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Aine Kelly
Associate Professor, Physiology
Associate Professor, Trinity Inst. of Neurosciences (TCIN)

Biography

Aine Kelly graduated from Trinity College Dublin in 1995 with a first class honours degree in Science, specialising in Physiology. She was awarded her PhD in Neuroscience in 1998 and was appointed to a lectureship in the Department of Physiology in 2002.

Publications and Further Research Outputs

Peer-Reviewed Publications

Ryan SM, Kelly ÁM, Exercise as a pro-cognitive, pro-neurogenic and anti-inflammatory intervention in transgenic mouse models of Alzheimer's disease., Ageing research reviews, 27, 2016, p77-92 Journal Article, 2016 TARA - Full Text DOI

Prenderville JA, Kelly ÁM, Downer EJ, The role of cannabinoids in adult neurogenesis., British journal of pharmacology, 2015 Journal Article, 2015

Non-pharmacological Approaches to Cognitive Enhancement in, editor(s)Kantak, K.M.; Wettstein, J.G. , Handbook of Experimental Pharmacology: Cognitive Enhancement, Springer Biomedicine, 2015, pp417 - 439, [Kelly, A.M.] Book Chapter, 2015

Bechara RG, Lyne R, Kelly AM, BDNF-stimulated intracellular signalling mechanisms underlie exercise-induced improvement in spatial memory in the male Wistar rat., Behavioural brain research, 2013 Journal Article, 2013 DOI TARA - Full Text

Callaghan, C.K., Kelly, A.M., Neurotrophins play differential roles in short and long-term recognition memory, Neurobiology of Learning and Memory, 2013 Journal Article, 2013 DOI

Bechara RG, Kelly ÁM, Exercise improves object recognition memory and induces BDNF expression and cell proliferation in cognitively enriched rats., Behavioural brain research, 245, 2013, p96-100 Journal Article, 2013 DOI

Birch AM, Kelly AM, Chronic intracerebroventricular infusion of nerve growth factor improves recognition memory in the rat., Neuropharmacology, 75, 2013, p255-61 Journal Article, 2013

Amy M. Birch, Niamh B. McGarry and Aine M. Kelly, Short-term environmental enrichment, in the absence of exercise, improves memory, and increases NGF concentration, early neuronal survival and synaptogenesis in the dentate gyrus in a time-dependent manner, Hippocampus, (75), 2013, p255 - 261 Journal Article, 2013 DOI

Blau CW, Cowley TR, O'Sullivan J, Grehan B, Browne TC, Kelly L, Birch A, Murphy N, Kelly AM, Kerskens CM, Lynch MA, The age-related deficit in LTP is associated with changes in perfusion and blood-brain barrier permeability., Neurobiology of aging, 33, (5), 2012, p1005.e23-35 Journal Article, 2012 TARA - Full Text DOI

Callaghan CK, Kelly AM, Differential BDNF signaling in dentate gyrus and perirhinal cortex during consolidation of recognition memory in the rat., Hippocampus, 22, (11), 2012, p2127 - 2135 Journal Article, 2012 DOI

Eadaoin W. Griffin, Sinéad Mulally, Carole Foley, Stuart A. Warmington, Shane M. O'Mara, Áine M. Kelly, Aerobic exercise improves hippocampal function and increases BDNF in the serum of young adult males, Physiology & Behavior, 104, (5), 2011, p934-941 Journal Article, 2011 TARA - Full Text

Hennigan, A., Callaghan, C.K., Kealy, J., Rouine, J, Kelly A.M., Deficits in LTP and recognition memory in the genetically hypertensive rat are associated with decreased expression of neurotrophic factors and their receptors in the dentate gyrus, Behavioural Brain Research, 197, (2), 2009, p371 - 377 Journal Article, 2009

Griffin, E.W., Bechara, R., Birch, A., Kelly A.M., Exercise enhances hippocampal-dependent learning in the rat: evidence for a BDNF-related mechanism, Hippocampus, 19, (10), 2009, p973 - 980 Journal Article, 2009

O'Callaghan, R.M., Griffin, E.W. Kelly A.M., Lomg-term treadmill exposure protects against age-related neurodegenerative change in the rat hippocampus, Hippocampus, 19, (10), 2009, p1019 - 1029 Journal Article, 2009

Larkin, A.E., Fahey, B., Gobbo, O., Callaghan, C.K., Cahill, E., O'Mara, S.M., Kelly, Á.M., Blockade of NMDA receptors pre-training, but not post-training, impairs object displacement learning in the rat, Brain Research, 1199, 2008, p126 - 132 Journal Article, 2008 URL

Hennigan, A., O'Callaghan, R.M. and Kelly, Á.M. , Neurotrophins and their receptors: roles in plasticity, neurodegeneration and neuroprotection, Biochemical Society Transactions , 35, (2), 2007, p424 - 427 Journal Article, 2007

O'Callaghan, R.M., Ohle, R. and Kelly, Á.M., The effects of forced exercise on hippocampal plasticity in the rat: a comparison of LTP, spatial- and non-spatial learning, Behavioral Brain Research, 176, (2), 2007, p362 - 366 Journal Article, 2007

Hennigan, A.,Trotter, C. and Kelly, Á.M. , Lipopolysaccharide impairs long-term potentiation and recognition memory and increases p75NTR expression in the rat dentate gyrus, Brain Research , 1130, 2007, p158 - 166 Journal Article, 2007

Griffin, E.W., Foley, C., Mullally, S., O'Mara, S.M. and Kelly, Á. , The effect of acute and chronic exercise on serum BDNF concentrations in young sedentary men; implications for cognitive function? , Irish Journal of Medical Science, 175, (3), 2006, pp67- Meeting Abstract, 2006

Hennigan, A. and Kelly, Á. , An investigation into the role of p75NTR in LTP , Irish Journal of Medical Science, 175, (3), 2006, pp32- Meeting Abstract, 2006

Maher FO, Clarke RM, Kelly A, Nally RE, Lynch MA, Interaction between interferon gamma and insulin-like growth factor-1 in hippocampus impacts on the ability of rats to sustain long-term potentiation, JOURNAL OF NEUROCHEMISTRY, 96, (6), 2006, p1560 - 1571 Journal Article, 2006

O'Callaghan, R.M. Ohle, R. and Kelly, Á. , Exercise-induced changes in hippocampal function in the male Wistar rat, Irish Journal of Medical Science, 175, (3), 2006, pp128- Meeting Abstract, 2006

Á.M. Kelly , Neurotrophins and their receptors: roles in neurodegeneration and neuroprotection, Irish Journal of Medical Science, 175, (3), 2006, pp10- Meeting Abstract, 2006

Callaghan, C and Kelly, Á. , Recognition memory ijn the rat is associated with increased BDNF release and ERK and PI3K activation in the dentate gyrus and perirhinal cortex, Irish Journal of Medical Science, 175, (3), 2006, pp45- Meeting Abstract, 2006

Callaghan, C., Loscher, C. and Kelly, Á. , Recognition memory in the rat is associated with increased BDNF release and ERK activation in the dentate gyrus , European Neuropsychopharmacology , 16, (1), 2006, ppS58- Meeting Abstract, 2006

Hennigan, A. and Kelly, Á. , The effect of neurotrophin receptor expression and signalling on recognition learning in the rat. , European Neuropsychopharmacology , 16, (1), 2006, ppS58 - S59 Meeting Abstract, 2006

Trotter, C., Callaghan, C.K. and Kelly, Á. , The effects of lipopolysaccharide (LPS) administration on long-term recognition memory and neurotrophin expression in the dentate gyrus of the rat, Irish Journal of Medical Science, 174, (1), 2005, pp11- Meeting Abstract, 2005

Hennigan, A. and Kelly, Á. , The effect of neuronal insult on P75NTR expression and signaling in the hippocampus of the rat, Irish Journal of Medical Science, 174, (1), 2005, pp12- Meeting Abstract, 2005

Griffin, E.W., Mullally, S., O'Mara, S.M., Warmington, S.A. and Kelly, Á.M. , Exercise-induced changes in cognitive function: a role for IGF? , Neurobiologiae Expermentalis , 65, 2005, pp56S- Meeting Abstract, 2005

Hennigan, A. and Kelly, Á. , Activation of p75NTR is linked to functional impairment in the rat hippocampus, Biochemical Society Transactions , 33, (4), 2005, pp46- Meeting Abstract, 2005

Larkin, A. Gobbo, O., Fahey, B., Hennigan, A., O'Mara, S.M., Kelly, Á.M. , Spatial learning in the rat is NMDA-receptor dependent: evidence from an object displacement task, Acta Neurobiologiae Expermentalis , 37th Annual General Meeting of the European Brain and Behaviour Society, August, 65, 2005, 65, 2005, pp52S- Meeting Abstract, 2005

Callaghan, C.K., Loscher, C.J. and Kelly, Á. , Recognition memory in the rat is associated with increased activation of ERK in the dentate gyrus, Irish Journal of Medical Science, 174, (1), 2005, pp10- Meeting Abstract, 2005

Hennigan, A. and Kelly, Á. , An investigation of the roles of P75NTR and TRK receptors in recognition memory in the rat, Irish Journal of Medical Science, 174, (4), 2005, pp4- Meeting Abstract, 2005

MAPK, CREB and zif268 are all required for the consolidation of recognition memory in, editor(s)T.V.P. Bliss G.L. Collingridge R.G.M. Morris , Long-Term Potentiation: Enhancing Neuroscience for 30 Years , Oxford, Oxford University Press, 2004, pp327 - 346, [B. Bozon, Á. Kelly, S.A. Josselyn, A.S. Silva, S. Davis and S. Laroche] Book Chapter, 2004

Dhanrajan TM, Lynch MA, Kelly A, Popov VI, Rusakov DA, Stewart MG., Expression of long-term potentiation in aged rats involves perforated synapses but dendritic spine branching results from high-frequency stimulation alone. , Hippocampus, 14, (2), 2004, p255 - 264 Journal Article, 2004

Dhanrajan, T.M., Lynch, M.A., Kelly, A., Popov, V.I., Rusakov, D.A. and Stewart, M.G., Expression of long-term potentiation in aged rats involves perforated synapses but dendritic spine branching results from high frequency stimulation alone, Hippocampus, 14, (2), 2003, p255 - 264 Journal Article, 2003 URL DOI

Hennigan, A. and Kelly, Á. , Lipopolysaccharide-induced inhibition of long-term potentiation in the dentate gyrus of the rat is associated with changes in neurotrophin receptor expression, Irish Journal of Medical Science, 172, (2), 2003, pp21- Meeting Abstract, 2003

Bozon B, Kelly A, Josselyn SA, Silva AJ, Davis S, Laroche S., MAPK, CREB and zif268 are all required for the consolidation of recognition memory, Philosophical Transactions of The Royal Society, London, 358, (1432), 2003, p805 - 814 Journal Article, 2003

Davies, H.A., Kelly, A., Dhanrajan, T.M., Lynch, M.A., Rodriguez, J.J., Stewart, M.G., Synaptophysin immunogold labelling of synapses decreases in dentate gyrus of the hippocampus of aged rats, Brain Res., 986, ((1-2):), 2003, p191 - 195 Journal Article, 2003 URL DOI

Kelly, A., Vereker, E., Brady, M., Barry, C., Loscher, C., Mills, K.H.G. and Lynch, M.A., Activation of p38 plays a pivotal role in the inhibitory effect of lipopolysaccharide and interleukin-1beta-induced inhibition of long-term potentiation in rat dentate gyrus, The Journal of Biological Chemistry, 278, 2003, p19453 - 19462 Journal Article, 2003 URL TARA - Full Text DOI

Kelly A, Laroche S, Davis S.Kelly A, Laroche S, Davis S., Activation of mitogen-activated protein kinase/extracellular signal-regulated kinase in hippocampal circuitry is required for consolidation and reconsolidation of recognition memory., Journal of Neuroscience, 23, (15), 2003, p5354 - 5360 Journal Article, 2003

Kelly, Á., Davis, S., McGahon, B., Laroche, S. and Lynch, M.A. , The role of mitogen-activated protein kinase (MAPK) in plasticity in the rat hippocampus, Irish Journal of Medical Science, 172, (1), 2003, pp7- Meeting Abstract, 2003

Davies HA, Kelly A, Dhanrajan TM, Lynch MA, Rodriguez JJ, Stewart MG., Synaptophysin immunogold labelling of synapses decreases in dentate gyrus of the hippocampus of aged rats, Brain Research, 986, (1-2), 2003, p191 - 195 Journal Article, 2003

Gooney M, Shaw K, Kelly A, O'Mara SM, Lynch MA. Gooney M, Shaw K, Kelly A, O'Mara SM, Lynch MA. Gooney M, Shaw K, Kelly A, O'Mara SM, Lynch MA., Long-term potentiation and spatial learning are associated with increased phosphorylation of TrkB and extracellular signal-regulated kinase (ERK) in the dentate gyrus: evidence for a role for brain-derived neurotrophic factor., Behavioural Neuroscience, 116, (3), 2002, p455 - 463 Journal Article, 2002 URL

Casey M, Maguire C, Kelly A, Gooney MA, Lynch MA., Analysis of the presynaptic signaling mechanisms underlying the inhibition of LTP in rat dentate gyrus by the tyrosine kinase inhibitor, genistein. , Hippocampus, 12, (3), 2002, p377 - 385 Journal Article, 2002

Loscher, C.E., Kelly, Á., Dunn, E., O'Neill, L.A., Lynch, M.A., and Mills, K.H.G. , The novel IL-1 protein, IL-1F5, antagonises the effects of IL-1b and IL-1RA in the brain, independent of the IL-1 type 1 receptor, Immunology, (107), 2002, pp45- Meeting Abstract, 2002

Kelly A, Lynch A, Vereker E, Nolan Y, Queenan P, Whittaker E, O'Neill LA, Lynch MA., The anti-inflammatory cytokine, interleukin (IL)-10, blocks the inhibitory effect of IL-1 beta on long term potentiation. A role for JNK. , Journal of Biological Chemistry, 276, (49), 2001, p45564 - 45572 Journal Article, 2001

Vereker, Emily and O'Donnell, Eamonn and Lynch, Ailenn and Nolan, Yvonne and Lynch, Marina A., Evidence that interleukin-1beta and reactive oxygen species production play a pivotal role in stress-induced impairment of LTP in the rat dentate gyrus, European Journal of Neuroscience, 14, (11), 2001, p1809 - 1819 Journal Article, 2001 DOI URL

Áine Kelly, Aileen Lynch, Emily Vereker, Yvonne Nolan, Patrice Queenan, Elizabeth Whittaker, Luke A. J. O' Neill, and Marina A. Lynch , The anti-inflammatory cytokine, interleukin (IL)-10, blocks the inhibatory effect of IL-1 beta on long term potentiation - a role for JNK, Journal of Biological Chemistry, 276, (49), 2001, p45564 - 45572 Journal Article, 2001 TARA - Full Text DOI

Vereker E, O'Donnell E, Lynch A, Kelly A, Nolan Y, Lynch MA., Evidence that interleukin-1beta and reactive oxygen species production play a pivotal role in stress-induced impairment of LTP in the rat dentate gyrus., European Journal of Neuroscience, 14, (11), 2001, p1809 - 1819 Journal Article, 2001

Kelly, Á. and Lynch M.A., The age-related impairment in LTP: a role for NGF? , Irish Journal of Medical Science, (169), 2000, pp279- Meeting Abstract, 2000

Kelly A, Lynch MA., Long-term potentiation in dentate gyrus of the rat is inhibited by the phosphoinositide 3-kinase inhibitor, wortmannin, Neuropharmacology, 39, (49), 2000, p643 - 651 Journal Article, 2000 DOI

Kelly A, Mullany PM, Lynch MA., Protein synthesis in entorhinal cortex and long-term potentiation in dentate gyrus., Hippocampus, 10, (49), 2000, p431 - 437 Journal Article, 2000 URL DOI

McGahon B, Maguire C, Kelly A, Lynch MA., Activation of p42 mitogen-activated protein kinase by arachidonic acid and trans-1-amino-cyclopentyl-1,3- dicarboxylate impacts on long-term potentiation in the dentate gyrus in the rat: analysis of age-related changes, Neuroscience, 90, (4), 1999, p1167 - 1175 Journal Article, 1999

Á. Kelly, C. Maguire and M. A. Lynch, Deficits in nerve growth factor release and tyrosine receptor kinase phosphorylation are associated with age-related impairment in long-term potentiation in the dentate gyrus, Neuroscience, 95, (2), 1999, p359 - 365 Journal Article, 1999 URL DOI

Conor Maguire, Marina Casey, Áine Kelly, Patricia M. Mullany, Marina A. Lynch , Activation of tyrosine receptor kinase plays a role in expression of long-term potentiation in the rat dentate gyrus, Hippocampus, 9, (5), 1999, p519 - 526 Journal Article, 1999 URL

McGahon B, Maguire C, Kelly A, Lynch MA., Activation of p42 mitogen-activated protein kinase by arachidonic acid and trans-1-amino-cyclopentyl-1,3- dicarboxylate impacts on long-term potentiation in the dentate gyrus in the rat: analysis of age-related changes., NEUROSCIENCE, 90, (4), 1999, p1167 - 1175 Journal Article, 1999 DOI URL

Kelly A, Conroy S, Lynch MA., Evidence that nerve growth factor plays a role in long-term potentiation in the rat dentate gyrus., Neuropharmacology, 37, (4-5), 1998, p561 - 570 Journal Article, 1998 URL DOI

Kelly A, Lynch MA., LTP occludes the interaction between arachidonic acid and ACPD and NGF and ACPD, Neuroreport, 9, (18), 1998, p4087 - 4091 Journal Article, 1998 URL

Kelly, Á. and Lynch, M.A. , Evidence indicating a role for nerve growth factor in long-term potentiation in the dentate gyrus of the rat, Journal of Physiology, (501P), 1997, pp89P- Meeting Abstract, 1997

Research Expertise

Description

The roles of the neurotrophin family of proteins in learning and memory, neuronal cell survival and death and exercise-induced cognitive enhancement and neuroprotection

Keywords

Ageing, memory and other cognitive processes; Exercise; Neurochemistry and neuropharmacology; Neurodegeneration; neurogenesis; Neurophysiology; Neuroscience; Physiology

Recognition

Awards and Honours

Fellow, Trinity College Dublin 2009

Memberships

Fellow, Royal Academy of Medicine in Ireland

Member, Physiological Society

Member, British Neuroscience Association