Barbara Ryan
Clinical Senior Lecturer, Clinical Medicine

Biography

Dr Barbara Ryan, MD, MSC, FRCPI is a Consultant Gastroenterologist and Clinical Lead of the Department of Gastroenterology in the Adelaide and Meath Hospital (AMNCH), Tallaght Dublin. She has a special interest in pancreatobiliary disease and complex endoscopic intervention and also in inflammatory bowel disease (IBD). She had a distinguished undergraduate career including TCD Scholarship in 1990. She gained her Doctorate of Medicine (MD) degree from Trinity College in 2000 and also completed a MSc in Molecular Medicine from Trinity in 2000. She finished her higher specialist training in Gastroenterology and General Internal Medicine in Ireland in 2001 and then moved to the Medische Klinikum Rechts der Isar (MRI), Technical University of Munich, Germany, where she was a visiting Fellow in Endoscopic Ultrasound (EUS). Following this, she took up a position as a Clinical and Research Fellow at the University Hospital of Maastricht, the Netherlands, where she worked from 2001-2003. Here she honed her skills in EUS and hepatobiliary intervention and also her clinical and research interest in Inflammatory Bowel Disease (IBD). A consultant position in the UK at the Manchester Royal Infirmary followed from 2003-2004, before she took up her current consultant post at AMNCH. She was voted a 'Rising Star' in Gastroenterology by the United European Gastroenterology Federation (UEGF) in 2003 and won numerous awards for her post-graduate research, from the Irish Society of Gastroenterology, the American Gastroenterological Association (AGA) and the UEGF. She was National Specialty Director for higher specialist training in Gastroenterology in Ireland from 2012-2015. She has been on the Executive Board of the Irish Society of Gastroenterology since 2005 and is also a former Treasurer. She has been on the gastroenterology advisory panel for Colorectal Cancer for the Irish National Cancer Control Programme (NCCP). She has been actively involved in teaching (undergraduate and post-graduate) and research for the past 20 years. She has been a reviewer for numerous international journals including the Digestive Diseases and Science, Gut, Alimentary Pharmacology and Therapeutics and the European Journal of Gastroenterology and Hepatology and has delivered invited lectures in Ireland and Europe and has also frequently been on faculty at national and international meetings.

Publications and Further Research Outputs

Peer-Reviewed Publications

Stack R, McLoughlin J, Gillis A, Ryan BM, Post-ERCP Emphysematous cholecystitis in a young woman: A rare and potentially fatal complication, Case Reports in Gastrointestinal Medicine, (March), 2017, pdoi: 10.1155/2017/1971457 Journal Article, 2017 DOI

Tighe D, Hall B, Jeyarajah SK, Smith S, Breslin N, Ryan B, McNamara D., One-Year Clinical Outcomes in an IBD Cohort Who Have Previously Had Anti-TNFa Trough and Antibody Levels Assessed, Inflammatory Bowel Disease, 23, (7), 2017, p1154 - 1159 Journal Article, 2017 DOI

Alakkari A, Stack R, Parihar V, Crowther S, Ryan B, Acute granulomatous hepatitis in an immunosuppressed patient secondary to Q fever, Quarterly Journal Of Medicine, (May 26 [Epub]), 2017, pdoi: 10.1093/qjmed/hcx 105 Journal Article, 2017

Parihar V, Ridgway PF, Conlon, KC, Huggett M, Ryan BM, 7. The Role of Endoscopic Intervention in the Management of Inflammatory Pancreatic Fluid Collections. , European Journal of Gastroenterology and Hepatology, Apr;29, (4), 2017, p371 - 379 Journal Article, 2017 DOI

Dominguez Castro P, Harkin G, Hussey M, Christopher B, Kiat C, Chin JL, Trimble V, McNamara D, MacMathuna P, Egan B, Ryan B, Kevans D, Farrell R, Byrnes V, Mahmud N, McManus R. , Changes in Presentation of Celiac Disease in Ireland From the 1960s to 2015, Clinical Gastroenterology and Hepatology, 15, (1), 2017, p864 - 871 Journal Article, 2017 DOI

Parihar V, Stack R. Alakkari A. Breslin N, Ryan B, Crowther S, McNamara D., Clinical Outcome of Patients with Raised Intraepithelial Lymphocytes with Normal Villous Architecture on Duodenal Biopsy, Digestion, 95, 2017, p288 - 292 Journal Article, 2017 DOI

Ryan BM, Venkatachalapathy SV, Huggett MT, Safety of lumen-apposing metal stents (LAMS) for pancreatic fluid collection drainage, Gut, Dec 16 , (EPub ahead of print), 2016 Journal Article, 2016

Stack R, Parihar V, Ryan B, Alakkari A, CMV pneumonitis in an immunosuppressed Crohn's disease patient., QJM : monthly journal of the Association of Physicians, 2016 Journal Article, 2016 DOI

Ní Chonchubhair HM, O Shea B,, Kavanagh DO, Ryan BM, Duggan SN, Conlon KC, 2. Chronic pancreatitis in primary and hospital-based care in Ireland: The management of an orphan disease, Journal of the Pancreas, 17, (4), 2016, p216 - 222 Journal Article, 2016

Veerappan SG, Healy M Walsh JB, O'Morain CA, Daly JS, Ryan BM, 1. A one-year prospective study of the effect of Infliximab on bone metabolism in inflammatory bowel disease patients, European Journal of Gastroenterology and Hepatology, August 9, 2016 Journal Article, 2016

Maung SW, Desmond R, McHugh J, Ryan B, Neary P, Jeffers M, Enright H, 5. A coincidence or a rare occurrence? A case of plasmablastic lymphoma of the small intestines following infliximab treatment for Crohn's disease., Annals of Haematology, 95, (1), 2016, p149 - 150 Journal Article, 2016

Hussey M, Mc Garrigle R, Kennedy U, Holleran G, Kevans D, Ryan B, Breslin N, Mahmud N, McNamara D, Long-term assessment of clinical response to adalimumab therapy in refractory ulcerative colitis., European journal of gastroenterology & hepatology, 28, (2), 2016, p217-21 Journal Article, 2016 DOI

Parihar V, Ridgway PF, Conlon KC, Huggett M, Ryan BM, The role of endoscopic intervention in the management of inflammatory pancreatic fluid collections, European Journal of Gastroenterology and Hepatology, 29, (4), 2016, p371-379 Journal Article, 2016 Other

V Parihar, R Stack, A Alakkiri, BM Ryan, A case of incidental diagnosis of renal cell carcinoma by endoscopic ultrasound, Journal of gastric disorders and therapy, 2, (4), 2016, p125 - 126 Journal Article, 2016 DOI

Veerappan S.G, Healy M, Walsh B.J, O†Morain C.A, Daly J.S, Ryan B.M, Adalimumab Therapy Has a Beneficial Effect on Bone Metabolism in Patients with Crohn†s Disease, Digestive Diseases and Sciences, 60, (7), 2015, p2119 - 2129 Journal Article, 2015 URL DOI

Hall B, Holleran G, Chin JL, Smith S, Ryan B, Mahmud N, McNamara D, A prospective 52 week mucosal healing assessment of small bowel Crohn's disease as detected by capsule endoscopy., Journal of Crohn's & colitis, 8, (12), 2014, p1601-9 Journal Article, 2014 DOI

O'Donnell S, O'Sullivan M, O'Morain C.A, Ryan B.M, The clinical significance of antimicrobial serologic responses within an Irish Crohn's disease population, European Journal of Gastroenterology and Hepatology, 25, (12), 2013, p1464 - 1469 Journal Article, 2013 DOI URL

O'Connor A, Taneike I, Nami A, Fitzgerald N, Ryan B, Breslin N, O'Connor H, McNamara D, Murphy P, O'Morain C, Helicobacter pylori resistance rates for levofloxacin, tetracycline and rifabutin among Irish isolates at a reference centre., Irish journal of medical science, 182, (4), 2013, p693-5 Journal Article, 2013

O'Donnell S, Crotty P.L, O'Sullivan M, Breslin N, O'Connor H.J, O'Morain C.A, Ryan B.M, Isolated active ileitis: Is it a mild subtype of Crohn's disease?, Inflammatory Bowel Diseases, 19, (9), 2013, p1815 - 1822 Journal Article, 2013 DOI URL

Thornhill J.A, Long R.M, Neary P, O'Connor H.J, Ryan B, Fraser I, The pitfalls of treating anorectal conditions after radiotherapy for prostate cancer., Irish medical journal, 105, (3), 2012, p91 - 93 Journal Article, 2012 URL

Keane R, O'Connor A, Ryan B, Breslin N, O'Connor H, Qasim A, O'Morain C, Inappropriate colonoscopic surveillance of hyperplastic polyps, Irish Medical Journal, 104, (7), 2011 Journal Article, 2011 URL

Qasim A, Ullah N, Crotty P, Swan N, Breslin N, Ryan B, Torreggiani W, Eguare E, Neary P, O'Connor H, O'Morain C, A changing trend in the management of patients with newly diagnosed Crohn's disease, Ir J Med Sci. , 180, (3), 2011, p643 - 647 Journal Article, 2011

O'Donnell S, Murphy S, Anwar MM, O'Sullivan M, Breslin N, O'Connor HJ, Ryan BM, O'Morain CA, Safety of infliximab in 10 years of clinical practice., Eur J Gastroenterol Hepatol, 23, (7), 2011, p603 - 606 Journal Article, 2011 DOI

O'Donnell S, Kelly OB, Breslin N, Ryan BM, O'Connor HJ, Swan N, O'Morain CA, Eosinophilic oesophagitis: an Irish experience., European journal of gastroenterology & hepatology, 23, (12), 2011, p1116-21 Journal Article, 2011 DOI

Shuhaibar M, Walsh C, Lindsay F, Lee N, Walsh P, O'Gorman P, Boran G, McLoughlin R, Qasim A, Breslin N, Ryan B, O'Connor H, O'Morain C, A comparative study of faecal occult blood kits in a colorectal cancer screening program in a cohort of healthy construction workers., Irish journal of medical science, 180, (1), 2011, p103-8 Journal Article, 2011 DOI

Veerappan S.G, O'Morain C.A, Daly J.S, Ryan B.M, Review article: The effects of antitumour necrosis factor-α on bone metabolism in inflammatory bowel disease, Alimentary Pharmacology and Therapeutics, 33, (12), 2011, p1261 - 1272 Journal Article, 2011 DOI URL

O'Donnell S, Kelly O.B, Breslin N, Ryan B.M, O'Connor H.J, Swan N, O'Morain C.A, Eosinophilic oesophagitis: An Irish experience, European Journal of Gastroenterology and Hepatology, 23, (12), 2011, p1116 - 1121 Journal Article, 2011 DOI URL

Veerappan SG, O'Morain CA, Daly JS, Ryan BM, Review article: the effects of antitumour necrosis factor-" on bone metabolism in inflammatory bowel disease., Alimentary pharmacology & therapeutics, 33, (12), 2011, p1261-72 Journal Article, 2011 DOI

O'Connor A, Keane RA, Egan B, Lee N, O'Connor H, Qasim A, Ryan B, Breslin N, McNamara D, O'Morain C, Adherence to colorectal polyp surveillance guidelines: is there scope to increase the opportunities for screening?, European Journal of Cancer Prevention : the official journal of the European Cancer Prevention Organisation (ECP), 20, (1), 2010, p40 - 45 Journal Article, 2010 DOI

Abbasakoor NO, Kavanagh DO, Moran DC, Ryan B, Neary PC, Midgut pain due to an intussuscepting terminal ileal lipoma: a case report., Journal of Medical Case Reports, 4, 2010, p51 Journal Article, 2010 TARA - Full Text DOI URL

Qasim A, Ryan B, Breslin N, O'Morain C, Gastric retention and wireless capsule endoscopy in adults: a modified technique for direct duodenal deployment., Gut, 59, (7), 2010, p1004-5 Journal Article, 2010 DOI

O'connor A, Taneike I, Nami A, Fitzgerald N, Murphy P, Ryan B, O'connor H, Qasim A, Breslin N, O'moráin C, Helicobacter pylori resistance to metronidazole and clarithromycin in Ireland., European journal of gastroenterology & hepatology, 22, (9), 2010, p1123-7 Journal Article, 2010 DOI

Murphy G, Thornton J, McManus R, Swan N, Ryan B, Hughes D, O'Morain C, O'Sullivan M, Association of gastric disease with polymorphisms in the inflammatory related genes IL-1B, IL-1RN, IL-10, TNF and TLR4 , European Journal of Gastroenterology and Hepatology, 21, (6), 2009, p630-635 Journal Article, 2009 DOI

O'Donnell S, Qasim A, Ryan BM, O'Connor HJ, Breslin N, O Morain CA, The role of capsule endoscopy in small bowel Crohn's disease., Journal of Crohn's & colitis, 3, (4), 2009, p282-6 Journal Article, 2009 DOI

O'Donnell S, Qasim A, Ryan B.M, O'Connor H.J, Breslin N, O'Morain C.A, The role of capsule endoscopy in small bowel Crohn's disease, Journal of Crohn's and Colitis, 3, (4), 2009, p282 - 286 Journal Article, 2009 URL DOI

Veerpan SG, Kennedy M, O'Morain CA, Ryan BM, Retinal vein thrombosis following infliximab treatment for severe left-sided ulcerative colitis, European Journal of Gastroenterolgy and Hepatology, 20, (6), 2008, p588 - 589 Journal Article, 2008

Sarwar S, Anwar MM, Ryan B, O'Morain C., Colonoscopy completion rates--are we prepared for a national screening programme?, Irish Medicial Journal, Oct;100 , (9), 2007, p585-7. Journal Article, 2007

Wolters FL, Joling C, Russel MG, Sijbrandij J, De Bruin M, Odes S, Riis L, Munkholm P, Bodini P, Ryan B, O'Morain C, Mouzas IA, Tsianos E, Vermeire S, Monteiro E, Limonard C, Vatn M, Fornaciari G, Rodriguez D, Groot W, Moum B, Stockbrügger RW, Treatment inferred disease severity in Crohn's disease: evidence for a European gradient of disease course., Scandinavian journal of gastroenterology, 42, (3), 2007, p333-44 Journal Article, 2007 DOI

De Vries G.J, Ryan B.M, De BiÚvre M, Driessen A, Stockbrugger R.W, Koek G.H, Cirrhosis related chylous ascites successfully treated with TIPS, European Journal of Gastroenterology and Hepatology, 17, (4), 2005, p463 - 466 Journal Article, 2005 DOI URL

Ryan B.M, Russel M.G.V.M, Schurgers L, Wichers M, Sijbrandij J, Stockbrugger R.W, Schoon E, Effect of antitumour necrosis factor-α therapy on bone turnover in patients with active Crohn's disease: A prospective study, Alimentary Pharmacology and Therapeutics, 20, (8), 2004, p851 - 857 Journal Article, 2004 DOI URL

Lo G.-H, Lai K.-H, Ryan B.M, Stockbrugger R.W, Ryan J.M, Should GOV1 be treated as for esophageal varices? [2] (multiple letters), Gastroenterology, 127, (3), 2004, p1014 - 1015 Journal Article, 2004 URL DOI

Russel M.G.V.M, Ryan B.M, Dagnelie P.C, De Rooij M, Sijbrandij J, Feleus A, Hesselink M, Muris J.W, Stockbrugger R, Insurance problems among inflammatory bowel disease patients: Results of a Dutch population based study, Gut, 52, (3), 2003, p358 - 362 Journal Article, 2003 URL DOI

Ryan B.M, Stockbrugger R.W, Ryan J.M, Tripathi D, Therapondos G, Hayes P.C, Redhead D.N, Tips for gastric varices [7] (multiple letters), Gut, 52, (5), 2003, p772- Journal Article, 2003 URL DOI

F. Khosa, J. G. McNulty, N. Hickey, P. O'Brien, A. Tobin, N. Noonan, B. Ryan, P. W. Keeling, D. P. Kelleher and G. S. McDonald, Transvenous liver biopsy via the femoral vein, Clinical radiology, 58, (6), 2003, p487-91 Journal Article, 2003 URL

Wolters F, Ryan B, Beets-Tan R, Dejong C, Delayed massive hemobilia after biliary stenting, Endoscopy, 35, (11), 2003, p976 - 977 Journal Article, 2003 URL DOI

Ryan B.M, Russel M.G.V.M, Langholz E, Stockbrugger R.W, Aminosalicylates and colorectal cancer in IBD: A not-so bitter pill to swallow, American Journal of Gastroenterology, 98, (8), 2003, p1682 - 1687 Journal Article, 2003 URL DOI

Ryan BM, Lefort L, McManus R, Daly J, Keeling PW, Weir DG, Kelleher D, A prospective study of circulating mutant KRAS2 in the serum of patients with colorectal neoplasia: strong prognostic indicator in postoperative follow up, Gut, 52, (1), 2003, p101-108 Journal Article, 2003 TARA - Full Text DOI

Ryan B.M, Weir D.G, Relevance of folate metabolism in the pathogenesis of colorectal cancer, Journal of Laboratory and Clinical Medicine, 138, (3), 2001, p164 - 176 Journal Article, 2001 DOI URL

B. M. Ryan, R. McManus, J. S. Daly, E. Carton, P. W. Keeling, J. V. Reynolds and D. Kelleher, A common p73 polymorphism is associated with a reduced incidence of oesophageal carcinoma, British Journal of Cancer, 85, (10), 2001, p1499-1503 Journal Article, 2001 DOI

B. M. Ryan, A. M. Molloy, R. McManus, Q. Arfin, D. Kelleher, J. M. Scott and D. G. Weir, The methylenetetrahydrofolate reductase (MTHFR) gene in colorectal cancer: role in tumor development and significance of allelic loss in tumor progression, International journal of gastrointestinal cancer, 30, (3), 2001, p105-111 Journal Article, 2001 URL DOI

Ryan B.M, Murphy G, O'Morain C.A, Host cytokine responses to Helicobacter pylori: An important determinant of clinical outcome, Irish Journal of Medical Science, 170, (2), 2001, p90 - 91 Journal Article, 2001 URL

B. M. Ryan and D. Kelleher, Refractory celiac disease, Gastroenterology, 119, (1), 2000, p243-51 Journal Article, 2000 URL

Ryan BM, McManus R, Daly JS, Keeling NWP, Weir DG, Lefort F, Kelleher D, Serum mutant K-ras in the colorectal adenoma-to-carcinoma sequence. Implications for diagnosis, postoperative follow-up, and early detection of recurrent disease, Annals of the New York Academy of Sciences, 906, 2000, p29-30 Journal Article, 2000 URL

B. M. Ryan, R. O. McManus, J. S. Daly, P. W. Keeling, D. G. Weir, F. Lefort and D. Kelleher, Serum mutant K-ras in the colorectal adenoma-to-carcinoma sequence. Implications for diagnosis, postoperative follow-up, and early detection of recurrent disease, Annals of the New York Academy of Sciences, 906, 2000, p29-30 Journal Article, 2000 URL

Ryan J.M, Kelsey P, Ryan B.M, Mueller P.R, Alendronate-induced esophagitis: Case report of a recently recognized form of severe esophagitis with esophageal stricture - Radiographic features, Radiology, 206, (2), 1998, p389 - 391 Journal Article, 1998 URL

B. M. Ryan, G. S. McDonald, R. Pilkington and D. Kelleher, The development of hepatic granulomas following interferon-alpha2b therapy for chronic hepatitis C infection, European journal of gastroenterology & hepatology, 10, (4), 1998, p349-51 Journal Article, 1998 URL

Research Expertise

Description

I have been involved in basic and translational research for all of my professional career. There are a number of strands to my research which reflect my clinical areas of interest / sub specialisation. 1. Inflammatory Bowel Disease, IBD -related metabolic bone disease and the effects of biologic therapy thereon. Biomarkers in IBD, social aspects of IBD including insurance problems encountered by patients, capsule endoscopy. 2. Chronic Pancreatic Disease. I am part of the Pancreatic research group in the Department of Surgery in Tallaght Hospital and am involved in a number of ongoing projects. I also have a special interest in Pancreatobiliary Endoscopy and have established a national tertiary referral practice for complex pancreatic intervention, including endoscopic cyst-gastrostomy. I am currently collaborating with groups in the UK investigating the efficacy of new pancreatic cystgastrostomy and metal stent deployment device. 3. BioInnovate NUIG: I am working with a group of researchers to help design and trial improved FNA needles for use in endoscopic ultrasound -guided FNA. 4. Coeliac disease genotype and phenotype. I have been collaborating with Prof Ross McManus, TCD for many years and am currently involved in a national phenotype /genotype study of coeliac disease in Ireland. 5. Colorectal cancer: I have published on plasma markers in colorecal cancer patients and am currently working with Exact Sciences USA looking at stool DNA markers of colorectal cancer.

Recognition

Representations

Irish Society of Gastroenterology - Member of Board and Scientific Organising Committee 2005- present

Irish Society of Gastroenterology Honorary Treasurer 2012-2015

Reviewer for European Journal of Gastroenterology

Reviewer for Alimentary Pharmacology and Therapeutics

Reviewer for Gut

Irish National Specialty Director for Higher Specialist Training in Gastroenterology 2012-2015

Member of Gastroenterology advisory panel for the Irish National Cancer Control Programme (NCCP). 2016

Reviewer for the United European Gastroenterology Journal (UEGJ)

Irish Representative to the European Society of Gastrointestinal Endoscopy 2016-present

Awards and Honours

Trinity College Scholarship in Medicine 1990 1990

The Henry Hutchinson Award , TCD 1988

The Walter G. Smith Prize in Pharmacology, TCD 1991

The Upjohn Prize in Pharmacology, TCD 1991

The Upjohn Essay Prize in Pharmacology 1991

Meath Hospital Prize in Clinical Medicine and Surgery. 1993

The Fitzpatrick Scholarship for first place in class TCD June 1993

The G.B. Hutchinson Bequest for highest overall results, TCD June 1993

Professor's Prize in Surgery, TCD June 1993

Professor's Prize in Obstetrics and Gynaecology, TCD June 1993

Professor's Prize in Paediatrics, TCD June 1993

The Reuben-Harvey Prize, TCD June 1993

The Arthur Ball Prize for highest mark in Surgery, TCD June 1993

The David Gault Memorial Prize , Rotunda Hospital June 1993

Adelaide Hospital Prize. 1993

Irish Society of Gastroenterology Prize for best Oral Presentation 1999

Royal Academy of Medicine in Ireland Registrar's Prize 2000

Irish Society for Cancer Research, Doctor in Training Award 2000

Irish Society of Gastroenterology Prize for best Oral Presentation 2000

'Rising Star' in Gastroenterology for Ireland at the United European Gastroenterology Week 2003

Irish HRB Research Fellowship (2 year) 1998

PPP Healthcare Medical Trust Project grant 1998

Irish HRB Project Grant (On oesophageal cancer) 2000

Irish HRB Project Grant (On Helicobacter pylori) 2000

Trinity College Postgraduate Travelling Scholarship in Medicine 2001

Astra Zeneca Research Grant 2007

Meath Foundation Grant 2007

Best Poster Prize EAGE European Bridging Meeting November 2007

IOIBD project grant (International organisation for the study of IBD 2008

Best Poster Prize EAGE Bridging Meeting October 2008

ASNEMGE National Scholar Award (Poster Prize UEGW) October 2010

British and Irish Gastroenterology (BIG) Meeting Best Oral Presentation April 2017

British and Irish Gastroenterology (BIG) Meeting Best Poster Presentation April 2017

Memberships

The Irish Society of Gastroenterology

The American Gastroenterology Association

The European Society for Gastrointestinal Endoscopy (ESGE)