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Maria Santos-Martinez
Assistant Professor, Pharmacy
Assistant Professor, Clinical Medicine


Dr Maria J Santos-Martinez is a medical doctor Specialist in Respiratory Medicine from the Universidad Autónoma de Barcelona (Spain). She started her training as basic researcher in The Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases at UTHealth (University of Texas Health Science-Houston-USA) in 2004. In 2006 she moved to Ireland and defended her PhD in 2009 (Trinity College Dublin). She was appointed as Assistant Professor (Ussher) in Nanopharmaceutical Drug Discovery (School of Pharmacy and Pharmaceutical Sciences & School of Medicine) in 2010.

Publications and Further Research Outputs

Peer-Reviewed Publications

Inkielewicz-Stepniak I, Tajber L, Behan G, Zhang H, Radomski MW, Medina C, Santos-Martinez MJ, The Role of Mucin in the Toxicological Impact of Polystyrene Nanoparticles, Materials, 11, (5), 2018, p1 - 12 Journal Article, 2018 DOI

Larkin CM, Hante NK, Breen EP, Tomaszewski KA, Eisele S, Radomski MW, Ryan TA, Santos-Martinez MJ, Role of matrix metalloproteinases 2 and 9, toll-like receptor 4 and platelet-leukocyte aggregate formation in sepsis-associated thrombocytopenia., PloS one, 2018 Journal Article, 2018

Nam, L.; Coll, C.; Erthal, L.C.S.; de la Torre, C.; Serrano, D.; Martínez-Máñez, R.; Santos-Martínez, M.J.; Ruiz-Hernández, E., Drug delivery nanosystems for the localized treatment of glioblastoma multiforme, Materials, 11, (5), 2018, p779- Journal Article, 2018

Larkin CM, Breen EP, Tomaszewski KA, Eisele S, Radomski MW, Ryan TA, Santos-Martinez MJ, Platelet microaggregation in sepsis examined by quartz crystal microbalance with dissipation technology., Platelets, 2017 Journal Article, 2017

Radziwon-Balicka A, Lesyk G, Back V, Fong T, Loredo-Calderon EL, Dong B, El-Sikhry H, El-Sherbeni AA, El-Kadi A, Ogg S, Siraki A, Seubert JM, Jurasz P, Differential eNOS-signalling by platelet subpopulations regulates adhesion and aggregation., Cardiovascular research, 2017 Journal Article, 2017

Larkin, C.M., Santos-Martinez, M.-J., Ryan, T., Radomski, M.W., Sepsis-associated thrombocytopenia, Thrombosis Research, 141, 2016, p11-16 Journal Article, 2016 DOI

Niska, K., Santos-Martinez, M.J., Radomski, M.W., Inkielewicz-Stepniak, I. , CuO nanoparticles induce apoptosis by impairing the antioxidant defense and detoxification systems in the mouse hippocampal HT22 cell line: protective effect of crocetin, Toxicology in vitro, 29, 2015, p663 - 671 Journal Article, 2015 DOI

Tomaszewski KA, Radomski MW, Santos-Martinez MJ. , Nanodiagnostics, Nanopharmacology and Nanotoxicology of Platelet - Vessel Wall Interactions., Nanomedicine (Lond.), 10, (9), 2015, p1451 - 1475 Review Article, 2015

Gaffney, A.M., Santos-Martinez, M.J., Satti, A., Major, T.C., Wynne, K.J., Gun'ko, Y.K., Annich, G.M., Elia, G., Radomski, M.W, Blood biocompatibility of surface-bound multiwall carbon nanotubes. , Nanomedicine: NBM Feature Article, 11, 2015, p39 - 46 Journal Article, 2015 DOI

Santos-Martinez, M.J., Tomaszewski, K., Medina, C., Bazou, D., Gilmer, J.F., Radomski, M.W. , Pharmacological characterization of nanoparticle-induced platelet microaggregation using quartz crystal microbalance with dissipation: comparison with light aggregometry, International Journal of Nanomedicine, 10, 2015, p5107 - 5119 Journal Article, 2015 TARA - Full Text DOI

Samuel S., Santos-Martinez M., Medina C., Jain N., Radomski MW., Prina-Mello A., Volkov Y., CdTe quantum dots induce activation of human platelets: Implications for nanoparticle hemocompatibility, International Journal of Nanomedicine, 10, 2015, p2723-2734 Journal Article, 2015 DOI TARA - Full Text

Gaffney, A.M., Santos-Martinez, M.J., Satti, A., (...), Elia, G., Radomski, M.W. , Blood biocompatibility of surface-bound multi-walled carbon nanotubes, Nanomedicine: Nanotechnology, Biology, and Medicine, 11, (1), 2015, p39-46 Journal Article, 2015 DOI

Umerska A, Paluch KJ, Santos-Martinez MJ, Medina C, Corrigan OI, Tajber L, Chondroitin-based nanoplexes as peptide delivery systems--Investigations into the self-assembly process, solid-state and extended release characteristics., European Journal of Pharmaceutics and Biopharmaceutics, 93, 2015, p242 - 253 Journal Article, 2015 DOI TARA - Full Text

Radziwon-Balicka A, Santos-Martinez MJ, Corbalan JJ, O'Sullivan S, Treumann A, Gilmer JF, Radomski MW, Medina C, Mechanisms of platelet-stimulated colon cancer invasion: role of clusterin and thrombospondin 1 in regulation of the P38MAPK-MMP-9 pathway., Carcinogenesis, 35, (2), 2014, p324 - 332 Journal Article, 2014 TARA - Full Text

Inkielewicz-Stepniak, I., Santos-Martinez, M.J., Medina, C., Radomski, M.W. , Pharmacological and toxicological effects of co-exposure of human gingival fibroblasts to silver nanoparticles and sodium fluoride, International Journal of Nanomedicine, 9, 2014, p1677 - 1687 Journal Article, 2014 TARA - Full Text

N Glezeva, M Santos-Martinez, C Watson, K Mcdonald, C Medina, J Gilmer, M Ledwidge, Inhibition of thromboxane pathways in monocytes impedes cell invasiveness, European Journal of Heart Failure, 16, 2014, pp208-209 Conference Paper, 2014

Umerska A, Paluch KJ, Santos-Martinez MJ, Corrigan OI, Medina C, Tajber L, Self-assembled hyaluronate/protamine polyelectrolyte nanoplexes: synthesis, stability, biocompatibility and potential use as peptide carriers, Journal of Biomedical Nanotechnology, 10, (12), 2014, p3658 - 3673 Journal Article, 2014 TARA - Full Text DOI

Santos-Martinez, M.J., Rahme, K., Corbalan, J.J., Faulkner, C., Holmes, J., Tajber, L., Medina, C., Radomski, M.W. , Pegylation increases platelet biocompatibility of gold nanoparticles. , Journal of Biomedical Nanotechnology, 10, 2014, p1004 - 1015 Journal Article, 2014

Lesniak, A., Salvati, A., Santos-Martinez, M.J., Radomski, M.W., Dawson, K.A., Aberg, C. , Nanoparticle adhesion to the cell membrane and its effect on nanoparticle uptake efficiency, Journal of American Chemical Society, 135, 2013, p1438 - 1444 Journal Article, 2013

Medina C, Harmon S, Inkielewicz I, Santos-Martinez MJ, Jones M, Cantwell P, Bazou D, Ledwidge M, Radomski MW, Gilmer JF., Differential Inhibition of Tumor Cell-Induced Platelet Aggregation by Nicotinate Aspirin Prodrug (ST0702) and Aspirin., British Journal of Pharmacology, 166, (3 ), 2012, p938 - 949 Journal Article, 2012 DOI TARA - Full Text

Santos-Martinez, M.J., Inkielewicz-Stepniak, I., Medina, C., Rahme, K., D'Arcy, D., Holmes J.D., Zhang, H., Radomski, M.W, The use of quartz crystal microbalance with dissipation for studying nanoparticle-induced platelet aggregation. , International Journal of Nanomedicine, 7, 2012, p243 - 255 Journal Article, 2012

Wahab, A.; Rahayu, I; Wong, Siu Hai N.; Santos-Martinez, M J ; Boylan, F., Alkaloids from Choisya ternata and their human antiplatelet activity., Planta Medica, International Conference on Natural Products Research, New York, USA, 2012, 78, (11), 2012, pp1205- Conference Paper, 2012

Harmon, S., Inkielewicz-Stepniak, I., Jones, M., Ledwidge, Santos-Martinez, M.J., Medina, C., Radomski, M.W., Gilmer, J.F, Mechanisms of aggregation inhibition by aspirin and nitrate-aspirin prodrugs in human platelets, Journal of Pharmacy and Pharmacology, 64, (1), 2012, p77 - 89 Journal Article, 2012 TARA - Full Text

Umerska A, Paluch KJ, Inkielewicz-Stępniak I, Santos-Martinez MJ, Corrigan OI, Medina C, Tajber L., Exploring the assembly process and properties of novel crosslinker-free hyaluronate-based polyelectrolyte complex nanocarriers, International Journal of Pharmaceutics, 436, (1-2), 2012, p75 - 87 Journal Article, 2012 DOI URL TARA - Full Text

Santos-Martinez, M.J., Prina-Mello, A., Medina, C., Radomski, M.W. , Analysis of platelet function: role of microfluidics and nanodevices, Analyst, 136, 2011, p5120 - 5126 Review Article, 2011 TARA - Full Text DOI

Medina C, Santos-Martinez MJ, Santana A, Paz-Cabrera MC, Johnston MJ, Mourelle M, Salas A, Guarner F., Transforming growth factor-beta type 1 receptor (ALK5) and Smad proteins mediate TIMP-1 and collagen synthesis in experimental intestinal fibrosis., The Journal of Pathology, 224, (4), 2011, p461 - 472 Journal Article, 2011 DOI

Bazou D, Santos-Martinez MJ, Medina C, radomski MW, Elucidation of flow-mediated tumour cell-induced platelet aggregation using an ultrasound standing wave trap, British journal of Pharmacology, 162, (7), 2011, p1577 - 1589 Journal Article, 2011

Santos-Martinez, MJ, Medina, C, Prina-Mello, A, Conroy, J, Samuels, SP, Volkov, Y, Radomski, MW, A nanoscale resolution assay of flow-induced platelet microaggregation, Kardiochirurgia i Torakochirurgia Polska, 7, (4), 2010, p365-375 Journal Article, 2010

Jones M, Inkielewicz I, Medina C, Santos-Martinez MJ, Radomski A, Radomski MW, Lally MN, Moriarty LM, Gaynor J, Carolan CG, Khan D, O'Byrne P, Harmon S, Clancy JM, Gilmer JF, ISOSORBIDE-BASED ASPIRIN PRODRUGS: INTEGRATION OF NITRIC OXIDE RELEASING GROUPS, J Med Chem. Nov 12;52(21):6588-6598, 2009 Journal Article, 2009

Jones, M., Inkielewicz, I., Medina, C., Santos-Martinzez, M.J., Radomski, M.W., Radomski, A., Lally, M.N., Moriarty, L.M., Gaynor, J., Carolan, C.G., Coyne, D., O'Byrne, P., Clancy, J.M., Gilmer, J.F. , Isosorbide-based aspirin prodrugs: integration of nitric oxide releasing groups. , Journal of Medicinal Chemistry, 52, (21), 2009, p6588-6598 Journal Article, 2009 DOI

Santos-Martinez, M.J., Medina, C., Gilmer, J.F., Radomski, M.W. , Matrix metalloproteinases in platelet function: coming of age. , Thrombosis and Haemostasis, 6, (3), 2008, p514-516 Review, 2008 URL DOI

Gilmer JF, Inkielewicz I, Jones M, Radomski A, Medina C, Santos Martinez MW, Radomski MW, Clancy JM, In vitro activation and platelet inhibition effects of the first true aspirin and nitro-aspirin prodrugs, Bioorganic Medicinal Chemistry, IBC's 13th Annual World Congress " Drug Discovery and Development of Innovative Therapeutics" August 4-7th 2008. , 2008 Conference Paper, 2008

Santos-Martínez MJ, Medina C, Jurasz P, Radomski MW., Role of metalloproteinases in platelet function, Thrombosis Research, 121, 2008, p535 - 542 Review Article, 2008

Santos-Martinez, M.J., Medina, C., Jurasz, P., Radomski, M.W. , Metalloproteinases in platelet function, Thrombosis Research, 121, (4), 2008, p535-542 Review, 2008 DOI URL

Jurasz, P., Santos-Martinez, M.J., Radomska, A., Radomski, M.W. , Development and pharmacological characterization of a novel, plasma-based angiogenesis assay, Kardiochirurgia i Torakochirurgia Polska, 4, (2), 2007, p126 - 130 Journal Article, 2007 URL

Santos-Martinez MJ, Medina C, Booth J, Radomski W. , A NOVEL METHOD FOR THE MEASUREMENT OF PLATELET AGGREGATION UNDER FLOW CONDITIONS USING NANOBALANCE, All-Ireland Schools of Pharmacy Research Seminar , Royal College of Surgeons, 2007 , 2007 Oral Presentation, 2007

Medina, C., Santos-Martinez, M.J., Radomski, A., Corrigan, O.I., Radomski, M.W., Nanoparticles: pharmacological and toxicological significance, British Journal of Pharmacology, 150, 2007 Review Article, 2007 DOI URL TARA - Full Text

C Medina, MJ Santos-Martinez, A. Radomski, I Owen, MW Radomski, NANOPARTICLES: PHARMACOLOGICAL AND TOXICOLOGICAL SIGNIFICANCE, British Journal of Pharmacology, 150, 2007, p552 - 558 Journal Article, 2007

Jurasz, P., Santos-Martinez, M.J., A. Radomska, Radomski, M.W. , Generation of platelet angiostatin mediated by urokinase plasminogen activator: effects of angiogenesis, Journal of Thrombosis and Haemostasis, 4, (5), 2006, p1095 - 1106 Journal Article, 2006 URL DOI

Medina, C., Jurasz, P., Santos-Martinez, M.J., Jeong, S.S., Mitzky, R., Chen, R., Radomski, M.W. , Platelet aggregation induced by Caco-2 cells: regulation by matrix metalloproteinase-2 and adenosine diphosphate, Journal of Pharmacology and Experimental Therapeutics, 317, (2), 2006, p739 - 745 Journal Article, 2006 TARA - Full Text DOI URL

D Alonso-Escolano, C Medina, K Cieslik, A Radomski, P Jurasz, MJ Santos-Martinez, P Ruvolo, MW Radomski, PKCä Mediates Platelet-Induced Breast Cancer Cell Invasion, Journal of Pharmacology Experimental therapeutics, 318, 2006, p373 - 380 Journal Article, 2006 TARA - Full Text

Jurasz P, Santos-Martinez MJ, Radomska A, Radomski MW. , GENERATION OF PLATELET ANGIOSTATIN MEDIATED BY UROKINASE PLASMINOGEN ACTIVATOR: EFFECTS ON ANGIOGENESIS., J Thromb Haemost. May;4(5):1095-1106, 2006 Journal Article, 2006

Alonso-Escolano, D., Medina, C., Cieslik, K., Radomski, A., Jurasz, P., Santos-Martinez, M.J., Jiffar, T., Ruvolo, P., Radomski, M.W, Protein Kinase C{delta} Mediates Platelet-Induced Breast Cancer Cell Invasion, Journal of Pharmacology and Experimental Therapeutics, 318, 2006, p372 - 380 Journal Article, 2006 URL DOI

Rosell A, Xaubet A, Agusti C, Castella J, Puzo C, Curull V, de Gracia J; RASTA study group., A NEW BAL FLUID INSTILLATION AND ASPIRATION TECHNIQUE: A MULTICENTER RANDOMIZED STUDY. , Respir Med. Mar;100(3):529-535., 2006 Journal Article, 2006

C Medina, P Jurasz, MJ Santos-Martinez, SS Jeong, T Mitsky, R Chen, MW Radomski, PLATELET AGGREGATION-INDUCED BY CACO-2 CELLS: REGULATION BY MATRIX METALLOPROTEINASE-2 AND ADENOSINE DIPHOSPHATE. , Journal of Pharmacology Experimental Therapeutics , 317, 2006, p739 - 745 Journal Article, 2006

Santos-Martinez MJ, Curull V, Blanco ML, Macia F, Mojal S, Vila J, Broquetas JM. , LUNG CANCER AT A UNIVERSITY HOSPITAL: EPIDEMIOLOGICAL AND HISTOLOGICAL CHARACTERISTICS OF A RECENT AND A HISTORICAL SERIES., Arch Bronconeumol ;41(6):307-312 , 2005 Journal Article, 2005

Santos-Martínez MJ, Curull V, Blanco ML, Macià F, Mojal S, Vila J, Broquetas JM, [Lung cancer at a university hospital: epidemiological and histological characteristics of a recent and a historical series], Archivos de bronconeumologia, 2005 Journal Article, 2005

Jericó Alba C, Nogués Solán X, Santos Martínez MJ, Félez Flor M, Garcés Jarque JM, Mariñosa Marré M, Sanz Salvador X, [Legionella pneumophila pneumonia community epidemic outbreak in Barcelona: "The Barceloneta outbreak". Effect on the early diagnosis and treatment], Revista clinica espanola, 2004 Journal Article, 2004

Jerico Alba C, Nogues Solan X, Santos-Martinez MJ, Felez Flor M, Garces Jarque JM, Marinosa Marre M, Sanz Salvador X. , LEGIONELLA PNEUMOPHILA PNEUMONIA COMMUNITY EPIDEMIC OUTBREAK IN BARCELONA: "THE BARCELONETA OUTBREAK". EFFECT ON THE EARLY DIAGNOSIS AND TREATMENT., Rev Clin Esp ;204(2):70-74., 2004 Journal Article, 2004

María Molina-Molina, Joan Ramon Badia, Alejandra Marín-Arguedas, Antoni Xaubet, María José Santos, José María Nicolás, Miguel Ferrer, Antoni Torres, Características clínicas y pronóstico de los pacientes con fibrosis pulmonar que ingresan en cuidados intensivos por insuficiencia respiratoria. Análisis de 20 casos, Medicina Clínica, 121, (2), 2003, p63--67 Journal Article, 2003

Molina-Molina M, Badía JR, Marín-Arguedas A, Xaubet A, Santos MJ, Nicolas JM, Ferrer M, Torres A., OUTCOMES AND CLINICAL CHARACTERISTICS OF PATIENTS WITH PULMONARY FIBROSIS AND RESPIRATORY FAILURE ADMITTED TO AN INTENSIVE CARE UNIT. A STUDY OF 20 CASES. , Med Clin;121(2):63-67., 2003 Journal Article, 2003

Non-Peer-Reviewed Publications

Santos-Martinez, M.J., Medina, C., Radomska, A., Radomski, M.W., Clinician-scientist: a hobby for few, career prosepects for some and training for all practicioners? , Kardiochirurgia i Torakochirurgia Polska, 2, 2005, p17-19 Review Article, 2005

Research Expertise


Dr Santos-Martinez reserach interests are focused on blood platelets; nanoparticle-cell and nanoparticle-platelet interactions (Nanotoxicology) and cancer. During her PhD studies she developed a novel method for measuring platelet aggregation using a Quartz Crystal Microbalance with Dissipation monitoring (QCM-D). This is a unique and very sensitive technology able to quantify and characterise surface-molecules-cells interactions at nanoscale. Her expertise on the use of QCM-D has been consolidated and she applies this technology for investigating the effect of different compounds, nanomaterials and novel formulations on platelet function and the interactions between nanoparticles developed for drug delivery, their targets and the potential barriers that they have to overcome to exert their action. In the field of cancer, her research is mainly focused on the contribution of platelets to cancer progression (tumor invasion, angiogenesis and blood metastasis).





Reviewer:PNAS; Nanomedicine: Nanotechnology, Biology, and Medicine (Nanomedicine); Critical Care Medicine, Thrombosis and Haemostasis

Awards and Honours

Dean's Research Initiatives Fund (Faculty of Health Sciences, TCD) 2015

Innovation Award CRANN 2010

Catalan Respiratory Medicine Association (FUCAP) 2003

Catalan Respiratory Medicine Association (SOCAP) 2003

Spanish Respiratory Medicine Association (SEPAR) 2002


Spanish Respiratory Medicine Association (SEPAR) 2002 – present

Member and founder of the Spanish Research Society in Ireland 2016

Irish Association of Pharmacologists (IAP) 2017