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Marina Lynch
Professor, Physiology

Biography

Qualifications: BSc (NUI), PhD (TCD) 1981-1983 Pharmacology Department, King's College, London. 1983-1992 National Institute for Medical Research, Mill Hill, London 1990-1992 Pharmacology Department, RFH School of Medicine, London (Honorary Lecturer) 1992-now Department of Physiology, Trinity College, Dublin 2. (Lecturer) 1999 Associate Professor 2006 Director, Trinity College Institute of Neuroscience 2006 Personal Chair in Cellular Neuroscience

Publications and Further Research Outputs

Peer-Reviewed Publications

McManus, R.M., Finucane, O.M., Wilk, M.M., Mills, K.H.G., Lynch, M.A. , FTY720 Attenuates Infection-Induced Enhancement of Aβ Accumulation in APP/PS1 Mice by Modulating Astrocytic Activation, Journal of Neuroimmune Pharmacology, 2017, p1-12 Journal Article, 2017 DOI

C. Dempsey, A. Rubio Araiz, K. J. Bryson, O. Finucane, C. Larkin, E. L. Mills, A. A. B. Robertson, M. A. Cooper, L. A. J. O'Neill and M. A. Lynch, Inhibiting the NLRP3 inflammasome with MCC950 promotes non-phlogistic clearance of amyloid-β and cognitive function in APP/PS1 mice, Brain, Behaviour and Immunity, 61, 2017, p306-316 Journal Article, 2017 TARA - Full Text

Wilk, M.M., Misiak, A., McManus, R.M., (...), Lynch, M.A., Mills, K.H.G. , Lung CD4 tissue-resident memory T cells mediate adaptive immunity induced by previous infection of mice with bordetella pertussis, Journal of Immunology . , 199, (1), 2017, p233-243 Journal Article, 2017 DOI

Costello D.A, Keenan K, McManus R.M, Falvey A, Lynch M.A, The age-related neuroinflammatory environment promotes macrophage activation, which negatively impacts synaptic function, Neurobiology of Aging, 43, 2016, p140 - 148 Journal Article, 2016 DOI URL

McDonald C.L, Hennessy E, Rubio-Araiz A, Keogh B, McCormack W, McGuirk P, Reilly M, Lynch M.A, Inhibiting TLR2 activation attenuates amyloid accumulation and glial activation in a mouse model of Alzheimer's disease, Brain, Behavior, and Immunity, 58, 2016, p191 - 200 Journal Article, 2016 URL DOI

Drechsler S, Lynch M.A, Novella S, González-Navarro H, Hecimovic S, Barini E, Tucci V, Castro R.E, Vandenbroucke R.E, Osuchowski M, Potter P.K, With mouse age comes wisdom: A review and suggestions of relevant mouse models for age-related conditions, Mechanisms of Ageing and Development, 160, 2016, p54 - 68 Journal Article, 2016 DOI URL

Andreasson K.I, Bachstetter A.D, Colonna M, Ginhoux F, Holmes C, Lamb B, Landreth G, Lee D.C, Low D, Lynch M.A, Monsonego A, O'Banion M.K, Pekny M, Puschmann T, Russek-Blum N, Sandusky L.A, Selenica M.-L.B, Takata K, Teeling J, Town T, Van Eldik L.J, Targeting innate immunity for neurodegenerative disorders of the central nervous system, Journal of Neurochemistry, 2016, p653 - 693 Journal Article, 2016 URL DOI

Lyons A, Minogue A.M, Jones R.S, Fitzpatrick O, Noonan J, Campbell V.A, Lynch M.A, Analysis of the Impact of CD200 on Phagocytosis, Molecular Neurobiology, 2016, p1-10 Journal Article, 2016 DOI URL

Lynch, MA, Bone Marrow-Derived Macrophages from AβPP/PS1 Mice are Sensitized to the Effects of Inflammatory Stimuli., Journal of Alzheimers Disease, 44 , (3), 2015, p949-962 Journal Article, 2015 TARA - Full Text Other

Raasay S. Jones, Aedín M. Minogue, Orla Fitzpatrick, Marina A. Lynch, Inhibition of JAK2 attenuates the increase in inflammatory markers in microglia from APP/PS1 mice, Experimental Cell Research, 36, (10), 2015, p2716-2724 Journal Article, 2015 TARA - Full Text DOI

Karen Bryson and Marina Lynch, Linking T cells to Alzheimer's disease: from neurodegeneration to neurorepair, Curr Opin Pharmacol. , 26,, 2015, 67-73. Review, 2015

Lynch, MA, Linking T cells to Alzheimer's disease: from neurodegeneration to neurorepair, Current Opinion in Pharmacology, 26, 2015, p67 - 73 Journal Article, 2015

Costello D.A, Carney D.G, Lynch M.A, α-TLR2 antibody attenuates the Aβ-mediated inflammatory response in microglia through enhanced expression of SIGIRR, Brain, Behavior, and Immunity, 46, 2015, p70 - 79 Journal Article, 2015 DOI URL

McManus R.M, Mills K.H.G, Lynch M.A, T Cells-Protective or Pathogenic in Alzheimer-s Disease?, Journal of Neuroimmune Pharmacology, 10, (4), 2015, p547-560 Journal Article, 2015 DOI URL

Barrett J., Minogue A., Falvey A., Lynch M., Involvement of IGF-1 and Akt in M1/M2 activation state in bone marrow-derived macrophages, Experimental Cell Research, 335, (2), 2015, p258-268 Journal Article, 2015 DOI

Raasay S. Jones and Marina A. Lynch, How dependent is synaptic plasticity on microglial phenotype?, Neuropharmacology, 96, (A), 2015, p3-10 Journal Article, 2015 DOI TARA - Full Text

Marina A Lynch, Neuroinflammatory changes negatively impact on LTP: a focus on IL-1β, Brain Research, 2015 Journal Article, 2015 TARA - Full Text

Barrett J., Costello D., O'Sullivan J., Cowley T., Lynch M., Bone marrow-derived macrophages from aged rats are more responsive to inflammatory stimuli, Journal of Neuroinflammation, 12, (1), 2015, p67 Journal Article, 2015 TARA - Full Text DOI

Lynch, MA, α-TLR2 antibody attenuates the Aβ-mediated inflammatory response in microglia through enhanced expression of SIGIRR. , Brain Behaviour Immunity, 46, 2015, p70-79 Journal Article, 2015 DOI Other TARA - Full Text

Distrutti E, O'Reilly JA, McDonald C, Cipriani S, Renga B, Lynch MA, Fiorucci S, Modulation of intestinal microbiota by the probiotic VSL#3 resets brain gene expression and ameliorates the age-related deficit in LTP., PloS one, 9, (9), 2014, pe106503 Journal Article, 2014 TARA - Full Text DOI

Aedín M. Minogue, Raasay S. Jones, Ronan J. Kelly, Claire L. McDonald, Thomas J. Connor and Marina A. Lynch., Age-associated dysregulation of microglial activation is coupled with enhanced BBB permeability and pathology in APP/PS1 mice, Neurobiology of Aging , 2014, p1-30 Journal Article, 2014 TARA - Full Text

Murphy, N., Grehan, B., Lynch, M.A., Glial Uptake of Amyloid Beta Induces NLRP3 Inflammasome Formation via Cathepsin-Dependent Degradation of NLRP10, NeuroMolecular Medicine, 16, (1), 2014, p205-215 Journal Article, 2014 DOI

Dungan LS, McGuinness NC, Boon L, Lynch MA, Mills KH, Innate IFN-gamma promotes development of experimental autoimmune encephalomyelitis: A role for NK cells and M1 macrophages., European Journal of Immunology, 44, (10), 2014, p2903-17 Journal Article, 2014 DOI URL TARA - Full Text

McManus R, Mills, KHG, Lynch MA, Respiratory infection promotes T cell infiltration and Aβ deposition in APP/PS1 mice., Neurobiol Aging, 35, (1), 2014, p109-121 Journal Article, 2014 DOI TARA - Full Text

McGuckin CP, Jurga M, Miller AM, Sarnowska A, Wiedner M, Boyle NT, Lynch MA, Jablonska A, Drela K, Lukomska B, Domanska-Janik K, Kenner L, Moriggl R, Degoul O, Perruisseau-Carrier C, Forraz N, Ischemic brain injury: a consortium analysis of key factors involved in mesenchymal stem cell-mediated inflammatory reduction., Archives of biochemistry and biophysics, 534, (1-2), 2013, p88-97 Journal Article, 2013 TARA - Full Text DOI

Kelly RJ, Minogue AM, Lyons A, Jones RS, Browne TC, Costello DA, Denieffe S, O'Sullivan C, Connor TJ, Lynch MA, Glial Activation in AßPP/PS1 Mice is Associated with Infiltration of IFN"-Producing Cells., Journal of Alzheimer's disease : JAD, 37, (1), 2013, p63-75 Journal Article, 2013 DOI TARA - Full Text

Downer EJ, Johnston DG, Lynch MA, Differential role of Dok1 and Dok2 in TLR2-induced inflammatory signaling in glia., Molecular and cellular neurosciences, 56C, 2013, p148-158 Journal Article, 2013 DOI TARA - Full Text

Gallagher JJ, Minogue AM, Lynch MA, Impaired performance of female APP/PS1 mice in the Morris water maze is coupled with increased Aß accumulation and microglial activation., Neuro-degenerative diseases, 11, (1), 2013, p33-41 Journal Article, 2013 DOI TARA - Full Text

Jones RS, Minogue AM, Connor TJ, Lynch MA, Amyloid-beta-Induced Astrocytic Phagocytosis is Mediated by CD36, CD47 and RAGE., Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology, 8, (1), 2013, p301-311 Journal Article, 2013 TARA - Full Text DOI

Ojo B, Gabbott PL, Rezaie P, Corbett N, Medvedev NI, Cowley TR, Lynch MA, Stewart MG, An NCAM Mimetic, FGL, Alters Hippocampal Cellular Morphometry in Young Adult (4 Month-Old) Rats., Neurochemical research, 38, (6), 2013, p1208-1218 Journal Article, 2013 DOI

Eric J. Downer, Raasay S. Jones, Claire L. McDonald, Eleonora Greco, Sabina Brennan, Thomas J. Connor, Ian H. Robertson, Marina A. Lynch, Identifying Early Inflammatory Changes in Monocyte-Derived Macrophages from a Population with IQ-Discrepant Episodic Memory, Plos One, 8, (5), 2013, ppe63194 Journal Article, 2013 DOI TARA - Full Text

Denieffe S, Kelly RJ, McDonald C, Lyons A, Lynch MA, Classical activation of microglia in CD200-deficient mice is a consequence of blood brain barrier permeability and infiltration of peripheral cells., Brain, behavior, and immunity, 34, 2013, p86-97 Journal Article, 2013 DOI TARA - Full Text

Cowley TR, González-Reyes RE, Richardson JC, Virley D, Upton N, Lynch MA, The Age-related Gliosis and Accompanying Deficit in Spatial Learning are Unaffected by Dimebon., Neurochemical research, 38, (6), 2013, p1190-5 Journal Article, 2013 DOI TARA - Full Text

Browne TC, McQuillan K, McManus RM, O'Reilly JA, Mills KH, Lynch MA, IFN-" Production by Amyloid ß-Specific Th1 Cells Promotes Microglial Activation and Increases Plaque Burden in a Mouse Model of Alzheimer's Disease., Journal of immunology (Baltimore, Md. : 1950), 190, (5), 2013, p2241-51 Journal Article, 2013 TARA - Full Text DOI

Lynch MA, The impact of neuroimmune changes on development of amyloid pathology; relevance to Alzheimer's disease., Immunology, 141, (3), 2013, p292-301 Journal Article, 2013 DOI TARA - Full Text

Derek A. Costello, and Marina A. Lynch., Toll-like receptor 3 activation modulates hippocampal network excitability, via glial production of interferon-β, Hippocampus, 23, (8), 2013, p696-707 Journal Article, 2013 DOI TARA - Full Text

Cox FF, Berezin V, Bock E, Lynch MA, The neural cell adhesion molecule-derived peptide, FGL, attenuates lipopolysaccharide-induced changes in glia in a CD200-dependent manner., Neuroscience, 235, 2013, p141-148 Journal Article, 2013 TARA - Full Text DOI

Lyons A, Downer EJ, Costello DA, Murphy N, Lynch MA, Dok2 mediates the CD200Fc attenuation of Aß-induced changes in glia., Journal of neuroinflammation, 9, 2012, p107 Journal Article, 2012 TARA - Full Text DOI

Cowley TR, O'Sullivan J, Blau C, Deighan BF, Jones R, Kerskens C, Richardson JC, Virley D, Upton N, Lynch MA, Rosiglitazone attenuates the age-related changes in astrocytosis and the deficit in LTP., Neurobiology of aging, 33, (1), 2012, p162-75 Journal Article, 2012 DOI TARA - Full Text

Marina A. Lynch, Rodney W. Johnson, The impact of aging on the brain - risk, resilience and repair, Brain, Behavior, and Immunity, 26, (5), 2012, p714-716 Journal Article, 2012 DOI TARA - Full Text

Murphy N, Cowley TR, Blau CW, Dempsey CN, Noonan J, Gowran A, Tanveer R, Olango WM, Finn DP, Campbell VA, Lynch MA, The fatty acid amide hydrolase inhibitor URB597 exerts anti-inflammatory effects in hippocampus of aged rats and restores an age-related deficit in long-term potentiation., Journal of neuroinflammation, 9, 2012, p79 Journal Article, 2012 TARA - Full Text DOI

F. Fionnuala Cox, Donal Carney, Anne-Marie Miller, Marina A. Lynch, CD200 fusion protein decreases microglial activation in the hippocampus of aged rats, Brain, Behavior, and Immunity, 26, (5), 2012, p789-796 Journal Article, 2012 DOI TARA - Full Text

Murphy N, Cowley TR, Richardson JC, Virley D, Upton N, Walter D, Lynch MA, The neuroprotective effect of a specific P2X" receptor antagonist derives from its ability to inhibit assembly of the NLRP3 inflammasome in glial cells., Brain pathology (Zurich, Switzerland), 22, (3), 2012, p295-306 Journal Article, 2012 DOI

Murphy N, Lynch MA, Activation of the P2X" receptor induces migration of glial cells by inducing cathepsin B degradation of tissue inhibitor of metalloproteinase 1., Journal of neurochemistry, 123, (5), 2012, p761-770 Journal Article, 2012 DOI

O'Reilly JA, Lynch M, Rosiglitazone improves spatial memory and decreases insoluble Aß(1-42) in APP/PS1 mice., Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology, 7, (1), 2012, p140-4 Journal Article, 2012 DOI TARA - Full Text

Bunmi Ojo, Payam Rezaie, Paul L. Gabbott, Heather Davies, Frances Colyer, Thelma R. Cowley, Marina Lynch, Michael G. Stewart, Age-related changes in the hippocampus (loss of synaptophysin and glial-synaptic interaction) are modified by systemic treatment with an NCAM-derived peptide, FGL, Brain, Behavior, and Immunity, 26, (5), 2012, p778-88 Journal Article, 2012 DOI TARA - Full Text

Minogue AM, Barrett JP, Lynch MA, LPS-induced release of IL-6 from glia modulates production of IL-1ß in a JAK2-dependent manner., Journal of neuroinflammation, 9, 2012, p126 Journal Article, 2012 TARA - Full Text DOI

Blau CW, Cowley TR, O'Sullivan J, Grehan B, Browne TC, Kelly L, Birch A, Murphy N, Kelly AM, Kerskens CM, Lynch MA, The age-related deficit in LTP is associated with changes in perfusion and blood-brain barrier permeability., Neurobiology of aging, 33, (5), 2012, p1005.e23-35 Journal Article, 2012 TARA - Full Text DOI

J. Kevin Murphy, Anne-Marie Miller, R. Thelma, F. Cowley, Fionnuala Cox and Marina A. Lynch, The age- and amyloid-beta-related increases in Nogo B contribute to microglial activation, Neurochemistry International, 58, (2), 2011, p161-168 Journal Article, 2011 TARA - Full Text

Bunmi Ojo, Payam Rezaie, Paul L. Gabbott, Thelma R. Cowely, Nikolay I. Medvedev, Marina A. Lynch, Michael G. Stewart, A neural cell adhesion molecule-derived peptide, FGL, attenuates glial cell activation in the aged hippocampus, Experimental Neurology, 232, (2), 2011, p318-328 Journal Article, 2011 TARA - Full Text

Kelly, L. , Grehan, B. , Chiesa, A.D. , O'Mara, S.M. , Downer, E. , Sahyoun, G. , Massey, K.A. , Nicolaou, A. , Lynch, M.A, The polyunsaturated fatty acids, EPA and DPA exert a protective effect in the hippocampus of the aged rat, Neurobiology of Aging, 32, (12), 2011, p2318.e1-2318.e15 Journal Article, 2011 DOI

Rebola N, Simões AP, Canas PM, Tomé AR, Andrade GM, Barry CE, Agostinho PM, Lynch MA, Cunha RA, Adenosine A(2A) receptors control neuroinflammation and consequent hippocampal neuronal dysfunction., Journal of Neurochemistry, 117, (1), 2011, p100-111 Journal Article, 2011 TARA - Full Text DOI

Murphy KJ, Miller AM, Thelma R, Cowley F, Cox FF, Lynch MA, The age- and amyloid-ß-related increases in Nogo B contribute to microglial activation., Neurochemistry international, 58, (2), 2011, p161-168 Journal Article, 2011 DOI

Marina A. Lynch and Kingston H.G. Mills, Immunology meets neuroscience - opportunities for immune intervention in neurodegenerative diseases, Brain, Behavior, and Immunity, 26, (1), 2011, p1-10 Journal Article, 2011 TARA - Full Text

Costello DA, Lyons A, Browne T, Denieffe S, Cox FF, Lynch MA, Long-term potentiation is impaired in CD200-deficient mice: a role for Toll-like receptor activation., The Journal of Biological Chemistry, 286, (40), 2011, p34722-34732 Journal Article, 2011 TARA - Full Text DOI

Lyons A, Murphy KJ, Clarke R, Lynch MA, Atorvastatin prevents age-related and amyloid-beta-induced microglial activation by blocking interferon-gamma release from natural killer cells in the brain, Journal of Neuroinflammation, 8, (27), 2011 Journal Article, 2011 DOI TARA - Full Text

Derek A. Costello, Melanie B. Watson, Thelma R. Cowley, Niamh Murphy, Ciarán Murphy Royal, Cecilia Garlanda & Marina A. Lynch, IL-1alpha and HMGB1 mediate hippocampal dysfunction in SIGIRR-deficient mice , Journal of Neuroscience, 31, (10), 2011, p3871-3879 Journal Article, 2011 TARA - Full Text

Gallagher JJ, Finnegan ME, Grehan B, Dobson J, Collingwood JF, Lynch MA, Modest Amyloid Deposition is Associated with Iron Dysregulation, Microglial Activation, and Oxidative Stress., Journal of Alzheimer's disease : JAD, 28, (1), 2011, p147-161 Journal Article, 2011 TARA - Full Text DOI

Murphy, AC, Lalor, SJ, Lynch, MA and Mills, KH, Infiltration of Th1 and Th17 cells and activation of microglia in the CNS during the course of experimental autoimmune encephalomyelitis, Brain, Behavior, and Immunity, 24, (4), 2010, p598-607 Journal Article, 2010 TARA - Full Text

Watson, M.B., Costello, D.A., Carney, D.G., McQuillan, K., Lynch, M.A., SIGIRR modulates the inflammatory response in the brain , Brain, Behavior, and Immunity, 24, (6), 2010, p985-995 Journal Article, 2010 TARA - Full Text

Downer, E.J., Cowley, T.R., Lyons, A., Mills, K.H.G., Berezin, V., Bock, E., Lynch, M.A. , A novel anti-inflammatory role of NCAM-derived mimetic peptide, FGL , Neurobiology of Aging , 31, (1), 2010, p118 - 128 Journal Article, 2010 DOI URL

Lynch MA, Age-related neuroinflammatory changes negatively impact on neuronal function., Frontiers in Aging Neuroscience, 2010, p1-6 Journal Article, 2010 TARA - Full Text

Mc Quillan, KL, Lynch MA, and Mills KH., Activation of mixed glia by A-beta-specific Th1 and Th17 cells and its regulation by Th2 cells, Brain, Behavior, and Immunity, 24, (4), 2010, p598-607 Journal Article, 2010 TARA - Full Text

Piazza A and Lynch MA, Neuroinflammatory changes increase the impact of stressors on neuronal function., Biochemical Society Transactions, 37, (1), 2009, p303-307 Journal Article, 2009 TARA - Full Text

Lynch MA., The multifaceted profile of activated microglia., Molecular Neurobiology, 40, (2), 2009, p139-156 Journal Article, 2009 DOI

Schmid AW, Lynch MA, Herron CE., The effects of IL-1 receptor antagonist on beta amyloid mediated depression of LTP in the rat CA1 in vivo., Hippocampus, 19, (7), 2009, p670-676 Journal Article, 2009 DOI

Loane DJ, Deighan BF, Clarke RM, Griffin RJ, Lynch AM, Lynch MA., Interleukin-4 mediates the neuroprotective effects of rosiglitazone in the aged brain., Neurobiology of Aging, 30 , (6), 2009, p920 - 931 Journal Article, 2009 DOI

Carpenter S, Carlson T, Dellacasagrande J, Garcia A, Gibbons S, Hertzog P, Lyons A, Lin LL, Lynch M, Monie T, Murphy C, Seidl KJ, Wells C, Dunne A, O'Neill LA. , TRIL, a functional component of the TLR4 signaling complex, highly expressed in brain., Journal of Immunology, 183, (6), 2009, p3989-3995 Journal Article, 2009 DOI

Martin, DS, Walsh M, Miller AM, Skerrett HE, Byrne P, Mandel A, Bolton AE and Lynch MA, A novel phospholipid-based drug formulation, VP025, modulates age- and LPS-induced microglial activity in the rat, Neuroimmunomodulation, 16, 2009, p400-410 Journal Article, 2009 DOI

Gallagher, JJ, Tekoriute, R, O'Reilly, JA, Kerskens, C, Gun'ko, YK, Lynch, M, Bimodal magnetic-fluorescent nanostructures for biomedical applications, Journal of Materials Chemistry, 19, 2009, p4081 - 4084 Journal Article, 2009 TARA - Full Text

Lyons, A, McQuillan, K, Deighan, BF, O'Reilly, JA, Downer, EJ, Murphy, AC, Watson, M, Piazza, A, O'Connell, F, Griffin, R, Mills, KH, Lynch, MA, Decreased neuronal CD200 expression in IL-4-deficient mice results in increased neuroinflammation in response to lipopolysaccharide., Brain, Behavior, and Immunity, 23, (7), 2009, p1020 - 1027 Journal Article, 2009 DOI

Miller AM, Piazza A, Martin DS, Walsh M, Mandel A, Bolton AE and Lynch MA , The deficit in long-term potentiation induced by chronic administration of amyloid-beta is attenuated by treatment of rats with a novel phospholipid-based drug formulation, VP025., Experimental Gerontology, 44, (4), 2009, p300-304 Journal Article, 2009 DOI

Lyons A, Lynch AM, Downer EJ, Hanley R, O'Sullivan JB, Smith A, Lynch MA, Fractalkine-induced activation of the phosphatidylinositol-3 kinase pathway attentuates microglial activation in vivo and in vitro., Journal of Neurochemistry, 110, (5), 2009, p1547 - 1556 Journal Article, 2009 TARA - Full Text

Lynch, Marina A , The risky business of ageing. , Brain Behav Immun, 22, 2008, p299 - 300 Journal Article, 2008 URL DOI

Clarke RM, Lyons A, O'Connell F, Deighan BF, Barry CE, Anyakoha NG, Nicolaou A, Lynch MA, A pivotal role for IL-4 in atorvastatin-associated, J Biol Chem., 283, (4), 2008, p1808-1817 Journal Article, 2008 URL DOI

Popov VI, Medvedev NI, Kraev IV, Gabbott PL, Davies H, Lynch MA, Cowley T,, A cell adhesion molecule mimetic, FGL peptide, induces alterations in synapse and dendritic spine structure in the dentate gyrus of aged rats: a three-dimensional ultrastructural study, Eur J Neurosci, 27, (2), 2008, p301-314 Journal Article, 2008 URL DOI

Costelloe C, Watson M, Murphy A, McQuillan K, Loscher C, Armstrong ME,, IL-1F5 mediates anti-inflammatory activity in the brain through induction, J Neurochem, 105, (5), 2008, p1960-1969 Journal Article, 2008 URL DOI

Corr, S.A., Byrne, S.J., Tekoriute, R., Meledandri, C.J., Brougham, D.F., Lynch, M., Kerskens, C, O'Dwyer, L, Gun'ko, Y.K. , Linear assemblies of magnetic nanoparticles as MRI contrast agents , Journal of the American Chemical Society , 130, (13), 2008, p4214-4215 Journal Article, 2008 URL DOI

Minogue AM, Lynch AM, Loane DJ, Herron CE, Lynch MA., Modulation of amyloid-beta-induced and age-associated changes in rat hippocampus by eicosapentaenoic acid., Journal of Neurochemistry, 2007 Journal Article, 2007 DOI URL

Loane DJ, Deighan, BF, Clarke RM, Lynch AM, Lynch MA, Interleukin-4 mediates the neuroprotective effects of rosiglitazone in the aged brain., Neurobiol Aging., 2007 Journal Article, 2007 URL DOI

Lyons A, Downer EJ, Crotty S, Nolan YM, Mills KH, Lynch MA., CD200 ligand receptor interaction modulates microglial activation in vivo and in vitro: a role for IL-4., Journal of Neuroscience, 27, (31), 2007, p8309 - 8313 Journal Article, 2007 TARA - Full Text DOI

Moore M, Piazza A, Nolan Y, Lynch MA., Treatment with dexamethasone and vitamin D(3) attenuates neuroinflammatory age-related changes in rat hippocampus., Synapse, 61, (10), 2007, p851-61 Journal Article, 2007 DOI URL

Griffin R, Nally R, Nolan Y, McCartney Y, Linden J and Lynch MA , The age-related attenuation in LTP is associated with microglial activation, Journal of Neurochemistry, 99, (44), 2007, p1263 - 1272 Journal Article, 2007 URL DOI

Little SJ, Lynch MA, Manku M and Nicolaou A, Docosahexaenoic acid-induced changes in phospholipids in cortex of young and aged rats: A lipidomic analysis., Prostaglandins Leukot Essent Fatty Acids, 77, (3-4), 2007, p155-162 Journal Article, 2007 URL DOI

Clarke RM, O'Connell, F. Lyons A and Lynch MA , The HMG-CoA reductase inhibitor, atorvastatin, attenuates the effects of acute administration of amyloid-β in rat hippocampus. The HMG-CoA reductase inhibitor, atorvastatin, attenuates the effects of acute administration of amyloid-β in rat hippocampus. , Neuropharmacology , 52 , 2007, p136 - 145 Journal Article, 2007 URL DOI

Lyons A., Griffin R, Costelloe C, Clarke RM and Lynch MA , IL-4 attenuates the neuroinflammation induced by amyloid-beta in vivo and in vitro, Journal of Neurochemistry, 101, (3), 2007, p771-781 Journal Article, 2007 DOI URL

Maher FO, Clarke RM, Kelly A, Nally RE, Lynch MA, Interaction between interferon gamma and insulin-like growth factor-1 in hippocampus impacts on the ability of rats to sustain long-term potentiation , JOURNAL OF NEUROCHEMISTRY , 96, 6, (MAR), 2006, p1560 - 1571 Journal Article, 2006 URL DOI

Lynch MA, Loane DJ, Minogue AM, Clarke RM, Kilroy D, Nally RE, Roche OJ, O'connell F, Lynch MA, Eicosapentaenoic acid confers neuroprotection in the amyloid-beta challenged aged hippocampus, Neurobiol Aging, (May 19), 2006 Journal Article, 2006 DOI URL

Moore ME, Piazza A, McCartney Y, Lynch MA, Evidence that vitamin D3 reverses age-related inflammatory changes in the rat hippocampus, Biochemical Society Transactions, 33, (4), 2005, p1628 - 1633 Journal Article, 2005 URL

Barry CE, Nolan Y, Clarke RM, Lynch A, Lynch MA, Activation of c-Jun-N-terminal kinase is critical in mediating lipopolysaccharide-induced changes in the rat hippocampus , Journal of Neurochemistry, 93, (1), 2005, p221 - 231 Journal Article, 2005 DOI URL

Nolan Y, Campbell VA, Bolton AE, Lynch MA, Evidence of an anti-inflammatory role for Vasogen's immune modulation therapy, Neuroimmunomodulation, 12, (2), 2005, p113 - 116 Journal Article, 2005 URL DOI

Lynch MA, Inflammatory changes in regulation of hippocampal synaptic plasticity in the aged hippocampus , JOURNAL OF NEUROCHEMISTRY , 94, Suppl. 2, (Aug), 2005, pp11 Meeting Abstract, 2005

Nolan Y, Maher FO, Clarke RM, Brady MT, Bolton AE, Mills KHG, Lynch MA, Role of interleukin-4 in regulation of age-related inflammatory changes in the hippocampus., Journal of Biological Chemistry, 280, (10), 2005, p9354 - 9362 Journal Article, 2005 DOI

Armstrong ME, Lavelle EC, Loscher CE, Lynch MA, Mills KHG, Proinflammatory Responses in the Murine Brain after Intranasal Delivery of Cholera Toxin: Implications for the Use of AB Toxins as Adjuvants in Intranasal Vaccines, Journal of Infectious Diseases, 192, (9), 2005, p1628 - 1633 Journal Article, 2005 TARA - Full Text

Maher FO, Nolan Y, Lynch MA, Downregulation of IL-4-induced signalling in hippocampus contributes to deficits in LTP in the aged rat., Neurobiology of Aging, 26, (5), 2005, p717 - 728 Journal Article, 2005 DOI URL

Lynch, M.A., Long-Term Potentiation and memory, Physiol. Rev., 84, 2004, p87 - 136 Journal Article, 2004 DOI

Lonergan PE, Martin DS, Horrobin DF, Lynch MA, Neuroprotective actions of eicosapentaenoic acid on lipopolysaccharide-induced dysfunction in rat hippocampus, Journal of Neurochemistry, 91, (1), 2004, p20 - 29 Journal Article, 2004

Gooney, M., Messaoudi, E., Maher, F.O., Bramham, C.R. and Lynch, M.A., BDNF-induced LTP is associated with enhanced release of endogenous BDNF and glutamate and presynaptic activation of CREB: analysis of deficits in aged rats, Neurobiol. Aging, 25, (10), 2004, p1323-1331 Journal Article, 2004 URL DOI

Kavanagh, T., Lonergan, P.E. and Lynch, M.A., Eicosapentaenoic acid and gamma-linolenic acid increase hippocampal concentrations of IL-4 and IL-10 and abrogate lipopolysaccharide-induced inhibition of long-term potentiation, Prostaglandins Leukot. Essent. Fatty Acids, 70, 2004, p391 - 397 Journal Article, 2004 URL DOI

Maher FO, Martin DS, Lynch MA, Increased IL-1beta in cortex of aged rats is accompanied by downregulation of ERK and PI-3 kinase., Neurobiology of Aging, 25, (6), 2004, p705 - 806 Journal Article, 2004 URL DOI

Lonergan PE, Martin DSD, Horrobin DF, Lynch MA, Neuroprotective actions of eicosapentaenoic acid on lipopolysaccharide-induced dysfunction in rat hippocampus, Journal of Neurochemistry, 91, (1), 2004, p20 - 29 Journal Article, 2004 TARA - Full Text

Lynch AM, Walsh C, Delaney A, Nolan Y, Campbell VA, Lynch MA , Lipopolysaccharide-induced increase in signalling in hippocampus is abrogated by IL-10 - a role for IL-1 beta?, Journal of Neurochemistry, 88, (3), 2004, p635 - 646 Journal Article, 2004 URL DOI

Dietrich WD, Pearse DD, Lo TP, Cho KS, Lynch MA, Gorg MS, Marcillo AE, Sanchez AR, Bunge MB, Experimental graded cervical contusion in rats using spinal cord displacement: Pathology and behavioral recovery, JOURNAL OF NEUROTRAUMA , 21, (9), 2004, p1346 Journal Article, 2004

Nolan, Y., Martin, D.S.D., Campbell, V.A., and Lynch, M.A., Evidence of a protective effect of phosphatidylserine on lipopolysaccharide-induced impairment of long-term potentiation in the rat hippocampus, J. Neuroimmunol., 151, (Issues 1-2,), 2004, p12-23 Journal Article, 2004 URL DOI

Armstrong, M.E., Loscher, C.E., Lynch, M.A., Mills, K.H., IL-beta-dependent neurological effects of the whole cell pertussis vaccine: a role for IL-1-associated signalling components in vaccine reactogenicity, J. Neuroimmunol., 136, 2003, p25 - 33 Journal Article, 2003 DOI URL

Minogue, A.M., Schmid, A.W., Fogarty, M.F., Moore, A.C., Campbell, V.A. and Herron, C.E., Activation of the JNK signalling cascade mediates the effect of A beta on LTP and cell death in hippocampus: a role for IL-1 beta, J. Biol. Chem., 278, (30), 2003, p27971 - 27980 Journal Article, 2003 DOI URL

Maher, F.O. and Lynch, M.A., Age-related downregulation in neurotrophin-induced signaling and upregulation of interleukin-1 beta-induced signaling combine to decrease synaptic function in rat cortex, Neurobiol. Aging, 2003, p794 - 804 Journal Article, 2003

Loscher, C.E., Mills, K.H.G. and Lynch, M.A., Interleukin-1 receptor antagonist exerts agonist activity in the hippocampus independent of the interleukin-1 type iota receptor, J. Neuroimmunol., 137, (1-2), 2003, p117 - 124 Journal Article, 2003 DOI URL

Armstrong, M.E., Loscher, C.E., Lynch, M.A. and Mills, K.H.G., IL-1beta-dependent neurological effects of the whole cell pertussis vaccine: a role for IL-1-associated signalling components in vaccine reactogenicity, J. Neuroimmunol., 136, (1-2), 2003, p25 - 33 Journal Article, 2003 DOI URL

Davies, H.A., Kelly, A., Dhanrajan, T.M., Lynch, M.A., Rodriguez, J.J., Stewart, M.G., Synaptophysin immunogold labelling of synapses decreases in dentate gyrus of the hippocampus of aged rats, Brain Res., 986, ((1-2):), 2003, p191 - 195 Journal Article, 2003 URL DOI

Nolan, Y., Vereker, E., Lynch, A.M., and Lynch, M.A., Evidence that lipopolysaccharide-induced cell death is mediated by accumulation of reactive oxygene species and activation of p38 in rat cortex and hippocampus, Exp. Neurol., 184, (2), 2003, p794 - 804 Journal Article, 2003 URL DOI

Dhanrajan, T.M., Lynch, M.A., Kelly, A., Popov, V.I., Rusakov, D.A. and Stewart, M.G., Expression of long-term potentiation in aged rats involves perforated synapses but dendritic spine branching results from high frequency stimulation alone, Hippocampus, 14, (2), 2003, p255 - 264 Journal Article, 2003 DOI URL

Loscher, C.E., Mills, K.H., Lynch, M.A., Interleukin-1 receptor antagonist exerts agonist activity in the hippocampus independent of the interleukin-1 type I receptor, J. Neuroimmunol., 137, 2003, p117 - 124 Journal Article, 2003 DOI URL

Lynch, A.M., Moore, M., Craig, S. Lonergan, P.E., Martin, D.S., Lynch, M.A., Analysis of IL-1beta -induced cell signalling activation in rat hippocampus following exposure to gamma irradiation: protective effect of eicosapentaenoic acid, J. Biol. Chem., 278, (51), 2003, p51075 - 51084 Journal Article, 2003 URL DOI

Kelly, A., Vereker, E., Brady, M., Barry, C., Loscher, C., Mills, K.H.G. and Lynch, M.A., Activation of p38 plays a pivotal role in the inhibitory effect of lipopolysaccharide and interleukin-1beta-induced inhibition of long-term potentiation in rat dentate gyrus, The Journal of Biological Chemistry, 278, 2003, p19453 - 19462 Journal Article, 2003 TARA - Full Text URL DOI

LYNCH, MA, INTERLEUKIN-1 BETA EXERTS A MYRIAD OF EFFECTS IN THE BRAIN AND IN PARTICULAR IN THE HIPPOCAMPUS: ANALYSIS OF SOME OF THESE ACTIONS, VITAMINS AND HORMONES-ADVANCES IN RESEARCH AND APPLICATIONS, 64, 2002 Review, 2002 DOI URL

LYNCH, MA , LIPOIC ACID CONFERS PROTECTION AGAINST OXIDATIVE INJURY IN NON-NEURONAL AND NEURONAL TISSUE, NUTRITIONAL NEUROSCIENCE, 4, 2002 Review, 2002

Lynch AM, Lynch MA, The age-related increase in IL-1 type I receptor in rat hippocampus is coupled with an increase in caspase-3 activation., European Journal of Neuroscience, 15, (11), 2002, p1779 - 1788 Journal Article, 2002 DOI URL

Gooney M, Shaw K, Kelly A, O'Mara SM, Lynch MA. Gooney M, Shaw K, Kelly A, O'Mara SM, Lynch MA. Gooney M, Shaw K, Kelly A, O'Mara SM, Lynch MA., Long-term potentiation and spatial learning are associated with increased phosphorylation of TrkB and extracellular signal-regulated kinase (ERK) in the dentate gyrus: evidence for a role for brain-derived neurotrophic factor., Behavioural Neuroscience, 116, (3), 2002, p455 - 463 Journal Article, 2002 URL

Darren S. D. Martin, Peter E. Lonergan, Barry Boland, Marie P. Fogarty, Marcella Brady, David F. Horrobin, Veronica A. Campbell, and Marina A. Lynch, Apoptotic changes in the aged brain are triggered by interleukin-1 beta-induced activation of P38 and reversed by treatment with eicosapentaenoic acid, Journal of Biological Chemistry, 277, (37), 2002, p34239 - 34246 Journal Article, 2002 DOI URL

M. Casey, C. Maguire, Á. Kelly, M.A. Gooney, M.A. Lynch, ANALYSIS OF THE PRESYNAPTIC SIGNALING MECHANISMS UNDERLYING THE INHIBITION OF LTP IN RAT DENTATE GYRUS BY THE TYROSINE KINASE INHIBITOR, GENISTEIN, HIPPOCAMPUS, 12, (3), 2002, p377 - 385 Journal Article, 2002 DOI URL

Martina Gooney, M. A. Lynch , LONG-TERM POTENTIATION IN AGED RATS IS RESTORED WHEN THE AGE-RELATED DECREASE IN POLYUNSATURATED FATTY ACID CONCENTRATION IS REVERSED, PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS, 67, (5), 2002, p121 - 130 Journal Article, 2002 URL DOI

Yvonne Nolan, Aedín Minogue, Emily Vereker, Anthony E. Bolton, Veronica A. Campbell, Marina A. Lynch, Attenuation of LPS-induced changes in synaptic activity in rat hippocampus by Vasogen's immune modulation therapy, Neuroimmunomodulation, 10, (1), 2002, p40 - 46 Journal Article, 2002 DOI URL

Lynch, M.A., IL-1beta exerts a myriad of effects in the brain and in particular in the hippocampus: analysis of some of these actions, Vitamins and Hormones, 64, 2002, p185 - 219 Journal Article, 2002 URL DOI

MURPHY, KJ, NEUROPLASTIC EVENTS REQUIRED-FOR LTP AND AVOIDANCE LEARNING ARE IMPAIRED BY OPIATE ADDICTION, unknown, 2001, 134, ISI Web of Science, 2002, ppU80 - U80 Miscellaneous, 2002

Peter E. Lonergan, Darren S. D. Martin, David F. Horrobin, and Marina A. Lynch, NEUROPROTECTIVE EFFECT OF EICOSAPENTAENOIC ACID IN HIPPOCAMPUS OF RATS EXPOSED TO GAMMA-IRRADIATION, JOURNAL OF BIOLOGICAL CHEMISTRY, 277, (23), 2002, p20804 - 20811 Journal Article, 2002 URL DOI

HAUSS-WEGRZYNIAK, B, CHRONIC BRAIN INFLAMMATION RESULTS IN CELL LOSS IN THE ENTORHINAL CORTEX AND IMPAIRED LTP IN PERFORANT PATH-GRANULE CELL SYNAPSES, EXPERIMENTAL NEUROLOGY, 176, 2002, p336 - 341 Journal Article, 2002 DOI URL

Martina Gooney, M. A. Lynch, LONG-TERM POTENTIATION IN THE DENTATE GYRUS OF THE RAT HIPPOCAMPUS IS ACCOMPANIED BY BRAIN-DERIVED NEUROTROPHIC FACTOR-INDUCED ACTIVATION OF TRKB, JOURNAL OF NEUROCHEMISTRY, 77, (5), 2001, p1198 - 1207 Journal Article, 2001 DOI URL

Lynch, M.A., Lipoic acid confers protection against oxidative injury in non-neuronal and neuronal tissue, Nut. Neurosci, 4, 2001, p419 - 438 Review, 2001

Sheila Donnelly, Christine E. Loscher, Marina A. Lynch, and Kingston H. G. Mills, Whole-cell but not acellular pertussis vaccines induce convulsive activity in mice: evidence of a role for toxin-induced interleukin-1 beta in a new murine model for analysis of neuronal side effects of vaccination, Infection and Immunity, 69, (7), 2001, p4217 - 4223 Journal Article, 2001 TARA - Full Text DOI

Áine Kelly, Aileen Lynch, Emily Vereker, Yvonne Nolan, Patrice Queenan, Elizabeth Whittaker, Luke A. J. O' Neill, and Marina A. Lynch , The anti-inflammatory cytokine, interleukin (IL)-10, blocks the inhibatory effect of IL-1 beta on long term potentiation - a role for JNK, Journal of Biological Chemistry, 276, (49), 2001, p45564 - 45572 Journal Article, 2001 TARA - Full Text DOI

LYNCH, MA, THE ROLE OF STRESS-ACTIVATED PROTEIN KINASES IN THE INHIBITION OF LONG-TERM POTENTIATION IN THE DENTATE GYRUS OF THE RAT HIPPOCAMPUS INDUCED BY IL-1, unknown, 2001, 77, ISI Web of Science, 2001, pp18 - 18 Miscellaneous, 2001

Vereker, Emily and O'Donnell, Eamonn and Lynch, Ailenn and Nolan, Yvonne and Lynch, Marina A., Evidence that interleukin-1beta and reactive oxygen species production play a pivotal role in stress-induced impairment of LTP in the rat dentate gyrus, European Journal of Neuroscience, 14, (11), 2001, p1809 - 1819 Journal Article, 2001 DOI URL

Veronica Campbell and Marina A. Lynch , The role of ceramide in the modulation of intracellular Ca2+ levels by interleukin 1beta in rat cortical synaptosomes, Cytokine, 12, (5), 2000, p487 - 490 Journal Article, 2000 URL DOI

Eamonn O'Donnell, Emily Vereker, M. A. Lynch, Age-related impairment in LTP is accompanied by enhanced activity of stress-activated protein kinases: analysis of underlying mechanisms , EUROPEAN JOURNAL OF NEUROSCIENCE, 12, (1), 2000, p345 - 352 Journal Article, 2000 DOI URL

Campbell, V. and Lynch, M.A , The role of ceramide in the interleukin-1ß-mediated modulation of [Ca2+]i in rat cortical synaptosomes., Cytokine, 12, (5), 2000, p487 - 490 Journal Article, 2000 DOI

MURPHY, KJ, OPIATE ADDICTION IMPAIRS NEUROPLASTIC EVENTS ASSOCIATED WITH MEMORY FORMATION, unknown, 2000, 12, ISI Web of Science, 2000, pp206 - 206 Miscellaneous, 2000

Vereker E, Campbell V, Roche E, McEntee E, Lynch MA., Lipoplysaccharide inhibits long term potentiation in the rat dentate gyrus by activating caspase-1, Journal of Biological Chemistry, 275, (34), 2000, p26252 - 26258 Journal Article, 2000 URL DOI

MARTIN, DSD, Lynch, MA, A DIET ENRICHED IN ALPHA-LIPOIC ACID REVERSES THE AGE-RELATED COMPROMISE IN ANTIOXIDANT DEFENCES IN RAT CORTICAL TISSUE, NUTRITIONAL NEUROSCIENCE, 3, 2000, p193 - 206 Journal Article, 2000

Christine E. Loscher, Sheila Donnelly, Marina A. Lynch Kingston H. G. Mills, Induction of inflammatory cytokines in the brain following respiratory infection with bordetella pertussis, Journal of Neuroimmunology, 102, (2), 2000, p172 - 181 Journal Article, 2000 URL DOI

OMARA, SM, THE EFFECTS OF THE ENDOTOXIN LIPOPOLYSACCHARIDE ON SYNAPTIC TRANSMISSION AND PLASTICITY IN THE CA1-SUBICULUM PATHWAY IN VIVO, unknown, 2000, 12, ISI Web of Science, 2000, pp250 - 250 Miscellaneous, 2000

CAMPBELL, V, INTRACEREBROVENTRICULAR ADMINISTRATION OF A CASPASE-1 INHIBITOR BLOCKS THE MODULATORY EFFECTS OF LIPOPOLYSACCHARIDE ON LONG-TERM POTENTIATION IN THE RAT DENTATE GYRUS, unknown, 2000, 526, ISI Web of Science, 2000, pp59P - 59P Miscellaneous, 2000

Kelly A, Mullany PM, Lynch MA., Protein synthesis in entorhinal cortex and long-term potentiation in dentate gyrus., Hippocampus, 10, (49), 2000, p431 - 437 Journal Article, 2000 URL DOI

E. Vereker, E. O'Donnell, and M. A. Lynch, The Inhibitory Effect of Interleukin-1b on Long-Term Potentiation Is Coupled with Increased Activity of Stress-Activated Protein Kinases, JOURNAL OF NEUROSCIENCE, 20, (18), 2000, p6811 - 6819 Journal Article, 2000 URL

Christine E. Loscher, Sheila Donnelly, Kingston H. G. Mills, and Marina A. Lynch, Interleukin-1â-dependent changes in the hippocampus following parenteral immunization with a whole cell pertussis vaccine , Journal of Neuroimmunology, 111, (1-2), 2000, p68 - 76 Journal Article, 2000 DOI URL

Kelly A, Lynch MA., Long-term potentiation in dentate gyrus of the rat is inhibited by the phosphoinositide 3-kinase inhibitor, wortmannin, Neuropharmacology, 39, (49), 2000, p643 - 651 Journal Article, 2000 DOI

CAMPBELL, V, INTRAPERITONEAL ADMINISTRATION OF LIPOPOLYSACCHARIDE INDUCES APOPTOSIS IN RAT ENTORHINAL CORTEX, unknown, 2000, 523, ISI Web of Science, 2000, pp189P - 189P Miscellaneous, 2000

VEREKER, E, LIPOPOLYSACCHARIDE INHIBITS LONG-TERM POTENTIATION AND GLUTAMATE RELEASE IN RAT DENTATE GYRUS, unknown, 2000, 523, ISI Web of Science, 2000, pp188P - 189P Miscellaneous, 2000

Christine E. Loscher, Sheila Donnelly, Kingston H. G. Mills, Marina A. Lynch, INTERLEUKIN-1 BETA-DEPENDENT CHANGES IN THE HIPPOCAMPUS FOLLOWING PARENTERAL IMMUNIZATION WITH A WHOLE CELL PERTUSSIS VACCINE, JOURNAL OF NEUROIMMUNOLOGY, 111, 2000, p68 - 76 Journal Article, 2000 DOI URL

SHAW, K, STRESS: HOW IT AFFECTS SPATIAL LEARNING AND BDNF EXPRESSION, unknown, 2000, 12, ISI Web of Science, 2000, pp330 - 330 Miscellaneous, 2000

Elizabeth Whittaker, Emily Vereker and M. A. Lynch, Neuropeptide Y inhibits glutamate release and long-term potentiation in rat dentate gyrus , Brain Research , 827, 1999, p229 - 233 Journal Article, 1999 DOI URL

Á. Kelly, C. Maguire and M. A. Lynch, Deficits in nerve growth factor release and tyrosine receptor kinase phosphorylation are associated with age-related impairment in long-term potentiation in the dentate gyrus, Neuroscience, 95, (2), 1999, p359 - 365 Journal Article, 1999 URL DOI

LYNCH, MA, WHAT IS THE BIOLOGICAL SIGNIFICANCE OF AN AGE-RELATED INCREASE IN IL-1 BETA IN HIPPOCAMPUS?, MOLECULAR PSYCHIATRY, 4, 1999, 15 - 18 Miscellaneous, 1999

Conor Maguire, Marina Casey, Áine Kelly, Patricia M. Mullany, Marina A. Lynch , Activation of tyrosine receptor kinase plays a role in expression of long-term potentiation in the rat dentate gyrus, Hippocampus, 9, (5), 1999, p519 - 526 Journal Article, 1999 URL

McGahon BM, Martin DS, Horrobin DF, Lynch MA., Age-related changes in synaptic function: analysis of the effect of dietary supplementation with omega-3 fatty acids., NEUROSCIENCE, 94, (1), 1999, p305 - 314 Journal Article, 1999 DOI URL

Donnelly, Sheila; Loscher, Christine; Mills, Kingston H.G.; Lynch, Marina, GLYCEROL-INDUCED SEIZURE: INVOLVEMENT OF IL-1 BETA AND GLUTAMATE, NEUROREPORT, 10, (9), 1999, p1821 - 1825 Journal Article, 1999 URL

McGahon, B.M., Murray, C.A., Horrobin, D.F. and Lynch, M.A., Age-related changes in oxidative mechanisms and LTP are reversed by dietary manipulation, Neurobiol. Aging, 20, (6), 1999, p643 - 653 Journal Article, 1999 URL DOI

B. M. McGahon, C. A. Murray, D. F. Horrobin and M. A. Lynch, Age-related changes in oxidative mechanisms and LTP are reversed by dietary manipulation, NEUROBIOLOGY OF AGING, 20, (6), 1999, p643 - 653 Journal Article, 1999 URL DOI

Bernadette M. McGahon, Donen S. D. Martin, David F. Horrobin and Marina A. Lynch, Age-related changes in LTP and antioxidant defenses are reversed by an á-lipoic acid-enriched diet, NEUROBIOLOGY OF AGING, 20, (6), 1999, p655 - 664 Journal Article, 1999 DOI URL

Donnelly, Sheila; Loscher, Christine; Mills, Kingston H.G.; Lynch, Marina , Glycerol-induced seizure: Involvement of IL-1[beta] and glutamate, NEUROREPORT, 10, (9), 1999, p1821 - 1825 Journal Article, 1999 URL

McGahon B, Maguire C, Kelly A, Lynch MA., Activation of p42 mitogen-activated protein kinase by arachidonic acid and trans-1-amino-cyclopentyl-1,3- dicarboxylate impacts on long-term potentiation in the dentate gyrus in the rat: analysis of age-related changes., NEUROSCIENCE, 90, (4), 1999, p1167 - 1175 Journal Article, 1999 URL DOI

C.A. Murray, M.P. Clements & M.A. Lynch, Interleukin-1 Induces Lipid Peroxidation and Membrane Changes in Rat Hippocampus: An Age-Related Study, Gerontology, 45, 1999, p136 - 142 Journal Article, 1999 URL

Kelly A, Lynch MA., LTP occludes the interaction between arachidonic acid and ACPD and NGF and ACPD, Neuroreport, 9, (18), 1998, p4087 - 4091 Journal Article, 1998 URL

E. O'Donnell and M. A. Lynch, DIETARY ANTIOXIDANT SUPPLEMENTATION REVERSES AGE-RELATED NEURONAL CHANGES, NEUROBIOLOGY OF AGING, 19, (5), 1998, p461 - 467 Journal Article, 1998 DOI URL

V. A. Campbell, R. Segurado and M. A. Lynch, Regulation of intracellular Ca2+ concentration by interleukin-1â in rat cortical synaptosomes: an age-related study , Neurobiology of Aging, 19, (6), 1998, p575 - 579 Journal Article, 1998 DOI URL

Campbell, Veronica; Lynch, Marina A, Biphasic modulation of intracellular Ca2+ concentration by interleukin-1[beta] in cortical synaptosomes: involvement of a pertussis toxin-sensitive G-protein and mitogen-activated protein kinase, NEUROREPORT, 9, (9), 1998, p1923 - 1927 Journal Article, 1998 URL

LYNCH, MA, AGE-RELATED IMPAIRMENT IN LONG-TERM POTENTIATION IN HIPPOCAMPUS: A ROLE FOR THE CYTOKINE, INTERLEUKIN-1 BETA?, PROGRESS IN NEUROBIOLOGY, 56, 1998 Review, 1998 DOI URL

CAMPBELL, VA, BIPHASIC MODULATION OF [CA2+](1) BY INTERLEUKIN-1 BETA IN RAT CORTICAL SYNAPTOSOMES, unknown, 1998, 509P, ISI Web of Science, 1998, pp55P - 55P Miscellaneous, 1998

LYNCH, MA, ANALYSIS OF THE MECHANISMS UNDERLYING THE AGE-RELATED IMPAIRMENT IN LONG-TERM POTENTIATION IN THE RAT, REVIEWS IN THE NEUROSCIENCES, 9, 1998, p169 - 201 Review, 1998

[DEPT. PHYSIOLOGY PUBLICATION] Campbell V.A. and Segurado R. and Lynch M. A., Regulation of intracellular Ca2+ concentration by interleukin-1beta in rat cortical synaptosomes: an age-related study, Neurobiology of Aging, 19, (6), 1998, p575 - 579 Journal Article, 1998 URL

Mullany PM, Lynch MA., Evidence for a role for synaptophysin in expression of long-term potentiation in rat dentate gyrus., NEUROREPORT, 9, (11), 1998, p2489 - 2494 Journal Article, 1998 URL

Ciara A. Murray and Marina A. Lynch , DIETARY SUPPLEMENTATION WITH VITAMIN E REVERSES THE AGE-RELATED DEFICIT IN LONG TERM POTENTIATION IN DENTATE GYRUS, JOURNAL OF BIOLOGICAL CHEMISTRY, 273, (20), 1998, p12161 - 12168 Journal Article, 1998 URL

Murray, C. and Lynch, M.A., Analysis of the mechanism by which dietary supplementation with vitamin E and vitamin C restores ability of aged animals to sustain long-term potentiation in dentate gyrus, J. Biol. Chem., 273, (20), 1998, p12161 - 12168 Journal Article, 1998 URL DOI

MCGAHON, B, MURRAY, CA, CLEMENTS, MP, LYNCH, MA, ANALYSIS OF THE EFFECT OF MEMBRANE ARACHIDONIC ACID CONCENTRATION ON MODULATION OF GLUTAMATE RELEASE BY INTERLEUKIN-1: AN AGE-RELATED STUDY, EXPERIMENTAL GERONTOLOGY, 33, 1998, p343 - 354 Journal Article, 1998

MCGAHON, B, LYNCH, MA, ANALYSIS OF THE INTERACTION BETWEEN ARACHIDONIC ACID AND METABOTROPIC GLUTAMATE RECEPTOR ACTIVATION REVEALS THAT PHOSPHOLIPASE C ACTS AS A COINCIDENCE DETECTOR IN THE EXPRESSION OF LONG-TERM POTENTIATION IN THE RAT DENTATE GYRUS, HIPPOCAMPUS, 8, 1998, p48 - 56 Journal Article, 1998

Loscher CE, Donnelly S, McBennett S, Lynch MA, Mills KH., Proinflammatory cytokines in the adverse systemic and neurologic effects associated with parenteral injection of a whole cell pertussis vaccine., Annals of the New York Academy of Sciences, 856, 1998, p274 - 277 Journal Article, 1998 URL

Murray, C A , Lynch, M A, Evidence That Increased Hippocampal Expression of the Cytokine Interleukin-1 Is a Common Trigger for Age- and Stress-Induced Impairments in Long-Term Potentiation, JOURNAL OF NEUROSCIENCE, 18, (8), 1998, p2974 - 2981 Journal Article, 1998 URL

Campbell, V. and Lynch, M.A, Biphasic modulation of intracellular Ca2+ concentration by interleukin-1ß in cortical synaptosomes: involvement of a pertussis toxin-sensitive G-protein and mitogen-activated protein kinase, Neuroreport , 9, (9), 1998, p1923 - 1927 Journal Article, 1998 URL

DHANRAJAN, TM, PLASTICITY OF DENDRITIC SPINES IN HIPPOCAMPUS OF YOUNG AND AGED RATS 45 MIN AFTER LTP INDUCTION., unknown, 1998, 10, ISI Web of Science, 1998, pp391 - 391 Miscellaneous, 1998

Kelly A, Conroy S, Lynch MA., Evidence that nerve growth factor plays a role in long-term potentiation in the rat dentate gyrus., Neuropharmacology, 37, (4-5), 1998, p561 - 570 Journal Article, 1998 DOI URL

P. Mullany and M. A. Lynch , CHANGES IN PROTEIN SYNTHESIS AND SYNTHESIS OF THE SYNAPTIC VESICLE PROTEIN, SYNAPTOPHYSIN, IN ENTORHINAL CORTEX FOLLOWING INDUCTION OF LONG-TERM POTENTIATION IN DENTATE GYRUS: AN AGE-RELATED STUDY IN THE RAT, NEUROPHARMACOLOGY, 36, (7), 1997, p973 - 980 Journal Article, 1997 DOI URL

KELLY, A, EVIDENCE INDICATING A ROLE FOR NERVE GROWTH FACTOR IN LONG-TERM POTENTIATION IN THE DENTATE GYRUS OF THE RAT, unknown, 1997, 501P, ISI Web of Science, 1997, ppP89 - P89 Miscellaneous, 1997

McGahon B, Holscher C, McGlinchey L, Rowan MJ, Lynch MA., Training in the Morris water maze occludes the synergism between ACPD and arachidonic acid on glutamate release in synaptosomes prepared from rat hippocampus., Learning and Memory, 3, (4), 1997, p296 - 304 Journal Article, 1997 DOI URL

McGahon B, Clements MP, Lynch MA., The ability of aged rats to sustain long-term potentiation is restored when the age-related decrease in membrane arachidonic acid concentration is reversed., NEUROSCIENCE, 81, (1), 1997, p9 - 16 Journal Article, 1997 DOI URL

MURRAY, CA, IMPAIRED ABILITY OF AGED RATS TO SUSTAIN LONG-TERM POTENTIATION MAY RESULT FROM INCREASED HIPPOCAMPAL EXPRESSION OF INTERLEUKIN-1 BETA, unknown, 1997, 501P, ISI Web of Science, 1997, ppP87 - P87 Miscellaneous, 1997

MCGAHON, B, EVIDENCE THAT LONG-TERM POTENTIATION IN RAT DENTATE GYRUS UTILIZES PHOSPHOLIPASE C AS A COINCIDENCE DETECTOR: INVESTIGATION OF THE INTERACTION BETWEEN ARACHIDONIC ACID AND THE METABOTROPIC GLUTAMATE RECEPTOR AGONIST, 1-AMINO-CYCLOPENTANE-1,3-DICARBOXYLATE, unknown, 1997, 501P, ISI Web of Science, 1997, ppP88 - P88 Miscellaneous, 1997

LYNCH, MA, AGE-RELATED CHANGES IN SYNAPTIC PLASTICITY IN RAT HIPPOCAMPUS, unknown, 1997, 501P, ISI Web of Science, 1997, ppS5 - S6 Miscellaneous, 1997

MULLANY, P, INDUCTION OF LONG-TERM POTENTIATION IN VIVO IN RAT DENTATE GYRUS IS ACCOMPANIED BY AN INCREASE IN PHOSPHORYLATION OF RECEPTOR TYROSINE KINASE, unknown, 1997, 501P, ISI Web of Science, 1997, ppP87 - P88 Miscellaneous, 1997

Murray CA, McGahon B, McBennett S, Lynch MA., Interleukin-1 beta inhibits glutamate release in hippocampus of young, but not aged, rats., NEUROBIOLOGY OF AGING, 18, (3), 1997, p343 - 348 Journal Article, 1997 DOI URL

McGahon B, Lynch MA., THE SYNERGISM BETWEEN ACPD AND ARACHIDONIC ACID ON GLUTAMATE RELEASE IN HIPPOCAMPUS IS AGE-DEPENDENT, EUROPEAN JOURNAL OF PHARMACOLOGY, 309, (3), 1996, p323 - 326 Journal Article, 1996 URL DOI

Cunningham AJ, Murray CA, O'Neill LA, Lynch MA, O'Connor JJ., Interleukin-1 beta (IL-1 beta) and tumour necrosis factor (TNF) inhibit long-term potentiation in the rat dentate gyrus in vitro., Neuroscience Letters, 203, (1), 1996, p17 - 20 Journal Article, 1996 URL DOI

B. McGahon and M. A. Lynch, The synergism between metabotropic glutamate receptor activation and arachidonic acid on glutamate release is occluded by induction of long-term potentiation in the dentate gyrus , NEUROSCIENCE, 72, (3), 1996, p847 - 855 Journal Article, 1996 DOI URL

Patricia Mullany, Shane Connolly and Marina A. Lynch, Ageing is associated with changes in glutamate release, protein tyrosine kinase and Ca2+/calmodulin-dependent protein kinase II in rat hippocampus , EUROPEAN JOURNAL OF PHARMACOLOGY, 309, (3), 1996, p311 - 315 Journal Article, 1996 DOI URL

Cunningham, A.J., Murray, C.A., O'Neill, L.A.J., Lynch, M.A. and O'Connor, J.J., Interleukin-1â (IL-1â) and tumour necrosis factor (TNF) inhibit long-term potentiation in the rat dentate gyrus in vitro, Neurosci. Letts., 203, (1), 1996, p17 - 20 Journal Article, 1996 URL DOI

MCGAHON, B, THE SYNERGISM BETWEEN ARACHIDONIC-ACID AND ACPD ON GLUTAMATE RELEASE IN DENTATE GYRUS IS OCCLUDED BY INDUCTION OF LONG-TERM POTENTIATION, unknown, 1995, 489P, ISI Web of Science, 1995, ppP6 - P7 Miscellaneous, 1995

Lynch MA, Voss KL., Membrane Arachidonic Acid Concentration Correlates with Age and Induction of Long-term Potentiation in the Dentate Gyrus in the Rat, EUROPEAN JOURNAL OF NEUROSCIENCE, 6, (6), 1994, p1008 - 1014 Journal Article, 1994 URL DOI

Lynch, M.A., Jaques-Berg, W., Lawson, P.R., Voss, K.L. and Bliss, T.V.P., The effect of arachidonic acid on uptake in cortical and hippocampal preparations, Neurosci. Res. Comm., 14, 1994, p53 - 61 Journal Article, 1994

McGahon B, Lynch MA., A STUDY OF THE SYNERGISM BETWEEN METABOTROPIC GLUTAMATE-RECEPTOR ACTIVATION AND ARACHIDONIC-ACID IN THE RAT HIPPOCAMPUS, NEUROREPORT, 5, (17), 1994, p2353 - 2357 Journal Article, 1994

Lynch, M.A., Voss, K.L., Rodriguez, J. and Bliss, T.V.P., Increase in synaptic vesicle proteins accompanies long-term potentiation in the dentate gyrus, Neuroscience, 60, (1), 1994, p1 - 5 Journal Article, 1994 DOI URL

Lynch MA, Voss KL, Gower AJ., Impaired spatial memory in aged rats is associated with alterations in inositol phospholipid metabolism., NEUROREPORT, 5, (12), 1994, p1493 - 1497 Journal Article, 1994

Williams, J.H., Errington, M.L., Li, Y-G., Lynch, M.A. and Bliss, T.V.P., The search for retrograde messangers in long-term potentiation, Seminars in the neurosciences, 5, 1993, p149 - 158 Journal Article, 1993

Lynch, M.A., Clements, M.P., Voss, K.L., Bramham, C.R. and Bliss, T.V.P., Is arachidonic acid a retrograde messanger inlong-term potentiation?, Biochem. Soc. Trans., 19, 1991, p391 - 386 Journal Article, 1991

Lynch, M.A. and Voss, K.L., Presynaptic changes in long-term potentiation: elevated synaptosomal calcium concentration and basal phosphoinositide turnover in dentate gyrus, J. Neurochem., 56, (1), 1991, p113 - 118 Journal Article, 1991 DOI URL

Clements, M.P., Bliss, T.V.P. and Lynch, M.A., Increase in arachidonic acid concentration in a postsynaptic density fraction following the induction of long-term potentiation in the dentate gyrus, Neuroscience, 45, (2), 1991, p379 - 389 Journal Article, 1991 URL DOI

Jeffreys, J.G.R., Mitchell, P., O'Hara, L., Tiley, C., Hardy, J., Jordan, S.J., Lynch, M.A. and Wandsworth, J., Ex vivo release of GABA from tetanus toxin induced chronic epileptic foci decreased during active seizure phase, Neurochem. Int., Int., (18), 1991, p373 - 379 Journal Article, 1991 URL DOI

Laroche, R., Redini-Del Negro, C., Clements, M.P., and Lynch, M.A., Long-term activation of phosphoinositide turnover associated with increased release of amino acides in the dentate gyrus and the hippocampus following classical conditioning in the rat., European J. Neurosci., 2, (6), 1990, p534 - 543 Journal Article, 1990 DOI URL

Lynch, M.A. and Voss, K.L., Arachidonic acid increases inositol phospholipid metabolims and glutamate release in synaptosomes prepared from hippocampal tissue, J. Neurochem., 55, (1), 1990, p215 - 221 Journal Article, 1990 DOI URL

Bliss, T.V.P., Clements, M.P., Errington, M.L., Lynch, M.A. and Williams, J.H., Presynaptic changes associated with long-term potentiation in the dentate gyrus, Semin. Neurosci., 2, 1990 Journal Article, 1990

Lynch, M.A., Errington, M.L., Celements, M.P., Bliss, T.V.P., Redini Del Negro, C. and Laroche, S., Increases in glutamate and phosphoinositide metabolism associated with long-term potentiation and classical conditioning, Progr. Brain Res., 83, 1990, p251 - 256 Journal Article, 1990

Bliss, T.V., Errington, M.L., Lynch, M.A., Long-term potentiation in the dentate gyrus in vivo is associated with a sustained increase in extracellular glutamate, Adv. Exp. Med. Biol., 268, 1990, p269 - 278 Journal Article, 1990

Clements, M.P., Errington, M.L., Bliss, T.V.P. and Lynch, M.A., Time-related changes in basal phosphoinositide turnover after induction of long-term potentiation in the dentate gyrus are blocked by commissural stimulation, Eur. J. Neurosci., 2, (4), 1990, p383 - 387 Journal Article, 1990 URL DOI

Lynch, M.A.., Errington, M.L. and Bliss, T.V.P., The increase in [3H]glutamate release associated with long-term potentiation in the dentate gyrus is blocked by commissural stimulation, Neuroscience Letters, 103, (3), 1989, p191 - 197 Journal Article, 1989 URL DOI

Williams, J.H., Errington, M.L., Lynch, M.A. and Bliss, T.V.P., Arachidonic acid induces a long-term, activity-dependent enhancement of synaptic transmission in the hippocampus, Nature, 341, (6244), 1989, p739 - 742 Journal Article, 1989 DOI URL

Lynch, M.A., Mechanisms underlying induction and maintenance of long-term potentiation in the hippocampus, Bioessays, 10, (2-3), 1989, p85 - 90 Journal Article, 1989 DOI URL

Lynch, M.A., Errington, M.L. and Bliss, T.V.P., Nordihydroguaiaretic acid blocks the synaptic component of long-term potentiation and the associated increases in release of glutamate and arachidonate: an in vivo study in the dentate gyrus of the rat., Neuroscience, 30, (3), 1989, p693 - 701 Journal Article, 1989 DOI URL

Lynch, M.A., Clements, M.P., Errington, M.L. and Bliss, T.V.P., Increased hydrolysis of phosphatidylinositol-4,5-bisphosphate in long-term potentiation , Neurosci. Letts., 84, (3), 1988, p291 - 296 Journal Article, 1988 URL DOI

Clements, M.P., Lynch, M.A. and Bliss, T.V.P., The increase in phosphoinositide turnover associated with long-term potentiation may be mediated through a GTP binding protein, Neuroscience Research Communnications, 3, 1988, p11 - 19 Journal Article, 1988

Laroche, S., Errington, M.L., Lynch, M.A., and Bliss, T.V.P., Increase in (3)H glutamate release from slices of dentate gyrus and hippocampus following classical conditioning in the rat, Behavioural Brain Res., 25, (1), 1987, p23 - 29 Journal Article, 1987 URL DOI

Errington, M.L., Lynch, M.A., and Bliss, T.V.P., Long-term potentiation in the dentate gyrus: induction and increased glutamate release are blocked by D(-)amino-phosphonovalerate, Neuroscience, 20, (1), 1987, p279 - 284 Journal Article, 1987 URL DOI

Bliss, T.V.P., Errington, M.L., Laroche, S. and Lynch, M.A., Increase in K+-stimulated, Ca2+-dependent release of [3H]glutamate from rat dentate gyrus three days after induction of long-term potentiation, Neurosci. Letts., 83, (1-2), 1987, p107 - 112 Journal Article, 1987 URL DOI

Lynch, M. and Bliss, T.V.P., Noradrenaline modulates release of (14)C glutamate from dentate but not from CAI/CA3 slices of rat hippocampus, Neuropharmacology, 25, (5), 1986, p493 - 498 Journal Article, 1986 DOI URL

Bliss, T.V.P., Douglas, R.M., Errington, M.L. and Lynch, M., Correlation between long-term potentiation and release of endogenous amino acids from dentate gyrus of anaesthetized rats, J. Physiol., 377, 1986, p391 - 408 Journal Article, 1986 URL

Lynch, M.A.and Bliss, T.V.P., Long-term potentiation of synaptic transmission in CA3: effect of calmodulin and OAG on release of (3)H glutamate, Neurosci. Letts., 65, (2), 1986, p171 - 176 Journal Article, 1986 URL DOI

Lynch, M., Errington, M.L. and Bliss, T.V.P., Long-term potentiation of synaptic transmission in dentate gyrus increased of (14)C glutamate without an increase in receptor binding, Neurosci. Letts., 65, (1), 1986, p123 - 129 Journal Article, 1986 DOI URL

Spencer, P., Lynch, M. and Bliss, T.V.P., In vitro release of (14)C glutamate from dentate gyrus in modulated by GABA, J. Pharm. Pharmacol., 38, (5), 1986, p393 - 395 Journal Article, 1986

Lynch, M., Archer, E.R.and Littleton, J.M., Increased sensitivity of transmitter release to calcium in ethanol tolerance, Biochem. Pharmacol., 35, (7), 1986, p1207 - 1209 Journal Article, 1986 URL DOI

Lynch, M. and Bliss, T.V.P., On the mechanism of enhanced release on (14)C glutamate in hippocampal long-term potentiation, Brian Res., 369, (1-2), 1986, p405-408 Journal Article, 1986 URL DOI

Lynch, M., Pagonis, C., Samuel, D. and Littleton, J.M., Alterations in Ca(2+) - dependent and Ca(2+) independent release of catecholamines in preparations of rat brain produced by ethanol treatment in vivo, Alcohol, 2, (1), 1985, p139 - 144 Journal Article, 1985 DOI URL

Feasey, K.J., Lynch, M.A., and Bliss, T.V.P., Long-term potentiation is associated with an increase in calcium-dependent, potassium-stimulated release of (14)C glutamate from hippocampla slices: an ex vivo study in the rat, Brain Res., 364, 1985, p39 - 44 Journal Article, 1985 DOI URL

M. A. Lynch, J. D. Bruton, J. F. Andrews and R. E. Moore , THE RAPID METABOLIC RESPONSE OF YOUNG LAMBS TO LOW-DOSES OF T3 - INTERACTION WITH RT3, JOURNAL OF THERMAL BIOLOGY, 10, (2), 1985, p71 - 77 Journal Article, 1985 DOI URL

Lynch, M.A. and Littleton, J.M., Enhanced (3)H noradrenaline release in synaptosomes from ethanol-tolerant animals: the role of nerve terminal Ca(2+), Alcohol and Alcoholism, 20, 1985, p5 - 11 Journal Article, 1985 URL

LYNCH, MA, LOW-DOSES OF T3 INDUCE A RAPID METABOLIC RESPONSE IN YOUNG LAMBS, HORMONE AND METABOLIC RESEARCH, 17, (2), 1985, p63 - 66 Journal Article, 1985

LYNCH, MA, ADMINISTRATION OF LOW-DOSES OF TSH RESULT IN A RAPID INCREASE IN THE METABOLIC-RATE OF YOUNG LAMBS, HORMONE AND METABOLIC RESEARCH, 17, (3), 1985, p136 - 140 Journal Article, 1985

SAMUEL, D., LYNCH, M. and LITTLETON, J.M., Picrotoxin inhibits the effect of ethanol on the spontaneous efflux of [3H]-dopamine from superfused slices of rat corpus striatum, Neuropharmacology, 22, (12), 1983, p1413-1415 Journal Article, 1983 DOI URL

FENN, G.C., LYNCH, M., NHAMBURO, P.T., CABEROS, L.P. and LITTLETON, J.M., A comparison of effects of ethanol on platelet function and synaptic trasmission, Pharmacology, Biochemisty and Behaviour, 18, Supplement 1., 1983, p37-43 Journal Article, 1983

Lynch, M. and Littleton, J.M.,, Possible association of alcohol tolerance with increased synaptic Ca2+ sensitivity, Nature, 303, 1983, p175 - 177 Journal Article, 1983 URL DOI

Lynch, M., Littleton, J.M., McKernan, R.M., Durcan, M.J., McMillan, J. and Campbell, I.C., Alpha-adrenoceptor number and function in rat cortex after ethanol and immobilization stress, Brain . Res., 288, (1-2), 1983, p145 - 149 Journal Article, 1983 URL DOI

Caberos, L.P., Lynch, M., Leroy, C., Fenn, G.C. and Littleton J.M., Interaction of ethanol with ionophore A23187 in human platelets and erythrocytes and in rat brain slices, Biochem. Pharmacol., 32, (14), 1983, p2211-2216 Journal Article, 1983 URL DOI

KENNY, M., LYNCH, M. and LEONARD, B.E., Induction of two distinct behavioural responses by chronic treatment with apomorphine, Journal of Neuroscience Research, 5, (1), 1980, p35-42 Journal Article, 1980

LYNCH, M. and LEONARD, B.E., Changes in brain gamma aminobutyric acid concentrations following acute and chronic amphetamine administration and during post amphetamine depression., Biochemical Pharmocology, 27, (14), 1978, p1853-1855 Journal Article, 1978

LYNCH, M. and LEONARD, B.E., Effect of chronic amphetamine administration on the behaviour of rats in the "open field" apparatus: reversal of post-withdrawl depression by 2 antidepressants, J Pharm Pharmacol. , 30, (12), 1978, p798-799 Journal Article, 1978

LYNCH, M., KENNY, M. and LEONARD, B.E., Effect of D-amphetamine on the behaviour of rats in the "open field": interaction with 4 neuroleptics and changes in biogenic amine metabolism in discrete brain regions., Irish Journal of Medical Science, 147, (10), 1978, p337-350 Journal Article, 1978

LYNCH, M., KENNY, M. and LEONARD, B.E., Changes in behaviour in rats in the "open field" apparatus after chronic amphetamine administration: acute effects of 3 antidepressants, I.C.R.S. Med. Sci., 5, 1977, pp.571 Journal Article, 1977

LYNCH, M., KENNY, M. and LEONARD, B.E., The effect of chronic administration of D-amphetamine on regional changes in catecholamines in the rat brain., Journal of Neuroscience Research, 3, 1977, p.295 Journal Article, 1977

LYNCH, M., KENNY, M. and LEONARD, B.E., Changes in the catecholamine content in 4 regions of the rat brain following acute ampetamine treatment: antagonistic effect of chlorpromazine, I.C.R.S. Med.Sci., 5, 1977, p561 Journal Article, 1977

Research Expertise

Description

RESEARCH INTERESTS 1. Analysis of the underlying cause(s) and consequences of age-related neuroinflammation in the brain, with a specific emphasis on assessing changes in microglial activation and the consequent inflammatory changes. 2. Assessment of the effect of neuroinflammation on synaptic function and modulation by anti-inflammatory strategies including neuroimmuneregulatory proteins, particularly CD200 ligand-receptor interaction. 3. Investigation of the different activation states of microglia in neuroinflammatory conditions including in the aged brain and in models of Alzheimer's disease. Assessment of the mechanisms by which activation states can be modulated. 4. Examination of the importance of polyunsaturated fatty acids in synaptic function, particularly in the aged brain. 5. Assessment of peripheral inflammatory changes as a means of identifying a biomarker which correlates with compromised cognitive function in prodromal Alzheimer's disease.

Projects

  • Summary
    • Current projects are as follows: 1. Analysis of the role of TLR2 activation in driving inflammation and the impact of decreasing activation on cognitive function, glial activation and amyloid pathology in APP/PS1 mice. 2. Investigation of the effects of a small molecule inhibitor of the NLRP3 inflammasome on glial and neuronal function in APP/PS1 mice. 3. Assessment of the impact of infiltrating IFNγ-producing peripheral cells on neuroinflammation and investigation of consequences of inhibiting cell infiltration by FTY720. 4. Investigation of the role of SLAM (Signalling lymphocyte activation molecule) on microglial function. 5. Identification of the metabolic and functional signatures of different microglial phenotypes

Keywords

Age related diseases; Aging/Gerontology; Antiinflammatory Cytokines ; Brain; HIPPOCAMPUS; Inflammation; POLYUNSATURATED FATTY ACIDS; PROINFLAMMATORY CYTOKINES; SYNAPTIC PLASTICITY

Recognition

Representations

2001-2005: Member of Irish government-appointed Commission on Assisted Human Reproduction; Workgroup Chair & member of drafting group for the final report. 2001-2009: Member of Board of Trinity College Institute of Neuroscience 2005-2008: Member of Board of Trinity College Dublin 2006-2009: Director, Trinity College Institute of Neuroscience

Awards and Honours

Royal Academy of Medicine in Ireland Conway Review Lecturer and Silver medal recipient 2006

Elected to membership of the Royal Irish Academy May 2009

Recipient of Tom Connor Distinguished Researcher Award In Neuroscience 2013

Recipient of the Irish Area Section of the Biochemical Society Silver Medal 2013

Elected Fellow of Trinity College, Dublin 1997

Memberships

British Neuroscience Association 1995 – 2017