Michael Clarke
Adjunct Professor, School of Nursing & Midwifery

Biography

Mike Clarke is an Adjunct Professor at the School of Nursing and Midwifery in Trinity College Dublin and Director of the UK Cochrane Centre. He has considerable experience in the conduct and methodology of randomised trials and systematic reviews, and in teaching about health services research. Mike was awarded a first class BA in Chemistry at the University of Oxford in 1984. This degree included a one-year thesis on the history of drug abuse, which led to a D.Phil on the history of suicide in England and Wales, with special emphasis on the use of poisons. From 1989, Mike worked at the Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU) in Oxford on collaborative overviews of cancer treatments. In these, individual patient data are collected and analysed for all participants in relevant trials. The largest of the projects concerns the treatment of operable breast cancer and has provided reliable estimates of the effects of a variety of treatments, which influence the care of women with breast cancer worldwide. In April 1999, he took up the new post of Associate Director (Research) at the UK Cochrane Centre, which is part of the National Institute for Health Research. He became Director of the Centre in October 2002. In 2007, Mike moved to Dublin where he is Adjunct Professor in the School of Nursing and Midwifery, and he continues to work in both Dublin and Oxford. Mike has wide experience in the conduct of large multicentre randomised trials and systematic reviews. He is actively involved with trials in pre-eclampsia, subarachnoid haemorrhage, maternity care, breast cancer and poisoning - each of which are among the largest ever randomised trials in these conditions. He is an author on more than 30 systematic reviews covering a wide range of health care research, including treatments for cancer, methodology, and risk factors for stroke. He has been part of the faculty for the University of Oxford's MSc in Evidence Based Health Care since the course began and was Acting Academic Director in 2007-2008. He developed the Randomised Trials and the Systematic Reviews elective modules for this MSc and continues to teach and examine both. Mike has supervised five successful PhD students: at the University of Oxford (3), Open University and University of Sydney. He is currently supervising four D.Phil students at the University of Oxford and two PhD students at Trinity College Dublin. He has also supervised more than 40 students on the University of Oxford's MSc on Evidence Based Health Care. He has examined D.Phil/PhD students at the University of Oxford (2), University of Liverpool (1), Sydney University (1), and the University of York (1); and the dissertations of approximately 25 students on the afore-mentioned MSc on Evidence Based Health Care. He was Chair of the Examining Board for this MSc and the associated Diploma from 2002 to 2005; and was external examiner for the MSc in Evidence Based Medicine at the University of Birmingham from 2001 to 2005. Mike received the title Professor of Clinical Epidemiology from the University of Oxford in October 2004, in recognition of seniority and distinction. He is a Visiting Professor of the Evidence Based Medicine and Clinical Epidemiology Centre of the West China School of Medicine in Chengdu, home of the Chinese Cochrane Centre, and a Honorary Professor at the School of Nursing and Midwifery in Queen's University, Belfast, Northern Ireland. In the last 20 years, Mike has been an author of more than 200 papers and book chapters.

Publications and Further Research Outputs

Peer-Reviewed Publications

Waldron C, Macgiolla Phadraig C, Nunn J, Comiskey C, Donnelly-Swift E, Guerin S, Clarke M.J, Oral hygiene programmes for people with intellectual disabilities, Cochrane Database of Systematic Reviews, 2017, (4), 2017, pCD012628- Journal Article, 2017 URL DOI

Higgins A (PI) N Elliott, C Begley, C Doherty, C Normand, M Clarke , An evaluation of the role of the Epilepsy Specialist Nurse and the impact on patient quality of life, Funded by Brainwave/HRB, 2015 Report, 2015

Gallagher L, Begley C, Clarke M, Determinants of breastfeeding initiation in Ireland., Irish journal of medical science, 185, (3), 2015, p663 - 668 Journal Article, 2015 DOI URL TARA - Full Text

Carroll, M. , Gallagher, L., Clarke, M. , Millar, S., Begley, C. , Artificial milk-feeding women's views of their feeding choice in Ireland , Midwifery, 31, (6), 2015, p640 - 646 Journal Article, 2015 TARA - Full Text DOI

Cecily Begley, Valerie Smith, Agnes Higgins, Declan Devane, Mike Clarke, and Michael Turner, Maternal health and Maternal Morbidity in Ireland: Phase 2 (MAMMI 2), Health Research Board, 2015 Report, 2015

Smith V. Clarke M. Begley C. Devane D., SWAT-1: The effectiveness of a 'site visit' intervention on recruitment rates in a multicentre randomised trial, 22nd Cochrane Colloquium, Hyderabad, India, 22-26 Sept 2014, 2014 Meeting Abstract, 2014

Smith V. Clarke M. Williamson P. Gargon E, Survey of new 2007 and 2011 Cochrane reviews found 37% of pre-specified outcomes not reported, Journal of Clinical Epidemiology, 68, (3), 2014, p237-45 Journal Article, 2014 DOI

Gerdin M, Clarke M, Allen C, Kayabu B, Summerskill W, Devane D, MacLachlan M, Spiegel P, Ghosh A, Zachariah R, Gupta S, Barbour V, Murray V, von Schreeb J., Optimal evidence in difficult settings: improving health interventions and decision making in disasters., PLoS Med., 11, (4), 2014, pe1001632- Journal Article, 2014 DOI TARA - Full Text

Smith V. Clarke M. Williamson P. Gargon E. , Towards core outcome set development: survey of outcomes in Cochrane reviews, 22nd Cochrane Colloquium, Hyderabad, India, 22-26 September 2014, 2014 Meeting Abstract, 2014

Daly D, Begley C, Clarke M., Faecal and urinary incontinence before and during pregnancy - preliminary findings from the MAMMI Study, 4th International Nursing and Midwifery Conference 2013, National University of Ireland, Galway, 15th-16th April, 2013 Oral Presentation, 2013 URL URL

Kayabu B, Clarke M., The use of systematic reviews and other research evidence in disasters and related areas: preliminary report of a needs assessment survey., PLoS Curr., 22, 2013, p5- Journal Article, 2013 DOI TARA - Full Text

McCann, M., Clarke, M., Mellotte, G., Plant, L. & Fitzpatrick, F. , Vascular access and infection prevention and control: a national survey of routine practices in Irish haemodialysis units, Clinical Kidney Journal , 6, (2), 2013, p176 - 182 Journal Article, 2013 TARA - Full Text DOI

Corry, M. Clarke, M. While, A. Lalor, J. , Developing complex interventions for nursing: a critical review of key guidelines.", Journal of clinical nursing, 22, (5-6), 2013, p1 - 15 Journal Article, 2013 DOI

Smith V, Clarke M, Devane D, Begley C, Shorter G, Maguire L., SWAT 1: what effects do site visits by the principal investigator have on recruitment in a multicentre randomized trial? , Journal of Evidence-Based Medicine , 6, (3), 2013, p136 - 137 Journal Article, 2013 URL

Daly D, Begley C and Clarke M., Urinary incontinence (UI) in primiparous women before and during pregnancy, 13th Annual Interdisciplinary Research Conference (Doctoral Colloquium), Trinity College Dublin , 6 November 2012 , 2012, pp1 Oral Presentation, 2012 URL

Daly D, Begley C and Clarke M., The multiple meanings of maternal morbidity, Eight Annual Cochrane in Ireland Conference, Dublin City University (DCU) Dublin, 27 January, 2012 Oral Presentation, 2012

Gallagher, L., Begley, C. & Clarke, M., The social context of breastfeeding in Ireland, 13th Annual Interdisciplinary Research Conference, Trinity College Dublin, 7th & 8th November, 2012, pp1 Meeting Abstract, 2012 URL

Daly D, Begley C, Clarke M., Urinary incontinence (UI) in primiparous women before and during pregnancy, Proceedings of the 13th Annual Research Conference, School of Nursing and Midwifery, Trinity College Dublin, 13th Annual Research Conference, School of Nursing and Midwifery, Trinity College Dublin, Dublin, Nov 2012, 2012, pp1 Oral Presentation, 2012 URL

Lalor, J. G., Clarke, M., & Sheaf, G, the effectiveness of information literacy training for undergraduate midwives to improve their ability to access evidence for practice, Nurse Education in Practice, 12, (5), 2012, 269-272 Journal Article, 2012 DOI

Corry, M. Clarke, M. Lalor, J. and While, A, Complex Intervention for Nursing: A systematic review, The Royal College of Nursing of the United Kingdom, The 2012 International Nursing Research Conference,, London , April , 2012, pp12- Oral Presentation, 2012

Maguire R, Mayock, P, Daly D, Begley C and Clarke M., Considerations Pregnant Women Take Into Account When Deciding to Participating in Research: The MAMMI Study, All Ireland Midwifery Conference, Armagh City, Co Armagh, 18 October, 2012 Poster, 2012

Lalor J.G., Clarke M. and Sheaf G., An evaluation of the effectiveness of information literacy training for undergraduate midwives to improve their ability to access evidence for practice, Nurse Education in Practice, 12, (5), 2012, p269 - 272 Journal Article, 2012 DOI

Smith V, Begley CM, Clarke M, Devane D., Professionals' views of fetal monitoring during labour: a systematic review and thematic analysis, BMC Pregnancy and Childbirth , 12, (1), 2012, p166 - 183 Journal Article, 2012 DOI TARA - Full Text

Corry, M. Clarke, M. Lalor, J. and While, A(ed.), Developing a nursing intervention using the Medical Research Council Framework (2000 and 2008), 31st Annual International Research Conference 2012, Royal College of Surgeons in Ireland , Dublin, February, 2012, 28 p Proceedings of a Conference, 2012 URL

Maguire R, Mayock P, Daly D, Begley C, Clarke M., The attitudes behind pregnant women's decisions for participating in research whilst pregnant, 13th Annual Interdisciplinary Research Conference, Trinity College Dublin, 7th-8th November, 2012, pp1 Meeting Abstract, 2012 URL

Corry, M. Clarke, M. Lalor, J. (ed.), Measuring caregiver burden in Multiple Sclerosis: a literature review, 12th Annual Interdisciplinary Research Conference, School of Nursing & Midwifery, TCD, School of Nursing & Midwifery TCD, November 8th, 2011, 17 p Proceedings of a Conference, 2011

Smith V, Devane D, Begley CM, Clarke M, Methodology in conducting a systematic review of systematic reviews of healthcare interventions., BMC medical research methodology, 11, (1), 2011, p15 Journal Article, 2011 TARA - Full Text URL DOI

OBoyle, C, Horey, D, Clarke, M, Begley, CM, Devane, D , The use of an e-delphi method to identify core maternity outcome measures , COMET Initiative, 2nd meeting, Bristol, 11th-12th July 2011, 2011, pp11- Meeting Abstract, 2011 URL

Colm OBoyle, Dell Horey, Mike Clarke, Cecily Begley, Declan Devane., The use of an e-delphi method to identify core maternity outcome measures. , COMET , Bristol , 11th July , 2011 Poster, 2011 TARA - Full Text

Daly D, Begley C and Clarke M., The multiple meanings of maternal morbidity, 12th Annual Interdisciplinary Research Conference: Transforming Healthcare through Research: Transforming Healthcare through Research, TCD, 9th-10th November, 2011 Meeting Abstract, 2011

Clarke M, Kayabu B, Evidence for disaster risk reduction, planning and response: design of the Evidence Aid survey., PLoS currents, 3, 2011, pRRN1270- Journal Article, 2011 TARA - Full Text DOI

Daly D, Begley, C and Clarke M., The MAMMI Study, All Ireland Midwifery Conference, Armagh, 14 October, 2010 Poster, 2010

Devane, D Begley C, Clarke M, McCann C, Hughes P, Reilly M, Maguire R, , Higgins S , A randomised trial of midwifery-led care in the Republic of Ireland: Maternal clinical outcomes of the MidU Study., 11th Annual Research Conference, School of Nursing and Midwifery, Trinity College Dublin, November , 2010, pp43 - 43 Conference Paper, 2010

Hopewell S, Loudon K, Clarke MJ, Oxman AD, Dickersin K, Publication bias in clinical trials due to statistical significance or direction of trial results, Cochrane Database of Systematic Reviews, (1), 2009, pMR000006 Journal Article, 2009 URL DOI

Bohlius J, Schmidlin K, Brillant C, Schwarzer G, Trelle S, Seidenfeld J, Zwahlen M, Clarke M et al, Recombinant human erythropoiesis-stimulating agents and mortality in patients with cancer: a meta-analysis of randomised trials, Lancet, 373, 2009, p1532 - 1542 Journal Article, 2009

Smith V, Devane D, Begley CM, Clarke M, Higgins S , A systematic review and quality assessment of systematic reviews of randomised trials of interventions for preventing and treating preterm birth. , European Journal of Obstetrics & Gynecology and Reproductive Biology , 142, 2009, p3 - 9 Journal Article, 2009 URL

Fealy, G., McCarron, M., O'Neill, D., McCallion, P., Clarke, M., Small, V., O'Driscoll, A., & Cullen, A. , Effectiveness of gerontologically informed nursing assessment and referral interventions for older persons attending the emergency department: systematic review, Journal of Advanced Nursing, 65, 2009, p934-945. Journal Article, 2009 DOI TARA - Full Text

Godlee F, Clarke M, Why don't we have all the evidence on oseltamivir?, BMJ, 339, 2009, p1321 - 1322 Journal Article, 2009 DOI URL

Liberati A, Altman DG, Tetzlaff J, Mulrow C, Gøtzsche,P, Ioannidis JP, Clarke M, Devereux PJ, Kleijnen J, Moher D, The PRISMA Statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration, PLoS Medicine , 6, (7), 2009, pe1000100 Journal Article, 2009

Bohlius J, Schmidlin K, Brillant C, Schwarzer G, Trelle S, Seidenfeld J, Zwahlen M, Clarke MJ et al, Erythropoietin or Darbepoetin for patients with cancer - meta-analysis based on individual patient data, Cochrane Database of Systematic Reviews , (3), 2009, pCD007303 Journal Article, 2009 URL

Edwards PJ, Roberts I, Clarke MJ, DiGuiseppi C, Wentz R, Kwan I, Cooper R, Felix LM, Pratap S, Methods to increase response to postal and electronic questionnaires, Cochrane Database of Systematic Reviews, (3), 2009, pMR000008 Journal Article, 2009 URL

Mike Clarke, Can you believe what you read in the papers?, Trials, 10, (55), 2009 Journal Article, 2009 TARA - Full Text

Smith V, Devane D, Begley CM, Clarke M, Higgins S, A systematic review and quality assessment of systematic reviews of randomised trials of interventions for preventing and treating preterm birth, European Journal of Obstetrics, Gynecology, and Reproductive Biology, 142, 2009, p3 - 11 Journal Article, 2009

Shepperd S, Doll H, Angus RM, Clarke MJ, Iliffe S, Kalra L, Ricauda NA, Tibaldi V, Wilson AD, Avoiding hospital admission through provision of hospital care at home: a systematic review and meta-analysis of individual patient data, CMAJ, 180, 2009, p175 - 182 Journal Article, 2009

Bender R, Bunce C, Clarke M, Gates S, Lange S, Pace NL, Thorlund K, Attention should be given to multiplicity issues in systematic reviews, Journal of Clinical Epidemiology, 61, 2008, p857 - 865 Journal Article, 2008

Clarke M, Systematic review of reviews of risk factors for intracranial aneurysms, Neuroradiology, 50, 2008, p653 - 664 Journal Article, 2008

Hopewell S, Eisinga A, Clarke M, Better reporting of randomized trials in biomedical journal and conference abstracts, Journal of Information Science , 34, 2008, p162 - 173 Journal Article, 2008

Early Breast Cancer Trialists' Collaborative Group, Adjuvant chemotherapy in oestrogen-receptor-poor breast cancer: patient-level meta-analysis of randomised trials, Lancet, 371, 2008, p29 - 40 Journal Article, 2008

Siegfried N, Clarke M, Volmink J, Van der Merwe L, African HIV/AIDS trials are more likely to report adequate allocation concealment and random generation than North American trials, PLoS ONE , 3, (10), 2008, pe3491 Journal Article, 2008

Clarke M, Evidence Aid - from the Asian tsunami to the Wenchuan earthquake, Journal of Evidence-based Medicine , 1, (1), 2008, p9 - 11 Journal Article, 2008

Ghersi D, Clarke M, Berlin J, Gulmezoglu M, Kush R, Lumbiganon P, Moher D, Rockhold F, Sim I, Wager E, Reporting the findings of clinical trials: a discussion paper, Bulletin of the World Health Organisation, 86, 2008, p492 - 493 Journal Article, 2008

Hopewell S, Wolfenden L, Clarke M, Reporting of adverse events in systematic reviews can be improved: survey results, Journal of Clinical Epidemiology , 61, 2008, p597 - 602 Journal Article, 2008

Djulbegovic B, Kumar A, Soares HP, Hozo I, Bepler G, Clarke M, Bennett CL, Treatment success in cancer: new cancer treatment successes identified in Phase 3 randomized controlled trials conducted by the National Cancer Institute-sponsored Cooperative Oncology Groups, 1955 to 2006, Archives of Internal Medicine , 168, 2008, p632 - 642 Journal Article, 2008

Hopewell S, Clarke M, Moher D, Wager E, Middleton P, Altman DG, Schulz KF, The CONSORT Group, CONSORT for reporting randomised trials in journal and conference abstracts, Lancet, 371, 2008, p281 - 283 Journal Article, 2008

Hopewell S, Clarke M, Moher D, Wager E, Middleton P, Altman DG, Schulz KF, The CONSORT Group, CONSORT for reporting randomized controlled trials in journal and conference abstracts: explanation and elaboration, PLoS Medicine , 5, (1), 2008, pe20 Journal Article, 2008

Clarke M, Clarke L, Clarke T, Yes Sir, no Sir, not much difference Sir., Journal of the Royal Society of Medicine, 100, (12), 2007, p571-2 Journal Article, 2007 DOI TARA - Full Text

Clarke M, Standardising outcomes for clinical trials and systematic reviews., Trials, 8, 2007, p39 Journal Article, 2007 TARA - Full Text URL DOI

Cahill S, Clark M, Walsh C, O'Connell H, & Lawlor B. , Dementia in primary care: the first survey of Irish general practitioners , International Journal of Geriatric Psychiatry, 21, 2006, p319-324 Journal Article, 2006 DOI

Journal of Evidence Based Medicine, Mike Clarke, [Editor in Chief], 2008 onwards Journal, URL

Non-Peer-Reviewed Publications

Sheaf G., Lalor J.G. and Clarke M., Trying to stop the kids using Google (and get a paper out of it too...), HSLG2013. Visible Evidence: the role of Health Science Libraries in Ireland, Dublin, 11-12 April, 2013 Oral Presentation, 2013 TARA - Full Text

Research Expertise

Description

Breast cancer Randomised trials Systematic reviews Health services research Knowledge translation and brokerage

Projects

  • Title
    • UK Cochrane Centre
  • Summary
    • [Principal Investigator]
  • Funding Agency
    • National Institute for Health Research (£7,000,000)
  • Date From
    • 2005
  • Date To
    • 2015
  • Title
    • UK Cochrane Centre
  • Summary
    • [Principal investigator]
  • Funding Agency
    • Health Research Board (£50,000 per year)
  • Date From
    • 2002
  • Title
    • Cochrane Methodology Register
  • Summary
    • To UK Cochrane Centre. [Principal investigator]
  • Funding Agency
    • The Cochrane Collaboration (£20,000)
  • Date From
    • 2009
  • Date To
    • 2009
  • Title
    • Disinvestment project
  • Summary
    • To UK Cochrane Centre. [Principal investigator]
  • Funding Agency
    • National Institute for Health and Clinical Excellence (£6000 per year)
  • Date From
    • 2006
  • Date To
    • 2009
  • Title
    • TENALEA
  • Summary
    • Initial deployment of TENALEA in UK and Ireland, to UK Cochrane Centre. [co-Principal investigator]
  • Funding Agency
    • European Commission (€400,000)
  • Date From
    • 2006
  • Date To
    • 2010
  • Title
    • National infant feeding survey (Phases 1 to 3)
  • Summary
    • With Cecily Begley (PI), Louise Gallagher, Margaret Carroll, Sally Millar
  • Funding Agency
    • Health Services Executive (HSE)
  • Date From
    • 2008
  • Date To
    • 2009
  • Title
    • MidU randomised trial
  • Summary
    • Randomised trial comparing midwifery-led versus consultant led care for pregnant women
  • Funding Agency
    • North-Eastern Health Board and its successors
  • Date From
    • 2004
  • Date To
    • 2009
  • Title
    • ADCAR trial
  • Summary
    • Randomised trial of fetal cardiotocography versus intermittent auscultation during labour ward admission
  • Funding Agency
    • Health Research Board
  • Date From
    • 2007
  • Date To
    • 2010
  • Title
    • Leukaemia Trials and Overviews programme
  • Summary
    • To CTSU. [co-Principal Investigator]
  • Funding Agency
    • Medical Research Council (£1,500,000)
  • Date From
    • 2003
  • Date To
    • 2008
  • Title
    • Cochrane Methodology Register
  • Summary
    • [Principal investigator]
  • Funding Agency
    • NHS Research and Development Programme (£30,000 per year)
  • Date From
    • 2001
  • Date To
    • 2007

Keywords

Breast cancer; Clinical research, trials; Epidemiology; Health attitudes and behaviour; Health informatics; Health outcomes; Health status and inequalities; Medical Sciences, Research; Midwifery; Population based intervention trials; Public health; Research issues specifice to any health profession; Therapeutic and Clinical oncology; Therapeutic radiography

Recognition

Awards and Honours

Amelia Jackson Scholarhsip, Exeter College, University of Oxford, UK 1984-1986

Thomas C Chalmers MD award, Cochrane Colloquium, Hamilton, Canada. 1994

EP Abraham Research Fellowship, Green College, University of Oxford, UK 1995-1998

Thomas C Chalmers MD award, Cochrane Colloquium, Oslo, Norway. 1995

Prix Raymond Bourgine, France 1996

Professor of Clinical Epidemiology, University of Oxford, UK 2004

Visiting Professor, School of Nursing and Midwifery, Trinity College Dublin, Ireland 2005

Visiting Professor, Sichuan University, Chengdu, China 2006

University of Oxford Oppenheimer Fund Fellowship to South Africa 2008

Honorary Professor, School of Nursing and Midwifery, Queen's University Belfast, Northern Ireland 2008