Funding Body: SFI PI award (15/IA/30524) €1,380,245.00
Title of Grant: Targeting glial plasticity to alleviate age-related loss of neuronal function in Alzheimer's disease
- To identify novel markers, focussing on metabolic changes, which reflect microglial activation and their associated functional state.
- To establish whether the loss of glial plasticity correlates with a shift in cell metabolism that impacts on synaptic density and thereby on synaptic function.
- To assess the potential beneficial effects of 4 strategies that are designed to reprogramme glia.
Current projects are as follows:
- Analysis of the role of TLR2 activation in driving inflammation and the impact of decreasing activation on cognitive function, glial activation and amyloid pathology in APP/PS1 mice.
- Investigation of the effects of a small molecule inhibitor of the NLRP3 inflammasome on glial and neuronal function in APP/PS1 mice.
- Assessment of the impact of infiltrating IFNg-producing peripheral cells on neuroinflammation and investigation of consequences of inhibiting cell infiltration by FTY720.
- Investigation of the role of SLAM (Signalling lymphocyte activation molecule) on microglial function.
- Identification of the metabolic and functional signatures of different microglial phenotypes.