The research conducted by our group investigates the mechanisms which control T cell immunity and tolerance particularly in the context of autoimmune diseases. We take a translational research approach investigating novel mechanisms implicated in the pathogenesis of diseases such as psoriasis and inflammatory bowel disease using both preclinical models and patient samples. Our laboratory is located at the National Children’s Research Centre at Our Ladys Childrens Hospital Crumlin allowing close collaboration with paediatric clinician scientists to facilitate these studies. Current areas of investigation include the role of novel Interleukin-1 family members in autoimmune disease as well as understanding the mechanisms through interleukin-2 acts in the maintenance of immune tolerance. Our aim is to translate our findings towards the development of improved therapeutics for autoimmune disease.
Image shows successful treatment of psoriatic skin inflammation through targeting autoimmune T cell responses.
For further information about Dr Patrick Walshe please view his CV Profile.