Prof Caldwell has been a PI at the Department for two years. She is a neuroscientist with a particular interest in Parkinson’s and Alzheimer’s disease. Her laboratory utilises human induced pluripotent stem cells (hiPSC) to generate clinically relevant neuronal populations such as midbrain dopamine neurons and cortical glutamatergic neurons. These serve as a platform to examine mechanisms of cell death in neurodegenerative disease. In addition, her laboratory utilises hiPSC to generate populations of astrocytes in order to gain a better understanding of their potential role in neuronal cell death.
- Differentiation of iPSC into clinically relevant neuronal populations.
- Investigating mechanisms of neuronal cell death
- Investigating the role of astrocytes in neuronal cell death in neurodegenerative disease.
- Studying the potential toxicity of nanoparticles to neurons.
Our research has and is currently supported, in part, by:
- Trinity College Dublin
- Parkinson’s UK