PhD Graduates 2000-2010

1. Drug Development from Natural Products

• Dr. Martina White (2008) Endothelium as a target in the design of novel tumour and anti-angiogenic/vascular targeting agents
  (Supervisor Dr. John Walsh)
• Dr. Adam Byrne (2007) Studies on Novel Compounds and Medicinal Plant Extracts as Potential Anti-allergy Agents
  (Supervisor Dr. John Walsh)
• Dr. Gillian Hudson (2007) Design, synthesis and evaluation of novel tumour antiogenic/vasculator targeting agents
  (Supervisor Dr. John Walsh)
• Dr. Cora Nestor (2006) Naphthoquinones from Dionaea and Streptocarpus cell cultures
  (Supervisors Ms. Ingrid Hook & Dr. Helen Sheridan)
• Dr. Lena Visdal-Johnsen (2006) Morphological and chemical characteristics of Taxus species
  (Supervisor Ingrid Hook)
• Dr. James Carolan (2004) Molecular systematics and chemical characterisation of Papaver (Poppy) species, hybrids and cultivars
  (Supervisors Ms. Ingrid Hook & Dr. T. Hodkinson)
• Dr. James Barlow (2003) Synthesis and pharmacological studies on a novel series of mast-cell-stabilising tetraphydronaphthalenes and related compounds (Supervisor Dr. John Walsh)
• Dr. Richard Shah (2003) The Design & Synthesis of Novel Inhibitors of Tubulin Polymerisation
  (Supervisor Dr. John Walsh)
• Dr. Emmet McCormack (2003) Design, synthesis and in vitro evaluation of novel anti-cancer compounds
  (Supervisor Dr. John Walsh)
• Dr. Sile O'Connor (2002) Pharmaceutical services for patients in methadone treatment in Ireland and the introduction of the Methadone Protocol Scheme (Supervisor Dr. Desmond Corrigan)
• Dr. Richard Maguire (2001) The Development, Validation and Application of Analytical Methods for the Analysis of Drugs of Abuse
  (Supervisor Dr. Desmond Corrigan)
• Dr. Dairine Dempsey (2000) Factors affecting paclitaxel contents in Yew
  (Supervisor Ms. Ingrid Hook)

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2. Drug Discovery and Design

• Dr. Ruchika Sharma (2010) Investigations into bile acid effects on the golgi apparatus, cell viability and glucocorticoid receptor distribution in esophageal cells
  (Supervisor Dr. John Gilmer)
• Dr. Niamh O’Boyle (2010) synthesis and biochemical evaluation of novel antiproliferative B-Lactams
  (Supervisor Dr. Mary Meegan)
• Dr. Jason Horan (2009) Design, synthesis and biochemical evaluation of novel 1,2,3,4, - tetrahydroisoquinolines as anti-proliferative agents in breast cancer cells. (Supervisor Prof. Mary Meegan)
• Dr. Niall Keely (2008) Design, synthesis and biochemical evaluation of dual-acting, estrogen receptor ligand conjugates.
  (Supervisor Prof. Mary Meegan)
• Dr. Thomas Greene (2008) The design, synthesis, and evaluation of the Azetidin-2-one ring as a scaffold for novel combreastastatin A4 analogues
  (Supervisor Prof. Mary Meegan)
• Dr. Juan Francisco Marquez Ruiz (2008) The design, synthesis and evaluation of novel steroid prodrugs for the treatment of gastrointestinal diseases
  (Supervisor Dr. John Gilmer)
• Dr. Ciaran Carolan (2008) Kinetic and Structural studies of novel isosorbide-based ligand binding to esterase enzymes
  (Supervisor Dr. John Gilmer)
• Dr. Miriam Carr (2007) Development of the b-lactum structure as a scaffold for biologically active compounds
  (Supervisor Prof. Mary Meegan)
• Dr. Gerald Dillon (2007) The synthesis and biological evaluation of a novel class of butyrylcholinesterase inhibitors using isosorbide as a building block
  (Supervisor Dr. John Gilmer)
• Dr. Andrew S Knox (2006) Development, validation and optimisation of a vHTS protocol for identification of estrogen receptor modulators.
  (Supervisor Prof. Mary Meegan)
• Dr. Helena M Smith (2005) Flexible estrogen receptor modulators
  (Supervisor Prof. Mary Meegan)
• Dr. Mary O'Sullivan (2005) The sythesis and biochemical evaluation of novel isoquinoline derivatives
  (Supervisor Prof. Mary Meegan)
• Dr. Joanne Gaynor (2005) Synthesis and testing of a novel class of cholinesterase inhibitors
  (Supervisors Dr. John Gilmer and Dr. Sean Reidy)
• Dr. Stephen G Butler (2005) Studies in the design and synthesis of novel selective serotonin reuptake inhibitors
  (Supervisor Prof. Mary Meegan)
• Dr. AnaLuisa Ferreira Simplicio (2004) Characterisation and analysis of beta-aminoketones as potential prodrugs for amines
  (Supervisors Dr. John Clancy and Dr. John Gilmer)
• Dr. Maeve Lally (2003) Studies into the in vitro metabolism and antiplatelet effects of novel aspirin prodrugs
  (Supervisor Dr. John Gilmer).
• Dr. Louise Moriarty (2003) Studies in the synthesis and in vitro hydrolysis of novel aspirin prodrugs
  (Supervisor Dr. John Gilmer)
• Dr. Mary Breen (2003) Design and synthesis of novel monoamineoxidase inhibitors
  (Supervisor Prof. Mary Meegan)
• Dr. Sandra M Lauhoff (2002) The design,synthesis and biochemical evaluation of analogues of dehydroepiandrosterone (DHEA) and novel selective oestrogen receptor modulators (SERMS)
  (Supervisor Prof. Mary Meegan)
• Dr. John J Keating (2002) Studies in the synthesis and impurity profiling of methylenedioxy and alkylthioamphetamines
  (Supervisor Prof. Mary Meegan)
• Dr. Rosario Hughes (2000) The design, sysnthesis and biochemical evaluation of novel flexible and conformationally restrained antiestrogens
  (Supervisor Prof. Mary Meegan)

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3. Drug Delivery and Pharmaceutical Technology

• Dr. Stephen T. Buckley: Cytokine-induced epithelial-mesenchymal transition: mechanisms and implications for fibrotic diseases of respiratory and intestinal epithelia
  (Supervisor Dr. Carsten Ehrhardt)
• Dr. Sibylle Endter: Characterisation of drug transporters in human respiratory epithelial cells
  (Supervisor Dr. Carsten Ehrhardt)
• Dr. Xue Li (2008) Formulation, production and biointeraction of micro and nano particulates with potential for use in drug delivery
  (Supervisor Prof. Owen I Corrigan & Dr. Lidia Tajber)
• Dr. Lorraine Nolan (2008) The production and characterisation of spray dried nanoporous microparticles (NPMPs) intended for dry powder inhalation drug delivery systems
  (Supervisor Dr. Anne Marie Healy & Prof. Owen I Corrigan)
• Dr. Orla Ní Ógáin (2008) Investigations of a spray-drying method for producing nanoporous/nano-particulate microparticles (NPMPs) of proteins and protein-excipient composites
  (Supervisor Dr. Anne Marie Healy & Prof. Owen I Corrigan)
• Dr. Alecia Rowena Barry (2008) Potential pharmaceutical applications of sepiolite
  (Supervisor Prof. Pat Deasy)
• Dr. Fiona Ní Chearúil (2008) Synthesis, characterisation and drug release from a range of novel "smart"-co-biodegradable systems
  (Supervisor Prof. Owen Corrigan)
• Dr. Almath Maire Spooner (2007) A pharmacokinetic and clinical evaluation of antimicrobial drugs in critically ill patients during continuous venovenous haemodiafiltration (CVVHDF) therapy
  (Supervisor Prof. Owen I Corrigan)
• Dr. Catherine Ryan (2007) Potential applications of Halloysite for improved topical drug delivery
  (Supervisor Prof. Pat Deasy)
• Dr. Deirdre Maria D'Arcy (2007) Use of computational fluid dynamics to investigate the relationship between hydrodynamics and rates of dissolution
  (Supervisor Dr. Anne Marie Healy & Prof. Owen I Corrigan)
• Dr. Lidia Tajber (2005) Investigations of physicochemical properties of spray dried drug-excipient composites directed to inhalable products
  (Supervisor Prof. Owen I Corrigan & Dr. Anne Marie Healy)
• Dr. David Coughlan (2005) The influence of drug physicochemical properties on release from thermoresponsive "smart" hydrogels
  (Supervisor Prof. Owen I Corrigan)
• Dr. Emma Christina Lawless (2005) In vivo and in vitro mechanistic studies on targeting of lipophilic compounds to the intestinal lymphatics using lipid-based vehicles (Supervisor Dr. Caitriona O’Driscoll & Dr. Anne Marie Healy )
• Dr. Anne Elizabeth Salter (2004) Use of halloysite for agrochemical applications
  (Supervisor Prof. Pat Deasy)
• Dr. Anthony McMahon (2004) Amphiphilic cyclodextrins for liver-targeted gene delivery
  (Supervisor Dr. Caitriona O’Driscoll)
• Dr. Fergal Seeballuck (2004) The use of the Caco-2 cell culture model to investigate lipid vehicle effects on lipid metabolism and drug permeation
  (Supervisor Dr. Caitriona O’Driscoll)
• Dr. Mark Hanlon (2004) Synthesis and evaluation of novel non-steroidal anti-inflammatory drug derivatives
  (Supervisor Dr. Majella Lane & Dr. John Gilmer)
• Dr. Robert Stephen Byrne (2004) Characterisation and use of porous aluminosilicate pellets for extended drug delivery
  (Supervisor Prof. Pat Deasy)
• Dr. Martina Ann Geraghty (2004) Investigation of Ibuprofen release from ethylcellulose matrix compacts
  (Supervisor Dr. Anne Marie Healy)
• Dr. Karl Levis (2003) Absorption properties of non-steroidal anti-inflammatory drugs and their amino acid derivatives
  (Supervisor Dr. Majella Lane & Prof. Owen I Corrigan)
• Dr. Deirdre Corrigan (2003) Preparation and characterisation of spray-dried composites of pharmaceutical materials
  (Supervisor Dr. Anne Marie Healy)
• Dr. Fiona Sheena Brennan (2003) Formulation of protein and DNA microparticulate vaccine systems
  (Supervisor Dr. Majella Lane & Prof. Owen I Corrigan)
• Dr. Helena Kelly (2003) Novel formulations for use in the oral cavity
  (Supervisor Prof. Pat Deasy)
• Dr. Leonard Gerard McCarthy (2003) Simulations of hydrodynamics in the paddle dissolution apparatus and dissolution from multi-layered compacts
  (Supervisor Dr. Anne Marie Healy & Prof. Owen I Corrigan)
• Dr. Brendan Thomas Griffin (2002) Intestinal lymphatic transport of DDT and saquinaver - the role of lipid based formulations and modulators of p-glycoprotein and cytochrome p450
  (Supervisor Dr. Caitriona O’Driscoll)
• Dr. Thomas Ciaran Loughman (2002) Transdermal delivery of somatostatin analogues
  (Supervisor Prof. Pat Deasy)
• Dr. Thomas Stephen Byrne (2002) Warfarin therapy in the Republic of Ireland: The potential role of neural networks in optimising therapy
  (Supervisor Prof. Owen I Corrigan)
• Dr. Sally-Ann Cryan (2002) Development of novel cyclodextrins as non-viral gene delivery vectors and assessment of differentiated cell culture models to predict in vivo gene expression
  (Supervisor Dr. Caitriona O’Driscoll)
• Dr. Nicole Kavanagh (2001) Mechanistic aspects of the release of drugs from hydrophilic swellable polymers
  (Supervisor Prof. Owen I Corrigan)
• Dr. Denis Noel O'Driscoll (2000) Assessment of the permeability enhancers for salmon calcitonin (SCT) across intestinal cell culture models
  (Supervisor Dr. Caitriona O’Driscoll)
• Dr. Bronagh Una Killen (2000) Characterisation of drug-fatty acid composites and their use in drug delivery systems
  (Supervisor Prof. Owen I Corrigan)
• Dr. Karen Margaret O'Connor (2000) Physicochemical studies of diclofenac salts and the effect of basic excipients on their dissolution
  (Supervisor Prof. Owen I Corrigan)
• Dr. Ana Rosario Mollo (2000) A study of the release of the amphoteric drug amoxycillin from biodegradable polymers
  (Supervisor Prof. Owen I Corrigan)

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4. Drug Action and Safety

• Dr. Juan Jose Corbalan Penas (2010) Synthetic amorphous silica nanoparticles induce human endothelial cell inflammation and platelet aggregation: role of NF-KB and reactive nitrogen species
  (Supervisor Dr. Carlos Medina and Prof. Marek Radomski)
• Dr. Aneta Radziwon (2010) Platelets decrease chemotherapy-induced cancer cell damage by increasing cell survival: Mechanisms and significance
  (Supervisor Prof. Marek Radomski)
• Dr. Johannah McCarthy (2010) The pharmacological and toxicological effects of polystrene and silica nanoparticles on human airway epithelial cells
  (Supervisor Prof. Marek Radomski)
• Dr. Lorna Gleeson (2010) Influence of anti-inflammatory interventions in the kainic acid model of hippocampal excitotoxicity
  (Supervisor Dr. Andrew Harkin)
• Dr. Natacha Vanattou Saifoudine (2010) Caffeine exacerbates the toxicity of 3,4 methylenedioxymethamphetamine (MDMA “Ecstasy”): A role for dopamine (Supervisor Dr. Andrew Harkin)
• Dr. Egle Passante (2009) RBL-2H3 and Primary Mast cells and their use in Screening Novel anti-inflammatory compounds
  (Supervisor Dr. Neil Frankish & Dr. Helen Sheridan)
• Dr. Jenny Coppins (2009) In vitro investigation of the potential anti-inflammatory properties of novel compounds with respect to LFA-1 mediated T cell motility and cytotoxicity profiling
  (Supervisor Dr. Neil Frankish & Dr Carsten Ehrhardt)
• Dr. Désirée Murphy (2007) An investigation into the behavioural effects of polyamines, polyamine antagonists and novel compounds in vivo
  (Supervisor Dr. Martin Henman)
• Dr. Brendan McHale (2006) An investigation into the effects of current immunosuppressants and novel compounds on animal models of asthma and delayed type hypersensitivity
  (Supervisor Dr. Neil Frankish)
• Dr. Jun Li (2005) Polyamines and polyamine antagonists in cerebral ischaemia
  (Supervisor Dr. Martin Henman)
• Dr. Carina Coogan (2000) An investigation on the Therapeutic Properties of Novel Compounds in Asthma, Inflammation and Delayed-type sensitivity
  (Supervisor Dr. Neil Frankish)

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5. Clinical Pharmacy & Pharmacy Practice

• Dr. Catriona Bradley (2009) Exploration of the role of community pharmacists in health promotion in Ireland
  (Supervisor Dr. Martin Henman)

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