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Laure Marignol
Associate Professor, Radiation Therapy

Biography

Laure is an Associate Professor in Radiobiology at the Discipline of Radiation Therapy, Trinity College Dublin, Ireland with qualifications from four European universities (B.Sc in health engineering (France, Germany), M. Sc in radiobiology (UK), PhD in clinical medicine (Ireland)). Since her tenured appointment at Trinity College Dublin in 2010, she has developed an internationally-recognised radiobiology laboratory in Ireland. In 2017, Laure was elected as a Fellow of Trinity College Dublin.

A year after completion of her phD, she was the recipient of the highly competitive St Luke's Young Investigator Award of the Royal Irish Academy of Medicine for my work on tumour hypoxia and radiation response of prostate tumours. She was appointed Head of Research of the Discipline of Radiation Therapy in 2011 and in this role drove the creation of the Applied Radiation Therapy Trinity (ARTT) research group. Following award of a prostate cancer project grant of the Irish Cancer Society in 2012, she took leadership of the Translational Radiobiology and Molecular Oncology strand within that group. she has since established a unique Irish radiotherapy research network to support translation of her work into improved practice, and developed strong international links. She has built up a good publication track record and mentored a number of PhD and MD candidates. All are now holding positions at leading national and international hospitals and institutions.

She was the first European member of the Scholar-In-Training Committee of the Radiation Research Society (USA) and since then, she took a leadership position for the Irish Radiation Research Society and recently became the youngest member of the Radiobiology committee, within the European Society for she holds an editorial role for the Nature Journal Scientific Reports.

A passionate radiobiologist with a multi-disciplinary view of radiation oncology, her ambition is to enable the development of radiobiology into the age of personalised medicine.

Publications and Further Research Outputs

Peer-Reviewed Publications

Marignol L., Predicting Treatment Outcomes: The Case for Hypoxia Gene Signatures., EBioMedicine, 2018 Journal Article, 2018 DOI

Inder, S., O'Rourke, S., McDermott, N., (...), Lynch, T., Marignol, L. , The Notch-3 receptor: A molecular switch to tumorigenesis?, Cancer treatment reviews, 60, 2017, p69-76 Journal Article, 2017 DOI

O'Brien, R. and Marignol, L., The Notch-1 receptor in prostate tumorigenesis, Cancer Treatment Reviews, 56, 2017, p36-46 Journal Article, 2017 DOI

Hutchinson, J., Marignol, L. , Clinical Potential of Statins in Prostate Cancer Radiation Therapy., Anticancer research, 37, (10), 2017, p5363-5372 Journal Article, 2017 DOI

Inder, S. and Bates, M. and McDermott, N. and Domad, J. and Schneider, J. and Erdmann, G. and Finn, S. and Manecksha, R. P. and Lynch, T. H. and Marignol, L., Profiling of radioresistant prostate cancer cells identifies deregulation of key protein, 120, 2017, pp24-24 Poster, 2017

Marignol, L., Notch signalling: The true driver of small cell lung cancer?, Translational Cancer Research, 6, 2017, pS1191-S1196 Journal Article, 2017 DOI

Haruna, F., Lipsett, A., Marignol, L. , Topical Management of Acute Radiation Dermatitis in Breast Cancer Patients: A Systematic Review and Meta-Analysis., Anticancer research, 37, (10), 2017, p5343-5353 Journal Article, 2017 DOI

Samsuri, N.A.B. and Leech, M. and Marignol, L., Metformin and improved treatment outcomes in radiation therapy â€" A review, Cancer Treatment Reviews, 55, 2017, p150-162 Journal Article, 2017 DOI

Fitzpatrick C, Lynch O, Marignol L., 68Ga-PSMA-PET/CT Has a Role in Detecting Prostate Cancer Lesions in Patients with Recurrent Disease., Anticancer research, 37, (6), 2017, p2753-2760 Journal Article, 2017 DOI

Wall, V. and Marignol, L. and Elbeltagi, M. N., Radiotherapy in Paediatrics: A Survey of International Patterns of Practice of Image Guided Radiation Therapy and Planning Target Volume, 63, 2016, ppS64-S64 Oral Presentation, 2016

McDermott N., Meunier A., Mooney B., Nortey G., Hernandez C., Hurley S., Hurley S., Lynam-Lennon N., Barsoom S., Bowman K., Marples B., Jones G., Marignol L., Fractionated radiation exposure amplifies the radioresistant nature of prostate cancer cells, Scientific Reports, 6, 2016 Journal Article, 2016 DOI

Lynam-Lennon N., Bibby B., Mongan A., Marignol L., Paxton C., Geiersbach K., Geiersbach K., Bronner M., Bronner M., O"Sullivan J., Reynolds J., Maher S., Maher S., Low MiR-187 expression promotes resistance to chemoradiation therapy in vitro and correlates with treatment failure in patients with esophageal adenocarcinoma, Molecular Medicine, 22, 2016, p388-397 Journal Article, 2016 DOI

Meunier A., Flores A., McDermott N., Rivera-Figueroa K., Perry A., Lynch T., Redalen K., Marignol L., Hypoxia regulates Notch-3 mRNA and receptor activation in prostate cancer cells, Heliyon, 2, (5), 2016 Journal Article, 2016 DOI

Devine A, Marignol L, Potential of Amifostine for Chemoradiotherapy and Radiotherapy-associated Toxicity Reduction in Advanced NSCLC: A Meta-Analysis., Anticancer research, 36, (1), 2016, p5-12 Journal Article, 2016

Lim D, Quah DS, Leech M, Marignol L, Clinical potential of boron neutron capture therapy for locally recurrent inoperable previously irradiated head and neck cancer., Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine, 2015 Journal Article, 2015 DOI TARA - Full Text

Dullea A, Marignol L, MGMT testing allows for personalised therapy in the temozolomide era., Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2015 Journal Article, 2015 DOI

McDermott, N. and Meunier, A. and Hernandez, C. and Bowman, K. J. and Jones, G. D. and Marignol, L., Identification of a miRNAs signature of radioresistance in a prostate cancer model, 75, 2015 Poster, 2015 DOI

Lawlor H, Meunier A, McDermott N, Lynch TH, Marignol L, Identification of suitable endogenous controls for gene and miRNA expression studies in irradiated prostate cancer cells., Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 36, (8), 2015, p6019-28 Journal Article, 2015 DOI

Marignol, L., Targeting notch in prostate cancer - Combination is the key, 11, (7), 2014 Journal Article, 2014

Martin, L.M., Marples, B., Lynch, T.H., Hollywood, D., Marignol, L., Erratum to Exposure to low dose ionizing radiation: Molecular and clinical consequences [Cancer Lett. 338 (2) (2013) 209-218], 349, (1), 2014 Journal Article, 2014

Kelada O, Marignol L, Erythropoietin-stimulating agents and clinical outcomes in metastatic breast cancer patients with chemotherapy-induced anemia: a closed debate?, Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 35, (6), 2014, p5095-100 Journal Article, 2014

Flores AN, McDermott N, Meunier A, Marignol L, NUMB inhibition of NOTCH signalling as a therapeutic target in prostate cancer., Nature reviews. Urology, 11, (9), 2014, p499-507 Journal Article, 2014

Scientific Report, Nature, [eds.], 2014-2018 Editorial Board, 2014

McLaughlin, J., Marignol, L., Radiotherapy scheduling using prime numbers, 13, (3), 2014, p317-321 Journal Article, 2014

Azmi A, Dillon RA, Borghesi S, Dunne M, Power RE, Marignol L, O'Neill BD, Active surveillance for low-risk prostate cancer: diversity of practice across Europe., Irish journal of medical science, 2014 Journal Article, 2014

Mongan, A. M. and Lynam-Lennon, N. and Marignol, L. and Maher, S. and O'Farrell, N. J. and Pidgeon, G. and O'Sullivan, J. and Reynolds, J. V., Obesity fuels genomic instability and radioresistance in oesophageal cancer, 182, 2013, ppS38-S38 Conference Paper, 2013

Perry, A.S. and O'Hurley, G. and Raheem, O.A. and Brennan, K. and Wong, S. and O'Grady, A. and Kennedy, A.M. and Marignol, L. and Murphy, T.M. and Sullivan, L. and Barrett, C. and Loftus, B. and Thornhill, J. and Hewitt, S.M. and Lawler, M. and Kay, E. and Lynch, T. and Hollywood, D., Erratum: Gene expression and epigenetic discovery screen reveal methylation of SFRP2 in prostate cancer (International Journal of Cancer (2013) 132:8 (1771-80) DOI: 10.1002/ijc.27798)), International Journal of Cancer, 132, (11), 2013 Journal Article, 2013 DOI

Vajda A, Marignol L, Barrett C, Madden SF, Lynch T, Hollywood D, Perry AS, Gene expression in prostate cancer: the importance of the endogenous control. , The Prostate, 2013 Journal Article, 2013

Bolton, E. M. and Moran, D. and Meunier, A. and Vajda, A. and O'Kelly, F. and Thurman, J. and O'Connor, R. and Marignol, L. and Hollywood, D. and Lynch, T. H. and Perry, A. S., Epigenetic profiling in urine for the detection of aggressive prostate cancer, 100, 2013, pp63-63 Conference Paper, 2013

Martin LM, Marples B, Davies AM, Atzberger A, Edwards C, Lynch TH, Hollywood D, Marignol L, DNA mismatch repair protein MSH2 dictates cellular survival in response to low dose radiation in endometrial carcinoma cells., Cancer letters, 2013 Journal Article, 2013

Røe K, Bratland A, Vlatkovic L, Ragnum HB, Saelen MG, Olsen DR, Marignol L, Ree AH, Hypoxic Tumor Kinase Signaling Mediated by STAT5A in Development of Castration-Resistant Prostate Cancer., PloS one, 8, (5), 2013, pe63723 Journal Article, 2013 DOI TARA - Full Text

Mongan, A. M. and Lynam-Lennon, N. and Marignol, L. and Maher, S. and Pidgeon, G. and O'Sullivan, J. N. and Reynolds, J. V., Obesity and radiosensitivity status influence genomic instability events: Anaphase bridge formation and spindle assembly checkpoint gene expression in oesophageal cancer, 100, 2013, pp48-48 Poster, 2013

Schoenherr D, Krueger SA, Martin L, Marignol L, Wilson GD, Marples B, Determining if low dose hyper-radiosensitivity (HRS) can be exploited to provide a therapeutic advantage: A cell line study in four glioblastoma multiforme (GBM) cell lines., International journal of radiation biology, 2013 Journal Article, 2013

Martin LM, Marples B, Lynch TH, Hollywood D, Marignol L, Exposure to Low Dose Ionizing Radiation: Molecular and Clinical Consequences., Cancer letters, 2013 Journal Article, 2013

McDermott N, Meunier A, Lynch T, Hollywood D, Marignol L, Isogenic radiation resistant cell lines: Development and Validation strategies., International journal of radiation biology, 2013 Journal Article, 2013

Davies, A.M., Vajda, A., Ryan, S.L., Marignol, L., New approaches to cell based assays for high content screening and analysis, 18, (3), 2013, p23-28 Journal Article, 2013

Bolton, E. M. and Moran, D. C. and Meunier, A. and O'Kelly, F. and Marignol, L. and Hollywood, D. and Lynch, T. H. and Perry, A. S., Real time expression analysis of a microRNA signature of prostate cancer in prostate cell lines and tissue specimens, 100, 2013, pp63-63 Conference Paper, 2013

Marignol L, Rivera-Figueroa K, Lynch T, Hollywood D, Hypoxia, notch signalling, and prostate cancer., Nature reviews. Urology, 10, (7), 2013, p405-13 Journal Article, 2013

Bolton, E. and Moran, D. and Meunieur, A. and Marignol, L. and Hollywood, D. and Lynch, T. H. and Perry, A., Real Time Expression Analysis of a Microrna Signature of Prostate Cancer in Prostate Cell Lines and Tissue Specimens, Irish Journal of Medical Science, 181, 2012, pS169-S170 Journal Article, 2012

James C. Forde, Laure Marignol, Ophelia Blake, Ted McDermott, Ronald Grainger, Vivien E. Crowley, Thomas H. Lynch, Standardization of assay methods reduces variability of total PSA measurements: an Irish study, British Journal of Urology International, 2012 Journal Article, 2012 DOI

Lynam-Lennon N, Reynolds JV, Marignol L, Sheils OM, Pidgeon GP, Maher SG, MicroRNA-31 modulates tumour sensitivity to radiation in oesophageal adenocarcinoma., Journal of molecular medicine (Berlin, Germany), 2012 Journal Article, 2012 DOI

Mongan, A. M. and Reynolds, J. and Lynam-Lennon, N. and Marignol, L. and Maher, S. and Pidgeon, G. and O'Sullivan, J., Obesity Status Influence Nuclear Instability Events: Anaphase Bridge Formation and Spindle Assembly Checkpoint Gene Expression in Oesophageal Cancer, Irish Journal of Medical Science, 181, 2012, pS152-S153 Journal Article, 2012

O'Kelly F, Marignol L, Meunier A, Lynch TH, Perry AS, Hollywood D, MicroRNAs as putative mediators of treatment response in prostate cancer., Nature reviews. Urology, 2012 Journal Article, 2012

O'Kelly, F. and Perry, A. S. and Meunier, A. and Wong, S. and Hollywood, D. and Marignol, L. and Lynch, T. H., Over-expression of a novel microRNA, miR-24, affects prostate cancer cell growth and proliferation, and contributes to radio-senstivity of prostate cancer cells in vitro, 11, (1), 2012, ppE849-U790 Poster, 2012

Røe K, Mikalsen LT, van der Kogel AJ, Bussink J, Lyng H, Ree AH, Marignol L, Olsen DR, Vascular responses to radiotherapy and androgendeprivation therapy in experimental prostate cancer., Radiation oncology (London, England), 7, (1), 2012, p75 Journal Article, 2012

Perry AS, O'Hurley G, Raheem OA, Brennan K, Wong S, O'Grady A, Kennedy AM, Marignol L, Murphy TM, Sullivan L, Barrett C, Loftus B, Thornhill J, Hewitt SM, Lawler M, Kay E, Lynch T, Hollywood D, Gene expression and epigenetic discovery screen reveal methylation of SFRP2 in prostate cancer., International journal of cancer. Journal international du cancer, 2012 Journal Article, 2012

Azmi, Aini and Dillon, Ruth and Marignol, Laure and Borghesi, Simona and Dunne, Mary and Power, Richard and O'Neill, Brian, Active surveillance for low-risk prostate cancer: Practice across Europe, Journal of Clinical Oncology, 30, (5), 2012 Journal Article, 2012

Mongan, A. M. and Reynolds, J. and Lynam-Lennon, N. and Marignol, L. and Maher, S. and Pidgeon, G. and O'Sullivan, J., Levels of obesity influences a nuclear instability event: Anaphase bridge formation in oesophageal cancer, Irish Journal of Medical Science, 180, 2011, pS262-S262 Journal Article, 2011

Forde JC, Maginn EN, McNamara G, Martin LM, Campiani G, Williams DC, Zisterer D, McElligott AM, Lawler M, Lynch TH, Hollywood D, Marignol L, Microtubule-targeting-compound PBOX-15 radiosensitizes cancer cells in vitro., Cancer biology & therapy, 11, (4), 2011, p421-8 Journal Article, 2011

Lennon, N. Lynam and Reynolds, J. V. and Marignol, Laura and Sheils, O. M. and Pidgeon, G. P. and Maher, S. G., MiR-31 modulates tumour sensitivity to radiation in oesophageal cancer, Irish Journal of Medical Science, 180, 2011, pS276-S276 Journal Article, 2011

Hennessey D, Martin LM, Atzberger A, Lynch TH, Hollywood D, Marignol L, Exposure to hypoxia following irradiation increases radioresistance in prostate cancer cells., Urologic oncology, 1, 2011 Journal Article, 2011 DOI

Hennessey, D. and Coffey, M. and Lynch, T. and Lawler, M. and Hollywood, D. and Marignol, L., Adaptation to low oxygenation levels modify the radioresponse of prostate cancer cells in vitro, British Journal of Surgery, 98, (6), 2011, pE8-E8 Journal Article, 2011

Forde, J. C. and Perry, A. and Hollywood, D. and Lawler, M. and Lynch, T. H. and Marignol, L., Downregulation of HIF-1 A and lowered TUBB3 expression levels leads to preferential sensitivity of hypoxic prostate cancer cells tol docetaxel, British Journal of Surgery, 98, (6), 2011, pE8-E8 Journal Article, 2011

Foley R, Marignol L, Keane JP, Lynch TH, Hollywood D., Androgen hypersensitivity in prostate cancer: molecular perspectives on androgen deprivation therapy strategies, Prostate, 71, (5), 2011 Journal Article, 2011 DOI

Forde, J. C. and Maginn, E. and McElligott, A. M. and Martin, L. M. and Williams, D. C. and Zisterer, D. and Lawler, M. and Hollywood, D. and Lynch, T. H. and Marignol, L., AN IN VITRO INVESTIGATION OF THE CYTOTOXIC AND RADIO-SENSITISING PROPERTIES OF A NOVEL MICROTUBULE TARGETING AGENT, PBOX-15, IN HYPOXIC PROSTATE CANCER CELL LINES, European Urology Supplements, 10, (2), 2011, p292-292 Journal Article, 2011

Vajda A, Marignol L, Foley R, Lynch TH, Lawler M, Hollywood D, Clinical potential of gene-directed enzyme prodrug therapy to improve radiation therapy in prostate cancer patients., Cancer treatment reviews, 37, (8), 2011, p643-54 Journal Article, 2011

Moran, D. and Marignol, L. and Fagan, A. and Hollywood, D. and Meaney, J. and Lynch, T., Functional endorectal MRI at 3 Tesla for the detection and staging of prostate cancer: Correlation with prostatectomy specimens, Irish Journal of Medical Science, 180, 2011, pS269-S270 Journal Article, 2011

Martin L, Coffey M, Lawler M, Hollywood D, Marignol L, DNA mismatch repair and the transition to hormone independence in breast and prostate cancer., Cancer letters, 291, (2), 2010, p142-9 Journal Article, 2010 DOI

Forde, J. C. and Maginn, E. and McElligott, A. M. and Martin, L. M. and Williams, D. C. W. and Zisterer, D. and Hollywood, D. and Lawler, M. and Lynch, T. H. and Marignol, L., RADIOSENSITIZATION OF HYPOXIC PROSTATE CANCER CELL LINES USING A NOVEL MICROTUBULE TARGETING AGENT: PBOX-15, Irish Journal of Medical Science, 179, 2010, pS372-S372 Journal Article, 2010

Forde JC, Perry AS, Brennan K, Martin LM, Lawler MP, Lynch TH, Hollywood D, Marignol L, Docetaxel maintains its cytotoxic activity under hypoxic conditions in prostate cancer cells., Urologic oncology, 1, 2010 Journal Article, 2010 DOI

Forde, J. C. and Blake, O. and Casey, R. G. and Marignol, L. and McDermott, T. E. and Grainger, R. and Crowley, V. E. and Lynch, T. H., THE INTER-HOSPITAL VARIABILITY OF 6 DIFFERENT PSA ASSAY KITS CURRENTLY IN USE THROUGHOUT IRELAND, Irish Journal of Medical Science, 179, 2010, pS372-S372 Journal Article, 2010

Forde, J. C. and Hollywood, D. and Lawler, M. and Lynch, T. H. and Marignol, L. and Marignol, L., Investigation of the cytotoxic properties of a novel microtubule-targeting compound, PBOX-15, in hypoxic prostate cancer cell lines, Bju International, 106, (1), 2010, p52-53 Journal Article, 2010

Foley R, Marignol L, Keane JP, Lynch TH, Hollywood D, Comment on "Androgen-hypersensitive preclinical model of prostate cancer" by Kawata et al., The Prostate, 71, (6), 2010, p559 - 560 Journal Article, 2010 DOI

Thomas, A. Z. and Foley, R. and Marignol, L. and Hollywood, D. and Lynch, T. and Lawlor, M., The effect of the HIF-1 alpha C1772T heterozygous genotype on prostate cancer risk and HIF-1 alpha expression in prostate tissue, British Journal of Surgery, 97, 2010, p3-4 Journal Article, 2010

Martin LM, Marples B, Coffey M, Lawler M, Lynch TH, Hollywood D, Marignol L, DNA mismatch repair and the DNA damage response to ionizing radiation: making sense of apparently conflicting data., Cancer treatment reviews, 36, (7), 2010, p518-27 Journal Article, 2010 DOI

Hennessey, D. and Martin, L. and Hollywood, D. and Lynch, T. H. and Marignol, L., EXPOSURE TO REDUCED OXYGENATION FOLLOWING RADIATION EXPOSURE ENHANCES THE SURVIVAL OF PROSTATE CANCER CELLS IN VITRO: IMPLICATIONS FOR RADIATION THERAPY DELIVERY, Irish Journal of Medical Science, 179, 2010, pS351-S351 Journal Article, 2010

Keane, J. P. and Foley, R. and Marignol, L. and Hollywood, D. and Lynch, T. H., THE EFFECT OF CALPAIN ACTIVATION IN THE 22Rv1 PROSTATE CANCER CELL LINE, Irish Journal of Medical Science, 179, 2010, pS350-S350 Journal Article, 2010

Lynam-Lennon N, Reynolds JV, Pidgeon GP, Lysaght J, Marignol L, Maher SG, Alterations in DNA repair efficiency are involved in the radioresistance of esophageal adenocarcinoma., Radiation research, 174, (6), 2010, p703 - 711 Journal Article, 2010 DOI

Foley R, Marignol L, Thomas AZ, Cullen IM, Perry AS, Tewari P, O'Grady A, Kay E, Dunne B, Loftus B, Watson WR, Fitzpatrick JM, Woodson K, Lehman T, Hollywood D, Lynch TH, Lawler M, The HIF-1alpha C1772T polymorphism may be associated with susceptibility to clinically localised prostate cancer but not with elevated expression of hypoxic biomarkers., Cancer biology & therapy, 8, (2), 2009, p118-24 Journal Article, 2009 TARA - Full Text

Vajda, Alice and Marignol, Laure and Foley, Ruth and Hollywood, Donal and Lawler, Mark, Hypoxia, androgen and radiation-inducible suicide gene therapy for the treatment of prostate cancer, Human Gene Therapy, 20, (11), 2009, p1519-1519 Journal Article, 2009

Lynn Martin, Brian Marples, Mary Coffey, Mark Lawler, Donal Hollywood, Laure Marignol, Recognition of O6MeG lesions by MGMT and mismatch repair proficiency may be a prerequisite for low-dose radiation hypersensitivity., Radiation Research, 172, (4), 2009, p405 - 413 Journal Article, 2009

Marignol, L., Foley, R., Southgate, T.D., Coffey, M., Hollywood, D., Lawler, M., Hypoxia response element-driven cytosine deaminase/5-fluorocytosine gene therapy system: a highly effective approach to overcome the dynamics of tumour hypoxia and enhance the radiosensitivity of prostate cancer cells in vitro., The Journal of Gene Medicine , 11, (2), 2009, p169-179 Journal Article, 2009 DOI

Raheem, O. A. and Powell, A. and Kennedy, A. M. and Murphy, T. and Foley, R. and Marignol, L., Investigation into methylation of the Secreted Frizzled Related Proteins (SFRP) family of Wnt antagonists in prostate cancer, Bju International, 103, 2009, p19-20 Journal Article, 2009

Marignol L, Coffey M, Lawler M, Hollywood D., Hypoxia in prostate cancer: a powerful shield against tumour destruction?, Cancer Treatment Review, 34, (4), 2008, p313-327 Journal Article, 2008 DOI

D'Arcy, F. and Foley, R. and Perry, A. and Marignol, L. and Lawler, M. and Gaffney, E. and Watson, R. G. W. and Fitzpatrick, J. M. and Lynch, T. H., No evidence of XMRV in irish prostate cancer patients with the R462q mutation, European Urology Supplements, 7, (3), 2008, p271-271 Journal Article, 2008 DOI

Marignol L, Robson T, McCarthy HO, Worthington J, Murray MM, Hollywood D, Lawler M, Hirst DG., The tissue plasminogen activator gene promoter: a novel tool for radiogenic gene therapy of the prostate?, Journal of Gene Medicine, 10, (9), 2008, p1032-1038 Journal Article, 2008 DOI

D'Arcy, F. and Foley, R. and Perry, A. and Marignol, L. and Gaffney, E. and Dunne, B. and Lawler, M. P. and Watson, R. W. G. and Fitzpatrick, J. M. and Lynch, T. H., RNASEL and its role in Irish prostate cancer patients, 100, 2007, pp12-13 Published Abstract, 2007

Martin, L. and Marignol, L., Sequence effect on the survival of prostate cancer cells may potentiate daily radiation therapy delivery, Radiotherapy and Oncology, 84, 2007, pS281-S281 Journal Article, 2007

Marignol, L. and Foley, R. and Southgate, T. D. and Coffey, M. and Hollywood, D. and Lawler, M., Hypoxia-inducible suicide gene therapy approach radiosensitises prostate cancer cells, 100, 2007, pp32-32 Published Abstract, 2007

Thomas, A. Z. and Marignol, L. and Foley, R. and Perry, A. and Tewari, P. and O'Grady, T. and Kay, E. and Dunne, B. and Loftus, B. and Hollywood, D. and Lynch, T. and Lawler, M., Enhanced expression of hypoxia markers in cell lines and in clinical specimens of malignant prostate tissue: A factor in disease progression?, Bju International, 100, 2007, p40-41 Journal Article, 2007

Marignol L, Coffey M, Hollywood D, Lawler M., Radiation to Control Transgene Expression in Tumors., Cancer Biological Therapy, 6, (7), 2007, p1005 - 1012 Journal Article, 2007 URL

Thomas, A. Z. and Marignol, L. and Foley, R. and Perry, A. and Tewari, P. and O'Grady, T. and Kay, E. and Dunne, B. and Loftus, B. and Hollywood, D. and Lynch, T. and Lawler, M., Enhanced expression of hypoxia markers in cell lines and in clinical specimens of malignant prostate tissue: A factor in disease progression?, Bju International, 100, 2007, p40-41 Journal Article, 2007

Foley, R. and Marignol, L. and Lawler, M., Prodrug activation therapy kills prostate cancer cells in a three-dimensional culture model, 100, 2007, pp24-24 Published Abstract, 2007

Traynor, S. and Gilham, C. and Foley, R. and Fairbairn, L. J. and Southgate, T. D. and Worthington, J. and Coffey, M. and Hollywood, D. and Lawler, M. and Marignol, L., Utilising a hypoxia-inducible suicide gene therapy strategy in combination with radiation to target prostate cancer cells, 81, 2006, ppS477-S477 Conference Paper, 2006

Marignol L, Lawler M, Coffey M, Hollywood D., Achieving Hypoxia-Inducible Gene Expression in Tumors., Cancer Biological Therapy, 4, (4), 2005, p359-364. Journal Article, 2005 URL

Research Expertise

Description

Molecular Mechanisms of radiation resistance in prostate tumours Development of biomarkers of biochemical treatment failure following radiation therapy Relevance of tumour hypoxia to disease progression and radiation treatment planning MRI imaging of the prostate

Projects

  • Title
    • Development of a Companion diAgnostic teSt for radiotheraPy prostAte canceR patients (CASPAR)
  • Summary
    • There is an unmet need to develop companion diagnostic tests that can guide patients and their clinicians through the treatment decision process. This project propose assesses a novel protein for its prognostic and therapeutic potential in high risk radiotherapy prostate cancer patients. The long-term focus of CASPAR is to develop a novel companion diagnostic test and therapeutic combination that can allow personalized prescription of radiotherapy for these patients.
  • Funding Agency
    • Science Foundation Ireland
  • Date From
    • 01/01/2017
  • Date To
    • 31/128/2017
  • Title
    • Prognosis potential of miRNAs in high risk radiotherapy prostate cancer patients
  • Summary
    • Failure to identify tumours with a radioresistant phenotype in the 1,000+ Irish prostate cancer patients/year receiving radiation therapy (RT) is associated with recurrence and decreased overall survival in approximatively 300-400 of these men, particularly those with localised Gleason 8-10 prostate carcinoma. This study aims to identify a miRNA panel that can be detected in diagnostic tissue biopsy specimen from high-risk patients, which will assist the identification of the 30-50% who are at greater risk of biochemical failure following RT.
  • Funding Agency
    • Irish Cancer Society
  • Date From
    • 01 December 2012
  • Date To
    • 01 December 2016
  • Title
    • Reduced oxygenation does not protect all prostate cancer cells from radiation: a new role for hypoxia in radiation therapy?
  • Summary
    • Oxygen is essential for optimal cytotoxicity of radiation therapy. In the absence of oxygen at the time of radiation exposure, cell survival is commonly expected to increase by up to three-fold. We proposed that the proportion of cells completely deprived of oxygen within tumours may not be sufficiently large to be clinically significant and hypothesised that the surrounding hypoxic cells in fact may govern tumour response to radiotherapy. To test this hypothesis, this study proposed to re-examine the radioresponse of hypoxic prostate cancer cells and determine the consequences of these potentially clinically relevant oxygen levels.

Keywords

Cancer genetics and cell biology including metastasis; Mathematical modelling; Molecular Biology; Prostate cancer; Radiomics; Radiotherapy, Biological response modifiers and chemoprevention; Therapeutic and Clinical oncology; Tissue Culture; Transgene Expression

Recognition

Representations

Oral Presentation, Radiation Research Society Annual Meeting, Cancun, Mexico 16/10/2017

Invited Presentation, MAASTRO Clinic, The Nederlands. "Developing therapeutic packages for prostate cancer radiotherapy" 14/09/2016

Oral Presentation: "Developing therapeutic packages for prostate cancer radiotherapy" Biomarkers in radiation oncology Workshop, OncoRay, Dresden, Germany 24 May 2016

Poster presentation - ESTRO Annual Meeting, Turin "Therapeutic potential of the YB-1/Notch-3 interaction in prostate cancer" 29/04/2016

Poster presentation "Identification of a miRNAs signature of radioresistance in a prostate cancer model" 18/04/2015

Poster presentation -ESTRO Annual Meeting, Barcelona, 2015 "Identification of MiRNAs associated with radioresistance in a prostate cancer model" 24/04/2015

Invited Talk " The treatment Field from the Radiobiologist and Molecular Oncologist's Eye" ESTRO Treatment Planning Course June 26th 2010

Invited Talk "5-step guide to the management of a research project" ESTRO Annual Meeting, Barcelona, September 12-16th 2010 15th September 2010

Poster Presentation "Reduced oxygenation does not protect all prostate cancer cells from radiation: a new role for hypoxia in radiation therapy?" Radiation Research Society Annual meeting, USA, September 2010( Winner Scholar-in-Training Travel award). September 2010

Poster Presentation "Reduced oxygenation does not protect all prostate cancer cells from radiation: a new role for hypoxia in radiation therapy?" Irish Association for Radiation Research, March 2010 March 2010

Poster Presentation "Reduced oxygenation does not protect all prostate cancer cells from radiation: a new role for hypoxia in radiation therapy?" ESTRO Annual Meeting, Barcelona, September 12-16th 2010 September 2010

Oral Presentation "Hypoxia may participates in disease progression and radioresistance through the induction of Notch-3 and upregulation of DNA repair genes in prostate cancer" Faculty of Radiologist Annual Meeting, Dublin, September 2009 September 2009

Poster Presentation "Hypoxia may participates in disease progression and radioresistance through the induction of Notch-3 and upregulation of DNA repair genes in prostate cancer" 11th International Wolfsberg Meeting on Molecular Radiation Biology/Oncology, Ermatingen, Switzerland, June 2009 June 2009

Oral Presentation "Hypoxia in prostate tumours: detection, consequences and clinical exploitation" St Lukes Young Investigator Award, Royal Academy of Medicine in Ireland, Dublin, Ireland, January 2009 (Winner St Luke's Young Investigator medal) January 2009

Oral Presentation "Hypoxia may participates in disease progression and radioresistance through the induction of Notch-3 and upregulation of DNA repair genes in prostate cancer" Association for Radiation Research, Annual Meeting, Glasgow, UK, June 2009 June 2009

Invited talk ""Radiation Activated Gene Therapy -A review" Royal College of Surgeons in Ireland, I Faculty Annual Scientific meeting, Dublin, September 2007 20th September 2007

Awards and Honours

Election to Fellowship, Trinity College Dublin 10/04/2017

Irish Cancer Society, Prostate Cancer Project Grant 01/12/2012

Early Career Investigator Award 13/10/2017

6th St Lukes Young Investigator Award 2009

Travel Award, Radiation Research Society, USA 2010

Early investigator award, Association for Radiation Research 2007

Student travel award, International Conference for Radiation Research 2006

Institute for Molecular Medicine Best PhD poster competition award 2006

Nominee for the St Lukes Young Investigator Award 2006

Memberships

Scholar In Training Committee member of the Radiation Research Society (USA) 2007 – 2010

Scholar In Training Committee member of the Association for Radiation Research (UK) 2008 – 2012

Scholar In Training Committee member European Society for Therapeutic Radiology and Oncology (ESTRO) 2009 – 2011

Treasurer, Irish Association for Radiation Research 2013 – 2016

Irish Association for Cancer Research 2003 – Present

Secretary, Irish Association for Radiation Research November 2016 – Present

Member, Radiobiology Committee, European Society for Radiotherapy and Oncology (ESTRO) May 2016 – Present