Skip to main content

Trinity College Dublin, The University of Dublin

Trinity Menu Trinity Search



You are here Physiology > Staff

Maeve Caldwell
Professor in Neuroscience, Physiology

Publications and Further Research Outputs

Peer-Reviewed Publications

Crompton LA, Cordero-Llana O, Caldwell MA, Astrocytes in a dish: Using pluripotent stem cells to model neurodegenerative and neurodevelopmental disorders., Brain pathology (Zurich, Switzerland), 2017 Journal Article, 2017

Jiménez-Moreno N, Stathakos P, Caldwell MA, Lane JD, Induced Pluripotent Stem Cell Neuronal Models for the Study of Autophagy Pathways in Human Neurodegenerative Disease., Cells, 2017 Journal Article, 2017

McMillan KJ, Murray TK, Bengoa-Vergniory N, Cordero-Llana O, Cooper J, Buckley A, Wade-Martins R, Uney JB, O'Neill MJ, Wong LF, Caldwell MA, Loss of MicroRNA-7 Regulation Leads to "-Synuclein Accumulation and Dopaminergic Neuronal Loss In Vivo., Molecular therapy : the journal of the American Society of Gene Therapy, 2017 Journal Article, 2017

Zhu B, Caldwell M, Song B, Development of stem cell-based therapies for Parkinson's disease., The International journal of neuroscience, 2016 Journal Article, 2016

Wang W, Wang X, Fujioka H, Hoppel C, Whone AL, Caldwell MA, Cullen PJ, Liu J, Zhu X, Parkinson's disease-associated mutant VPS35 causes mitochondrial dysfunction by recycling DLP1 complexes., Nature medicine, 2016 Journal Article, 2016

Cordero-Llana Ó, Houghton BC, Rinaldi F, Taylor H, Yáñez-Muñoz RJ, Uney JB, Wong LF, Caldwell MA, Enhanced efficacy of the CDNF/MANF family by combined intranigral overexpression in the 6-OHDA rat model of Parkinson's disease., Molecular therapy : the journal of the American Society of Gene Therapy, 2015 Journal Article, 2015

Nistor Paul A., May Paul W., Tamagnini Francesco, Randall Andrew D., Caldwell Maeve A., Long-term culture of pluripotent stem-cell-derived human neurons on diamonds" A substrate for neurodegeneration research and therapy , Biomaterials , 61 , ( ), 2015, p139 - 149 Journal Article, 2015 TARA - Full Text URL DOI

Damseh N, Danson CM, Al-Ashhab M, Abu-Libdeh B, Gallon M, Sharma K, Yaacov B, Coulthard E, Caldwell MA, Edvardson S, Cullen PJ, Elpeleg O, A defect in the retromer accessory protein, SNX27, manifests by infantile myoclonic epilepsy and neurodegeneration., Neurogenetics, 2015 Journal Article, 2015

Cordero-Llana O, Rinaldi F, Brennan PA, Wynick D, Caldwell MA, Galanin promotes neuronal differentiation from neural progenitor cells in vitro and contributes to the generation of new olfactory neurons in the adult mouse brain., Experimental neurology, 2014 Journal Article, 2014

Rinaldi F, Hartfield EM, Crompton LA, Badger JL, Glover CP, Kelly CM, Rosser AE, Uney JB, Caldwell MA, Cross-regulation of Connexin43 and ß-catenin influences differentiation of human neural progenitor cells., Cell death & disease, 2014 Journal Article, 2014

McGough IJ, Steinberg F, Jia D, Barbuti PA, McMillan KJ, Heesom KJ, Whone AL, Caldwell MA, Billadeau DD, Rosen MK, Cullen PJ, Retromer Binding to FAM21 and the WASH Complex Is Perturbed by the Parkinson Disease-Linked VPS35(D620N) Mutation., Current biology : CB, 2014 Journal Article, 2014

Crompton LA, Byrne ML, Taylor H, Kerrigan TL, Bru-Mercier G, Badger JL, Barbuti PA, Jo J, Tyler SJ, Allen SJ, Kunath T, Cho K, Caldwell MA, Stepwise, non-adherent differentiation of human pluripotent stem cells to generate basal forebrain cholinergic neurons via hedgehog signaling., Stem cell research, 2013 Journal Article, 2013

Rinaldi F, Caldwell MA, Modeling astrocytic contribution toward neurodegeneration with pluripotent stem cells: focus on Alzheimer's and Parkinson's diseases., Neuroreport, 2013 Journal Article, 2013

Höglinger GU, Barker RA, Hagg T, Arias-Carrión O, Caldwell MA, Hirsch EC, Quantitative evaluation of the human subventricular zone., Brain : a journal of neurology, 2012 Journal Article, 2012

Badger JL, Byrne ML, Veraitch FS, Mason C, Wall IB, Caldwell MA, Hypoxic culture of human pluripotent stem cell lines is permissible using mouse embryonic fibroblasts., Regenerative medicine, 2012 Journal Article, 2012

Hartfield EM, Rinaldi F, Glover CP, Wong LF, Caldwell MA, Uney JB, Connexin 36 expression regulates neuronal differentiation from neural progenitor cells., PloS one, 2011 Journal Article, 2011

Sood A, Salih S, Roh D, Lacharme-Lora L, Parry M, Hardiman B, Keehan R, Grummer R, Winterhager E, Gokhale PJ, Andrews PW, Abbott C, Forbes K, Case CP, Signalling of DNA damage and cytokines across cell barriers exposed to nanoparticles depends on barrier thickness., Nature nanotechnology, 2011 Journal Article, 2011

Cordero-Llana O, Cordero-Llana O, Scott SA, Maslen SL, Anderson JM, Boyle J, Chowhdury RR, Tyers P, Barker RA, Kelly CM, Rosser AE, Stephens E, Caldwell MA, Clusterin secreted by astrocytes enhances neuronal differentiation from human neural precursor cells., Cell Death and Differentiation, 2011 Journal Article, 2011

Cogan N, Baird DM, Phillips R, Crompton LA, Caldwell MA, Rubio MA, Newson R, Lyng F, Case CP, DNA damaging bystander signalling from stem cells, cancer cells and fibroblasts after Cr(VI) exposure and its dependence on telomerase., Mutation research, 2010 Journal Article, 2010

Barraud P, He X, Zhao C, Caldwell MA, Franklin RJ, FGF but not EGF induces phosphorylation of the cAMP response element binding protein in olfactory mucosa-derived cell cultures., Experimental cell research, 2010 Journal Article, 2010

Thomas M, Tyers P, Lazic SE, Caldwell MA, Barker RA, Beazley L, Ziman M, Graft outcomes influenced by co-expression of Pax7 in graft and host tissue., Journal of anatomy, 2009 Journal Article, 2009

Lee YB, Bantounas I, Lee DY, Phylactou L, Caldwell MA, Uney JB, Twist-1 regulates the miR-199a/214 cluster during development., Nucleic acids research, 2009 Journal Article, 2009

Kelly S, Caldwell M, Keasey MP, Cooke JA, Uney JB, Identifying neural progenitor cells in the adult brain., Methods in molecular biology (Clifton, N.J.), 2009 Journal Article, 2009

O'Keeffe GC, Barker RA, Caldwell MA, Dopaminergic modulation of neurogenesis in the subventricular zone of the adult brain., Cell cycle (Georgetown, Tex.), 2009 Journal Article, 2009

O'Keeffe GC, Tyers P, Aarsland D, Dalley JW, Barker RA, Caldwell MA, Dopamine-induced proliferation of adult neural precursor cells in the mammalian subventricular zone is mediated through EGF., Proceedings of the National Academy of Sciences of the United States of America, 2009 Journal Article, 2009

Ormerod BK, Palmer TD, Caldwell MA, Neurodegeneration and cell replacement., Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2008 Journal Article, 2008

O'Keeffe FE, Scott SA, Tyers P, O'Keeffe GW, Dalley JW, Zufferey R, Caldwell MA, Induction of A9 dopaminergic neurons from neural stem cells improves motor function in an animal model of Parkinson's disease., Brain : a journal of neurology, 2008 Journal Article, 2008

Chandran S, Caldwell M, Allen N, Introduction: stem cells and brain repair., Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2008 Journal Article, 2008

Hall PE, Lathia JD, Caldwell MA, Ffrench-Constant C, Laminin enhances the growth of human neural stem cells in defined culture media., BMC neuroscience, 2008 Journal Article, 2008

Barraud P, He X, Caldwell MA, Franklin RJ, Secreted factors from olfactory mucosa cells expanded as free-floating spheres increase neurogenesis in olfactory bulb neurosphere cultures., BMC neuroscience, 2008 Journal Article, 2008

Lim JC, Wolpaw AJ, Caldwell MA, Hladky SB, Barrand MA, Neural precursor cell influences on blood-brain barrier characteristics in rat brain endothelial cells., Brain research, 2007 Journal Article, 2007

Barraud P, He X, Zhao C, Ibanez C, Raha-Chowdhury R, Caldwell MA, Franklin RJ, Contrasting effects of basic fibroblast growth factor and epidermal growth factor on mouse neonatal olfactory mucosa cells., The European journal of neuroscience, 2007 Journal Article, 2007

Prosser HM, Bradley A, Caldwell MA, Olfactory bulb hypoplasia in Prokr2 null mice stems from defective neuronal progenitor migration and differentiation., The European journal of neuroscience, 2007 Journal Article, 2007

Lathia JD, Patton B, Eckley DM, Magnus T, Mughal MR, Sasaki T, Caldwell MA, Rao MS, Mattson MP, ffrench-Constant C, Patterns of laminins and integrins in the embryonic ventricular zone of the CNS., The Journal of comparative neurology, 2007 Journal Article, 2007

Joannides AJ, Webber DJ, Raineteau O, Kelly C, Irvine KA, Watts C, Rosser AE, Kemp PJ, Blakemore WF, Compston A, Caldwell MA, Allen ND, Chandran S, Environmental signals regulate lineage choice and temporal maturation of neural stem cells from human embryonic stem cells., Brain : a journal of neurology, 2007 Journal Article, 2007

Anderson L, Caldwell MA, Human neural progenitor cell transplants into the subthalamic nucleus lead to functional recovery in a rat model of Parkinson's disease., Neurobiology of disease, 2007 Journal Article, 2007

Anderson L, Burnstein RM, He X, Luce R, Furlong R, Foltynie T, Sykacek P, Menon DK, Caldwell MA, Gene expression changes in long term expanded human neural progenitor cells passaged by chopping lead to loss of neurogenic potential in vivo., Experimental neurology, 2007 Journal Article, 2007

Gaughwin PM, Caldwell MA, Anderson JM, Schwiening CJ, Fawcett JW, Compston DA, Chandran S, Astrocytes promote neurogenesis from oligodendrocyte precursor cells., The European journal of neuroscience, 2006 Journal Article, 2006

Joannides A, Fiore-Hériché C, Westmore K, Caldwell M, Compston A, Allen N, Chandran S, Automated mechanical passaging: a novel and efficient method for human embryonic stem cell expansion., Stem cells (Dayton, Ohio), 2006 Journal Article, 2006

Hall PE, Lathia JD, Miller NG, Caldwell MA, ffrench-Constant C, Integrins are markers of human neural stem cells., Stem cells (Dayton, Ohio), 2006 Journal Article, 2006

Strappe PM, Hampton DW, Brown D, Cachon-Gonzalez B, Caldwell M, Fawcett JW, Lever AM, Identification of unique reciprocal and non reciprocal cross packaging relationships between HIV-1, HIV-2 and SIV reveals an efficient SIV/HIV-2 lentiviral vector system with highly favourable features for in vivo testing and clinical usage., Retrovirology, 2005 Journal Article, 2005

Caldwell MA, He X, Svendsen CN, 5-Bromo-2'-deoxyuridine is selectively toxic to neuronal precursors in vitro., The European journal of neuroscience, 2005 Journal Article, 2005

Burnstein RM, Foltynie T, He X, Menon DK, Svendsen CN, Caldwell MA, Differentiation and migration of long term expanded human neural progenitors in a partial lesion model of Parkinson's disease., The international journal of biochemistry & cell biology, 2004 Journal Article, 2004

Le Belle JE, Caldwell MA, Svendsen CN, Improving the survival of human CNS precursor-derived neurons after transplantation., Journal of neuroscience research, 2004 Journal Article, 2004

Caldwell MA, Garcion E, terBorg MG, He X, Svendsen CN, Heparin stabilizes FGF-2 and modulates striatal precursor cell behavior in response to EGF., Experimental neurology, 2004 Journal Article, 2004

Wright LS, Li J, Caldwell MA, Wallace K, Johnson JA, Svendsen CN, Gene expression in human neural stem cells: effects of leukemia inhibitory factor., Journal of neurochemistry, 2003 Journal Article, 2003

Barker RA, Jain M, Armstrong RJ, Caldwell MA, Stem cells and neurological disease., Journal of neurology, neurosurgery, and psychiatry, 2003 Journal Article, 2003

Lewis SJ, Caldwell MA, Barker RA, Modern therapeutic approaches in Parkinson's disease., Expert reviews in molecular medicine, 2003 Journal Article, 2003

Bahn S, Mimmack M, Ryan M, Caldwell MA, Jauniaux E, Starkey M, Svendsen CN, Emson P, Neuronal target genes of the neuron-restrictive silencer factor in neurospheres derived from fetuses with Down's syndrome: a gene expression study., Lancet (London, England), 2002 Journal Article, 2002

Ostenfeld T, Joly E, Tai YT, Peters A, Caldwell M, Jauniaux E, Svendsen CN, Regional specification of rodent and human neurospheres., Brain research. Developmental brain research, 2002 Journal Article, 2002