Sharon works in the area of gynaecological cancer with a specific interest in ovarian cancer. She works in both Obstetrics and Gynaecology and Histopathology under the auspices of the DISCOVARY consortium. The DISCOVARY consortium was formed to specifically address issues in relation to ovarian and endometrial cancer diagnostics and prognostics and supports the development of translational research in Ireland. Sharon manages the DISCOVARY bioresource which is an invaluable collection of matched bloods and tissue from ovarian cancer patients with full clinical details. Her research addresses two of the main challenges in ovarian cancer; lack of a sensitive diagnostic test and development of chemoresistance. Much of the work focuses on identification of novel biomarkers for both diagnosis and prognosis using auto antibody profiling, miRNA profiling and isolation of circulating tumour cells. Other studies include the interrogation of chemoresistance mechanisms in ovarian cancer.
For further information on Dr Sharon O'Toole please view her CV profile