Sinead Cristin Corr
Assistant Professor, Microbiology

Publications and Further Research Outputs

Peer-Reviewed Publications

Johnston DGW, Kearney J, ZasÅ'ona Z, Williams MA, O'Neill LAJ, Corr SC., MicroRNA-21 Limits Uptake of Listeria monocytogenes by Macrophages to Reduce the Intracellular Niche and Control Infection., Frontiers in cellular and infection microbiology, 7, 2017, p201 Journal Article, 2017 DOI TARA - Full Text

Daniel Johnston, Luke O'Neill, Sinéad Corr, Modulation of Intestinal Homeostasis and Microbial Activities by miR-21 in the Pathogenesis of Inflammatory Bowel Disease, Gastroenterology, Digestive Disease Week, San Diego, 2016, 150, (4), 2016 Conference Paper, 2016

Westermann, C., Gleinser, M., Corr, S.C., Riedel, C.U., A critical evaluation of bifidobacterial adhesion to the host tissue, Frontiers in Microbiology, 7, (AUG), 2016 Journal Article, 2016

McGettrick AF, Corcoran SE, Barry PJ, McFarland J, Crès C, Curtis AM, Franklin E, Corr SC, Mok KH, Cummins EP, Taylor CT, O'Neill LA, Nolan DP, Trypanosoma brucei metabolite indolepyruvate decreases HIF-1α and glycolysis in macrophages as a mechanism of innate immune evasion., Proc Natl Acad Sci U S A. , 113, (48), 2016, E7778-E7787 Journal Article, 2016 DOI

Toll-like receptor signalling and the control of intestinal barrier function in, Methods in Molecular Biology, 2016, [Johnston, D.G.W. and Corr, S.C.] Book Chapter, 2016 URL

Ní Cheallaigh C, Sheedy FJ, Harris J, Muñoz-Wolf N, Lee J, West K, McDermott EP, Smyth A, Gleeson LE, Coleman M, Martinez N, Hearnden CH, Tynan GA, Carroll EC, Jones SA, Corr SC, Bernard NJ, Hughes MM, Corcoran SE, O'Sullivan M, Fallon CM, Kornfeld H, Golenbock D, Gordon SV, O'Neill LA, Lavelle EC, Keane J, A Common Variant in the Adaptor Mal Regulates Interferon Gamma Signaling., Immunity, 44, (2), 2016, p368-79 Journal Article, 2016 URL TARA - Full Text

Mills E.L, Kelly B, Logan A, Costa A.S.H, Varma M, Bryant C.E, Tourlomousis P, DÀbritz J.H.M, Gottlieb E, Latorre I, Corr S.C, McManus G, Ryan D, Jacobs H.T, Szibor M, Xavier R.J, Braun T, Frezza C, Murphy M.P, O'Neill L.A, Succinate Dehydrogenase Supports Metabolic Repurposing of Mitochondria to Drive Inflammatory Macrophages, Cell, 167, (2), 2016, p457 - 470.e13 Journal Article, 2016 DOI URL

Oficjalska K, Raverdeau M, Aviello G, Wade SC, Hickey A, Sheehan KM, Corr SC, Kay EW, O'Neill LA, Mills KH, Creagh EM, Protective role for caspase-11 during acute experimental murine colitis., Journal of immunology (Baltimore, Md. : 1950), 194, (3), 2015, p1252-60 Journal Article, 2015 TARA - Full Text DOI

Corr, S.C., Palsson-Mcdermott, E.M., Grishina, I., Barry, S.P., Aviello, G., Bernard, N.J., Casey, P.G., Ward, J.B.J., Keely, S.J., Dandekar, S., Fallon, P.G., O'Neill, L.A.J., MyD88 adaptor-like (Mal) functions in the epithelial barrier and contributes to intestinal integrity via protein kinase C, Mucosal Immunology, 7, (1), 2014, p57-67 Journal Article, 2014 DOI TARA - Full Text

Aviello G, Corr SC, Johnston DG, O'Neill LA, Fallon PG., MyD88 adaptor-like (Mal) regulates intestinal homeostasis and colitis-associated colorectal cancer in mice. , Am J Physiol Gastrointest Liver Physiol., 306, 2014, pG769 - G778 Journal Article, 2014 TARA - Full Text DOI

Dowling, J.K., Becker, C.E., Bourke, N.M., (...), Mansell, A., O'Neill, L.A.J., Promyelocytic leukemia protein interacts with the apoptosis-associated speck-like protein to limit inflammasome activation, Journal of Biological Chemistry, 289, (10), 2014, p6429-6437 Journal Article, 2014 TARA - Full Text DOI

Tannahill, GM, Curtis, AM, Adamik, J, Palsson-McDermott, EM, McGettrick, AF, Goel, G, Frezza, C, Bernard, NJ, Kelly, B, Foley, NH, Zheng, L, Gardet, A, Tong, Z, Jany, SS, Corr, SC, Haneklaus, M, Caffrey, BE, Pierce, K, Walmsley, S, Beasley, FC, Cummins, E, Nizet, V, Whyte, M, Taylor, CT, Lin, H, Masters, SL, Gottlieb, E, Kelly, VP, Clish, C, Auron, PE, Xavier, RJ, O'Neill, LAJ, Succinate is an inflammatory signal that induces IL-1 beta through HIF-1 alpha, NATURE, 496, (7444), 2013, p238-+ Journal Article, 2013 TARA - Full Text DOI

AS Nugent, S Corr, S Daly, L Keogh, C Martin, K Fitzgerald, LA O'Neill, JJ O'Leary, Free Fetal DNA Incites a Local Inflammatory Response in Murine Placentae Via TLR-9 Resulting in Fetal Loss and Preterm Delivery, LABORATORY INVESTIGATION, 92, NATURE PUBLISHING GROUP, 2012 Conference Paper, 2012

Scharfe-Nugent A, Corr SC, Carpenter SB, Keogh L, Doyle B, Martin C, Fitzgerald KA, Daly S, O'Leary JJ, O'Neill LA, TLR9 provokes inflammation in response to fetal DNA: mechanism for fetal loss in preterm birth and preeclampsia., Journal of immunology (Baltimore, Md. : 1950), 188, (11), 2012 Journal Article, 2012 DOI TARA - Full Text

Aubry C, Corr SC, Wienerroither S, Goulard C, Jones R, Jamieson AM, Decker T, O'Neill LA, Dussurget O, Cossart P, Both TLR2 and TRIF contribute to interferon-ß production during Listeria infection., PloS one, 7, (3), 2012, pe33299 Journal Article, 2012 TARA - Full Text DOI

Gantier, M.P., Stunden, H.J., McCoy, C.E., Behlke, M.A., Wang, D., Kaparakis-Liaskos, M., Sarvestani, S.T., Yang, Y.H., Xu, D., Corr, S.C., Morand, E.F., Williams, B.R.G., A miR-19 regulon that controls NF-"B signaling, Nucleic Acids Research, 40, (16), 2012, p8048-8058 Journal Article, 2012

Andrea Scharfe Nugent, Sinead Corr, John O'leary, Sean Daly, Luke O'neill, A novel role for free fetal DNA in non-infectious preterm birth, American Journal of Obstetrics & Gynecology, 204, Elsevier, 2011 Conference Paper, 2011

AS Nugent, S Daly, S Corr, JJ O'Leary, LAJ O'Neill, A Non-Infectious Mechanism for Pre-Term Delivery: Free Fetal DNA Sensed by Maternal TLR-9, LABORATORY INVESTIGATION, LABORATORY INVESTIGATION, 90, NATURE PUBLISHING GROUP, 2010 Conference Paper, 2010

Moloney, G., Corr, S.C, Hall, L.J., Murphy, C., Quinlan, A., Kruidenier, L., Calver, A.R., McLean, P.G., Lee, K., Shanahan, F., Nally, K. and Melgar, S. , The effect of the Farnesoid X Receptor (FXR) and it's agonist - GSK488062B - on experimental models of colitis and cytokine production from IBD tissue. , Gastroenterology, 2009, pp243 Conference Paper, 2009

Chapter 1 Understanding the Mechanisms by Which Probiotics Inhibit Gastrointestinal Pathogens in, Advances in Food and Nutrition Research, 2009, pp1-15 , [Corr, S.C., Hill, C., Gahan, C.G.M.] Book Chapter, 2009

Corr, S.C. and O'Neill, L.A.J. , Genetic Variation in Toll-Like Receptor Signalling and the Risk of Inflammatory and Immune Diseases, Journal of Innate Immunity, 1, (4), 2009, p350 - 357 Journal Article, 2009 DOI

Corr SC, O'Neill LA, Listeria monocytogenes infection in the face of innate immunity., Cellular microbiology, 11, (5), 2009, p703 - 709 Journal Article, 2009 DOI

Corr, S.C., Gahan, C.G. and Hill, C. , M-cells: origin, morphology and role in mucosal immunity and microbial pathogenesis. , FEMS Immunology & Medical Microbiology, 52, (1), 2008, p2-12 Journal Article, 2008 DOI

Corr, S.C., Gahan, C.G. and Hill, C., Impact of selected Lactobacillus and Bifidobacterium species on Listeria monocytogenes infection and the mucosal immune response, FEMS Immunology & Medical Microbiology, 50, (3), 2007, p380-388 Journal Article, 2007 DOI

Corr, S.C., Li, Y., Riedel, C.U., O'Toole, P.W., Hill, C. and Gahan, C.G. , Bacteriocin production as a mechanism for the anti-infective activity of Lactobacillus salivarius UCC118., Proceedings of the National Academy of Sciences of the USA, 104, (8), 2007, p7617-7621 Journal Article, 2007 DOI

Corr, S.C., O'Hara, A.M., O'Mahony, L., Shanahan, F., Hill, C. and Gahann, C.G. , Induction of CCL20 by Listeria monocytogenes is dependent upon entry to the host cell cytosol., Gastroenterology, 2007, pp132 Conference Paper, 2007

Bron, P.A., Monk, I.R., Corr, S.C., Hill, C. and Gahan, C.G., Novel luciferase reporter system for in vitro and organ-specific monitoring of differential gene expression in Listeria monocytogenes., Applied and Environmental Microbiology, 72, (4), 2006, p2876-2884 Journal Article, 2006 DOI

Corr, S., Hill, C. and Gahan, C.G., An in vitro cell-culture model demonstrates internalin- and hemolysin-independent translocation of Listeria monocytogenes across M cells., Microbial Pathogenesis, 41, (6), 2006, p241-250 Journal Article, 2006 DOI

Research Expertise

Description

My research interests lie at the host-microbe interface within the gastrointestinal (GI) tract, with an overall focus on microbial modulation of gut immunity. This work aims to understand the molecular mechanisms which govern the interplay that occurs between pathogenic bacteria, the microbiota and the host organism, namely the epithelial barrier and innate immunity. The subsequent maintenance of health or development of disease is of particular interest. Gastroenteritis, including bacterial infectious diseases, are a major cause of morbidity and mortality worldwide, while inflammatory bowel diseases (IBDs) affect over 2 million people in Europe. My work hopes to characterize the host mechanisms which mediate gut health in response to infectious and resident microbes and to determine how microbes can alter this intestinal homeostasis giving rise to disease. This will enable strategic manipulation of intestinal epithelial defences or probiotic treatment strategies with the ultimate goal of reducing the severity of intestinal infectious and inflammatory diseases. Key Themes: .Gut barrier: Molecular mechanisms governing gut homeostasis and disease. .Microbiota: Microbiota-Host-Epithelium Interaction Anti-microbial and anti-inflammatory activity of probiotics. .Infection & Immunity: Microbial determinants of infection. Innate Immunity to infection. Gut Barrier: The epithelial cells lining the GI tract form a barrier between the body and the luminal environment which not only contains nutrients and commensal microbiota, but also potentially harmful microorganisms and toxins. This epithelial barrier is pivotal to intestinal health or disease, with loss of barrier integrity or "leaky gut" being implicated in a range of diseases including infectious enterocolitis and IBD. Epithelial cells express pattern recognition receptors (PRRs) which orchestrate mucosal defences during infection and respond to gut commensals to maintain intestinal wellbeing. As a result, the GI epithelium is a crucial site of immune regulation and the integrity of this barrier determines health or development of disease. My work investigates the host immune mechanisms and microbial factors which control the functional integrity of the gut epithelial barrier. Microbiota: The gut microbiota presents a significant barrier that must be overcome for a pathogen to initiate an infection or inflammatory onslaught. The relationship between the host and its microbiota is largely a beneficial one, with members of the microbiota being instrumental to human physiology and wellbeing. Microbial presence and activity influences the function of intestinal defences, and has a key role in improving digestive function, in the reduction of chronic inflammation, and in hastening recovery from intestinal disease. However this relationship can become detrimental due to disturbances including alterations in diet and antibiotic use, and the resulting microbial dysbiosis has been linked to infection, IBD, diabetes and obesity. My research focusses on the host-microbiota dialogue, investigating the signalling interactions between the host and its microbiota which mediate immune-inflammatory responses. It hopes to decipher to what extent the microbiota can modulate the intestinal epithelial barrier and inflammation, and how members of the microbiota can be used to directly inhibit infection by bacterial pathogens. Infection&Immunity: Work to date has focussed on understanding the intestinal phase of infection with gut pathogens, specifically Listeria monocytogenes and Salmonella Typhimurium. We are interested in the characterization of bacterial virulence factors involved in infection of host cells, and in deciphering the host mechanisms to combat infection. Furthermore, the strategies evolved by bacteria to subvert these host defence mechanisms and immune responses enabling spread within the host in a research focus.

Keywords

; BACTERIAL INFECTION; EPITHELIAL PERMEABILITY; GUT BARRIER FUNCTION; IBD; Infection and immunity; INFLAMMATION; Intestinal Barrier Function; INTESTINAL EPITHELIAL-CELLS; INTESTINAL INFECTIONS; INTESTINAL INFLAMMATION; MICROBIOTA; miRNA; Molecular basis to inflammation and innate immunity; MOUSE MODELS; Probiotic

Recognition

Memberships

Adjunct Faculty Member APC Microbiome Institute – Present

Microbiology Society 2002 – Present

Irish Society of Immunology 2008 – Present

Irish Epithelial Physiology Group – Present

Irish Society of Gastroenterology 2006 – Present

American Gastroenterological Association