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Maeve Lowery
Professor of Translational Cancer Medici, Surgery

Biography

Professor Maeve Lowery is Professor of Translational Cancer Medicine at Trinity College Dublin and Consultant Medical Oncologist at St James Hospital. Professor Lowery is chairperson of the Cancer Molecular Diagnostics Advisory Group of the National Cancer Control Program (NCCP). Her clinical and translational research involves design and conduction of phase 1/2 clinical trials in patients with gastrointestinal malignancies, incorporating translational study endpoints to validate predictive and prognostic biomarkers, identify mechanisms of resistance and guide the development of rational therapeutic strategies.Her preclinical work includes the use of immunocompetent murine models of cancer to facilitate assessment of drug delivery and host immune response to therapy. She works closely with industry to develop core collaborative projects with the potential to impact care of cancer patients on both an individual and disease specific level.

Publications and Further Research Outputs

Peer-Reviewed Publications

, Stereotactic body radiation vs. intensity-modulated radiation for unresectable pancreatic cancer., Acta oncologica (Stockholm, Sweden), 2017 Journal Article, 2017

, A phase 1/1B trial of ADI-PEG 20 plus nab-paclitaxel and gemcitabine in patients with advanced pancreatic adenocarcinoma., Cancer, 2017 Journal Article, 2017

Lowery, M.A., Yu, K.H., Kelsen, D.P., Harding, J.J., Bomalaski, J.S., Glassman, D.C., Covington, C.M., Brenner, R., Hollywood, E., Barba, A., Johnston, A., Liu, K.C.-W., Feng, X., Capanu, M., Abou-Alfa, G.K., O'Reilly, E.M., A phase 1/1B trial of ADI-PEG 20 plus nab-paclitaxel and gemcitabine in patients with advanced pancreatic adenocarcinoma, Cancer, 2017 Journal Article, 2017

Lowery, M.A., Yu, K.H., Kelsen, D.P., Harding, J.J., Bomalaski, J.S., Glassman, D.C., Covington, C.M., Brenner, R., Hollywood, E., Barba, A., Johnston, A., Liu, K.C.-W., Feng, X., Capanu, M., Abou-Alfa, G.K., O'Reilly, E.M., A phase 1/1B trial of ADI-PEG 20 plus nab-paclitaxel and gemcitabine in patients with advanced pancreatic adenocarcinoma, Cancer, 2017 Journal Article, 2017

, Mutation Detection in Patients With Advanced Cancer by Universal Sequencing of Cancer-Related Genes in Tumor and Normal DNA vs Guideline-Based Germline Testing., JAMA, 2017 Journal Article, 2017

Creasy, J.M., Goldman, D.A., Dudeja, V., Lowery, M.A., Cercek, A., Balachandran, V.P., Allen, P.J., DeMatteo, R.P., Kingham, T.P., D'Angelica, M.I., Jarnagin, W.R., Systemic Chemotherapy Combined with Resection for Locally Advanced Gallbladder Carcinoma: Surgical and Survival Outcomes, Journal of the American College of Surgeons, 224, (5), 2017, p906-916 Journal Article, 2017

, Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients., Nature medicine, 2017 Journal Article, 2017

, Erratum: Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients., Nature medicine, 2017 Journal Article, 2017

, In Vitro and In Vivo Comparison of Gemcitabine and the Gemcitabine Analog 1-(2'-deoxy-2'-fluoroarabinofuranosyl) Cytosine (FAC) in Human Orthotopic and Genetically Modified Mouse Pancreatic Cancer Models., Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging, 2017 Journal Article, 2017

Russell, J., Pillarsetty, N., Kramer, R.M., Romesser, P.B., Desai, P., Haimovitz-Friedman, A., Lowery, M.A., Humm, J.L., In Vitro and In Vivo Comparison of Gemcitabine and the Gemcitabine Analog 1-(2"-deoxy-2"-fluoroarabinofuranosyl) Cytosine (FAC) in Human Orthotopic and Genetically Modified Mouse Pancreatic Cancer Models, Molecular Imaging and Biology, 2017, p1-8 Journal Article, 2017

Park, J.J., Hajj, C., Reyngold, M., Shi, W., Zhang, Z., Cuaron, J.J., Crane, C.H., O"Reilly, E.M., Lowery, M.A., Yu, K.H., Goodman, K.A., Wu, A.J., Stereotactic body radiation vs. intensity-modulated radiation for unresectable pancreatic cancer, Acta Oncologica, 2017, p1-8 Journal Article, 2017

, Real-Time Genomic Profiling of Pancreatic Ductal Adenocarcinoma: Potential Actionability and Correlation with Clinical Phenotype., Clinical cancer research : an official journal of the American Association for Cancer Research, 2017 Journal Article, 2017

, OncoKB: A Precision Oncology Knowledge Base., JCO precision oncology, 2017 Journal Article, 2017

, Mutation Detection in Patients With Advanced Cancer by Universal Sequencing of Cancer-Related Genes in Tumor and Normal DNA vs Guideline-Based Germline Testing., JAMA, 2017 Journal Article, 2017

Park, J.J., Hajj, C., Reyngold, M., Shi, W., Zhang, Z., Cuaron, J.J., Crane, C.H., O"Reilly, E.M., Lowery, M.A., Yu, K.H., Goodman, K.A., Wu, A.J., Stereotactic body radiation vs. intensity-modulated radiation for unresectable pancreatic cancer, Acta Oncologica, 2017, p1-8 Journal Article, 2017

, Erratum: Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients., Nature medicine, 2017 Journal Article, 2017

Zehir, A., Benayed, R., Shah, R.H., Syed, A., Middha, S., Kim, H.R., Srinivasan, P., Gao, J., Chakravarty, D., Devlin, S.M., Hellmann, M.D., Barron, D.A., Schram, A.M., Hameed, M., Dogan, S., Ross, D.S., Hechtman, J.F., DeLair, D.F., Yao, J., Mandelker, D.L., Cheng, D.T., Chandramohan, R., Mohanty, A.S., Ptashkin, R.N., Jayakumaran, G., Prasad, M., Syed, M.H., Rema, A.B., Liu, Z.Y., Nafa, K., Borsu, L., Sadowska, J., Casanova, J., Bacares, R., Kiecka, I.J., Razumova, A., Son, J.B., Stewart, L., Baldi, T., Mullaney, K.A., Al-Ahmadie, H., Vakiani, E., Abeshouse, A.A., Penson, A.V., Jonsson, P., Camacho, N., Chang, M.T., Won, H.H., Gross, B.E., Kundra, R., Heins, Z.J., Chen, H.-W., Phillips, S., Zhang, H., Wang, J., Ochoa, A., Wills, J., Eubank, M., Thomas, S.B., Gardos, S.M., Reales, D.N., Galle, J., Durany, R., Cambria, R., Abida, W., Cercek, A., Feldman, D.R., Gounder, M.M., Hakimi, A.A., Harding, J.J., Iyer, G., Janjigian, Y.Y., Jordan, E.J., Kelly, C.M., Lowery, M.A., Morris, L.G.T., Omuro, A.M., Raj, N., Razavi, P., Shoushtari, A.N., Shukla, N., Soumerai, T.E., Varghese, A.M., Yaeger, R., Coleman, J., Bochner, B., Riely, G.J., Saltz, L.B., Scher, H.I., Sabbatini, P.J., Robson, M.E., Klimstra, D.S., Taylor, B.S., Baselga, J., Schultz, N., Hyman, D.M., Arcila, M.E., Solit, D.B., Ladanyi, M., Berger, M.F., Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients, Nature Medicine, 23, (6), 2017, p703-713 Journal Article, 2017

, Systemic Chemotherapy Combined with Resection for Locally Advanced Gallbladder Carcinoma: Surgical and Survival Outcomes., Journal of the American College of Surgeons, 2017 Journal Article, 2017

, A phase 1/1B trial of ADI-PEG 20 plus nab-paclitaxel and gemcitabine in patients with advanced pancreatic adenocarcinoma., Cancer, 2017 Journal Article, 2017

Zehir, A., Benayed, R., Shah, R.H., Syed, A., Middha, S., Kim, H.R., Srinivasan, P., Gao, J., Chakravarty, D., Devlin, S.M., Hellmann, M.D., Barron, D.A., Schram, A.M., Hameed, M., Dogan, S., Ross, D.S., Hechtman, J.F., DeLair, D.F., Yao, J., Mandelker, D.L., Cheng, D.T., Chandramohan, R., Mohanty, A.S., Ptashkin, R.N., Jayakumaran, G., Prasad, M., Syed, M.H., Rema, A.B., Liu, Z.Y., Nafa, K., Borsu, L., Sadowska, J., Casanova, J., Bacares, R., Kiecka, I.J., Razumova, A., Son, J.B., Stewart, L., Baldi, T., Mullaney, K.A., Al-Ahmadie, H., Vakiani, E., Abeshouse, A.A., Penson, A.V., Jonsson, P., Camacho, N., Chang, M.T., Won, H.H., Gross, B.E., Kundra, R., Heins, Z.J., Chen, H.-W., Phillips, S., Zhang, H., Wang, J., Ochoa, A., Wills, J., Eubank, M., Thomas, S.B., Gardos, S.M., Reales, D.N., Galle, J., Durany, R., Cambria, R., Abida, W., Cercek, A., Feldman, D.R., Gounder, M.M., Hakimi, A.A., Harding, J.J., Iyer, G., Janjigian, Y.Y., Jordan, E.J., Kelly, C.M., Lowery, M.A., Morris, L.G.T., Omuro, A.M., Raj, N., Razavi, P., Shoushtari, A.N., Shukla, N., Soumerai, T.E., Varghese, A.M., Yaeger, R., Coleman, J., Bochner, B., Riely, G.J., Saltz, L.B., Scher, H.I., Sabbatini, P.J., Robson, M.E., Klimstra, D.S., Taylor, B.S., Baselga, J., Schultz, N., Hyman, D.M., Arcila, M.E., Solit, D.B., Ladanyi, M., Berger, M.F., Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients, Nature Medicine, 23, (6), 2017, p703-713 Journal Article, 2017

, A Combination of Radiation and the Hypoxia-Activated Prodrug Evofosfamide (TH-302) is Efficacious against a Human Orthotopic Pancreatic Tumor Model., Translational oncology, 2017 Journal Article, 2017

, In Vitro and In Vivo Comparison of Gemcitabine and the Gemcitabine Analog 1-(2'-deoxy-2'-fluoroarabinofuranosyl) Cytosine (FAC) in Human Orthotopic and Genetically Modified Mouse Pancreatic Cancer Models., Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging, 2017 Journal Article, 2017

Mandelker, D., Zhang, L., Kemel, Y., Stadler, Z.K., Joseph, V., Zehir, A., Pradhan, N., Arnold, A., Walsh, M.F., Li, Y., Balakrishnan, A.R., Syed, A., Prasad, M., Nafa, K., Carlo, M.I., Cadoo, K.A., Sheehan, M., Fleischut, M.H., Salo-Mullen, E., Trottier, M., Lipkin, S.M., Lincoln, A., Mukherjee, S., Ravichandran, V., Cambria, R., Galle, J., Abida, W., Arcila, M.E., Benayed, R., Shah, R., Yu, K., Bajorin, D.F., Coleman, J.A., Leach, S.D., Lowery, M.A., Garcia-Aguilar, J., Kantoff, P., Sawyers, C.L., Dickler, M.N., Saltz, L., Motzer, R.J., O'Reilly, E.M., Scher, H.I., Baselga, J., Klimstra, D.S., Solit, D.B., Hyman, D.M., Berger, M.F., Ladanyi, M., Robson, M.E., Offit, K., Mutation detection in patients with advanced cancer by universal sequencing of cancer-related genes in tumor and normal DNA vs guideline-based germline testing, JAMA - Journal of the American Medical Association, 318, (9), 2017, p825-835 Journal Article, 2017

, Stereotactic body radiation vs. intensity-modulated radiation for unresectable pancreatic cancer., Acta oncologica (Stockholm, Sweden), 2017 Journal Article, 2017

, Real-Time Genomic Profiling of Pancreatic Ductal Adenocarcinoma: Potential Actionability and Correlation with Clinical Phenotype., Clinical cancer research : an official journal of the American Association for Cancer Research, 2017 Journal Article, 2017

Russell, J., Pillarsetty, N., Kramer, R.M., Romesser, P.B., Desai, P., Haimovitz-Friedman, A., Lowery, M.A., Humm, J.L., In Vitro and In Vivo Comparison of Gemcitabine and the Gemcitabine Analog 1-(2"-deoxy-2"-fluoroarabinofuranosyl) Cytosine (FAC) in Human Orthotopic and Genetically Modified Mouse Pancreatic Cancer Models, Molecular Imaging and Biology, 2017, p1-8 Journal Article, 2017

, A Combination of Radiation and the Hypoxia-Activated Prodrug Evofosfamide (TH-302) is Efficacious against a Human Orthotopic Pancreatic Tumor Model., Translational oncology, 2017 Journal Article, 2017

Mandelker, D., Zhang, L., Kemel, Y., Stadler, Z.K., Joseph, V., Zehir, A., Pradhan, N., Arnold, A., Walsh, M.F., Li, Y., Balakrishnan, A.R., Syed, A., Prasad, M., Nafa, K., Carlo, M.I., Cadoo, K.A., Sheehan, M., Fleischut, M.H., Salo-Mullen, E., Trottier, M., Lipkin, S.M., Lincoln, A., Mukherjee, S., Ravichandran, V., Cambria, R., Galle, J., Abida, W., Arcila, M.E., Benayed, R., Shah, R., Yu, K., Bajorin, D.F., Coleman, J.A., Leach, S.D., Lowery, M.A., Garcia-Aguilar, J., Kantoff, P., Sawyers, C.L., Dickler, M.N., Saltz, L., Motzer, R.J., O'Reilly, E.M., Scher, H.I., Baselga, J., Klimstra, D.S., Solit, D.B., Hyman, D.M., Berger, M.F., Ladanyi, M., Robson, M.E., Offit, K., Mutation detection in patients with advanced cancer by universal sequencing of cancer-related genes in tumor and normal DNA vs guideline-based germline testing, JAMA - Journal of the American Medical Association, 318, (9), 2017, p825-835 Journal Article, 2017

Creasy, J.M., Goldman, D.A., Dudeja, V., Lowery, M.A., Cercek, A., Balachandran, V.P., Allen, P.J., DeMatteo, R.P., Kingham, T.P., D'Angelica, M.I., Jarnagin, W.R., Systemic Chemotherapy Combined with Resection for Locally Advanced Gallbladder Carcinoma: Surgical and Survival Outcomes, Journal of the American College of Surgeons, 224, (5), 2017, p906-916 Journal Article, 2017

, OncoKB: A Precision Oncology Knowledge Base., JCO precision oncology, 2017 Journal Article, 2017

, Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients., Nature medicine, 2017 Journal Article, 2017

, Systemic Chemotherapy Combined with Resection for Locally Advanced Gallbladder Carcinoma: Surgical and Survival Outcomes., Journal of the American College of Surgeons, 2017 Journal Article, 2017

Smith, J. D., Lowery, M. A., Fell, D., Gallagher, D. J., Nash, G. M., Kemeny, N. E., Young patients with synchronous colorectal liver metastases, Journal of Surgical Oncology, 113, 2016, p473 -- 476 Journal Article, 2016

Golan, T., Raitses-Gurevich, M., Kelley, R. K., Bocobo, A. G., Borgida, A., Shroff, R. T., Holter, S., Gallinger, S., Lowery, M. A., Abou-Alfa, G. K., Ahn, D. H., Jain, A., Bekaii-Saab, T. S., Friedman, E., Javle, M. M., Overall survival and clinical characteristics of BRCA germline/somatic cholangiocarcinoma (CCA), Journal of Clinical Oncology, 34, 2016 Journal Article, 2016

Lowery, M. A., Goff, L. W., Jordan, E., Wang, R., Bocobo, A. G., Chou, J. F., O'Reilly, E. M., Harding, J. J., Kemeny, N. E., Capanu, M., Griffin, A., McGuire, J. P., Venook, A. P., Abou-Alfa, G. K., Kelley, R. K., Second-line chemotherapy (CTx) outcomes in advanced biliary cancers (ABC): A retrospective multicenter analysis, Journal of Clinical Oncology, 34, 2016 Journal Article, 2016

Lowery, M. A., You, D., Samoila, A., Peerschke, E., Viale, A., Patel, R., Selcuklu, D., Rusek, M., Cercek, A., Kemeny, N., Harding, J., Mellinghoff, I., Tap, W., Abou-Alfa, G. K., Moynahan, M., Detection of IDH1 mutations in circulating free DNA in patients with cholangiocarcinoma, European Journal of Cancer, 69, 2016, pS141 -- S142 Journal Article, 2016

Ben-Aharon, I., Elkabets, M., Pelossof, R., Yu, K. H., Allen, P. J., Iacobuzio-Donahue, C. A., Leach, S. D., Lowery, M. A., Goodman, K. A., O'Reilly, E. M., Genomic landscape of pancreatic adenocarcinoma: Does age matter?, Journal of Clinical Oncology, 34, 2016 Journal Article, 2016

Sahin, I. H., Lowery, M. A., Stadler, Z. K., Salo-Mullen, E., Iacobuzio-Donahue, C. A., Kelsen, D. P., O'Reilly, E. M., Genomic instability in pancreatic adenocarcinoma: A new step towards precision medicine and novel therapeutic approaches, Expert Review of Gastroenterology and Hepatology, 10, 2016, p893 -- 905 Journal Article, 2016

Sahin, I.H., Lowery, M.A., Stadler, Z.K., Salo-Mullen, E., Iacobuzio-Donahue, C.A., Kelsen, D.P., O"Reilly, E.M., Genomic instability in pancreatic adenocarcinoma: a new step towards precision medicine and novel therapeutic approaches, Expert Review of Gastroenterology and Hepatology, 10, (8), 2016, p893-905 Journal Article, 2016

Silva, V.W.K., Askan, G., Daniel, T.D., Lowery, M., Klimstra, D.S., Abou-Alfa, G.K., Shia, J., Biliary carcinomas: Pathology and the role of DNA mismatch repair deficiency, Chinese Clinical Oncology, 5, (5), 2016 Journal Article, 2016

Hicks, A. M., Chou, J., Capanu, M., Lowery, M. A., Yu, K. H., O'Reilly, E. M., Pancreas adenocarcinoma: Ascites, clinical manifestations, and management implications, Clinical Colorectal Cancer, 15, 2016, p360 -- 368 Journal Article, 2016

Jordan, E. J., Basturk, O., Leach, S. D., Klimstra, D. S., Allen, P. J., Berger, M. F., Askan, G., Iacobuzio-Donahue, C. A., Yu, K. H., O'Reilly, E. M., Lowery, M. A., Clinical and molecular analysis of adenosquamous carcinoma of the pancreas, Journal of the Pancreas, 17, 2016, p620 -- 628 Journal Article, 2016

Javle, M. M., Shroff, R. T., Zhu, A., Sadeghi, S., Choo, S., Borad, M. J., Lowery, M. A., El-Khoueiry, A., Macarulla, T., Philip, P. A., Oh, D. Y., Van Cutsem, E., Yeh, K. H., Isaacs, R., McGarry, C., Sen, S., Bekaii-Saab, T. S., A phase 2 study of BGJ398 in patients (pts) with advanced or metastatic FGFR-altered cholangiocarcinoma (CCA) who failed or are intolerant to platinum-based chemotherapy, Journal of Clinical Oncology, 34, 2016 Journal Article, 2016

Abou-Alfa, G. K., Andersen, J. B., Chapman, W., Choti, M., Forbes, S. J., Gores, G. J., Hong, T. S., Harding, J. J., Vander Heiden, M. G., Javle, M., Kelley, R. K., Kwong, L. N., Lowery, M., Merrell, A., Miyabe, K., Rhim, A., Saha, S., Sia, D., Tanasanvimon, S., Venook, A., Valle, J. W., Walesky, C., Whetstine, J., Willenbring, H., Zhu, A. X., Mayer, D., Stanger, B. Z., Advances in cholangiocarcinoma research: Report from the third cholangiocarcinoma foundation annual conference, Journal of Gastrointestinal Oncology, 7, 2016, p819 -- 827 Journal Article, 2016

Jordan, E., Braghiroli, M. I. F., Lowery, M. A., The role of novel biologics in biliary cancers, Minerva Gastroenterologica e Dietologica, 62, 2016, p325 -- 339 Journal Article, 2016

Hicks, A. M., O'Reilly, E. M., Capanu, M., Lowery, M. A., Yu, K. H., Presentation, clinical behavior, outcomes and therapies for patients with advanced pancreas adenocarcinoma (PAC) who present with or develop ascites, Journal of Clinical Oncology, 34, 2016 Journal Article, 2016

Jordan, E., Basturk, O., Leach, S. D., Klimstra, D. S., Allen, P. J., Berger, M. F., Askan, G., Yu, K. H., O'Reilly, E. M., Lowery, M. A., Assessment of genomic alterations in adenosquamous carcinoma of the pancreas (ASCOP), Journal of Clinical Oncology, 34, 2016 Journal Article, 2016

Varghese, A. M., Lowery, M. A., Yu, K. H., O'Reilly, E. M., Current management and future directions in metastatic pancreatic adenocarcinoma, Cancer, 122, 2016, p3765 -- 3775 Journal Article, 2016

, Biliary carcinomas: pathology and the role of DNA mismatch repair deficiency., Chinese clinical oncology, 2016 Journal Article, 2016

Kennedy MJ, Systemic therapy of breast cancer, Current Opinion in Oncology, 9, 1997, p532 - 539 Journal Article, 1997

Research Expertise

Keywords

ADVANCED GASTRIC-CANCER; ANTI-CANCER DRUG DESIGN; ANTICANCER DRUGS; CANCER; Cancer Biology; CANCER CHEMOTHERAPY; Cancer drug discovery; Cancer Genetics; Cancer Molecular Diagnostics; CANCER PATIENTS; CANCER TREATMENT; COLORECTAL CANCER; DNA-REPAIR; hereditary cancer; Immunotherapies for Cancer; Liver Cancer; ONCOGENES; PANCREATIC CANCER; TUMOR SUPPRESSOR GENES; tumour micro-enviroment


Last updated 23 November 2016 Surgery - Web Administrator (Email).