Andrew Knox
Adjunct Assistant Professor, Biochemistry
Adjunct Assistant Professor, Sch Office - Biochemistry & Immunology

Publications and Further Research Outputs

Peer-Reviewed Publications

O'Boyle, NM, Barrett, I, Greene, LM, Carr, M, Fayne, D, Twamley, B, Knox, AJS, Keely, NO, Zisterer, DM, Meegan, MJ, Lead Optimization of Benzoxepin-Type Selective Estrogen Receptor (ER) Modulators and Downregulators with Subtype-Specific ERα and ERβ Activity, Journal of Medicinal Chemistry, 2017 Journal Article, 2017 URL DOI TARA - Full Text

Doherty W, Adler N, Knox A, Nolan D, McGouran J, Nikalje A.P, Lokwani D, Sarkate A, Evans P, Synthesis and Evaluation of 1,2,3-Triazole-Containing Vinyl and Allyl Sulfones as Anti-Trypanosomal Agents, European Journal of Organic Chemistry, 2017, (1), 2017, p175 - 185 Journal Article, 2017 URL DOI

O'Boyle NM, Barrett I, Greene LM, Carr M, Fayne D, Twamley B, Knox AJS, Keely NO, Zisterer DM, Meegan MJ., Lead Optimization of Benzoxepin-Type Selective Estrogen Receptor (ER) Modulators and Downregulators with Subtype-Specific ERα and ERβ Activity., Journal of medicinal chemistry, 2017 Journal Article, 2017 DOI

Carr M, Knox AJ, Lloyd DG, Zisterer DM, Meegan MJ., Development of the β-lactam type molecular scaffold for selective estrogen receptor α modulator action: synthesis and cytotoxic effects in MCF-7 breast cancer cells., Journal of Enzyme Inhibition and Medicinal Chemistry, 31, 2016, p117-130 Journal Article, 2016 DOI

O'Boyle, NM, Pollock, JK, Carr, M, Knox, AJS, Nathwani, SM, Wang, S, Caboni, L, Zisterer, DM, Meegan, MJ, β-Lactam Estrogen Receptor Antagonists and a Dual-Targeting Estrogen Receptor/Tubulin Ligand, Journal of Medicinal Chemistry, 57, (22), 2014, p9370 - 9382 Journal Article, 2014 URL DOI TARA - Full Text

Doherty W, James J, Evans P, Martin L, Adler N, Nolan D, Knox A. , Preparation, anti-trypanosomal activity and localisation of a series of dipeptide-based vinyl sulfones., Organic & Biomolecular Chemistry, 12, (38), 2014, p12(38):756 - 7571 Journal Article, 2014

Doherty W, James J, Evans P, Martin L, Adler N, Nolan D, Knox A, Preparation, anti-trypanosomal activity and localisation of a series of dipeptide-based vinyl sulfones., Organic & biomolecular chemistry, 12, (38), 2014, p7561-71 Journal Article, 2014 DOI

O'Boyle NM, Pollock JK, Carr M, Knox AJ, Nathwani SM, Wang S, Caboni L, Zisterer DM, Meegan MJ., β-Lactam estrogen receptor antagonists and a dual-targeting estrogen receptor/tubulin ligand., Journal of medicinal chemistry, 57, (22), 2014, p9370-9382 Journal Article, 2014 DOI

O'Boyle, N.M., Pollock, J.K., Carr, M., Knox, A.J.S., Nathwani, S.M., Wang, S., Caboni, L., Zisterer, D.M., Meegan, M.J., ß-Lactam estrogen receptor antagonists and a dual-targeting estrogen receptor/tubulin ligand, Journal of Medicinal Chemistry, 57, (22), 2014, p9370-9382 Journal Article, 2014

Dunny E, Doherty W, Evans P, Malthouse JP, Nolan D, Knox AJ, Vinyl sulfone-based peptidomimetics as anti-trypanosomal agents: design, synthesis, biological and computational evaluation., Journal of medicinal chemistry, 56, (17), 2013, p6638-50 Journal Article, 2013 DOI

Dunny E, Doherty W, Evans P, Malthouse JP, Nolan D, Knox AJ., Vinyl sulfone-based peptidomimetics as anti-trypanosomal agents: design, synthesis, biological and computational evaluation., Journal of Medicinal Chemistry, 56, (17), 2013, p6638 - 6650 Journal Article, 2013

Hintersteiner M, Knox AJ, Mudd G, Auer M, Towards mimicking short linear peptide motifs: identification of new mixed ",ß-peptidomimetic ligands for SLAM-Associated Protein (SAP) by confocal on-bead screening., Journal of chemical biology, 5, (2), 2012, p63-79 Journal Article, 2012 DOI

Dinour, D., Gray, N.K., Ganon, L., Knox, A.J.S., Shalev, H., Sela, B.-A., Campbell, S., Sawyer, L., Shu, X., Valsamidou, E., Landau, D., Wright, A.F., Holtzman, E.J., Two novel homozygous SLC2A9 mutations cause renal hypouricemia type 2, Nephrology Dialysis Transplantation, 27, (3), 2012, p1035-1041 Journal Article, 2012

Yvonne M. McNamara, Suzanne M. Cloonan, Andrew J.S. Knox, John J. Keating, Stephen G. Butler, Günther H. Peters, Mary J. Meegan and D. Clive Williams, Synthesis and serotonin transporter activity of 1,3-bis(aryl)-2-nitro-1-propenes as a new class of anticancer agents, Bioorganic & Medicinal Chemistry, 19, (3), 2011, p1328 - 1348 Journal Article, 2011 TARA - Full Text

O'Boyle, N.M., Knox, A.J.S., Price, T.P., Williams, D.C., Zisterer, D.M., Lloyd, D.G., Meegan, M.J.,, Lead identification of beta-lactam and related imine inhibitors of the molecular chaperone heat shock protein 90, Bioorganic & Medicinal Chemistry, 19, (20), 2011, p6055-6068 Journal Article, 2011 TARA - Full Text DOI

O'Boyle, NM, Carr, M, Greene, LM, Keely, NO, Knox, AJS, McCabe, T, Lloyd, DG, Zisterer, DM, Meegan, MJ, Synthesis, Biochemical and Molecular Modelling Studies of Antiproliferative Azetidinones causing Microtubule Disruption and Mitotic Catastrophe, European Journal of Medicinal Chemistry, 46, (9), 2011, p4595 - 4607 Journal Article, 2011 TARA - Full Text

Barrett,Irene I., Carr,Miriam G. M.G., O'Boyle,Niamh M. N.M., Greene,Lisa M. L.M., J. S. Knox,Andrew A., Lloyd,David G. D.G., Zisterer,Daniela M. D.M., Meegan,Mary Jane M.J., Lead identification of conformationally restricted benzoxepin type combretastatin analogs: Synthesis, antiproliferative activity, and tubulin effects, Journal of Enzyme Inhibition and Medicinal Chemistry, 25, (2), 2010, p180-194 Journal Article, 2010 DOI

Yang Y, Carta G, Peters MB, Price T, O'Boyle N, Knox AJ, Fayne D, Williams DC, Meegan MJ, Lloyd DG , 'tieredScreen' - Layered Virtual Screening Tool for the Identification of Novel Estrogen Receptor Alpha, Molecular Informatics, 29, 2010, p421 - 430 Journal Article, 2010 DOI

Miriam Carr, Lisa M. Greene, Andrew J.S. Knox, David G Lloyd, Daniela M. Zisterer and Mary J. Meegan, Lead identification of conformationally restricted β-lactam type combretastatin analogues: synthesis, antiproliferative activity and tubulin targeting effects, European Journal of Medicinal Chemistry, 45, (12), 2010, p5752-5766 Journal Article, 2010 TARA - Full Text

Barrett I, Carr M, O'Boyle N, Greene LM, Knox AJ, Lloyd DG, Zisterer DM, Meegan MJ, Lead identification of conformationally restricted benzoxepin type combretastatin analogs: synthesis, antiproliferative activity, and tubulin effects., Journal of enzyme inhibition and medicinal chemistry, 25, (2), 2010, p180-94 Journal Article, 2010 DOI

Hintersteiner M, Ambrus G, Bednenko J, Schmied M, Knox A.J.S, Meisner N.-C, Gstach H, Seifert J.-M, Singer E.L, Gerace L, Auer M, Identification of a small molecule inhibitor of importin ? mediated nuclear import by confocal on-bead screening of tagged one-bead one-compound libraries, ACS Chemical Biology, 5, (10), 2010, p967-979- Journal Article, 2010 URL DOI

Carr M, Greene LM, Knox AJ, Lloyd DG, Zisterer DM, Meegan MJ, Lead identification of conformationally restricted ß-lactam type combretastatin analogues: Synthesis, antiproliferative activity and tubulin targeting effects., European journal of medicinal chemistry, 45, (12), 2010, p5752 - 5766 Journal Article, 2010 DOI

Knox AJ, Price T, Pawlak M, Golfis G, Flood CT, Fayne D, Williams DC, Meegan MJ, Lloyd DG, Integration of ligand and structure-based virtual screening for the identification of the first dual targeting agent for heat shock protein 90 (Hsp90) and tubulin., Journal of medicinal chemistry, 52, (8), 2009, p2177-80 Journal Article, 2009 DOI

Cloonan, SM, Keating, JJ, Butler, SG, Knox, AJ, Jørgensen, AM, Peters, GH, Rai, D, Corrigan, D, Lloyd, DG, Williams, DC, Meegan, MJ, Synthesis and serotonin transporter activity of sulphur-substituted alpha-alkyl phenethylamines as a new class of anticancer agents., European Journal of Medicinal Chemistry, 44, 2009, p4862 - 4888 Journal Article, 2009 DOI

Suzanne M. Cloonan, John J. Keating, Stephen G. Butler, Andrew J.S. Knox, Anne M. Jørgensen, Günther H. Peters, Dilip Rai,Desmond Corrigan, David G. Lloyd, D. Clive Williams and Mary J. Meegan, Synthesis and serotonin transporter activity of sulphur-substituted á-alkyl phenethylamines as a new class of anticancer agents, European Journal of Medicinal Chemistry, 44, (12), 2009, p4862 - 4888 Journal Article, 2009 TARA - Full Text DOI

Knox, AJS; Yang, YD; Lloyd, DG; Meegan, MJ, Virtual screening of the estrogen receptor , EXPERT OPINION ON DRUG DISCOVERY , 3, (8), 2008, p853-866 Journal Article, 2008

Barrett, I., Meegan, M. J.,Hughes, R. B., Carr, M., Knox, A. J., Artemenko, N., Golfis, G., Zisterer, D. M., Lloyd, D. G.,, Synthesis, biological evaluation, structural-activity relationship, and docking study for a series of benzoxepin-derived estrogen receptor modulators, Bioorg Med Chem; , 16, (21), 2008, p9554-73- Journal Article, 2008

Meegan, M.J., Carr, M., Knox, A.J.S., Zisterer, D.M., Lloyd, D.G., ß-Lactam type molecular scaffolds for antiproliferative activity: Synthesis and cytotoxic effects in breast cancer cells, Journal of Enzyme Inhibition and Medicinal Chemistry, 23, (5), 2008, p668-685 Journal Article, 2008

Meegan, M.J., Carr, M., Knox, A.J.S., Zisterer, D.M. & Lloyd, D.G., Beta-Lactam type molecular scaffolds for antiproliferative activity: Synthesis and cytotoxic effects in breast cancer cells., Journal of Enzyme Inhibition and Medicinal Chemistry, 23, (5), 2008, p668-685 Journal Article, 2008 URL URL DOI

Knox AJS, Yang YD, Lloyd DG, Meegan, MJ, Virtual screening of the estrogen receptor, Expert opinion on drug discovery, 3, (8), 2008, p853 - 866 Journal Article, 2008 DOI

Meegan M.J, Carr M, Knox A.J.S, Zisterer D.M, Lloyd D.G, -Lactam type molecular scaffolds for antiproliferative activity: Synthesis and cytotoxic effects in breast cancer cells, Journal of Enzyme Inhibition and Medicinal Chemistry, 23, (5), 2008, p668-685- Journal Article, 2008 URL DOI

Barrett, I., Meegan, M.J., Hughes, R.B., Carr, M., Knox, A.J.S. Artemenko, N., Golfis, G., Zisterer, D.M. & Lloyd, D.G., Synthesis, biological evaluation, structural-activity relationship, and docking study for a series of benzoxepin-derived estrogen receptor modulators., Bioorganic & Medicinal Chemistry, 16, (21), 2008, p9554-9973 Journal Article, 2008 URL DOI

Barrett, I, Meegan, MJ, Hughes, RB, Carr, M, Knox, AJ, Artemenko, N, Golfis, G, Zisterer, DM, Lloyd, DG, Synthesis, biological evaluation, structural-activity relationship, and docking study for a series of benzoxepin-derived estrogen receptor modulators., Bioorganic & medicinal chemistry, 16, (21), 2008, p9554 - 9573 Journal Article, 2008 DOI

Carta G, Knox AJS, Lloyd DG, Unbiasing Scoring Functions: a new normalisation and re-scoring strategy, Journal of Chemical Information and Modelling, 47, (4), 2007, p1564 - 1571 Journal Article, 2007

Agrafiotis D.K, Bandyopadhyay D, Carta G, Knox A.J.S, Lloyd D.G, On the effects of permuted input on conformational sampling of drug-like molecules: An evaluation of stochastic proximity embedding, Chemical Biology and Drug Design, 70, (2), 2007, p123-133- Journal Article, 2007 URL DOI

Meegan, M.J., Barrett, I., Zimmmermann, J., Knox, A.J.S., Zisterer, D.M. & Lloyd, D.G. , Benzothiepin-derived molecular scaffolds for estrogen receptor modulators: synthesis and antagonistic effects in breast cancer cells. , Journal of Enzyme Inhibition and Medicinal Chemistry, 22, (5), 2007, p655-66 Journal Article, 2007

Meegan MJ, Barrett I, Zimmermann J, Knox AJS, Zisterer DM, Lloyd DG, Benzothiepin-derived molecular scaffolds for estrogen receptor modulators: synthesis and antagonistic effects in breast cancer cells, Journal of Enzyme inhibition and medicinal chemistry , 5, (22), 2007, p655 - 666 Journal Article, 2007

Smith, H.M., Knox, A.S., Zisterer, D.M., Lloyd, D.G., & Meegan, M.J. , Flexible estrogen receptor modulators: synthesis, biochemistry and molecular modeling studies for 3-benzyl-4,6-diarylhex-3-ene and 3,4,6-triarylhex-3-ene derivatives., Medicinal Chemistry, 3, (2), 2007, p135 - 155 Journal Article, 2007

Knox AJ, Meegan MJ, Sobolev V, Frost D, Zisterer DM, Williams DC, Lloyd DG., Target specific virtual screening: optimization of an estrogen receptor screening platform., Journal of Medicinal Chemistry, 50, (22), 2007, p5301-5310 Journal Article, 2007 DOI URL

David G. Lloyd, Georgia Golfis, Andrew J.S. Knox, Darren Fayne, Mary J. Meegan and Tudor I. Oprea, Oncology Exploration : Charting Cancer Medicinal Chemistry Space , Drug Discovery Today, 11, (3/4), 2006, p149 - 159 Journal Article, 2006

Lloyd, D.G., Smith, H.M., O'Sullivan, T., Knox, A.S., Zisterer, D.M. & Meegan, M.J. , Antiestrogenically active 2-benzyl-1,1-diarylbut-2-enes : Synthesis, Structure-Activity Relationships and Molecular Modeling Study for Flexible Estrogen Receptor Antagonists , Medicinal Chemistry, 2, (2), 2006, p147 - 168 Journal Article, 2006 URL

Lloyd DG, Smith HM, O'Sullivan T, Knox AS, Zisterer DM, Meegan MJ, Antiestrogenically Active 2-benzyl-1,1-diarylbut-2-enes: Synthesis, Structure-Activity Relationships and Molecular Modeling Study for Flexible Estrogen Receptor Antagonists , Medicinal Chemistry, 2, (2), 2006, p147 - 168 Journal Article, 2006

Knox AJS, Meegan MJ, Lloyd DG, Estrogen Receptor: Molecular Interactions, Virtual Screening and Future Prospects., Current Topics in Medicinal Chemistry, 6, (3), 2006, p217 - 243 Journal Article, 2006 URL

Andrew J S Knox, Mary J Meegan and David G Lloyd, Estrogen Receptors; Molecular Interactions, Virtual screening and Future Prospects, Current Topics in Medicinal Chemistry, 6, (2), 2006, p211 - 237 Journal Article, 2006

Lloyd DG, Golfis G, Knox AJS, Fayne D, Meegan MJ, Oprea TI, Oncology exploration: charting cancer medicinal chemistry space, Drug discovery today, 11, (3-4), 2006, p149 - 159 Journal Article, 2006

Carta G, Onnis V, Knox AJS, Fayne D, Lloyd DG, Permuting input for more effective sampling of 3D conformer space, Journal of Computer-Aided Molecular Design , 20, (6), 2006, p179 - 190 Journal Article, 2006 URL DOI

David G. Lloyd, Helena M. Smith, Timothy O'Sullivan, Andrew S. Knox,, Antiestrogenically active 2-benzyl-1,1-diarylbut-2-enes : Synthesis, Structure-Activity Relationships and Molecular Modeling Study for Flexible Estrogen Receptor Antagonists;, Medicinal Chemistry, 2, (2), 2006, p147 - 168 Journal Article, 2006

Knox AS, Meegan MJ, Carta G, Lloyd DG, Considerations in Compound Database Preparations Hidden Impact on Virtual Screening Results, Journal of Chemical Information and Modelling, 45, (6), 2005, p1908 - 1919 Journal Article, 2005 URL DOI

Research Expertise

Keywords

ANTIMICROBIAL PEPTIDES; BIOACTIVE PEPTIDES; Bioinformatics & Computational Biology Techniques; Computational Biology; Computational chemistry and modelling; Computer assisted drug design; computer-assisted language learning; Drug Design; Oral administration of macromolecules, peptides and proteins; PEPTIDE; PEPTIDE DRUGS; PEPTIDE STRUCTURE; Protein Design and Engineering; PROTEIN PURIFICATION; structural biology; STRUCTURAL PROTEINS; Virtual Screening

Recognition

Memberships

Full Membership of the Biochemical Society