Publications and Further Research Outputs
Fitzpatrick, J-M., Downer, E.J., Toll-like Receptor Signalling as a Cannabinoid Target in Multiple Sclerosis. , Neuropharmacology. , 113(Pt B), 2017, p618 - 626
Downer, E.J., Galpha(q) takes centre stage in multiple sclerosis pathogenesis., Cellular and Molecular Immunology , 14(5):, 2017, p401 - 402
Lone, M., McKenna, J.P., Cryan, J.F., Downer, E.J., Toulouse, A., Assessment of Thiel-embalmed cadavers as a teaching tool for oral anatomy and local anaesthesia., J Dent Education, 81(4):, 2017, p420 - 426
Fallarino F, Gargaro M, Mondanell G, Downer EJ, Hossain MJ, Gran B, Delineating the Role of Toll-Like Receptors in the Neuro-inflammation Model EAE., Methods in molecular biology (Clifton, N.J.), 1390, 2016, p383-411
Barry, A., Cronin, O, Ryan, A.M., Sweeney, B., Yap, S., O'Toole, O., Allen, A.P., Clarke, G., O'Halloran, K.D., and Downer, E.J., Impact of Exercise on Innate Immunity in Multiple Sclerosis Progression and Symptomatology., Frontiers in Physiology. , 7, 2016, p194-
Crowley T, Cryan JF, Downer EJ, O'Leary OF, Inhibiting Neuroinflammation: The Role and Therapeutic Potential of Gaba in Neuro-Immune Interactions., Brain, behavior, and immunity, 2016
Prenderville JA, Kelly ÁM, Downer EJ, The role of cannabinoids in adult neurogenesis., British journal of pharmacology, 2015
Crowley T, Fitzpatrick JM, Kuijper T, Cryan JF, O'Toole O, O'Leary OF, Downer EJ, Modulation of TLR3/TLR4 inflammatory signaling by the GABAB receptor agonist baclofen in glia and immune cells: relevance to therapeutic effects in multiple sclerosis., Frontiers in cellular neuroscience, 9, 2015, p284
Collins, L.M., Downer, E.J., Toulouse, A. and Nolan, Y.M. , Mitogen-Activated Protein Kinase Phosphatase (MKP)-1 in Nervous System Development and Disease. , Molecular Neurobiology. 51(3):1158-67., 2015
Fallarino, F., Gargaro, M., Mondanell, G., Downer, E.J., Hossain, M.J. and Gran, B, Delineating the Role of Toll-Like Receptors in the Neuro-inflammation Model EAE., Methods Molecular Biology, (in press), 2015
Downer, E.J. and Finn, D.P. , Cannabinoids: Clearing the smoke on pain, inflammation and neurodegeneration., British Journal of Pharmacology. , 171(6):, 2014, p1341-
Downer EJ, High hopes for CB(2) receptors in neurogenesis., British journal of pharmacology, 171, (6), 2014, p1345-6
O'Halloran, S., O'Leary, A., Kuijper, T. and Downer, E.J. , MyD88 acts as an adaptor protein for inflammatory signalling induced by amyloid-β in macrophages. , Immunology Letters. 162(1 Pt A):109-18., 2014
McDonough P, McKenna JP, McCreary C, Downer EJ, Neuropathic orofacial pain: cannabinoids as a therapeutic avenue., The international journal of biochemistry & cell biology, 55, 2014, p72-8
Downer EJ, Johnston DG, Lynch MA, Differential role of Dok1 and Dok2 in TLR2-induced inflammatory signaling in glia., Molecular and cellular neurosciences, 56C, 2013, p148-158
Downer EJ, Jones RS, McDonald CL, Greco E, Brennan S, Connor TJ, Robertson IH, & Lynch MA, Identifying early inflammatory changes in monocyte-derived macrophages from a population with IQ-discrepant episodic memory, PloS one, 8, (5), 2013, pe63194
Downer EJ, Clifford E, Amu S, Fallon PG, Moynagh PN, The synthetic cannabinoid R(+)WIN55,212-2 augments interferon-ß expression via peroxisome proliferator-activated receptor-"., The Journal of biological chemistry, 287, (30), 2012, p25440-53
Lyons A, Downer EJ, Costello DA, Murphy N, Lynch MA, Dok2 mediates the CD200Fc attenuation of Aß-induced changes in glia., Journal of neuroinflammation, 9, 2012, p107
Downer EJ, Clifford E, Gran B, Nel HJ, Fallon PG, Moynagh PN, Identification of the synthetic cannabinoid R(+)WIN55,212-2 as a novel regulator of IFN regulatory factor 3 activation and IFN-beta expression: relevance to therapeutic effects in models of multiple sclerosis., The Journal of biological chemistry, 286, (12), 2011, p10316-28
Downer EJ, Cannabinoids and innate immunity: taking a toll on neuroinflammation., TheScientificWorldJournal, 11, 2011, p855-65
Analysis of the impact of CD200 on neurodengeneration. in, Neurodegenerative Diseases - Processes, Prevention, Protection and Monitoring. , InTec, 2011, [1. Miller, A-M., Deighan, B., Downer, E.J., Lyons, A., Henric-Noak, P., Nolan, Y. and Lynch, M.A. ]
Kelly L, Grehan B, Chiesa AD, O'Mara SM, Downer E, Sahyoun G, Massey KA, Nicolaou A, Lynch MA, The polyunsaturated fatty acids, EPA and DPA exert a protective effect in the hippocampus of the aged rat., Neurobiology of aging, 32, (12), 2011, p2318.e1-15
Downer EJ, Campbell VA, Phytocannabinoids, CNS cells and development: a dead issue?, Drug and alcohol review, 29, (1), 2010, p91-8
Lyons A, Lynch AM, Downer EJ, Hanley R, O'Sullivan JB, Smith A, Lynch MA, Fractalkine-induced activation of the phosphatidylinositol-3 kinase pathway attentuates microglial activation in vivo and in vitro., Journal of neurochemistry, 110, (5), 2009, p1547-56
Lyons, A, McQuillan, K, Deighan, BF, O'Reilly, JA, Downer, EJ, Murphy, AC, Watson, M, Piazza, A, O'Connell, F, Griffin, R, Mills, KH, Lynch, MA, Decreased neuronal CD200 expression in IL-4-deficient mice results in increased neuroinflammation in response to lipopolysaccharide., Brain, Behavior, and Immunity, 23, (7), 2009, p1020 - 1027
Downer EJ, Cowley TR, Cox F, Maher FO, Berezin V, Bock E, Lynch MA, A synthetic NCAM-derived mimetic peptide, FGL, exerts anti-inflammatory properties via IGF-1 and interferon-gamma modulation., Journal of neurochemistry, 109, (5), 2009, p1516-25
Cannabinoids and Neuroprotection. in, Cannabinoids and the Brain. , Spinger Verlag, 2008, pp317 - 332, [Campbell, V.A. and Downer, E.J. ]
Lyons A, Downer EJ, Crotty S, Nolan YM, Mills KH, Lynch MA, CD200 ligand receptor interaction modulates microglial activation in vivo and in vitro: a role for IL-4., The Journal of neuroscience : the official journal of the Society for Neuroscience, 27, (31), 2007, p8309-13
Downer EJ, Gowran A, Campbell VA, A comparison of the apoptotic effect of Delta(9)-tetrahydrocannabinol in the neonatal and adult rat cerebral cortex., Brain research, 1175, 2007, p39-47
Downer EJ, Gowran A, Murphy AC, Campbell VA, The tumour suppressor protein, p53, is involved in the activation of the apoptotic cascade by Delta9-tetrahydrocannabinol in cultured cortical neurons., European journal of pharmacology, 564, (1-3), 2007, p57-65
Downer EJ, Fogarty MP, Campbell VA, Tetrahydrocannabinol-induced neurotoxicity depends on CB1 receptor-mediated c-Jun N-terminal kinase activation in cultured cortical neurons., British journal of pharmacology, 140, (3), 2003, p547-57
Fogarty MP, Downer EJ, Campbell V, A role for c-Jun N-terminal kinase 1 (JNK1), but not JNK2, in the beta-amyloid-mediated stabilization of protein p53 and induction of the apoptotic cascade in cultured cortical neurons., The Biochemical journal, 371, (Pt 3), 2003, p789-98
Downer E, Boland B, Fogarty M, Campbell V, Delta 9-tetrahydrocannabinol induces the apoptotic pathway in cultured cortical neurones via activation of the CB1 receptor., Neuroreport, 12, (18), 2001, p3973-8
DescriptionMy research background is in neuroimmunology, and I interested in how neuroimmune interactions are controlled under normal physiological conditions and disease states. My laboratory is particularly interested in the pathogenesis of Multiple Sclerosis (MS), and have published data demonstrating that cells associated with MS pathology display evidence of altered innate immune signalling signatures that may be linked directly with disease pathology. Specifically, my research efforts have focused on Toll-like Receptor (TLR) signalling, and my interest in this area is harboured by the established role of TLRs in innate immunity, in addition to emerging evidence that TLRs are implicated as pivotal players in the pathogenesis of neuroinflammatory disorders including MS. My long-term goal is to consolidate a research group that conducts patient-orientated research by investigating the links between cellular innate immune signalling signatures in peripheral blood cells and the impact of disease on central read-outs of cognition, pain, depression and neurologic disability. By conducting such investigations my research team aims to (a) delineate the role of the innate immune system in disease progression and symptomatology and, (b) investigate the impact of novel therapeutic strategies (cannabinoid-based drugs and exercise) on innate immune responses and disease symptoms in patients. To address this I have built clinical collaborations with Neurologists to access patient cohorts and have begun to profile innate immune profiles with disease parameters in MS patient cohorts. Media articles on my research: Irish Examiner http://www.irishexaminer.com/lifestyle/features/irish-scientists-leading-street-drug-research-229863.html Irish Times http://www.irishtimes.com/news/science/medical-marvel-the-uses-of-cannabis-continue-to-grow-1.2169988 Summary of research interests: Neuroimmunology Multiple Sclerosis Innate immune signalling Cannabinoid pharmacology Neuropathology Neuropathic orofacial pain Novel teaching innovations Funding: IRC HRB Physiological Society British Neuropathological Society
External examiner at NUIG and UCC.
Engagement with patient societies' by writing for the MS Ireland patient eZine
Organising committee: RAMI annual meeting, Trinity College.
Organising committee: Neuroscience Ireland Brain Awareness Outreach Event, Trinity College.
Represented the University as a speaker at the iWISH conference in the RDS (2017) attended by 4,000 students.
Organising committee: Physiology Friday Outreach Event, Trinity College.
Council member: Neuroscience Ireland
Research highlighted in the Irish Times.
Grant Reviewer: Orthopaedic Research UK.
Director: Biosciences Imaging Centre, Biosciences Building, University College Cork (UCC), Cork, Ireland.
Writer for MS patient website (www.livinglikeyou.com).
Editor (guest): British Journal of Pharmacology
Grant Reviewer: NUI Postdoctoral Fellowships in the Sciences, NUI Traveling Studentships in the Sciences, Medical Research Council.
Research highlighted in the Irish Examiner.
Organising committee: 6th European Workshop on Cannabinoid Research.
Programme co-ordinator: Structured PRTLI Ph.D programme. Trinity College Institute of Neuroscience, Trinity College, Dublin 2, Ireland.
Organising committee: 4th Annual Workshop on Cannabinoid Research in Ireland, Trinity College Dublin.
Secretary: Irish Cannabinoid Research Committee
Organising committee: 3rd Annual Workshop on Cannabinoid Research in Ireland, NUIM.
Council member: Royal Academy of Medicine in Ireland Council member (Biomedical Sciences section)
Journal Reviewer for approx 20 journals
Awards and Honours
. Invited speaker at the Personalised Medicine in MS International Symposium, Milan.
. Co-recipient of the Deans Award for Teaching and Learning, Trinity College
. Invited Speaker at iWISH STEM conference, RDS, Dublin, Ireland
. Co-organiser of the RAMI annual meeting, Trinity College
. Co-organiser of the Neuroscience Ireland Brain Awareness Outreach Event, Trinity College.
. Recipient of the Deans Award for Teaching and Learning, Trinity College
. Co-organiser of the Physiology Friday Outreach Event, Trinity College
. Research highlighted in MS Ireland's research eZine
. Research highlighted in the Irish Times
. Selected as Young Colloquia to present research at the Society for Neurochemistry meeting in Cairns, Australia
. Nominated by students (Dental: year 1) for Presidents Award for Excellence in Teaching, UCC
. Invited writer for Industry sponsored patient website (www.livinglikeyou.com)
. Invited writer for MS Ireland patient newsletter
. Winner of the Neuroscience Ireland Early Career Investigator Award
. Research highlighted by the Irish Examiner
. Host/Organiser of the 6th European Workshop on Cannabinoid Research
. Host of the 4th Annual Workshop on Cannabinoid Research in Ireland, Trinity College Dublin
. Elected council member of the Royal Academy of Medicine in Ireland
. Shortlisted finalist for the Roche Researcher of the Year Award
. Winner of Early Career Award from the Royal Academy of Medicine in Ireland
. One of three early career investigators funded by The Cannabinoid Research Society to present at the NIDA mini convention in Chicago, USA
. Host of the 3rd Annual Workshop on Cannabinoid Research in Ireland, NUIM
. Research highlighted in the Health Research Board "Neuroscience: Brain Matters" bulletin
. Commentary on research in British Journal of Pharmacology (Guzmán, M. 2003, British Journal of Pharmacology, 149, 439-440).
. Research highlighted in the Irish Times and Trinity Student Medical Journal
. Recipient of Enterprise Ireland Postgraduate Award
. Recipient of a Postgraduate Award from Trinity College Dublin in recognition of final year undergraduate results
. Final undergraduate research project ranked 1st in Senior Sophister class
Neuroscience Ireland Council member
Member of the TCD School of Medicine Appeals committee
Chair of the Human Health and Disease BSc curriculum committee, Trinity College Dublin
Chair of the ERASMUS exchange committee (Human Health and Disease; TCD)
Member of the Anatomical Society of Great Britain and Ireland
Secretary of Irish Cannabinoid Research Committee
Royal Academy of Medicine in Ireland Council member (Biomedical Sciences section)