I run a translational medicine research programme focused on investigation of pathogenesis and discovery of biomarkers of disease in glomerulonephritis. My principal research interest is in ANCA-associated vasculitis, an autoimmune condition that causes multi-organ failure as a consequence of overwhelming necrotising inflammation affecting small blood vessels. We are addressing the following questions: 1. What urinary biomarkers accurately track glomerular inflammation in ANCA associated vasculitis? 2. What molecular and cellular events prevent resolution of vasculitic injury after the initial insult? 3. What underpins the large variability in clinical phenotype obeserved in ANCA associated vasculitis? 4. How can we minimise the adverse events associated with existing immunosuppressive therapies? To assist in answering these questions, we have set up infrastructure that allows collection of longitudinal clinical data in the form of a national registry and biobank, which is linked to a basic science laboratory.
For further information about Professor Mark Little please view his CV Profile