Dania Movia
Research Fellow, Clinical Medicine

Biography

Dr Dania Movia is a Senior Research Fellow at the Laboratory for Biological Characterization of Advanced Materials (LBCAM), part of the Trinity Translational Medicine Institute (TTMI) of Trinity College Dublin. She is also a part-time lecturer at the School of Medicine of Trinity College Dublin, where she teaches on the MSc in Molecular Medicine, and mentors students from various undergraduate and postgraduate degrees. Dania was awarded an MSc in Chemistry and Pharmaceutical Technologies (1st with honors) at the School of Pharmacy of the University of Trieste (Italy) (2007), the national accreditation to the Italian pharmacists' registers (2008) and a PhD in Chemistry at Trinity College Dublin (Ireland) (2012). Her research interests are: ► Design and preclinical testing of oncological nanomedicine products; ► Development and validation of advanced 3D in vitro systems for preclinical testing to accelerate the translation of anti-cancer nanomedicine products; ► Nanosafety and nanotoxicology.

Publications and Further Research Outputs

Peer-Reviewed Publications

Adriele Prina-Mello, Namrata Jain, Baiyun Liu, Jason I. Kilpatrick, Melissa A. Tutty, Alan P. Bell, Suzanne P Jarvis, Yuri Volkova, Dania Movia, Culturing substrates influence the morphological, mechanical and biochemical features of lung adenocarcinoma cells cultured in 2D or 3D, Tissue and Cell, 50, 2018, p15 - 30 Journal Article, 2018 DOI

Movia D., Di Cristo L., Alnemari R., McCarthy J. E., Moustaoui H., Lamy de la Chapelle M., Spadavecchia J., Volkov Y., Prina-Mello A., The curious case of how mimicking physiological complexity in in vitro models of the human respiratory system influences the inflammatory responses. A preliminary study focused on gold nanoparticles, Journal of Interdisciplinary Nanomedicine, 2, (2), 2017, p110 - 130 Journal Article, 2017 DOI

Nanotoxicity in cancer research: technical protocols and tips considerations for the use of 3D tumour spheroids in, editor(s)Ferreira de Castro Gomes Andreia, Sárria Pereira Passos Marisa. , Nanotoxicity, InTech, 2017, [Movia D., Prina-Mello A.] Book Chapter, 2017

Moore C., Movia D., Smith R., Hanlon D., Lebre F., Lavelle E., Byrne H., Coleman J., Volkov Y., McIntyre J., Industrial grade 2D molybdenum disulphide (MoS2): an in vitro exploration of the impact on cellular uptake, cytotoxicity, and inflammation, 2D Materials, 4, (2), 2017 Journal Article, 2017 URL DOI

Multilayered nanoparticles for personalized medicine: translation into clinical markets in, editor(s)Raj Bawa, Gerald F. Audette, Israel Rubinstein , Handbook of Clinical Nanomedicine: Nanoparticles, Imaging, Therapy and Clinical Applications, Pan Stanford Publishing, 2016, pp299 - 318, [Dania Movia, Craig Poland, Lang Tran, Yuri Volkov, Adriele Prina-Mello] Book Chapter, 2016 DOI

Di Cristo L, Movia D, Bianchi MG, Allegri M, Mohamed BM, Bell AP, Moore C, Pinelli S, Rasmussen K, Riego-Sintes J, Prina-Mello A, Bussolati O, Bergamaschi E, Proinflammatory Effects of Pyrogenic and Precipitated Amorphous Silica Nanoparticles in Innate Immunity Cells., Toxicological sciences, 150, (1), 2016, p40-53 Journal Article, 2016 DOI TARA - Full Text

Dekkers S, Oomen AG, Bleeker EA, Vandebriel RJ, Micheletti C, Cabellos J, Janer G, Fuentes N, Vázquez-Campos S, Borges T, Silva MJ, Prina-Mello A, Movia D, Nesslany F, Ribeiro AR, Leite PE, Groenewold M, Cassee FR, Sips AJ, Dijkzeul A, van Teunenbroek T, Wijnhoven SW, Towards a nanospecific approach for risk assessment., Regulatory toxicology and pharmacology : RTP, 80, 2016, p46-59 Journal Article, 2016 DOI TARA - Full Text

Moustaoui H, Movia D, Dupont N, Bouchemal N, Casale S, Djaker N, Savarin P, Prina-Mello A, De La Chapelle M.L, Spadavecchia J, Tunable Design of Gold(III)-Doxorubicin Complex-PEGylated Nanocarrier. the Golden Doxorubicin for Oncological Applications, ACS Applied Materials and Interfaces, 8, (31), 2016, p19946 - 19957 Journal Article, 2016 URL DOI

Spadavecchia J, Movia D, Moore C, Maguire CM, Moustaoui H, Casale S, Volkov Y, Prina-Mello A, Targeted polyethylene glycol gold nanoparticles for the treatment of pancreatic cancer: from synthesis to proof-of-concept in vitro studies., International journal of nanomedicine, 11, 2016, p791-822 Journal Article, 2016 TARA - Full Text DOI

Bianca M Rotoli, Rita Gatti, Dania Movia, Massimiliano G Bianchi, Luisana Di Cristo, Ivana Fenoglio, Fabio Sonvico, Enrico Bergamaschi, Adriele Prina-Mello, Ovidio Bussolati, Identifying contact-mediated, localized toxic effects of MWCNT aggregates on epithelial monolayers: a single-cell monitoring toxicity assay, Nanotoxicology, 9, (2), 2015, p230-241 Journal Article, 2015 DOI

Mahfoud, O.K., Rakovich, T.Y., Prina-Mello, A., Movia, D., Alves, F., Volkov, Y., Detection of ErbB2: Nanotechnological solutions for clinical diagnostics, RSC Advances, 4, (7), 2014, p3422-3442 Review, 2014 DOI TARA - Full Text

Catherine A Schütz, Davide Staedler, Kieran Crosbie-Staunton, Dania Movia, Catherine Chapuis Bernasconi, Blanka Halamoda Kenzaoui, Adriele Prina-Mello, Lucienne Juillerat-Jeannere, Differential stress reaction of human colon cells to oleic-acid-stabilized and unstabilized ultrasmall iron oxide nanoparticles, International Journal of Nanomedicine, 9, 2014, p3481 - 3498 Journal Article, 2014 DOI TARA - Full Text

Movia, D., Gerard, V., Maguire, C.M., Jain, N., Bell, A.P., Nicolosi, V., O'Neill, T., Scholz, D., Gun'ko, Y., Volkov, Y., Prina-Mello, A., A safe-by-design approach to the development of gold nanoboxes as carriers for internalization into cancer cells, Biomaterials, 35, (9), 2014, p2543-2557 Journal Article, 2014 DOI

Bashir Mustafa Mohamed, Dania Movia, Anton Knyazev, Dominique Langevin, Anthony Mitchell Davies, Adriele Prina-Mello, Yuri Volkov, Citrullination as early-stage indicator of cell response to Single-Walled Carbon Nanotubes, Scientific Reports, 3, (1124), 2013, p1 - 7 Journal Article, 2013 DOI

Singh, M., Movia, D., Mahfoud, O.K., Volkov, Y., Prina-Mello, A., Silver nanowires as prospective carriers for drug delivery in cancer treatment: An in vitro biocompatibility study on lung adenocarcinoma cells and fibroblasts, European Journal of Nanomedicine, 5, (4), 2013, p195-204 Journal Article, 2013 DOI

Toxicity of carbon nanotubes in, Handbook of Green Chemistry - Green Processes (- Green Nanoscience), Germany, Wiley - VCH, 2013, pp175 - 216 , [Movia D. and Giordani S.] Book Chapter, 2013

Del Canto E., Natali M., Movia D. and Giordani S., Photo-controlled Uptake and Release of Zinc Metal Ions by Spiropyran receptors anchored to Single-Walled Carbon Nanotubes, Phys. Chem. Chem. Phys. , 14, (17), 2012, p6034 - 6043 Journal Article, 2012 DOI TARA - Full Text

Anja Schinwald, Fiona A Murphy, Adriele Prina-Mello, Craig A Poland, Fiona Byrne, Dania Movia, James R Glass, Janet C Dickerson, David A Schultz, Chris E Jeffree, William Macnee, Ken Donaldson, The threshold length for fiber-induced acute pleural inflammation: shedding light on the early events in asbestos-induced mesothelioma, Toxicological Sciences, 128, (2), 2012, p461 - 470 Journal Article, 2012 DOI

Del Canto, E., Flavin, K., Movia, D., Navio, C., Bittencourt, C., Giordani, S., Critical investigation of defect site functionalization on single-walled carbon nanotubes, Chemistry of Materials, 23, (1), 2011, p67-74 Journal Article, 2011 DOI

Thakur G., Micic M., Yang Y., Li W., Movia D., Giordani S., Zhang H. and Leblanc R., Conjugated Quantum Dots Inhibit the Amyloid β (1-42) Fibrillation Process, International Journal of Alzheimer's Disease, 2011, 2011, p502386 Journal Article, 2011 DOI TARA - Full Text

Movia D, Prina-Mello A, Bazou D, Volkov Y, Giordani S, Screening the Cytotoxicity of Single-Walled Carbon Nanotubes Using Novel 3D Tissue-Mimetic Models., ACS Nano, 5, (11), 2011, p9278-9290 Journal Article, 2011 DOI

Del Canto E., Flavin K., Movia D., Giordani S., Oxidized Single-Walled Carbon Nanotubes: removal of carbonaceous functionalized material by washing with solvents or base, MRS Proceedings, 1362, 2011, pmrss11-1362-qq09-44 Journal Article, 2011 DOI

Del Canto E., Flavin K., Movia D., Navio C., Bittencourt C., Giordani S., A Critical Investigation of Defect Site Functionalization on Single Walled Carbon Nanotubes, Chemistry of Materials, 23, (1), 2011, p67-74 Journal Article, 2011 DOI

Movia D., Del Canto E., Giordani S., Purified and Oxidized Single Walled Carbon Nanotubes as Robust Near IR Fluorescent Probes for Molecular Imaging, Journal of Physical Chemistry C, 114, (43), 2010, p18407-18413 Journal Article, 2010 DOI

Movia, D., Prina-Mello, A. , Volkov, Y. , Giordani, S, Determination of spiropyran cytotoxicity by high content screening and analysis for safe application in bionanosensing, Chemical Research in Toxicology , 23, (9), 2010, p1459 - 1466 Journal Article, 2010 DOI

Movia D., Del Canto E. and Giordani S., Spectroscopy of Single-Walled Carbon Nanotubes in Aqueous Surfactant Dispersion, physica status solidi (b), 246, (11-12), 2009, p2704 - 2707 Journal Article, 2009 DOI TARA - Full Text

Non-Peer-Reviewed Publications

Susan Dekkers, Agnes G Oomen, Eric AJ Bleeker, Rob J Vandebriel, Christian Micheletti, Joan Cabellos, Gemma Janer, Natalia Fuentes, Socorro Vázquez-Campos, Teresa Borges, Maria João Silva, Adriele Prina-Mello, Dania Movia, Fabrice Nesslany, Ana Ribeiro, Paulo Emílio Leite, Monique Groenewold, Flemming R Cassee, Adrienne JAM Sips, Aart Dijkzeul, Tom van Teunenbroek, Susan WP Wijnhoven, NANoREG Deliverable D 5.8-Decision tree for risk assessment of MNMs , 2016 Report, 2016

Movia D., Alnemari R., Volkov Y., Prina-Mello A., The influence of in vitro complexity on detectable inflammatory responses induced by gold nanoparticles, European Society For Alternatives To Animal Testing (EUSAAT) Congress 2016, Linz, Austria , 24-27/08/2016, 2016 Oral Presentation, 2016

Movia D., Prina-Mello Y., INEDITED - Improve NanomEDIcine Translation into clinical lung cancEr Drugs, European Association for Cancer Research (EACR) Conference Series "Goodbye Flat Biology: Models, Mechanisms and Microenvironment", Berlin, Germany , 02-05/10/2016, 2016 Oral Presentation, 2016

Movia D., Spadavecchia J., Moustaoui H., Moore C., Maguire C.M., Casale S., Prina-Mello A., Targeted polyethylene glycol gold nanoparticles for the treatment of pancreatic cancer: from synthesis to a proof-of-concept in vitro studies, 10th International Cancer Conference 2016, session: "Advances in targeted therapies/Precision Medicine", Dublin, Ireland , 17-18/10/2016, 2016 Oral Presentation, 2016

Movia D., Spadavecchia J., Moustaoui H., Moore C., Maguire C.M., Casale S., Prina-Mello A., Targeted polyethylene glycol gold nanoparticles for the treatment of pancreatic cancer: from synthesis to a proof-of-concept in vitro studies. , Nanobiotechnology International Workshop, JRC, Ispra, Italy , 23-25/11/2015, 2015 Invited Talk, 2015

Movia D., Volkov Y., Prina-Mello A., Nanomedicine: A multidisciplinary solution towards improving the benefit of existing anticancer treatments , "Let's Talk about Nano" Seminar series, Centre for Research on Adaptive Nanostructures and Nanodevices (CRANN), Dublin, Ireland , 03/09/2014, 2014 Invited Talk, 2014

Prina-Mello A., Movia D., Maguire C.M., Nanomedicine: science fiction or solution to unmet challenges? One step closer to translation, IMM Monday Talk series, Dublin, Ireland , 10/02/2014, 2014 Invited Talk, 2014

Gavigan-Imedio J.D., Movia D., Volkov Y., Prina-Mello A., Nanomedicine translational oncology: a perspective to cancer treatment, EuroNanoForum, Dublin, Ireland, June 2013, 2013 Oral Presentation, 2013

Movia D., Prina-Mello A., NANoREG - A common European approach to the regulatory testing of Manufactured Nanomaterials, AMBER Launch, Dublin, Ireland , October 2013, 2013 Oral Presentation, 2013

Movia D., Gerard V., Maguire C.M., Jain N., Bell A.P., Nicolosi V., O'Neill T., Scholz D., Gun'ko Y., Volkov Y., Prina-Mello A., Gold nanoboxes: a step forward in the personalized treatment of lung cancer, AMBER Launch, Dublin, Ireland, October 2013, 2013 Oral Presentation, 2013

Movia D., Bazou D., Volkov Y., Prina-Mello A., In vitro 3D cell models for nanomaterials' safety assessment: are we one step closer to a representative in vivo model?, QualityNano conference, Prague, Czech Republic, March 2013, 2013 Oral Presentation, 2013

Movia D., Gerard V., Maguire C.M., Jain N., Bell A.P., Nicolosi V., O'Neill T., Scholz D., Gun'ko Y., Volkov Y., Prina-Mello A., Gold nanoboxes as multifunctional nanotools for companion diagnostic, IMM Annual Meeting, Dublin, Ireland, October 2013, 2013 Oral Presentation, 2013

Movia D., Volkov Y., Prina-Mello A., Translational focus on Nanomedicine research at Trinity College Dublin, The European CLINAM & ETPN Summit, Basel, Switzerland , 23-26/06/2013, 2013 Oral Presentation, 2013

Movia D., Gerard V., Maguire C.M., Jain N., Bell A.P., Nicolosi V., O'Neill T., Scholz D., Gun'ko Y., Volkov Y., Prina-Mello A., Gold nanoboxes as multifunctional nanotools for companion diagnostic, EuroNanoForum, Dublin, Ireland , June 2013, 2013 Oral Presentation, 2013

Movia D., Bazou D., Giordani S., Volkov Y., Prina-Mello A., Screening the Cytotoxicity of Single-Walled Carbon Nanotubes Using Novel 3D Tissue-Mimetic Models, NanoImpactNet - QNano Conference, Dublin, Ireland, 27/02-02/03/2012, 2012 Oral Presentation, 2012

Movia D., Bazou D., Giordani S., Volkov Y., Prina-Mello A., Novel 3D Tissue-Mimetic Model for Biomaterial Evaluation: Single-Walled Carbon Nanotubes Assessment and Comparison to 2D Model, 18th Bioengineering in Ireland, Belfast, UK, 27-28/01/2012, 2012 Oral Presentation, 2012

Movia D., Prina-mello A., Imaging cell and tissue interaction with Nanomaterials: from 2D to 3D models, Nanotechnology in Diagnostic, Monitoring and Treatment of Cancer Advanced in Molecular Imaging Workshop, World Molecular Imaging Congress 2012, Dublin, Ireland, 05/09/2012, 2012 Oral Presentation, 2012

Del Canto E., Natali M., Flavin K., Movia D., Giordani S., Single-Walled Carbon Nanotubes and Photo Switchable Spiropyrans: Novel Multifunctional Platforms for Sensing and Biological Applications, ERIC Intel Conference 2011, Intel Ireland Campus, Leixlip, Ireland, 12-14/10/2011, 2011 Oral Presentation, 2011

Movia D., Giordani S., Towards SWNTs as NIR Fluorescent Probes: Spectroscopic and Toxicological Investigation, 3rd Year Talk Day, Dublin Chemistry, Dublin, Ireland, 19/05/2011, 2011 Oral Presentation, 2011

Movia D., Del Canto E., Giordani S., Purified and Oxidized SWNTs: potential NIR fluorescence probes for molecular imaging, ChemOnTubes 2010, Arcachon, France, 11-15/04/2010, 2010 Oral Presentation, 2010

Movia D., Del Canto E., Giordani S., Purified and Oxidized SWNTs: potential NIR fluorescence probes for molecular imaging, INSPIRE BioNano Postgraduate Research Workshop, Conway Institute (UCD), Dublin, Ireland, 20-21/10/2010, 2010 Oral Presentation, 2010

Movia D., Del Canto E. Giordani S., Spectroscopy of Single-Walled Carbon Nanotubes in Aqueous Surfactant Dispersion, International Winterschool on Electronic Properties of Novel Materials 2009 (IWEPNM 09), Kirchberg, Austria, 07-14/03/2009, 2009 Oral Presentation, 2009

Movia D., Del Canto E., Flavin K., Giordani S., Spectroscopic characterization of acid treated single-walled carbon nanotubes, 61st Irish Universities Chemistry Colloquium, Dublin, Ireland, 17-19/06/2009, 2009 Oral Presentation, 2009

Movia D., Del Canto E. and Giordani S., Microscopy and spectroscopic characterization of acid treated single-walled carbon nanotubes, 33rd Annual Microscopy Society of Ireland (MSI) meeting, Dublin, Ireland, 26-29/08/2009, 2009 Oral Presentation, 2009

Research Expertise

Description

Research areas: ► Oncological nanomedicine ► Tissue-mimetic in vitro cell models for cancer research ► Alternatives to animal research and 3Rs principle ► Medicinal chemistry ► Risk assessment of nanomaterials ► Nanotechnology

Projects

  • Title
    • INEDITED - Improve NanomEDIcine Translation into clinical lung cancEr Drugs
  • Funding Agency
    • Irish Research Council
  • Date From
    • 01/10/2015
  • Date To
    • 30/09/2017
  • Title
    • EU FP7 flagship NANoREG project
  • Summary
    • "A common European approach to the regulatory testing of Manufactured Nanomaterials" (http://www.nanoreg.eu)
  • Funding Agency
    • European Commission
  • Date From
    • 01/06/2013
  • Date To
    • 31/09/2015
  • Title
    • EU FP7 NAMDIATREAM project
  • Summary
    • "NAnotechnological toolkits for Multi-modal cancer DIAgnostics and TREAtment Monitoring" (http://www.namdiatream.eu/joomla/)
  • Funding Agency
    • European Commission
  • Date From
    • 01/06/2013
  • Date To
    • 31/09/2015
  • Title
    • EU FP7 QualityNano Research Infrastructure project
  • Summary
    • "Quality in nanomaterials safety testing" (http://www.qualitynano.eu/)
  • Funding Agency
    • European Commission
  • Date From
    • 01/06/2013
  • Date To
    • 30/09/2015
  • Title
    • CRANN Pathfinder Fellowship
  • Summary
    • "Methodology for Nanomaterials Safety Assessment"
  • Date From
    • 01/01/2012
  • Date To
    • 31/05/2013
  • Title
    • Post-graduate EMBARK Scheme scholarship
  • Summary
    • "Photochromic Network Polymers and Supramolecular Modification of Single-Walled Carbon Nanotubes"
  • Funding Agency
    • Irish Research Council
  • Date From
    • 2008

Keywords

Alternatives to Animal Testing; Biology; Biomaterials; Cellular Biology; Imaging Techniques; In vitro alternatives to animal studies; In vitro testing, trial methods; Lung cancer; Medicinal Chemistry; Nanochemistry; Nanomedicine; Nanotechnology; Pancreatic cancer; Physical Chemistry; Spectroscopy

Recognition

Representations

Reviewer for various international scientific journals (IF > 2). Present

Awards and Honours

Research Award in recognition for the publication of an internationally peer-reviewed publication of the highest quality. 2012

Best Material Science Poster, 33rd Annual Microscopy Society of Ireland (MSI) meeting 2009

Paper of the Year 2012, Society of Toxicology Board 2012

Memberships

EACR (European Association for Cancer Research) membership.