies taken from healthy donors and patients with liver malignancy IR£75,000.
  • Funding Agency
    • Liver Unit, St. Vincent's University Hospital
  • Date From
    • 1996
  • Date To
    • 1998
  • Title
    • Phenotypic, molecular and functional characterisation of a novel lymphocyte in the normal human liver
  • Summary
    • Consumable funds for the characterisation of a novel type of T cell in human liver. IR£16,300.
  • Funding Agency
    • Forbairt
  • Date From
    • 1996
  • Date To
    • 1998
  • Title
    • Immunogenetic studies on liver transplantation tolerance and chronic liver disease
  • Summary
    • Determining the influence of donor-specific microchimerism in liver allograft acceptance. Stg £7,131.
  • Funding Agency
    • King's College Liver Unit Trust
  • Date From
    • 1992
  • Date To
    • 1993
  • Title
    • Cirrhosis in cystic fibrosis: use of DNA probes to evaluate the genetic basis of liver damage
  • Summary
    • Investigating the role of alleles of the cystic fibrosis gene and the immunogenetic loci in susceptibility to liver disease in patients with cysticv fibrosis. Stg £53,508.
  • Funding Agency
    • Cystic Fibrosis Research Trust
  • Date From
    • 1990
  • Date To
    • 1992
  • Title
    • Cirrhosis and cystic fibrosis: mechanisms of autoimmune liver damage: use of cDNA probes to evaluate its genetic basis.
  • Summary
    • An investigation of the role of major histocompatibility complex alleles in the pathogenesis of liver disease in children with cystic fibrosis. Stg £79,601.
  • Funding Agency
    • Cystic Fibrosis Research Trust
  • Date From
    • 1988
  • Date To
    • 1990

Keywords

ADIPOSE-TISSUE; AUTOIMMUNE DISEASES; B-CELLS; CANCER; CELL-MEDIATED IMMUNE RESPONSES; DENDRITIC CELLS; GAMMA DELTA TCR; HEPATITIS B; HEPATITIS-C; HEPATOCELLULAR-CARCINOMA; HIV; HUMAN LIVER; IMMUNE SYSTEM; IMMUNODEFICIENCY; INFECTIOUS DISEASES; INNATE IMMUNITY; LEUKOCYTE; LIPIDS; LYMPHOCYTES; NATURAL-KILLER-CELLS

Recognition

Awards and Honours

Elected to Fellowship of Trinity College Dublin 2012

Memberships

Committee member of the Irish Society for Immunology; secretary 2000-2004. 2000 – 2004