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Veronica O'Keane
Associate Professor Consultant, Psychiatry

Publications and Further Research Outputs

Peer-Reviewed Publications

Tozzi L., Tozzi L., Tozzi L., Doolin K., Doolin K., Farrel C., Farrel C., Joseph S., O'Keane V., O'Keane V., Frodl T., Frodl T., Frodl T., Functional magnetic resonance imaging correlates of emotion recognition and voluntary attentional regulation in depression: A generalized psycho-physiological interaction study, Journal of Affective Disorders, 208, 2017, p535-544 Journal Article, 2017 DOI

Lodhi R., Masand S., Malik A., Malik A., Shivakumar K., Shivakumar K., McAllister V., O'Keane V., Young L., Heald A., Sherwood R., Aitchison K., Aitchison K., Aitchison K., Aitchison K., Changes in biomarkers of bone turnover in an aripiprazole add-on or switching study, Schizophrenia Research, 170, (2-3), 2016, p245-251 Journal Article, 2016 DOI

Leonardo Tozzi, Angela Carballedo, Friedrich Wetterling, Hazel McCarthy, Veronica O'Keane, Michael Gill, Derrek Morris, Ciara Fahey, James Meaney, Thomas Frodl, Single Nucleotide Polymorphism of the FKBP5 Gene and Childhood Maltreatment as Predictors of Structural Changes in Brain Areas Involved in Emotional Processing in Depression., Neuropsychopharmacology, 41, 2016, p487-497 Journal Article, 2016 DOI

Integrating the Stress Systems and Neuroimaging in Depression in, Syst. Neurosci. in Depress., Elsevier Inc., 2016, pp269 - 308, [Frodl T, O'Keane V] Book Chapter, 2016 DOI

Tozzi, L., Carballedo, A., Lavelle, G., Doolin, K., Doyle, M., Amico, F., Mccarthy, H., Gormley, J., Lord, A., O'Keane, V., Frodl, T., Longitudinal functional connectivity changes correlate with mood improvement after regular exercise in a dose-dependent fashion, European Journal of Neuroscience, 43, (8), 2016, p1089-1096 Journal Article, 2016

Farrell C, O'Keane V, Epigenetics and the glucocorticoid receptor: A review of the implications in depression., Psychiatry research, 242, 2016, p349-356 Journal Article, 2016 DOI

Doyle M, Carballedo A, O'Keane V, Perinatal depression and psychosis: An update, Advances in Psychiatric Treatment, 21, (1), 2015, p5 - 14 Journal Article, 2015 DOI URL

Frodl T, Carballedo A, Frey EM, O'Keane V, Skokauskas N, Morris D, Gill M, Hughes MM, Harkin A, Connor T, Expression of glucocorticoid inducible genes is associated with reductions in cornu ammonis and dentate gyrus volumes in patients with major depressive disorder., Development and psychopathology, 26, (4 Pt 2), 2014, p1209-17 Journal Article, 2014 TARA - Full Text DOI

Leahy D, Schaffalitzky E, Armstrong C, Bury G, Cussen-Murphy P, Davis R, Dooley B, Gavin B, Keane R, Keenan E, Latham L, Meagher D, McGorry P, McNicholas F, O'Connor R, O'Dea E, O'Keane V, O'Toole TP, Reilly E, Ryan P, Sanci L, Smyth BP, Cullen W, Primary care and youth mental health in Ireland: qualitative study in deprived urban areas., BMC family practice, 14, 2013, p194 Journal Article, 2013 TARA - Full Text DOI

Thomas Frodl, Veronica O'Keane, How does the brain deal with cumulative stress? A review with focus on developmental stress, HPA axis function and hippocampal structure in humans, Neurobiology of Disease, 52, 2012, p24 - 37 Journal Article, 2012 TARA - Full Text

Frodl, T., Carballedo, A., Hughes, M.M., (...), O'Keane, V., Connor, T.J. , Reduced expression of glucocorticoid-inducible genes GILZ and SGK-1: High IL-6 levels are associated with reduced hippocampal volumes in major depressive disorder, Translational Psychiatry, 2, 2012, pe88- Journal Article, 2012 DOI

O'Keane V, Frodl T, Dinan TG, A review of Atypical depression in relation to the course of depression and changes in HPA axis organization., Psychoneuroendocrinology, 37, (10), 2012, p1589-99 Journal Article, 2012

O'Keane V, Lightman S, Patrick K, Marsh M, Papadopoulos AS, Pawlby S, Seneviratne G, Taylor A, Moore R, Changes in the maternal hypothalamic-pituitary-adrenal axis during the early puerperium may be related to the postpartum 'blues'., Journal of Neuroendocrinology, 23, (11), 2011, p1149-55 Journal Article, 2011

Dayan J, Creveuil C, Dreyfus M, Herlicoviez M, Baleyte JM, O'Keane V, Developmental model of depression applied to prenatal depression: role of present and past life events, past emotional disorders and pregnancy stress., PloS one, 5, (9), 2010, pe12942 Journal Article, 2010 DOI

Bajbouj M, Merkl A, Schlaepfer TE, Frick C, Zobel A, Maier W, O'Keane V, Corcoran C, Adolfsson R, Trimble M, Rau H, Hoff HJ, Padberg F, Müller-Siecheneder F, Audenaert K, van den Abbeele D, Matthews K, Christmas D, Eljamel S, Heuser I, Two-year outcome of vagus nerve stimulation in treatment-resistant depression., Journal of clinical psychopharmacology, 30, (3), 2010, p273-81 Journal Article, 2010 DOI

O'Keane V, Lightman S, Marsh M, Pawlby S, Papadopoulos AS, Taylor A, Moore R, Patrick K, Increased pituitary-adrenal activation and shortened gestation in a sample of depressed pregnant women., Journal of affective disorders, 23, (11), 2010, p1149 - 1155 Journal Article, 2010 DOI

Aitchison KJ, Mir A, Shivakumar K, McAllister VD, O'Keane V, McCrone P, Costs and outcomes associated with an aripiprazole add-on or switching open-label study in psychosis., Journal of psychopharmacology (Oxford, England), 25, (5), 2010, p675 - 684 Journal Article, 2010 DOI

Goodwin G, Fleischhacker W, Arango C, Baumann P, Davidson M, de Hert M, Falkai P, Kapur S, Leucht S, Licht R, Naber D, O'Keane V, Papakostas G, Vieta E, Zohar J, Advantages and disadvantages of combination treatment with antipsychotics ECNP Consensus Meeting, March 2008, Nice., European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 19, (7), 2009, p520-32 Journal Article, 2009 DOI

Pawlby S, Hay DF, Sharp D, Waters CS, O'Keane V, Antenatal depression predicts depression in adolescent offspring: prospective longitudinal community-based study., Journal of affective disorders, 113, (3), 2009, p236-43 Journal Article, 2009 DOI

Mir A, Shivakumar K, Williamson RJ, McAllister V, O'Keane V, Aitchison KJ, Change in sexual dysfunction with aripiprazole: a switching or add-on study., Journal of psychopharmacology (Oxford, England), 22, (3), 2008, p244-53 Journal Article, 2008 DOI

Schlaepfer TE, Frick C, Zobel A, Maier W, Heuser I, Bajbouj M, O'Keane V, Corcoran C, Adolfsson R, Trimble M, Rau H, Hoff HJ, Padberg F, Müller-Siecheneder F, Audenaert K, Van den Abbeele D, Matthews K, Christmas D, Stanga Z, Hasdemir M, Vagus nerve stimulation for depression: efficacy and safety in a European study., Psychological medicine, 38, (5), 2008, p651-61 Journal Article, 2008 DOI

Pawlby S, Sharp D, Hay D, O'Keane V, Postnatal depression and child outcome at 11 years: the importance of accurate diagnosis., Journal of affective disorders, 107, (1-3), 2008, p241-5 Journal Article, 2008 DOI

Peveler RC, Branford D, Citrome L, Fitzgerald P, Harvey PW, Holt RI, Howard L, Kohen D, Jones I, O'Keane V, Pariente CM, Pendlebury J, Smith SM, Yeomans D, Antipsychotics and hyperprolactinaemia: clinical recommendations., Journal of psychopharmacology (Oxford, England), 22, (2 Suppl), 2008, p98-103 Journal Article, 2008 DOI

O'Keane V, Antipsychotic-induced hyperprolactinaemia, hypogonadism and osteoporosis in the treatment of schizophrenia., Journal of psychopharmacology (Oxford, England), 22, (2 Suppl), 2008, p70-5 Journal Article, 2008 DOI

O'Keane V, Marsh MS, Depression during pregnancy., BMJ (Clinical research ed.), 334, (7601), 2007, p1003-5 Journal Article, 2007 DOI

Meaney AM, O'Keane V, Bone mineral density changes over a year in young females with schizophrenia: relationship to medication and endocrine variables., Schizophrenia research, 93, (1-3), 2007, p136-43 Journal Article, 2007 DOI

Howard L, Hunt K, Slade M, O'Keane V, Senevirante T, Leese M, Thornicroft G, Assessing the needs of pregnant women and mothers with severe mental illness: the psychometric properties of the Camberwell Assessment of Need - Mothers (CAN-M)., International journal of methods in psychiatric research, 16, (4), 2007, p177-85 Journal Article, 2007 DOI

O'Keane V, Marsh MS, Antidepressant prescribing and pregnancy: comment on 'Prevalence and predictors of antidepressant use in a cohort of pregnant women', by Ramos et al., BJOG : an international journal of obstetrics and gynaecology, 114, (9), 2007, p1051-4 Journal Article, 2007 DOI

Corcoran CD, Thomas P, Phillips J, O'Keane V, Vagus nerve stimulation in chronic treatment-resistant depression: preliminary findings of an open-label study., The British journal of psychiatry : the journal of mental science, 189, 2006, p282-3 Journal Article, 2006 DOI

O'Keane V, Meaney AM, Antipsychotic drugs: a new risk factor for osteoporosis in young women with schizophrenia?, Journal of clinical psychopharmacology, 25, (1), 2005, p26-31 Journal Article, 2005

Howes OD, Wheeler MJ, Meaney AM, O'Keane V, Fogelman I, Blake G, Murray RM, Smith S, Bone mineral density and its relationship to prolactin levels in patients taking antipsychotic treatment., Journal of clinical psychopharmacology, 25, (3), 2005, p259-61 Journal Article, 2005

O'Keane V, Dinan TG, Scott L, Corcoran C, Changes in hypothalamic-pituitary-adrenal axis measures after vagus nerve stimulation therapy in chronic depression., Biological psychiatry, 58, (12), 2005, p963-8 Journal Article, 2005 DOI

Corcoran C, Connor TJ, O'Keane V, Garland MR, The effects of vagus nerve stimulation on pro- and anti-inflammatory cytokines in humans: a preliminary report., Neuroimmunomodulation, 12, (5), 2005, p307-9 Journal Article, 2005 DOI

Cleare AJ, O'Keane V, Miell JP, Levels of DHEA and DHEAS and responses to CRH stimulation and hydrocortisone treatment in chronic fatigue syndrome., Psychoneuroendocrinology, 29, (6), 2004, p724-32 Journal Article, 2004 DOI

Meaney AM, Smith S, Howes OD, O'Brien M, Murray RM, O'Keane V, Effects of long-term prolactin-raising antipsychotic medication on bone mineral density in patients with schizophrenia., The British journal of psychiatry : the journal of mental science, 184, 2004, p503-8 Journal Article, 2004

Cassidy E, O'Connor R, O'Keane V, Prevalence of post-stroke depression in an Irish sample and its relationship with disability and outcome following inpatient rehabilitation., Disability and rehabilitation, 26, (2), 2004, p71-7 Journal Article, 2004 DOI

Corcoran C, Wong ML, O'Keane V, Bupropion in the management of apathy., Journal of psychopharmacology (Oxford, England), 18, (1), 2004, p133-5 Journal Article, 2004 DOI

Gafoor R, O'Keane V, Three case reports of secondary mania: evidence supporting a right frontotemporal locus., European psychiatry : the journal of the Association of European Psychiatrists, 18, (1), 2003, p32-3 Journal Article, 2003

Cassidy EM, Tomkins E, Dinan T, Hardiman O, O'Keane V, Central 5-HT receptor hypersensitivity in migraine without aura., Cephalalgia : an international journal of headache, 23, (1), 2003, p29-34 Journal Article, 2003

Meaney AM, O'Keane V, Reduced bone mineral density in patients with schizophrenia receiving prolactin raising anti-psychotic medication., Journal of psychopharmacology (Oxford, England), 17, (4), 2003, p455-8 Journal Article, 2003

Cassidy EM, Tomkins E, Sharifi N, Dinan T, Hardiman O, O'Keane V, Differing central amine receptor sensitivity in different migraine subtypes? A neuroendocrine study using buspirone., Pain, 101, (3), 2003, p283-90 Journal Article, 2003

Cassidy EM, Tomkins E, Hardiman O, O'Keane V, Factors associated with burden of primary headache in a specialty clinic., Headache, 43, (6), 2003, p638-44 Journal Article, 2003

Cassidy EM, Walsh MT, O'Connor R, Condren RM, Ryan M, O'Keane V, Kenny D, Dinan T, Platelet surface glycoprotein expression in post-stroke depression: a preliminary study., Psychiatry research, 118, (2), 2003, p175-81 Journal Article, 2003

Smith S, Wheeler MJ, Murray R, O'Keane V, The effects of antipsychotic-induced hyperprolactinaemia on the hypothalamic-pituitary-gonadal axis., Journal of clinical psychopharmacology, 22, (2), 2002, p109-14 Journal Article, 2002

Meaney AM, O'Keane V, Prolactin and schizophrenia: clinical consequences of hyperprolactinaemia., Life sciences, 71, (9), 2002, p979-92 Journal Article, 2002

Smith SM, O'Keane V, Murray R, Sexual dysfunction in patients taking conventional antipsychotic medication., The British journal of psychiatry : the journal of mental science, 181, 2002, p49-55 Journal Article, 2002

Cassidy EM, Manning D, Byrne S, Bolger E, Murray F, Sharifi N, Wallace E, Keogan M, O'Keane V, Acute effects of low-dose interferon-alpha on serum cortisol and plasma interleukin-6., Journal of psychopharmacology (Oxford, England), 16, (3), 2002, p230-4 Journal Article, 2002

Cleare AJ, Miell J, Heap E, Sookdeo S, Young L, Malhi GS, O'Keane V, Hypothalamo-pituitary-adrenal axis dysfunction in chronic fatigue syndrome, and the effects of low-dose hydrocortisone therapy., The Journal of clinical endocrinology and metabolism, 86, (8), 2001, p3545-54 Journal Article, 2001 DOI

Cassidy EM, O'Brien M, Osman MF, Finucane J, O'Keane V, Lethal catatonia responding to high-dose olanzapine therapy., Journal of psychopharmacology (Oxford, England), 15, (4), 2001, p302-4 Journal Article, 2001

Cleare AJ, O'Keane V, Miell J, Plasma leptin in chronic fatigue syndrome and a placebo-controlled study of the effects of low-dose hydrocortisone on leptin secretion., Clinical endocrinology, 55, (1), 2001, p113-9 Journal Article, 2001

Michael A, O'Keane V, Sexual dysfunction in depression., Human psychopharmacology, 15, (5), 2000, p337-345 Journal Article, 2000 DOI

Pittock SJ, Joyce C, O'Keane V, Hugle B, Hardiman MO, Brett F, Green AJ, Barton DE, King MD, Webb DW, Rapid-onset dystonia-parkinsonism: a clinical and genetic analysis of a new kindred., Neurology, 55, (7), 2000, p991-5 Journal Article, 2000

Cleare AJ, Sookdeo SS, Jones J, O'Keane V, Miell JP, Integrity of the growth hormone/insulin-like growth factor system is maintained in patients with chronic fatigue syndrome., The Journal of clinical endocrinology and metabolism, 85, (4), 2000, p1433-9 Journal Article, 2000 DOI

Cleare AJ, Heap E, Malhi GS, Wessely S, O'Keane V, Miell J, Low-dose hydrocortisone in chronic fatigue syndrome: a randomised crossover trial., Lancet, 353, (9151), 1999, p455-8 Journal Article, 1999 DOI

Head L, Campbell-Hewson GL, O'Keane V, No harm done? Psychological assessment in the A&E department of patients who deliberately harm themselves., Journal of the Royal College of Physicians of London, 33, (1), 1999, p51-5 Journal Article, 1999

Cleare AJ, Murray RM, Sherwood RA, O'Keane V, Abnormal 5-HT1D receptor function in major depression: a neuropharmacological challenge study using sumatriptan., Psychological medicine, 28, (2), 1998, p295-300 Journal Article, 1998

Cleare AJ, Murray RM, O'Keane V, Assessment of serotonergic function in major depression using d-fenfluramine: relation to clinical variables and antidepressant response., Biological psychiatry, 44, (7), 1998, p555-61 Journal Article, 1998

Ismail K, Murray RM, Wheeler MJ, O'Keane V, The dexamethasone suppression test in schizophrenia., Psychological medicine, 28, (2), 1998, p311-7 Journal Article, 1998

Cleare AJ, Murray RM, O'Keane V, Do noradrenergic reuptake inhibitors affect serotonergic function in depression?, Psychopharmacology, 134, (4), 1997, p406-10 Journal Article, 1997

Abel KM, O'Keane V, Murray RM, Cleare AJ, Serotonergic function and negative and depressive symptomatology in schizophrenia and major depression., Psychoneuroendocrinology, 22, (7), 1997, p539-48 Journal Article, 1997

Cooney JM, Lucey JV, O'Keane V, Dinan TG, Specificity of the pyridostigmine/growth hormone challenge in the diagnosis of depression., Biological psychiatry, 42, (9), 1997, p827-33 Journal Article, 1997

Cleare AJ, O'Keane V, Re: Endocrine responses to fenfluramine challenge in chronic fatigue syndrome., Canadian journal of psychiatry. Revue canadienne de psychiatrie, 41, (2), 1996, p129-31 Journal Article, 1996

Abel KM, O'Keane V, Murray RM, Enhancement of the prolactin response to d-fenfluramine in drug-naive schizophrenic patients., The British journal of psychiatry : the journal of mental science, 168, (1), 1996, p57-60 Journal Article, 1996

Cleare AJ, Murray RM, O'Keane V, Reduced prolactin and cortisol responses to d-fenfluramine in depressed compared to healthy matched control subjects., Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 14, (5), 1996, p349-54 Journal Article, 1996 DOI

Thakore JH, O'Keane V, Dinan TG, d-fenfluramine-induced prolactin responses in mania: evidence for serotonergic subsensitivity., The American journal of psychiatry, 153, (11), 1996, p1460-3 Journal Article, 1996 DOI

Cleare AJ, McGregor A, Chambers SM, Dawling S, O'Keane V, Thyroxine replacement increases central 5-hydroxytryptamine activity and reduces depressive symptoms in hypothyroidism., Neuroendocrinology, 64, (1), 1996, p65-9 Journal Article, 1996

Abel KM, O'Keane V, Sherwood RA, Murray RM, Plasma homovanillic acid profile at different phases of the ovulatory cycle in healthy women., Biological psychiatry, 39, (12), 1996, p1039-43 Journal Article, 1996 DOI

Cleare AJ, McGregor A, O'Keane V, Neuroendocrine evidence for an association between hypothyroidism, reduced central 5-HT activity and depression., Clinical endocrinology, 43, (6), 1995, p713-9 Journal Article, 1995

Cleare AJ, Bearn J, Allain T, McGregor A, Wessely S, Murray RM, O'Keane V, Contrasting neuroendocrine responses in depression and chronic fatigue syndrome., Journal of affective disorders, 34, (4), 1995, p283-9 Journal Article, 1995

Dinan TG, Thakore J, O'Keane V, Lowering cortisol enhances growth hormone response to growth hormone releasing hormone in healthy subjects., Acta physiologica Scandinavica, 151, (3), 1994, p413-6 Journal Article, 1994 DOI

Dinan TG, O'Keane V, Thakore J, Pyridostigmine induced growth hormone release in mania: focus on the cholinergic/somatostatin system., Clinical endocrinology, 40, (1), 1994, p93-6 Journal Article, 1994

O'Keane V, Abel K, Murray RM, Growth hormone responses to pyridostigmine in schizophrenia: evidence for cholinergic dysfunction., Biological psychiatry, 36, (9), 1994, p582-8 Journal Article, 1994

Ur E, Dinan TG, O'Keane V, Clare AW, McLoughlin L, Rees LH, Turner TH, Grossman A, Besser GM, Effect of metyrapone on the pituitary-adrenal axis in depression: relation to dexamethasone suppressor status., Neuroendocrinology, 56, (4), 1992, p533-8 Journal Article, 1992

O'Keane V, McLoughlin D, Dinan TG, D-fenfluramine-induced prolactin and cortisol release in major depression: response to treatment., Journal of affective disorders, 26, (3), 1992, p143-50 Journal Article, 1992

Bakheit AM, Behan PO, Dinan TG, Gray CE, O'Keane V, Possible upregulation of hypothalamic 5-hydroxytryptamine receptors in patients with postviral fatigue syndrome., BMJ (Clinical research ed.), 304, (6833), 1992, p1010-2 Journal Article, 1992

O'Keane V, Dinan TG, Sex steroid priming effects on growth hormone response to pyridostigmine throughout the menstrual cycle., The Journal of clinical endocrinology and metabolism, 75, (1), 1992, p11-4 Journal Article, 1992 DOI

O'Keane V, O'Flynn K, Lucey J, Dinan TG, Pyridostigmine-induced growth hormone responses in healthy and depressed subjects: evidence for cholinergic supersensitivity in depression., Psychological medicine, 22, (1), 1992, p55-60 Journal Article, 1992

Lucey JV, O'Keane V, Butcher G, Clare AW, Dinan TG, Cortisol and prolactin responses to d-fenfluramine in non-depressed patients with obsessive-compulsive disorder: a comparison with depressed and healthy controls., The British journal of psychiatry : the journal of mental science, 161, 1992, p517-21 Journal Article, 1992

O'Keane V, Moloney E, O'Neill H, O'Connor A, Smith C, Dinan TG, Blunted prolactin responses to d-fenfluramine in sociopathy. Evidence for subsensitivity of central serotonergic function., The British journal of psychiatry : the journal of mental science, 160, 1992, p643-6 Journal Article, 1992

Lucey JV, O'Keane V, O'Flynn K, Clare AW, Dinan TG, Gender and age differences in the growth hormone response to pyridostigmine., International clinical psychopharmacology, 6, (2), 1991, p105-9 Journal Article, 1991

O'Keane V, Dinan TG, Prolactin and cortisol responses to d-fenfluramine in major depression: evidence for diminished responsivity of central serotonergic function., The American journal of psychiatry, 148, (8), 1991, p1009-15 Journal Article, 1991 DOI

O'Flynn K, O'Keane V, Lucey JV, Dinan TG, Effect of fluoxetine on noradrenergic mediated growth hormone release: a double blind, placebo-controlled study., Biological psychiatry, 30, (4), 1991, p377-82 Journal Article, 1991

O'Keane V, O'Hanlon M, Webb M, Dinan T, d-fenfluramine/prolactin response throughout the menstrual cycle: evidence for an oestrogen-induced alteration., Clinical endocrinology, 34, (4), 1991, p289-92 Journal Article, 1991

Dinan TG, Yatham LN, O'Keane V, Barry S, Blunting of noradrenergic-stimulated growth hormone release in mania., The American journal of psychiatry, 148, (7), 1991, p936-8 Journal Article, 1991 DOI

Dinan TG, O'Keane V, O'Boyle C, Chua A, Keeling PW, A comparison of the mental status, personality profiles and life events of patients with irritable bowel syndrome and peptic ulcer disease., Acta psychiatrica Scandinavica, 84, (1), 1991, p26-8 Journal Article, 1991

Dinan TG, O'Keane V, The premenstrual syndrome: a psychoneuroendocrine perspective., Baillière's clinical endocrinology and metabolism, 5, (1), 1991, p143-65 Journal Article, 1991

Research Expertise

Projects

  • Title
    • A Longitudinal study of the clinical features, stress biomarkers and brain imaging findings in young adults with depression
  • Summary
    • A key problem in clinical psychiatry is identifying biomarkers for psychiatric disorders. The clinical presentation of depression is very variable, but there are no biomarkers to identify one form from another and thus look for targeted treatments. We are examining the clinical features, biomarkers, and neuroimaging data, with an emphasis on stress systems, in first-episode depression in young adults. We are particularly focusing on biomarkers related to the function of the hypothalamic-pituitary-adrenalaxis (HPAA). This study is being conducted in our local psychiatry service based in Tallaght, South Dublin. The population is demographically stable and the clinical services are well developed allowing for a longitudinal cohort study. Our aims are to get a detailed baseline evaluation of the following measures in young adults at their first episode of depression and look at possible changes in these measures over time: - Clinical features of depression, particularly suicidal ideation, biological features and response to treatment; - HPAA: by examining the cortisol awakening response (CAR) and diurnal pattern of salivary cortisol concentrations; and detailed steroid metabolite profile in the urine; - fMRI, DTI and resting state MRI of limbic and associated brain areas; - blood biomarkers, particularly inflammatory and kyneurenine pathway markers - genetic and epigenetic markers. We will observe how these measures change over time: in the first instance at 1 year. The project is a collaboration between the School of Medicine, TCIN, TCD; and the clinical psychiatry services in south dublin.
  • Funding Agency
    • Meath Foundation, Tallaght Hospital
  • Date From
    • 2013
  • Date To
    • 2017
  • Title
    • Depression in pregnant women: effects on the baby's stress systems
  • Summary
    • "Fetal programming" is the process whereby fetal systems, via adaption to intra-uterine conditions, become programmed to respond to the post-uterine environment in a similar way. Animal studies demonstrate that baby/pup hypothalamic-pituitary-adrenal (HPA) axis function is programmed by maternal HPA axis during gestation via transplacental cortisol transmission. Cortisol alters neuronal development and reduces hippocampal glucocorticoid receptor (GR) expression. GRs determine the homeostatic set point of the HPA axis because of their function in terminating the stress response centrally. Maternal gestational stress, in animals, results in abnormal HPA axis homeostasis and responses to stressors, and behaviours similar to those in animal models of depression, in the offspring. There is accumulating evidence in humans that high maternal cortisol levels during pregnancy, associated with psychosocial stress, can have a negative impact on baby HPA axis function and confer developmental disadvantage up to adulthood, and depression thereafter. The point where psychosocial stress has a negative impact on the maternal HPA axis remains undefined. In previous work we established that depression during pregnancy is specifically associated with increased diurnal cortisol secretion during the second trimester and that, in a small sample of babies, those born to depressed women had higher cortisol levels and blunted cortisol stress responses. Our main aim is to confirm, in a large sample, that depression in pregnant women defines a clinical state that is likely to impact on baby HPA axis homeostasis and stress responses at week 8 post-birth. Our second aim is to observe how baby HPA axis function, behaviour and development alter over the first year of life in relation to the maternal HPA axis, taking into account maternal-baby attachment and parenting style. We will also examine the hypothesis that epigenetic processes in the GR gene are involved in the fetal programming of the HPA axis.
  • Funding Agency
    • HRB
  • Date From
    • 2013
  • Date To
    • 2016

Keywords

ANTENATAL DEPRESSION; DEPRESSED-PATIENTS; DEPRESSION ILLNESS; Developmental and mental disorders; Epigenetics; GENETIC-MARKER; HYPOTHALAMICO-PITUITARY-ADRENAL (HPA) AXIS; INFLAMMATION; LONG-TERM DEPRESSION; Stress

Recognition

Awards and Honours

Health Research AwardAn investigation of the effects of maternal depression during pregnancy on the baby's HPA (hypothalamic-pituitary-adrenal) axis and development during the first year of life 2013

National Children's Research Centre: project funding awarded. "Effects of maternal hypothalamic-pituitary-adrenal (HPA) axis function during pregnancy on baby HPA axis stress responses following birth: possible epigenetic mechanisms." 2014

National Children's Research Centre: PhD funding awarded. "Effects of maternal hypothalamic-pituitary-adrenal (HPA) axis function during pregnancy on baby HPA axis stress responses following birth: possible epigenetic mechanisms." 2013

Memberships

Fellow of the Irish College of Psychiatrists 2008 – ongoing

Member of the Royal College of Psychiatrists 1989

Member of the International Society for Psychoneuroendocrinology 1993

Member of European Congress Neuro-psychopharmacology 2014


Last updated 23 November 2016 School Web Administrator (Email).