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Neil Docherty
Visiting Research Fellow, Psychiatry

Biography

CAREER PROFILE Following undergraduate studies in Biochemistry and Immunology at University of Aberdeen, Scotland, I undertook my doctoral studies at The Department of Physiology and Pharmacology, University of Salamanca, Spain, studying the link between the inflammatory and fibrotic processes in models of acute renal failure. I subsequently moved to Ireland to The School of Medicine and Medical Sciences at University College Dublin (UCD) where I completed a 3-year post-doctoral fellowship. I examined functional, inflammatory and fibrotic aspects of renal injury in obstructive nephropathy using relevant animal and cellular models of disease. From 2007-2009, also at UCD, I supervised MD research theses in chronic inflammation and tissue remodelling in obstructive nephropathy, inflammatory bowel disease and glaucoma whilst building experience in teaching and learning. In 2009 I was appointed to a lectureship at the Department of Physiology, Trinity College Dublin. This position has entailed acting as academic lead for the prospective design and implementation of an integrated 4-year programme of undergraduate study in applied biomedical science. I continue to develop my research profile and contribution to the field through national and international research collaboration, peer-reviewed publication, research ethics committee work and journal editorial duties.

Publications and Further Research Outputs

Peer-Reviewed Publications

Docherty NG, Murphy M, Martin F, Brennan EP, Godson C, Targeting Cellular Drivers and Counter-regulators of Hyperglycaemia and TGF-ß1 Associated Pro-fibrotic Responses in Diabetic Kidney Disease., Experimental physiology, 2014 Journal Article, 2014

Vallon V, Docherty NG, Intestinal Regulation of Urinary Sodium Excretion and the Pathophysiology of Diabetic Kidney Disease: A Focus on GLP-1 and DPP-4., Experimental physiology, 2014 Journal Article, 2014

Docherty NG, le Roux CW, Improvements in The Metabolic Milieu following Roux-en-Y Gastric Bypass and the Arrest of Diabetic Kidney Disease., Experimental physiology, 2014 Journal Article, 2014

Lennon, G, Balfe, A, Bambury, N, Lavelle, A, Maguire, A, Docherty, NG, Coffey, JC, Winter, DC, Sheahan, K, O'Connell, PR, Correlations between colonic crypt mucin chemotype, inflammatory grade and Desulfovibrio species in ulcerative colitis, COLORECTAL DISEASE, 16, (5), 2014, pO161-O169 Journal Article, 2014 DOI

Rodriguez-Pena, AB, Fuentes-Calvo, I, Docherty, NG, Arevalo, M, Grande, MT, Eleno, N, Perez-Barriocanal, F, Lopez-Novoa, JM, Effect of Angiotensin II and Small GTPase Ras Signaling Pathway Inhibition on Early Renal Changes in a Murine Model of Obstructive Nephropathy, BIOMED RESEARCH INTERNATIONAL, 2014, p124902- Journal Article, 2014 TARA - Full Text DOI

Irnaten, M, Barry, RC, Wallace, DM, Docherty, NG, Quill, B, Clark, AF, O'Brien, CJ, Elevated maxi-K+ ion channel current in glaucomatous lamina cribrosa cells, EXPERIMENTAL EYE RESEARCH, 115, 2013, p224-229 Journal Article, 2013 DOI

Corcoran JB, McCarthy S, Griffin B, Gaffney A, Bhreathnach U, Börgeson E, Hickey FB, Docherty NG, Higgins DF, Furlong F, Martin F, Godson C, Murphy M, IHG-1 must be localised to mitochondria to decrease Smad7 expression and amplify TGF-ß1-induced fibrotic responses., Biochimica et biophysica acta, 1833, (8), 2013, p1969-1978 Journal Article, 2013 DOI

Lavelle, A, Lennon, G, Docherty, N, Balfe, A, Mulcahy, HE, Doherty, G, O'Donoghue, D, Hyland, JM, Shanahan, F, Sheahan, K, Coffey, JC, Winter, DC, O'Connell, PR, Depth-Dependent Differences in Community Structure of the Human Colonic Microbiota in Health, PLOS ONE, 8, (11), 2013, p78835- Journal Article, 2013 DOI TARA - Full Text

Brennan EP, Nolan KA, Börgeson E, Gough OS, McEvoy CM, Docherty NG, Higgins DF, Murphy M, Sadlier DM, Ali-Shah ST, Guiry PJ, Savage DA, Maxwell AP, Martin F, Godson C, Lipoxins Attenuate Renal Fibrosis by Inducing let-7c and Suppressing TGFßR1., Journal of the American Society of Nephrology : JASN, 24, (4), 2013, p627-37 Journal Article, 2013 DOI

Rowan F, Coffey JC, O'Connell PR, Docherty NG, Murphy M, Murphy TB, Ileal Pouch Microbial Diversity., Annals of surgery, 254, (4), 2011, p669 - 670 Journal Article, 2011 DOI

Börgeson E, Docherty NG, Murphy M, Rodgers K, Ryan A, O'Sullivan TP, Guiry PJ, Goldschmeding R, Higgins DF, Godson C., Lipoxin A©þ and benzo-lipoxin A©þ attenuate experimental renal fibrosis., FASEB Journal, 25, (9), 2011, p2967 - 2979 Journal Article, 2011 DOI

Hickey FB, Corcoran JB, Docherty NG, Griffin B, Bhreathnach U, Furlong F, Martin F, Godson C, Murphy M, IHG-1 Promotes Mitochondrial Biogenesis by Stabilizing PGC-1{alpha}., Journal of the American Society of Nephrology : JASN, 22, (8), 2011, p1475-85 Journal Article, 2011 DOI

Perez-Barriocanal F, Docherty NG, Arevalo M, Duwell A, Riva-Elena JV, Gonzalez-Buitrago JM, Esteller A, Bernabeu C and Lopez-Novoa JM, Endoglin Upregulation in the Liver after Bile Duct Ligation in Rats, The Open Gastroenterology Journal , 5, (1), 2011, p1 - 9 Journal Article, 2011

Docherty NG, Godson C, Fibrinogen as a damage-associated mitogenic signal for the renal fibroblast., Kidney international, 80, (10), 2011, p1014-6 Journal Article, 2011 DOI

Burke JP, Cunningham MF, Sweeney C, Docherty NG, O'Connell PR, N-cadherin is overexpressed in Crohn's stricture fibroblasts and promotes intestinal fibroblast migration., Inflammatory bowel diseases, 17, (8), 2011, p1665-73- Journal Article, 2011 DOI

Quill B Docherty NG Clark AF O'Brien CJ, The effect of graded cyclic stretching on extracellular matrix-related gene expression profiles in cultured primary human lamina cribrosa cells., Investigative Ophthalmology & Visual Sciences, 52, (3), 2011, p1908 - 1915 Journal Article, 2011 DOI

McElnea EM, Quill B, Docherty NG, Irnaten M, Siah WF, Clark AF, O'Brien CJ, Wallace DM, Oxidative stress, mitochondrial dysfunction and calcium overload in human lamina cribrosa cells from glaucoma donors., Molecular vision, 17, 2011, p1182-91 Journal Article, 2011 TARA - Full Text

Mazzei LJ, García IM, Altamirano L, Docherty NG, Manucha W, Rosuvastatin Preserves Renal Structure following Unilateral Ureteric Obstruction in the Neonatal Rat., American journal of nephrology, 35, (2), 2011, p103-113 Journal Article, 2011 DOI

Medani M, Collins D, Docherty NG, Baird AW, O'Connell PR, Winter DC, Emerging role of hydrogen sulfide in colonic physiology and pathophysiology., Inflammatory bowel diseases, 17, (7), 2010, p1620-5 Journal Article, 2010 DOI

Upper Urinary Tract Obstruction in, editor(s)Mundy A, Fitzpatrick J.M, Neal D. and George J.R , The Scientific Basis of Urology, London, Informa Healthcare , 2010, pp103 - 113, [Docherty N.G. and Fitzpatrick J.M] Book Chapter, 2010

Rowan F, Docherty NG, Murphy M, Murphy TB, Coffey JC, O'connell PR, Bacterial colonization of colonic crypt mucous gel and disease activity in ulcerative colitis., Annals of surgery, 252, (5), 2010, p869-75 Journal Article, 2010 DOI

Burke JP, Watson RW, Mulsow JJ, Docherty NG, Coffey JC, O'Connell PR, Endoglin negatively regulates transforming growth factor beta1-induced profibrotic responses in intestinal fibroblasts., The British journal of surgery, 97, (6), 2010, p892-901 Journal Article, 2010 DOI

Cunningham MF, Docherty NG, Burke JP, O'Connell PR, S100A4 expression is increased in stricture fibroblasts from patients with fibrostenosing Crohn's disease and promotes intestinal fibroblast migration., American journal of physiology. Gastrointestinal and liver physiology, 299, (2), 2010, pG457-66 Journal Article, 2010 DOI

Burke JP, Cunningham MF, Watson RW, Docherty NG, Coffey JC, O'Connell PR, Bacterial lipopolysaccharide promotes profibrotic activation of intestinal fibroblasts., The British journal of surgery, 97, (7), 2010, p1126-34 Journal Article, 2010 DOI

Cunningham MF, Docherty NG, Coffey JC, Burke JP, O'Connell PR, Postsurgical recurrence of ileal Crohn's disease: an update on risk factors and intervention points to a central role for impaired host-microflora homeostasis., World J Surg, 34, (7), 2010, p1615 - 1626 Journal Article, 2010

Quinlan MR, Cronin P, Daly PJ, Watson RW, Manucha W, Docherty NG, Fitzpatrick JM, A Gender Comparison of Postobstructive Injury in the Rat Kidney., Kidney & blood pressure research, 33, (4), 2010, p266-273 Journal Article, 2010 DOI

Rowan F, Docherty NG, Murphy M, Murphy B, Calvin Coffey J, O'Connell PR, Desulfovibrio bacterial species are increased in ulcerative colitis., Diseases of the colon and rectum, 53, (11), 2010, p1530-6 Journal Article, 2010 DOI

Rowan F, Docherty N.G, Coffey J.C. and O'Connell P.R, Sulphate Reducing Bacteria and Hydrogen Sulphide in the Aetiology of Ulcerative Colitis, British Journal of Surgery, 96(2):151-158, 2009 Journal Article, 2009

Daly PJ, Docherty NG, Healy DA, McGuire BB, Fitzpatrick JM, Watson RW, The single insult of hypoxic preconditioning induces an antiapoptotic response in human proximal tubular cells, in vitro, across cold storage., British Journal of Urology International, 103(2):254-259, 2009 Journal Article, 2009

Docherty N.G, Fuentes Calvo I, Quinlan M.R, Perez-Barriocanal F, McGuire B.B, Fitzpatrick J.M and Watson R.W.G., Increased E-cadherin Expression in the Ligated Kidney Following Unilateral Ureteric Obstruction , Kidney International, 75(2):205-213, 2009 Journal Article, 2009

Coffey J.C, Rowan F, Burke J.P, Docherty N.G, Kirwan W.O. and O'Connell P.R. , Pathogenesis of and Unifying Hypothesis for Idiopathic Pouchitis , American Journal of Gastroenterology, 104(4):1013, 2009 Journal Article, 2009

. Burke J.P, Coffey J.C, Docherty N.G, Watson R.W.G. and O'Connell P.R, Simvastatin impairs smad-3 phosphorylation and modulates TGF-β1 mediated activation of intestinal fibroblasts , British Journal of Surgery, 96(5):541-5, 2009 Journal Article, 2009

Tumour Necrosis Factor Alpha Neutralization in the Medical Management of Crohn's Disease in, editor(s)Rossard, TP , Tumour Necrosis Factor Alpha, New York, Nova Publishing, 2009, [Docherty N.G. and O'Connell P.R] Book Chapter, 2009

Burke J.P, Ferrante M, Dejaegher K Watson R.W.G, Docherty N.G, De Hertogh G, Vermeire S, Rutgeerts P, D'Hoore A, Penninckx F, Geboes K, Van Assche G, and O'Connell P.R, Transcriptomic Analysis of Intestinal Fibrosis-Associated Gene Expression in Response to Medical Therapy in Crohn's Disease , Inflammatory Bowel Disease, 14(9):1197-1204, 2008 Journal Article, 2008

Quinlan M.R, Docherty N.G, Watson R.W.G. and Fitzpatrick J.M. , Exploring Mechanisms Involved in Renal Tubular Sensing of Mechanical Stretch Following Ureteric Obstruction, American Journal of Physiology (Renal Physiology), 295(1):F1-F11, 2008 Journal Article, 2008

Quinlan M.R, Perez-Barriocanal F, Wright E, Dillon-Murphy R, Watson R.W.G, Fitzpatrick J.M. and Docherty NG. , Analysis of Urinary and Plasma Electrolytes in a Rat Model of Unilateral Ureteric Obstruction (UUO) , The Open Journal of Urology and Nephrology, 1(1) 16-21, 2008 Journal Article, 2008

Murphy M, Docherty N.G , Griffin B, Howlin J, McArdle E, McMahon R, Schmid H, Kretzler M, Droguett A, Mezzano S, Brady H.R, Furlong F, Godson C and Martin F, IHG-1 Amplifies TGF-β1 Signaling and is Increased in Renal Fibrosis , Journal of The American Society of Nephrology, 19(9):1672-1680, 2008 Journal Article, 2008

Docherty N.G, Morales A.I, López Novoa J.M. and Pérez Barriocanal F, The Transition of Epithelial Cells to Myofibroblasts. Mechanisms Involved and Possible Relationship With Renal Fibrosis , Nefrologia, 27(6):681-688, 2007 Journal Article, 2007

McGuire B.B, Watson R.W, Pérez-Barriocanal F. Fitzpatrick J.M. and Docherty N.G, Gender Differences In The Renin-Angiotensin And Nitric Oxide Systems: Relevance In The Normal And Diseased Kidney, Kidney Blood Pressure Research, 30(2):67-80, 2007 Journal Article, 2007

Burke J.P, Mulsow J.J, O'Keane C, Docherty N.G, Watson R.W, and O'Connell P.R., Fibrogenesis in Crohn's Disease , Amercian Journal of Gastroenterology, 102(2):439-448, 2006 Journal Article, 2006

Docherty N.G, O'sullivan O.E, Healy D.A, Murphy M, O'neill A.J, Fitzpatrick J.M, and Watson R.W., TGF-beta1 Induced EMT Can Occur Independently of its Pro-apoptotic Effects And Is Aided By EGF Receptor Activation, The American Journal of Physiology (Renal Physiology), 290(5):F1202-F1212, 2006 Journal Article, 2006

Docherty N.G, O'Sullivan O.E, Healy D.A, Fitzpatrick J.M, and Watson R.W.G, Evidence That Inhibition of Tubular Cell Apoptosis Protects Against Renal Damage and the Development of Fibrosis Following Ureteric Obstruction , The American Journal of Physiology (Renal Physiology), 290(1) F4-F13, 2006 Journal Article, 2006

Healy DA, Daly PJ, Docherty N.G, Murphy M, Fitzpatrick J.M and Watson R.W, Heat Shock-Induced Protection of Renal Proximal Tubular Epithelial Cells From Cold Storage and Re-warming Injury , Journal of The American Society of Nephrology, 17(3):805-812, 2006 Journal Article, 2006

Docherty N.G, Lopez-Novoa J.M, Arevalo M, Duwel A, Rodriguez-Pena A, Perez-Barriocanal F, Bernabeu C. and Eleno N., Endoglin Regulates Renal Ischemia-Reperfusion Injury, Nephrology, Dialysis and Transplantation, 21(8):2106-2119, 2006 Journal Article, 2006

Prieto M. Rodriguez-Pena, A.B, Duwell A, Rivas J.V, Docherty N, Perez Barriocanal, F, Arevalo M, Vary C.P.H, Bernabeu C, Lopez-Novoa J.M, and Eleno N, Temporal Changes in Renal Endoglin and TGF-β1 Expression Following Ureteral Obstruction in Rats, Journal of Physiology and Biochemistry, 2005 61(3):457-467, 2005 Journal Article, 2005

Rodriguez-Pena A, Eleno N, Duwell A, Arevalo M, Perez-Barriocanal F, Flores O, Docherty N, Bernabeu C, Letarte M, and Lopez-Novoa J.M, Endoglin Upregulation During Experimental Renal Interstitial Fibrosis in Mice, Hypertension, 40(5):713-720, 2002 Journal Article, 2002

Docherty N.G, Perez-Barriocanal F, Balboa N.E, and Lopez-Novoa J.M, Transforming Growth Factor-Beta1 (TGF-beta1): A Potential Recovery Signal in the Post-ischemic Kidney, Renal Failure, 24(4):391-406, 2002 Journal Article, 2002

Research Expertise

Description

My current research interests are in the area of chronic inflammation and fibrosis in renal disease and inflammatory bowel disease. specifically; 1)Anti-fibrotic Potential of Macrophage Phenotype Modulation in Chronic Renal and Gastrointestinal Disease. 2)Stricture Fibroblast Phenotype and its Role in Stricture Formation in Crohn's Disease. 3) Molecular Microbiology Based Examination of The Mucosa-Adherent Microbiota in Ulcerative Colitis. 4) The Gut-Brain Axis and Central Neuroinflammation in Ulcerative Colitis

Keywords

Chronic inflamation; Inflammatory bowel disease; Medical Sciences, Research; Renal fibrosis; Renal Physiology; Research-led teaching; Self- and Peer- Assessment Tools in Undergraduate Students

Recognition

Representations

Associate Editor BMC Gastroenterology 2010-2012

Associate Editor-Irish Journal of Medical Science 2011-present

Memberships

Royal Academy of Medicine in Ireland (Fellow) European Society for Clinical Investigation


Last updated 23 November 2016 School Web Administrator (Email).