Concepta Merry
Lecturer in Therapeutics -Part-Time, Clinical Medicine

Biography

GLOBAL HEALTH INITIATIVES & ACTIVITIES Founder of the Réalta Global HIV/AIDS Foundation; May 2004. Funding raised to date: €3.99 million. Training Research and Community Projects through the Réalta Global HIV/AIDS Foundation. Training: Founder of the AIDS Treatment Information Centre, University of Makerere; 2004.This center now takes calls from thirteen countries in sub-Saharan Africa. This center has been awarded a grant from the Irish government to provide continuing medical education for the staff at the Irish Medical Missionaries of Mary Hospital in Kitovu Uganda. Building capacity in HIV pharmacology among Ugandan, Nigerian, South African, Zambian, Malawian, Rwandese and Irish healthcare providers. I am supervising two Ugandan and one Nigerian PhD student. Establishing a diploma in HIV medicine for African doctors working in Ireland to prepare them for their return home and providing career advice to assist these doctors to secure employment. Helping Irish doctors secure suitable employment in sub-Saharan Africa and working with the higher training authorities to ensure that their time in selected posts in Africa will receive accreditation for training. Member of the Scientific Advisory Board of the Academic alliance for HIV/AIDS Care and Prevention; 2002-date. Training co-ordinator and trainer in the development of an HIV/AIDS Training Course for African doctors in Ireland. 2004. Investigator on project to evaluate the role of hand-held computers in providing information to HIV healthcare providers in Uganda. Collaboration with IT departments at Trinity College Dublin and Dublin City University sponsored by the Higher Education Authority; 2004. Training programmes on the role of pharmacology in optimising management of HIV/ AIDS in Africa, Europe, North America, Australia and South America; 1999-2004 Expert advisor to Nigerian government on HIV care initiatives; 2004. Advisor on HIV post-exposure prophylaxis to NGOs, Concern and Suas; 2004. Pharmacology advisor to the International AIDS Society; 2001. Board member of Friends of Ireland Charity established by Marianne Finucane to support poverty reduction strategies in South Africa. Co-founder/board member of MEREPA a charity based in Ghana to support early childhood development. Regular contributor to the Irish Medical Times and Irish Medical News to raise awareness of issues relating to global health. In 2003, originated and delivered a series of talks for Irish GPs on "The care of non-EU patients" through the auspices of the ICGP. Organised meeting on international health at RCPI 2003

Publications and Further Research Outputs

Peer-Reviewed Publications

Lamorde M, Fillekes Q, Sigaloff K, Kityo C, Buzibye A, Kayiwa J, Merry C, Nakatudde-Katumba L, Burger D, de Wit TF, Therapeutic drug monitoring of nevirapine in saliva in Uganda using high performance liquid chromatography and a low cost thin-layer chromatography technique., BMC infectious diseases, 14, 2014, p473 Journal Article, 2014 TARA - Full Text DOI

Scarsi K, Lamorde M, Darin K, Penchala SD, Else L, Nakalema S, Byakika-Kibwika P, Khoo S, Cohn S, Merry C, Back D, Efavirenz- but not nevirapine-based antiretroviral therapy decreases exposure to the levonorgestrel released from a sub-dermal contraceptive implant., Journal of the International AIDS Society, 17, (4 Suppl 3), 2014, p19484 Journal Article, 2014 TARA - Full Text

Parkes-Ratanshi R, Elbireer A, Mbambu B, Mayanja F, Coutinho A, Merry C, Ebola outbreak response; experience and development of screening tools for viral haemorrhagic fever (VHF) in a HIV center of excellence near to VHF epicentres., PloS one, 9, (7), 2014, pe100333 Journal Article, 2014 TARA - Full Text DOI

Lamorde M, Byakika-Kibwika P, Mayito J, Nabukeera L, Ryan M, Hanpithakpong W, Lefèvre G, Back DJ, Khoo SH, Merry C, Lower artemether, dihydroartemisinin and lumefantrine concentrations during rifampicin-based tuberculosis treatment., AIDS (London, England), 27, (6), 2013, p961-5 Journal Article, 2013

Byakika-Kibwika P, Lamorde M, Mayito J, Nabukeera L, Mayanja-Kizza H, Katabira E, Hanpithakpong W, Obua C, Pakker N, Lindegardh N, Tarning J, de Vries PJ, Merry C, Pharmacokinetics and pharmacodynamics of intravenous artesunate during severe malaria treatment in Ugandan adults., Malaria journal, 11, 2012, p132 Journal Article, 2012

Byakika-Kibwika P, Lamorde M, Mayito J, Nabukeera L, Namakula R, Mayanja-Kizza H, Katabira E, Ntale M, Pakker N, Ryan M, Hanpithakpong W, Tarning J, Lindegardh N, de Vries PJ, Khoo S, Back D, Merry C, Significant pharmacokinetic interactions between artemether/lumefantrine and efavirenz or nevirapine in HIV-infected Ugandan adults., The Journal of antimicrobial chemotherapy, 67, (9), 2012, p2213-21 Journal Article, 2012

Lamorde M, Byakika-Kibwika P, Merry C, Pharmacokinetic interactions between antiretroviral drugs and herbal medicines., British journal of hospital medicine (London, England : 2005), 73, (3), 2012, p132-6 Journal Article, 2012

P. Byakika-Kibwika, M. Lamorde, H Mayanja-Kizza, S. Khoo, C. Merry, JP Van geertruyden, Cardiac conduction safety during Artemether-Lumefantrine Combination Therapy for Treatment of Uncomplicated Malaria: The Potential for Complex Interactions with Antiretroviral Drugs in HIV-infected individuals., Chemotherapy Research and Practice, 2011, p5pp Journal Article, 2011

Byakika-Kibwika P, Lamorde M, Lwabi P, Nyakoojo WB, Okaba-Kayom V, Mayanja-Kizza H, Boffito M, Katabira E, Back D, Khoo S, Merry C, Cardiac Conduction Safety during Coadministration of Artemether-Lumefantrine and Lopinavir/Ritonavir in HIV-Infected Ugandan Adults., Chemotherapy research and practice, 2011, 2011, p393976 Journal Article, 2011

Lamorde M, Byakika-Kibwika P, Okaba-Kayom V, Flaherty JP, Boffito M, Namakula R, Ryan M, Nakabiito C, Back DJ, Khoo S, Merry C, Scarsi KK, Suboptimal nevirapine steady-state pharmacokinetics during intrapartum compared with postpartum in HIV-1-seropositive Ugandan women., Journal of acquired immune deficiency syndromes (1999), 55, (3), 2010, p345-50 Journal Article, 2010

Mohammed Lamorde, John R.S. Tabuti, Celestino Obua, Collins Kukunda-Byobona, Hindam Lanyero, Pauline Byakika-Kibwika, Godfrey S. Bbosa, Aloysius Lubega, Jasper Ogwal-Okeng, Mairin Ryan, Paul J. Waako and Concepta Merry, Medicinal plants used by traditional medicine practitioners for the treatment of HIV/AIDS and related conditions in Uganda, Journal of Ethnopharmacology, 2010 Journal Article, 2010 TARA - Full Text

Clinical Pharmacology of Antretroviral Drugs in, editor(s)Ed Sande M, Volberding P& Lange J. , Global HIV/AIDS Medicine, Elsevier, 2008, pp10pp , [Merry, C.] Book Chapter, 2008

The contribution of pharmacoeconomics and pharmacology to HIV/AIDS treatment in resource-poor settings in, editor(s)Ed Sande M, Volberding P& Lange J. , Global HIV/AIDS Medicine, Elsevier, 2005, pp171 - 180, [Ryan, M. & Merry, C.] Book Chapter, 2005

L. Kyne, C. Merry, B. O'Connell, P. Harrington, C. Keane and D. O'Neill, Simultaneous outbreaks of two strains of toxigenic Clostridium difficile in a general hospital, The Journal of hospital infection, 38, (2), 1998, p101-12 Journal Article, 1998 URL

C. Merry, P. Puri and D. J. Reen, Effect of major surgery on neutrophil chemotaxis and actin polymerization in neonates and children, Journal of pediatric surgery, 32, (6), 1997, p813-7 Journal Article, 1997 URL

C. Merry, P. Puri and D. J. Reen, Defective neutrophil actin polymerisation and chemotaxis in stressed newborns, Journal of pediatric surgery, 31, (4), 1996, p481-5 Journal Article, 1996 URL

Research Expertise

Description

Role of pharmacology (genomics/kinetics & economics) in optimising outcomes for HIV infected individuals in the resource limited setting. Pharmacokinetics - I have established a HIV pharmacology research laboratory at the University of Makerere, Kampala and am studying the quality of generic drugs; the management of patients who are co-infected with TB and HIV or malaria and HIV; and drug dosing in pregnancy, for children and low-weight adults. I am the principal investigator on a grant from the European Commission's EDCTP for a large project with the University of Cape Town and a co-recipient of funding from the Dutch government for a project between Uganda and Rwanda thereby establishing an expert HIV pharmacology network through south-south and northsouth research collaborations. Pharmacoeconomics, Investigator on study in collaboration with the University of North Carolina evaluating the cost-effectiveness of prevention of mother-to-child transmission in Malawi. I have previously worked in Botswana on a WHO sponsored programme evaluating the cost-effectiveness of public-private partnerships to support the roll-out of antiretroviral drugs I co-ordinated the application from the University of Makerere in collaboration with Johns Hopkins and UCSF to the National Institutes of Health call for a collaborative clinical trial and prevention sites.

Keywords

Role of pharmacology (genomics/kinetics & economics) in optimising outcomes for HIV infected individuals in the resource limited setting

Recognition

Representations

Member, DMMC Inflammation, Immunity & Infection Principal Investigators, DMMC Principal Investigators leading research in inflammation, immunit and infection.

Member, Centre for Research into Global Disease (Proposed), This consortium combines researchers with complementary interests in globally significant infectious disease. Interests include innate immunity, immune regulation, regional immunity, immune evasiob, vaccine & adjuvant development as well as drug & target development.

Member of the Scientific Advisory Board of the Academic alliance for HIV/AIDS Care and Prevention 2002-date

Expert advisor to Nigerian government on HIV care initiatives 2004

Advisor on HIV post-exposure prophylaxis to NGOs, Concern and Suas 2004

Pharmacology advisor to the International AIDS Society 2001

Co-founder/board member of MEREPA a charity based in Ghana to support early childhood development.

Memberships

Royal College of Physicians of Ireland 1994 – Present

Ugandan Medical Council 2005 – present

Irish Medical Council: (15444) 1992 – present

Illinois Department of Professional Regulation 1999 – 2001