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Declan Mc Loughlin
Academic Consultant, Psychiatry
Academic Consultant, Trinity Inst. of Neurosciences (TCIN)

Biography

Prof McLoughlin took up the new post of Research Professor of Psychiatry on July 1, 2007. Prior to this I was a Senior Lecturer in the MRC Centre for Neurodegeneration Research at the Institute of Psychiatry, King's College London.

Publications and Further Research Outputs

Peer-Reviewed Publications

Kolshus E, Dalton VS, Ryan KM, McLoughlin DM, When less is more - microRNAs and psychiatric disorders., Acta psychiatrica Scandinavica, 129, (4), 2014, p241 - 256 Journal Article, 2014 DOI

Lambe S, Mogg A, Eranti A, Pluck G, Hastilow S, McLoughlin DM, Trends in use of electroconvulsive therapy in South London from 1949 to 2006, J ECT, 30, (4), 2014, p309 - 314 Journal Article, 2014

Noone M, Semkovska M, Carton M, Dunne R, Horgan JP, O'Kane B, McLoughlin DM , Construction and updating of a public events questionnaire for repeated measures longitudinal studies, Front Psychol, 5:230., 2014 Journal Article, 2014 TARA - Full Text URL

Smith KJ, Mullally S, McLoughlin D, O'Mara SM , Validation of the Face-Name Pairs Task in Major Depression: Impaired recall but not recognition. , Frontiers in Psychology , Feb 12;5:92. , 2014 Journal Article, 2014

O'Donovan SM, O'Mara S, Dunn MJ, McLoughlin DM , The persisting effects of electroconvulsive stimulation on the hippocampal proteome, Brain Research , 1593, 2014, p106 - 116 Journal Article, 2014

O'Donovan S*, Dalton VS*, Harkin A, McLoughlin DM; * joint first author, Effects of brief pulse and ultrabrief pulse electroconvulsive stimulation on rodent brain and behaviour in the corticosterone model of depression. , International Journal of Neuropsychopharmacology. DOI: 10.1017/S1461145714000500, 17, (9), 2014, p1477 - 1486 Journal Article, 2014 DOI

Dalton, VS, Kolshus, E, McLoughlin, DM, Epigenetics and depression: return of the repressed, Journal of Affective Disorders , 155, (1), 2014, p1-12 Journal Article, 2014 DOI TARA - Full Text

Glaviano A, O'Donovan SM, Ryan KM, O'Mara S, Dunn MJ, McLoughlin DM , Acute phase plasma proteins are altered by electroconvulsive stimulation, J Psychopharmacol , 28, (12), 2014, p1125 - 1134 Journal Article, 2014

Ryan, K.M., O'Donovan, S.M., McLoughlin, D.M., Electroconvulsive stimulation alters levels of BDNF-associated microRNAs, Neuroscience Letters , 549, 2013, p125-129 Journal Article, 2013 DOI

Skelly N, Schnittger RI, Butterly L, Frorath C, Morgan C, McLoughlin DM, Fearon P, Quality of care in psychosis and bipolar disorder from the service user perspective., Qualitative health research, 23, (12), 2013, p1672-85 Journal Article, 2013 DOI

Jelovac, A., Kolshus, E., McLoughlin, D.M., Relapse following successful electroconvulsive therapy for major depression: A meta-analysis, Neuropsychopharmacology, 38, (12), 2013, p2467-2474 Journal Article, 2013 DOI TARA - Full Text

Agyapong, V.I.O., McLoughlin, D.M., Farren, C.K., Six-months outcomes of a randomised trial of supportive text messaging for depression and comorbid alcohol use disorder, Journal of Affective Disorders, 151, (1), 2013, p100-104 Journal Article, 2013 DOI

Practical administration of ECT in, editor(s)A. Easton , The ECT Handbook., London, Royal College of Psychiatrists, 2013, [Dunne, R., McLoughlin, D.M.] Book Chapter, 2013

Thekiso, T.B., Heron, E.A., Masood, B., Murphy, M., McLoughlin, D.M., Kennedy, N., Mauling of the "celtic Tiger": Clinical characteristics and outcome of first-episode depression secondary to the economic recession in Ireland, Journal of Affective Disorders, 151, (2), 2013, p455-460 Journal Article, 2013 DOI

Semkovska M, McLoughlin DM, Measuring Retrograde Autobiographical Amnesia Following Electroconvulsive Therapy: Historical Perspective and Current Issues., The journal of ECT, 29, (2), 2013, p127-133 Journal Article, 2013 DOI

Agyapong V.I.O., Singh K., Savage M., Thekiso B.T., Finn M, Farren C.K. McLoughlin D.M., Use of codeine-containing medicines by Irish psychiatric in-patients before and after regulatory limitations on their supply. , Irish Journal of Psychological Medicine, 30, (01), 2013, p7 - 12 Journal Article, 2013 DOI TARA - Full Text

Agyapong VI, Milnes J, McLoughlin DM, Farren CK, Perception of patients with alcohol use disorder and comorbid depression about the usefulness of supportive text messages., Technology and health care : official journal of the European Society for Engineering and Medicine, 21, (1), 2013, p31-39 Journal Article, 2013 DOI

Ryan KM, O'Donovan SM, McLoughlin DM, Electroconvulsive stimulation alters levels of BDNF-associated microRNAs., Neuroscience letters, 549, 2013, p125-9 Journal Article, 2013 DOI

Sinead O'Donovan, Mark Kennedy, Blaithin Guinan, Shane O'Mara, Declan M. McLoughlin, A comparison of brief pulse and ultrabrief pulse electroconvulsive stimulation on rodent brain and behaviour, Progress in Neuropsychopharmacology & Biological Psychiatry, 37, (1), 2012, p147-52 Journal Article, 2012 DOI TARA - Full Text

Agyapong VI, McLoughlin D, Promoting psychiatry as a career option for Ghanaian medical students through a public-speaking competition., Academic psychiatry : the journal of the American Association of Directors of Psychiatric Residency Training and the Association for Academic Psychiatry, 36, (3), 2012, p229-32 Journal Article, 2012 DOI

Hao Y, Chai KH, McLoughlin DM, Chan HY, Lau KF, Promoter characterization and genomic organization of the human X11ß gene APBA2., Neuroreport, 23, (3), 2012, p146-51 Journal Article, 2012

Electroconvulsive therapy, brain stimulation and neurosurgery for mental illness in, editor(s)P. Wright , Core Psychiatry, London, Elsevier, 2012, [Dunne, R., McLoughlin, D.M.] Book Chapter, 2012

Semkovska M, Noone M, Carton M, McLoughlin DM, Measuring consistency of autobiographical memory recall in depression., Psychiatry research, 197, (1-2), 2012, p41-8 Journal Article, 2012 DOI

Frodl T, Carballedo A, Hughes MM, Saleh K, Fagan A, Skokauskas N, McLoughlin DM, Meaney J, O'Keane V, Connor TJ, Reduced expression of glucocorticoid-inducible genes GILZ and SGK-1: high IL-6 levels are associated with reduced hippocampal volumes in major depressive disorder., Translational psychiatry, 2, 2012, pe88 Journal Article, 2012 DOI

Hughes MM, Carballedo A, McLoughlin DM, Amico F, Harkin A, Frodl T, Connor TJ, Tryptophan depletion in depressed patients occurs independent of kynurenine pathway activation., Brain, behavior, and immunity, 26, (6), 2012, p979-987 Journal Article, 2012 DOI

Dunne RA, McLoughlin DM, Systematic review and meta-analysis of bifrontal electroconvulsive therapy versus bilateral and unilateral electroconvulsive therapy in depression., The World Journal of Biological Psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry, 13, (4), 2012, p248-258 Review Article, 2012

Agyapong VI, Ahern S, McLoughlin DM, Farren CK, Supportive text messaging for depression and comorbid alcohol use disorder: single-blind randomised trial., Journal of affective disorders, 141, (2-3), 2012, p168-76 Journal Article, 2012 DOI

Chai KH, McLoughlin DM, Chan TF, Chan HY, Lau KF, Genomic organization and promoter cloning of the human X11" gene APBA1., DNA and cell biology, 31, (5), 2012, p651-9 Journal Article, 2012 DOI

O'Donovan S, Kennedy M, Guinan B, O'Mara S, McLoughlin DM, A comparison of brief pulse and ultrabrief pulse electroconvulsive stimulation on rodent brain and behaviour., Progress in neuro-psychopharmacology & biological psychiatry, 37, (1), 2012, p147-52 Journal Article, 2012 DOI

Ross A. Dunne, Declan M. McLoughlin, Regional Variation in Electroconvulsive Therapy Use, Irish Medical Journal, 104, (3), 2011, p84 - 87 Journal Article, 2011 TARA - Full Text URL

Semkovska M, Keane D, Babalola O, McLoughlin DM, Unilateral brief-pulse electroconvulsive therapy and cognition: effects of electrode placement, stimulus dosage and time., Journal of psychiatric research, 45, (6), 2011, p770-80 Journal Article, 2011

Dunne R, McLoughlin DM, Regional variation in electroconvulsive therapy use., Irish medical journal, 104, (3), 2011, p84-7 Journal Article, 2011

Eranti SV, Thirthalli J, Pattan V, Mogg A, Pluck G, Velayudhan L, Chan J, Gangadhar BN, McLoughlin DM, Comparison of electroconvulsive therapy practice between London and Bengaluru., The journal of ECT, 27, (4), 2011, p275-80 Journal Article, 2011

Agyapong V.I.O., Farren C.K. and McLoughlin D, Mobile phone text message interventions in psychiatry- what are the possibilities?, Current Psychiatry Reviews, 7, (1), 2011, p1 - 7 Journal Article, 2011

Maria Semkovska, Deborah Keane, Oyemi Babalola, Declan M. McLoughlin, Unilateral brief-pulse electroconvulsive therapy and cognition: Effects of electrode placement, stimulus dosage and time, Journal of Psychiatric Research, 45, (6), 2011, p770-780 Journal Article, 2011

Manser C, Guillot F, Vagnoni A, Davies J, Lau KF, McLoughlin DM, De Vos KJ, Miller CC, Lemur tyrosine kinase-2 signalling regulates kinesin-1 light chain-2 phosphorylation and binding of Smad2 cargo., Oncogene, 2011 Journal Article, 2011

Wassif, WS, McLoughlin, DM, Vincent, RP, Conroy, S, Russell, GFM, Taylor, NF, Steroid metabolism and excretion in severe anorexia nervosa: effects of refeeding, AMERICAN JOURNAL OF CLINICAL NUTRITION, 93, 2011 Journal Article, 2011

Semkovska M, McLoughlin DM , Cognitive effects of electroconvulsive therapy for depression: a systematic review and meta-analysis., Biological Psychiatry, 2010 Journal Article, 2010

Jacqueline C. Mitchell, Michael S. Perkinton, Darran M. Yates, Kwok-Fai Lau, Boris Rogelj, Christopher C.J. Miller, Declan M. McLoughlin, Expression of the Neuronal Adaptor Protein X11alpha Protects Against Memory Dysfunction in a Transgenic Mouse Model of Alzheimer's Disease, Journal of Alzheimer's Disease, 20, (1), 2010, p31-36 Journal Article, 2010 TARA - Full Text

Semkovska M, McLoughlin DM, Objective cognitive performance associated with electroconvulsive therapy for depression: a systematic review and meta-analysis., Biological psychiatry, 68, (6), 2010, p568-77 Journal Article, 2010 DOI

Yu HT, Chan WW, Chai KH, Lee CW, Chang RC, Yu MS, McLoughlin DM, Miller CC, Lau KF, Transcriptional regulation of human FE65, a ligand of Alzheimer's disease amyloid precursor protein, by Sp1., Journal of Cellular Biochemistry, 109, (4), 2010, p782-93 Journal Article, 2010 DOI

Tracy DK, O'Daly O, Joyce DW, Michalopoulou PG, Basit BB, Dhillon G, McLoughlin DM, Shergill SS, An evoked auditory response fMRI study of the effects of rTMS on putative AVH pathways in healthy volunteers., Neuropsychologia, 48, (1), 2010, p270-7 Journal Article, 2010 DOI

Lau KF, Perkinton MS, Rodriguez L, McLoughlin DM, Miller CC, An X11[alpha]/FSBP complex represses transcription of the GSK3[beta] gene promoter., NeuroReport, 21, (11), 2010, p1-6 Journal Article, 2010 TARA - Full Text

Tudor EL, Galtrey CM, Perkinton MS, Lau KF, De Vos KJ, Mitchell JC, Ackerley S, Hortobágyi T, Vámos E, Leigh PN, Klasen C, McLoughlin DM, Shaw CE, Miller CC, Amyotrophic lateral sclerosis mutant vesicle-associated membrane protein-associated protein-B transgenic mice develop TAR-DNA-binding protein-43 pathology., Neuroscience, 167, (3), 2010, p774-785 Journal Article, 2010 DOI TARA - Full Text

Transcranial magnetic stimulation. in, editor(s)Gelder M, Andrreasen, Lopez-Ibor J, Geddes J , New Oxford Textbook of Psychiatry, Oxford University Press, 2009, [McLoughlin D, Mogg A] Book Chapter, 2009

Eranti, SV, Mogg, AJ, Pluck, GC, Landau, S, McLoughlin, DM, Methohexitone, propofol and etomidate in electroconvulsive therapy for depression: a naturalistic comparison study., Journal of Affective Disorders, 113, (1-2), 2009, p165 - 171 Journal Article, 2009 DOI

McLoughlin DM, Review: high frequency repetitive transcranial magnetic stimulation improves symptoms of major depression. , Evidence Based Mental Health., 12, (3), 2009, p80-81 Journal Article, 2009 DOI

Stevenson A, Yates DM, Manser C, De Vos KJ, Vagnoni A, Leigh PN, McLoughlin DM, Miller CCJ, Riluzole protects against glutamate-induced slowing of neurofilament axonal transport. , Neuroscience Letters, 454, (2), 2009, p161-164 Journal Article, 2009 DOI

Dunne R, Kavanagh A, McLoughlin DM, Electroconvulsive therapy, capacity and the law in Ireland., Irish Journal of Psychological Medicine, 26, 2009, p3-5 Journal Article, 2009 TARA - Full Text URL

Yates, DM, Manser, C, De Vos, KJ, Shaw, CE, McLoughlin, DM, Miller, CC, Neurofilament subunit (NFL) head domain phosphorylation regulates axonal transport of neurofilaments., European Journal of Cell Biology, 88, (4), 2009, p193 - 202 Journal Article, 2009 DOI

Nicholson TRJ, Pariante C, McLoughlin D, Stendhal syndrome: a case of cultural overload., BMJ Case Reports, 2009 Journal Article, 2009 DOI

Mitchell JC, Ariff BB, Yates DM, Lau KF, Perkinton MS, Rogelj B, Stephenson JD, Miller CC, McLoughlin DM., X11beta rescues memory and long-term potentiation deficits in Alzheimer's disease APPswe Tg2576 mice., Human Molecular Genetics, 18, (23), 2009, p4492-4500 Journal Article, 2009 TARA - Full Text DOI URL

Kelly, B.D., McLoughlin, D.M., Physician-assisted suicide and psychiatry, Psychiatry, 8, (7), 2009, p276-279 Journal Article, 2009 DOI URL

Mogg, A, Pluck, G, Eranti, SV, Landau, S, Purvis, R, Brown, RG, Curtis, V, Howard, R, Philpot, M, McLoughlin, DM, A randomized controlled trial with 4-month follow-up of adjunctive repetitive transcranial magnetic stimulation of the left prefrontal cortex for depression., Psychological Medicine, 38, (3), 2008, p323 - 333 Journal Article, 2008 DOI

Lau, KF, Chan, WM, Perkinton, MS, Tudor, EL, Chang, RC, Chan, HY, McLoughlin, DM, Miller, CC, Dexras1 interacts with FE65 to regulate FE65-amyloid precursor protein-dependent transcription., The Journal of Biological Chemistry, 283, (50), 2008, p34728 - 34737 Journal Article, 2008 DOI TARA - Full Text

Dunne R, McLoughlin DM, Physical treatments., Medicine, 36, (9), 2008, p499-500 Journal Article, 2008 DOI

McLoughlin DM, Vagus rules still apply., Psychological Medicine, 38, 2008, p625-627 Journal Article, 2008 DOI

Knapp, M, Romeo, R, Mogg, A, Eranti, S, Pluck, G, Purvis, R, Brown, RG, Howard, R, Philpot, M, Rothwell, J, Edwards, D, McLoughlin, DM, Cost-effectiveness of transcranial magnetic stimulation vs. electroconvulsive therapy for severe depression: a multi-centre randomised controlled trial., Journal of Affective Disorders, 109, (3), 2008, p273 - 285 Journal Article, 2008 DOI

McLoughlin, DM, Miller, CC, The FE65 proteins and Alzheimer's disease., Journal of Neuroscience Research, 86, (4), 2008, p744 - 754 Journal Article, 2008 DOI

Yates D, McLoughlin DM, The molecular pathology of Alzheimer's disease, Psychiatry, 7, (1), 2008, p1-5 Journal Article, 2008 DOI

Hotopf M, Laird B, Singh I, Churchill R, David AS, McLoughlin DM, Richardson G, Szmukler G, Capacity, consent and electroconvulsive therapy: A qualitative and cross-sectional study, Journal of Mental Health, 17, (3), 2008, p315-325 Journal Article, 2008 DOI

Manser, C, Stevenson, A, Banner, S, Davies, J, Tudor, EL, Ono, Y, Leigh, PN, McLoughlin, DM, Shaw, CE, Miller, CC, Deregulation of PKN1 activity disrupts neurofilament organisation and axonal transport., FEBS Letters, 582, (15), 2008, p2303 - 2308 Journal Article, 2008 DOI

Eranti S, Mogg A, Pluck G, Landau S, Purvis R, Brown RG, Howard R, Knapp M, Philpot M, Rabe-Hesketh S, Romeo R, Rothwell J, Edwards D, McLoughlin DM, A Randomized, Controlled Trial With 6-Month Follow-Up of Repetitive Transcranial Magnetic Stimulation and Electroconvulsive Therapy for Severe Depression , American Journal of Psychiatry, 164, 2007, p73-81 Journal Article, 2007 TARA - Full Text DOI

McLoughlin DM , Repetitive Transcranial Magnetic Stimulation Versus Electroconvulsive Therapy: Efficacy of Treatment in Nonpsychotic Patients With Depression , 2007, - 1118-1119. Miscellaneous, 2007 DOI

McLoughlin, DM, Mogg, A, Eranti, S, Pluck, G, Purvis, R, Edwards, D, Landau, S, Brown, R, Rabe-Heskith, S, Howard, R, Philpot, M, Rothwell, J, Romeo, R, Knapp, M, The clinical effectiveness and cost of repetitive transcranial magnetic stimulation versus electroconvulsive therapy in severe depression: a multicentre pragmatic randomised controlled trial and economic analysis., Health Technology Assessment (Winchester, England), 11, (24), 2007, p1 - 54 Journal Article, 2007 URL

Mogg, A, Purvis, R, Eranti, S, Contell, F, Taylor, JP, Nicholson, T, Brown, RG, McLoughlin, DM, Repetitive transcranial magnetic stimulation for negative symptoms of schizophrenia: a randomized controlled pilot study., Schizophrenia Research, 93, (1-3), 2007, p221 - 228 Journal Article, 2007 DOI

De Vos, KJ, Chapman, AL, Tennant, ME, Manser, C, Tudor, EL, Lau, KF, Brownlees, J, Ackerley, S, Shaw, PJ, McLoughlin, DM, Shaw, CE, Leigh, PN, Miller, CC, Grierson, AJ, Familial amyotrophic lateral sclerosis-linked SOD1 mutants perturb fast axonal transport to reduce axonal mitochondria content., Human Molecular Genetics, 16, (22), 2007, p2720 - 2728 Journal Article, 2007 DOI

Kelly BD, McLoughlin DM, Physician-assisted suicide and psychiatry, Psychiatry, 5, (8), 2006, p289-291 Journal Article, 2006 DOI

Miller, CC, McLoughlin, DM, Lau, KF, Tennant, ME, Rogelj, B, The X11 proteins, Abeta production and Alzheimer's disease., Trends in Neurosciences, 29, (5), 2006, p280 - 285 Journal Article, 2006 DOI

Rogelj, B, Mitchell, JC, Miller, CC, McLoughlin, DM, The X11/Mint family of adaptor proteins., Brain Research Reviews, 52, (2), 2006, p305 - 315 Journal Article, 2006 DOI

Mineur YS, McLoughlin D, Crusio WE, Sluyter F, Genetic mouse models of Alzheimer's disease., Neural Plast, 12, (4), 2005, p299-310 Journal Article, 2005 TARA - Full Text DOI

Tudor, EL, Perkinton, MS, Schmidt, A, Ackerley, S, Brownlees, J, Jacobsen, NJ, Byers, HL, Ward, M, Hall, A, Leigh, PN, Shaw, CE, McLoughlin, DM, Miller, CC, ALS2/Alsin regulates Rac-PAK signaling and neurite outgrowth., The Journal of Biological Chemistry, 280, (41), 2005, p34735 - 34740 Journal Article, 2005 DOI TARA - Full Text

Uher, R, Yoganathan, D, Mogg, A, Eranti, SV, Treasure, J, Campbell, IC, McLoughlin, DM, Schmidt, U, Effect of left prefrontal repetitive transcranial magnetic stimulation on food craving., Biological Psychiatry, 58, (10), 2005, p840 - 842 Journal Article, 2005 DOI

Is ECT given in bipolar disorder and does TMS offer more? in, editor(s)McDonald C, Schulz K, Murray RM, Tohen M , Bipolar Disorder: The Upswing in Research and Treatment., London, Parthenon Publishing, 2005, [Mogg A, Erranti S, Pluck G, McLoughlin DM. ] Book Chapter, 2005

Lee J-H, Lau K-F, Perkinton MS, Standen CL, Rogelj B, Falinska A, McLoughlin DM, Miller CCJ, The Neuronal Adaptor Protein X11beta Reduces Amyloid beta-Protein Levels and Amyloid Plaque Formation in the Brains of Transgenic Mice*, Journal of Biological Chemistry, 279, 2004, p49099-49104 Journal Article, 2004 TARA - Full Text DOI

Perkinton, MS, Standen, CL, Lau, KF, Kesavapany, S, Byers, HL, Ward, M, McLoughlin, DM, Miller, CC, The c-Abl tyrosine kinase phosphorylates the Fe65 adaptor protein to stimulate Fe65/amyloid precursor protein nuclear signaling., The Journal of Biological Chemistry, 279, (21), 2004, p22084 - 22091 Journal Article, 2004 DOI TARA - Full Text

Lee, JH, Lau, KF, Perkinton, MS, Standen, CL, Shemilt, SJ, Mercken, L, Cooper, JD, McLoughlin, DM, Miller, CC, The neuronal adaptor protein X11alpha reduces Abeta levels in the brains of Alzheimer's APPswe Tg2576 transgenic mice., The Journal of Biological Chemistry, 278, (47), 2003, p47025 - 47029 Journal Article, 2003 DOI TARA - Full Text

Kesavapany, S, Lau, KF, Ackerley, S, Banner, SJ, Shemilt, SJ, Cooper, JD, Leigh, PN, Shaw, CE, McLoughlin, DM, Miller, CC, Identification of a novel, membrane-associated neuronal kinase, cyclin-dependent kinase 5/p35-regulated kinase., The Journal of Neuroscience, 23, (12), 2003, p4975 - 4983 Journal Article, 2003 TARA - Full Text

McLoughlin DM, Review: repetitive transcranial magnetic stimulation is of unknown effectiveness in people with depression., Evidence Based Mental Health, 6, (4), 2003, p118 Journal Article, 2003 TARA - Full Text DOI

Eranti SV, McLoughlin DM, Electroconvulsive therapy - state of the art, British Journal of Psychiaty, 182, 2003, p8 - 9 Journal Article, 2003 TARA - Full Text

Eranti SV, McLoughlin DM. , Changing use of ECT, 2003, - 173 Miscellaneous, 2003 URL

Kesavapany, S, Banner, SJ, Lau, KF, Shaw, CE, Miller, CC, Cooper, JD, McLoughlin, DM, Expression of the Fe65 adapter protein in adult and developing mouse brain., Neuroscience, 115, (3), 2002, p951 - 960 Journal Article, 2002 DOI

Lovestone, S, McLoughlin, DM, Protein aggregates and dementia: is there a common toxicity?, Journal of Neurology, Neurosurgery, and Psychiatry, 72, (2), 2002, p152 - 161 Journal Article, 2002

Kelly, B.D., McLoughlin, D.M., Euthanasia, assisted suicide and psychiatry: a Pandora's box, Journal of Psychiatry, 181, (4), 2002, p278-279 Journal Article, 2002 DOI TARA - Full Text URL URL

Lau, KF, Howlett, DR, Kesavapany, S, Standen, CL, Dingwall, C, McLoughlin, DM, Miller, CC, Cyclin-dependent kinase-5/p35 phosphorylates Presenilin 1 to regulate carboxy-terminal fragment stability., Molecular and Cellular Neurosciences, 20, (1), 2002, p13 - 20 Journal Article, 2002 DOI

Lyons, D, McLoughlin, DM, Recent advances: Psychiatry., BMJ (Clinical research ed.), 323, (7323), 2001, p1228 - 1231 Journal Article, 2001

McLoughlin, DM, Standen, CL, Lau, KF, Ackerley, S, Bartnikas, TP, Gitlin, JD, Miller, CC, The neuronal adaptor protein X11alpha interacts with the copper chaperone for SOD1 and regulates SOD1 activity., The Journal of Biological Chemistry, 276, (12), 2001, p9303 - 9307 Journal Article, 2001 TARA - Full Text DOI

Standen, CL, Brownlees, J, Grierson, AJ, Kesavapany, S, Lau, KF, McLoughlin, DM, Miller, CC, Phosphorylation of thr(668) in the cytoplasmic domain of the Alzheimer's disease amyloid precursor protein by stress-activated protein kinase 1b (Jun N-terminal kinase-3)., Journal of Neurochemistry, 76, (1), 2001, p316 - 320 Journal Article, 2001 DOI

Kesavapany S, Lau K-F, McLoughlin DM, Brownlees J, Ackerley S, Leigh NP, Shaw CE, Miller CCJ, p35/cdk5 binds and phosphorylates β-catenin and regulates β-catenin/presenilin-1 interaction, European Journal of Neuroscience, 13, (2), 2001, p241-247 Journal Article, 2001 DOI

Lau K-F, McLoughlin DM, Standen C, Irving NG, Miller CCJ, Fe65 and X11beta co-localise with and compete for binding to the amyloid precursor protein. , Neuroreport, 11, (16), 2000, p3607-3610 Journal Article, 2000 URL

Lau K-F, McLoughlin DM, Standen C, Miller CCJ, X11α and X11β Interact with Presenilin-1 via Their PDZ Domains , Molecular Cell Neuroscience, 16, (5), 2000, p555-563 Journal Article, 2000 DOI

Morton J, McLoughlin DM, Whiting S, Russell GFM, Carnitine levels in patients with skeletal myopathy due to anorexia nervosa before and after refeeding., International Journal of Eating Disorders, 26, 1999, p341-344 Journal Article, 1999 URL

McLoughlin DM, Irving NG, Brownlees J, Brion J-P, Leroy K, Miller CCJ, Mint2/X11-like co-localises with the Alzheimer's disease amyloid precursor protein and is associated with neuritic plaques in Alzheimer's disease., European Journal of Neuroscience, 11, (6), 1999, p1988-1994 Journal Article, 1999 DOI

Guidato S, McLoughlin DM, Grierson A, Miller CCJ., Cyclin D2 interacts with cdk-5 and modulates cellular cdk-5/p35 activity., Journal of Neurochemistry, 70, (1), 1998, p335-340 Journal Article, 1998 DOI

McLoughlin DM, Spargo T, Wassif W, Newham D, Peters TJ, Lantos P, Russell GFM, Structural and functional changes in skeletal muscle in anorexia nervosa., Acta Neuropathologica, 95, (6), 1998, p632-640 Journal Article, 1998 DOI

Physical disorders and psychiatric illness. in, editor(s)Wheatley D, Smith D , Psychopharmacology of Cognitive and Psychiatric Disorders in the Elderly., London, Chapman & Hall, 1998, [Krasucki C, McLoughlin DM.] Book Chapter, 1998

Dementia: Basic Neurosciences. in, editor(s)Brocklehurst J, Tallis R, Flint H , Brocklehurst's Textbook of Geriatric Medicine & Gerontology, Edinburgh, Churchill Livingstone, 1998, [Carter J, McLoughlin DM.] Book Chapter, 1998

Blanco G, Brown SDM, Irving N, Miller CCJ, McLoughlin DM. , Mapping of the human and murine X11-like genes, the murine Fe65 gene and the human Fe65-like gene: genes encoding for phosphotyrosine binding domain proteins that interact with the Alzheimer's disease amyloid precursor protein., Mammalian Genome, 9, (6), 1998, p473-475 Journal Article, 1998 DOI

McLoughlin DM, Irving NG, Miller CCJ, The Fe65 and X11 families of proteins: proteins that interact with the Alzheimer's disease amyloid precursor protein., Biochemical Society Transactions, 26, 1998, p497-500 Journal Article, 1998

Substance misuse in the elderly in, Norman IJ, Redfern SJ , Mental Health Care for Elderly People. , London, Churchill Livingstone, 1997, [McLoughlin DM, Farrell M.] Book Chapter, 1997

Holmes C, McLoughlin D, Powell J, Lovestone S., Apolipoprotein E: non-cognitive symptoms and cognitive decline in late onset Alzheimer's disease, 1997, - 274 Miscellaneous, 1997 DOI

McLoughlin DM, Miller CCJ. , The intracellular cytoplasmic domain of the Alzheimer's disease amyloid precursor protein interacts with phosphotyrosisine-binding domain proteins in the yeast two-hybrid system. , FEBS Letters, 397, (2-3), 1996, p197-200 Journal Article, 1996 DOI

McLoughlin D, Levy R., The differential diagnosis of dementia. , Acta Neurologica Scandinavica, S165, 1996, p92-100 Journal Article, 1996

McLoughlin DM, Cooney C, Holmes C, Levy R. , Carer informants for dementia sufferers: carer awareness of cognitive impairment in an elderly-community resident sample., Age and Ageing, 25, (5), 1996, p367-371 Journal Article, 1996 URL

McLoughlin D., A Palpable Hit (review of the movie "Trainspotting") , 1996, - 585 Miscellaneous, 1996 URL

Holmes C, Levy R, McLoughlin DM, Powell JF, Lovestone S. , Apolipoprotein E: non-cognitive symptoms and cognitive decline in late onset Alzheimer's disease., Journal of Neurology, Neurosurgery, and Psychiatry , 61, 1996, p580-583 Journal Article, 1996 DOI

McLoughlin D, Realism about mental illness (review of the television documentary series "Minders")., 1995, - 1205 Miscellaneous, 1995 URL

Richards M, McLoughlin D, Levy R. , The relationship between extrapyramidal signs and cognitive function in patients with moderate to severe Alzheimer's disease., International Journal of Geriatric Psychiatry, 10, (5), 1995, p395-399 Journal Article, 1995 DOI

McLoughlin D, Natural Born Killers, 1995, - 499-500 Miscellaneous, 1995

McLoughlin D, Carter J., Conference Report: The Fourth International Conference on Alzheimer's Disease and Related Disorders, International Journal of Geriatric Psychiatry, 9, 1994, pp1003-1004 Conference Paper, 1994

McLoughlin D, Lovestone S., Alzheimer's disease: recent advances in molecular pathology and genetics., International Journal of Geriatric Psychiatry, 9, (6), 1994, p431-444 Journal Article, 1994 DOI

McLoughlin D, Lucey J, Dinan T., Central serotonergic hyperresponsivity in late-onset Alzheimer's disease. , American Journal of Psychiatry, 151, (11), 1994, p1701-1703 Journal Article, 1994 URL

Farren C, McLoughlin D, Clare A. , Procedures for involuntary admission to public and private psychiatric facilities. , Irish Journal of Psychological Medicine, 9, (2), 1992, p96-100 Journal Article, 1992

O'Keane V, McLoughlin D, Dinan T. , D-fenfluramine-induced prolactin and cortisol release in major depression: response to treatment., Journal of Affective Disorders, 26, (3), 1992, p143-150. Journal Article, 1992 DOI

McLoughlin D, McKeon P., Bipolar disorder and cerebral sarcoidosis., British Journal of Psychiatry, 158, 1991, p410-413 Journal Article, 1991 URL

McLoughlin D, Priest R., Life after Halcion: what are the remaining options?, 1991, - 13-15 Miscellaneous, 1991

McLoughlin D, Priest R., Halcyon days over for our favourite hypnotic, 1991, - 13 Miscellaneous, 1991

Non-Peer-Reviewed Publications

Semkovska M, McLoughlin DM , Retrograde autobiographical amnesia following ECT: on the difficulty of finding the baby and clearing murky bathwater, J ECT, 30, (3), 2014, p187 - 188 Journal Article, 2014

Dunne RA, McLoughlin DM, Physical treatments, Medicine , 40, 2012, p672 - 673 Journal Article, 2012

McLoughlin, DM, Vagus rules still apply., Psychological Medicine, 38, (5), 2008, p625 - 627 Journal Article, 2008

McLoughlin, DM, Review: repetitive transcranial magnetic stimulation is of unknown effectiveness in people with depression., Evidence-Based Mental Health, 6, (4), 2003, p118 - 118 Journal Article, 2003

Cigeroglu YB, McLoughlin D., Psychotherapy training in Turkey, 1994, - 650-651 Miscellaneous, 1994 URL

Lovestone S, McLoughlin D., Alzheimer's disease: molecular biology and the quest for a treatment. , Care of the Elderly, 6, 1994, p149-152 Journal Article, 1994

Research Expertise

Description

I have been investigating the neuronal signalling function of the Alzheimer's disease amyloid precursor protein (APP) and was among the first to identify the FE65 and X11 adaptor proteins as APPbinding partners. To study their functions in vivo, we have made X11 transgenic mice and have demonstrated that the X11s regulate APP processing and reduce cerebral Ab production and deposition. The neuronal X11 proteins are therefore novel therapeutic targets for Alzheimer's disease. I am now leading a research group studying behavioural and electrophysiological effects of X11- mediated reduction in cerebral Ab in an Alzheimer's animal model. On the clinical side, I have also been leading randomised controlled trials of therapeutic neuromodulation techniques (e.g. transcranial magnetic stimulation, electroconvulsive therapy) for neuropsychiatric disorders such as depression and schizophrenia. In St Patrick's Hospital and TCD, we are about to start a 5-year research programme called the EFFECT-Dep Study (enhancing the effectiveness of electroconvulsive therapy in severe depression and understanding its molecular mechanism of action). This programme is supported by a HRB Translational Research Award and its purpose is to improve ECT practice and use it to interrogate the molecular neurobiology of depression. We will carry out a definitive randomised controlled trial comparing bilateral and high-dose unilateral ECT, recruiting 140 patients with severe depression. We will also use an animal model of ECT treatment to characterise changes in global protein expression (i.e. the proteome) in both brain and blood plasma and also carry out similar studies using plasma from depressed patients recruited into the clinical trial. The results of these studies will improve clinical ECT and also help us understand better the molecular mechanism of action of ECT, as well as antidepressant drugs, and lead to identification of candidate peripheral biomarkers for depression, treatment response and depression relapse.

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