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Research Staff Profiles

Professor John Reynolds
Professor John V. Reynolds, Head of Department

Professor John V. Reynolds

Professor John V. Reynolds (PDF CV 100 kB) is Professor of Surgery and Head of Department at Trinity College Dublin. He took up this position in July 2001. He is a specialist oesophageal and gastric surgeon and is based at St. James’s Hospital. He is the regional director of cancer services in the south-west area of the Eastern Regional Health Authority. His clinical and research training involved periods at the University of Pennsylvania, Philadelphia, the Memorial Sloan-Kettering Cancer Centre in New York, and St. Mary’s Hospital, London. He was consultant oesophageal surgeon and senior lecturer in St. James’s University Hospital in Leeds before returning to Dublin in 1997. His research interests are in molecular understanding of Barrett’s oesophagus and oesophageal cancer, the molecular prediction of response or resistance to chemotherapy and radiation therapy, obesity, inflammation and cancer, and the modulation of the immune response following complex major surgery. Professor Reynolds has published over 140 articles in high impact peer-reviewed journals.


Dr Graham Pigeon Picture
Dr Graham Pigeon, Professor in Translational Oncology

Dr. Graham Pidgeon

Dr. Graham Pidgeon graduated from DCU with a degree in Analytical Science and obtained a Ph.D. in Cancer Research from the Dept. Surgery, RCSI/DCU in 2000. Awarded an American Cancer Foundation Fellowship, he worked as research fellow at Wayne State University, Michigan with Prof. Kenneth Honn on the regulation of prostate cancer survival by bioactive lipids. In 2002 he returned to Ireland as a senior postdoctoral fellow in the Dept. Clinical Pharmacology at RCSI. He was awarded a HRB postdoctoral fellowship in 2004, and joined Prof. Dermot Kelleher and Dr. Ken O’Byrne in the Thoracic Oncology Research Group at the Institute of Molecular Medicine at TCD/St. James as research lecturer. He developed his own research group focused on the regulation of VEGF-mediated survival pathways by COX and LOX in lung cancer and combining inhibitors of these pathways with conventional chemotherapy.

He was appointed senior lecturer in Dept. Surgery at TCD/St. James's Hospital in 2007 and has expanded these research areas into other prevalent solid malignancies, including oesophageal, colorectal and breast cancer. He has published in a number of high impact journals including Cancer Research and Circulation, and was awarded the IJS doctor award 2005 for Cardiology. His current research unit are investigating the molecular and immunological mechanisms linking obesity and visceral adipose tissue with the development progression of oesophageal and colorectal cancer. Recent scientific literature highlights the importance of central obesity and metabolic syndrome as negatively impacting on cancer risk, tumour size, metastatic potential, and both disease free and overall survival. The group are prospectively investigating the incidence of central adiposity, metabolic syndrome and adipocyte secretion amongst newly diagnosed patients with these cancers to determine the link between these parameters and tumour size, metastases, response to conventional treatments and survival.

Other aspects of his research includes the role of downstream mediators of cyclooxygenase signalling in thrombosis and angiogenesis in cancer, and the effect of cyclooxygenase and lipoxygenase in the growth and metastasis of lung and oesophageal cancer.  He lectures on the undergraduate and postgraduate Molecular Medicine modules within the School of Medicine and is currently developing a new MSc in Molecular Oncology.


Dr Jacintha O'Sullivan Picture
Dr Jacintha O'Sullivan, Senior Lecturer

Prof. Jacintha O’Sullivan

Prof. Jacintha O'Sullivan is a Professor in Translational Oncology, based at the Trinity Translational Medicine Institute (TTMI), St. James’s Hospital. She also acts as Education and Outreach Coordinator in TTMI and course co-ordinator for the MSc. in Translational Oncology. Jacintha graduated from University College Dublin in 1995 with a first class honours degree in Cell Biology and Molecular Genetics. She then carried out Ph.D. training at the Adrinodack Biomedical Research Institute, Lake Placid, New York and at the University of Notre Dame, Indiana in cancer cell biology. In 2000, she moved to the University of Washington, Seattle as a NIH funded postdoctoral fellow where she investigated how cellular instability events are crucial in driving disease progression in inflammatory diseases and cancer. In 2003, Jacintha returned to Dublin to the Centre for Colorectal Disease, St. Vincent's University Hospital/UCD as a Senior Scientist to establish and direct a translational gastrointestinal research program. She was appointed as Associate Professor in the Department of Surgery, Trinity College Dublin/St. James Hospital in 2010 and promoted to Professor in 2016.
Currently, Dr. O'Sullivan directs a translational gastrointestinal (GI) research team in the Trinity Translational Medicine Institute (TTMI) in collaboration with clinical and surgical colleagues. She utilises well established bio-banking structures to drive this GI translational research program. She is internationally recognised in the area of translational gastrointestinal work with many publications in high impact journals and her work has attracted funding from many different sources; Science Foundation Ireland, Health Research Board, Irish Cancer Society, Irish Research Council and from industry collaborators. She has published 3 patents and has graduated a large number of postgraduate Ph.D. and MD students. She is passionate about career mentoring for Ph.D's and research fellows.
Dr. O'Sullivan's current translational research themes include;

  1. Development of diagnostic platforms to stratify cancer risk and response to targeted therapies for gastrointestinal diseases.
  2. Development of novel patented therapeutics to be used in the neoadjuvant and adjuvant treatment setting for gastrointestinal cancer patients (Colorectal and Oesophageal cancers).
  3. Elucidating how the tumour microenvironment cross talks to the immune system in GI patients.
  4. Importance of metabolism, inflammation and obesity in driving disease progression and in regulating treatment response.

The outputs of these translational themes will benefit patient care, treatment and management for gastrointestinal diseased patients

Contact information:
Tel: 01 896 2149
e-mail: osullij4@tcd.ie


Dr Joanne Lysaght
Dr. Joanne Lysaght, Assistant Professor

Dr Joanne Lysaght

Dr. Joanne Lysaght graduated from N.U.I Maynooth with a first class Honours Degree in Science in 2001. She then went on to complete a PhD in 2005, in the Department of Biochemistry and Immunology in Trinity College Dublin under the supervision of Prof. Kingston Mills. The main focus of her Ph.D was the modulation of innate and adaptive anti-tumour immunity. Following completion of her Ph.D, she began work as a clinical scientist in the Cancer Molecular Diagnostic Laboratory based in St. James’s Hospital. She then took up a post-doctoral position in the Department of Haematology and Oncology, TCD, where she worked on a novel family of chemotherapeutic drugs for the treatment of childhood acute lymphoblastic leukemia. In 2008, she began working with Prof. John Reynolds in the Department of Surgery, TCD/St. James's Hospital as a CROSS funded post-doctoral fellow. In 2009, Dr. Lysaght was awarded a HRB Post-Doctoral fellowship to continue her work in the area of obesity-associated cancer and tumour immunity. In 2011 Dr. Lysaght was appointed as Ussher Lecturer in Molecular Oncology and currently leads the Tumour Immunology Research Group within the Department of Surgery.  In 2012 Dr. Lysaght was involved in the creation of the M.Sc. in Translational Oncology and is currently Course Co-ordinator. Dr. Lysaght is actively involved in teaching both at undergraduate and post-graduate levels in the areas of tumour immunology and immunotherapies, obesity and inflammation.  She has an active research group, which focuses primarily on T cells in cancer and the identification of novel immunotherapies.  



Last updated 10 April 2017 Surgery - Web Administrator (Email).