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Read an interview with Dr. Eric Downer regarding his MS/cannabinoid research in the Dept of Physiology

http://ow.ly/B54J30daD93

 

Frontiers in Neurology (FIN6)

6th Annual Meeting, Friday 18th November 2016
Trinity Biomedical Sciences Institute (TBSI), Pearse Street, Dublin

 


Click here to download a larger PDF version.

 

Professor M. Lynch awarded SFI grant

Prof. Lynch, Dept of Physiology, has been awarded €1.38 for the research project "Targeting glial plasticity to alleviate age-related loss of neuronal function in Alzheimer’s disease"

The aims of this project are

  1. To identify novel markers, with an emphasis on metabolic changes, which reflect microglial activation and functional state. The ultimate objective is to utilize these markers to develop MRI tools and therefore assess changes with age, in particular in a mouse model of Alzheimer's disease, in a non-invasive manner.
  2. To establish whether the age-related loss of glial plasticity correlates with a shift in their metabolism that impacts on synaptic density and thereby on synaptic function.
  3. To assess the potential beneficial effects of 4 strategies designed to reprogramme glia in alleviating the deficits that develop with age and in Alzheimer's disease.

Funding source: Science Foundation Ireland
Duration: 4 year from September 2016
Grant: €1.38m

 

 

Dean’s Award for Teaching Innovation, Faculty of Health Sciences

Facilitator: Dr Eric Downer, School of Medicine, Department of Physiology

Embryology is a core subject undertaken by Health Science students, with the aim to bring together core knowledge in Cell Biology, Anatomy and Physiology to describe the developmental process from fertilization to birth. For the 2015-16 academic year student feedback indicated difficulty visualising key embryological concepts in 2D, particularly embryonic folding/flexion and cell layer migration during gastrulation. This project will develop an interactive audio-visual animation that will be implemented into the Junior Freshman curriculum for teaching embryology and will be assessed via pre- and post- animation surveys to determine if the audio-visual aid improves student learning in embryology. Furthermore, the collation of questionnaire data associated with the animation will be conducted by a Senior Sophister student as part of their final year undergraduate research project. Overall, this will explore how the animation can be used to supplement student education beyond the traditional classroom. This project will act as the first steps to develop a prospective pilot animation, which will be introduced in 2016-17, and will act as a platform to develop/implement new audio-visual teaching tools into degree programmes throughout the School/Faculty, including Medicine, Nursing and Occupational Therapy.


Please see our website for further details and to register:
https://www.tcd.ie/CAPSL/staff/learning-teaching/professional-development-events/

Date: Tuesday November 15th 2016

Time: 13:00 – 14:00

Venue: Auk Room, Zoology Building

 

TBSI image competition - 1st place for Physiology post grad.

Maria Velasco from Prof. Kumlesh K.Dev's Lab, Dept of Physiology, wins 1st place for her image: "Cerebellar neuron-glia network "

This image represents the cellular organization between neurons and glial cells in a mouse cerebellar organotypic slice. Organotypic cultures of brain tissue allow you to study different parts of the brain –e.g. the cerebellum- in their original structure, keeping the cellular organization and neuronal networks almost as they are in vivo.  This can be used to study different development features of the brain in vitro, as well as to perform electrophysiological and pharmacological experiments. In the brain, neurons are outnumbered by glial cells, amongst we can distinguish astrocytes, microglia and oligodendrocytes. Here it is shown the interaction between neurons (red), astrocytes (yellow) and microglia (green) in one of the lobules of the cerebellum. The imaging is done by confocal microscopy with the Leica SP8 microscope in TBSI. This image is 300µm wide.

Further reading at Trinity News and Events

 

 

AMBER image competition - 3rd place for Physiology post grad.

Sibylle Bechet from Prof. Kumlesh K.Dev's Lab, Dept of Physiology, wins 3rd place for her image: "Stop Twitching - Start Smyelin"

This fluorescent image was generated using confocal microscopy. It depicts the complex interplay of glial and neuronal cells in the cerebellum of a Twitcher mouse, an animal model for Krabbe’s Disease (KD). This infantile neurodegenerative disease affects all cell types in the brain and is mainly characterised by accumulations of a toxic metabolite called psychosine. This, in turn, is detrimental to oligodendrocytes, causing dismantling of their protective myelin sheath around neurons. Although clinical practice lacks a curative treatment, emerging evidence suggests beneficial effects of pre-treatment with fingolimod, a drug used for the treatment of Multiple Sclerosis. In this image, oligodendrocytes (green), neurons (red) and astrocytes (yellow) were stained using immunohistochemistry, in order to monitor effects of treatment with fingolimod in the Twitcher mouse. This technique allows evaluating this compound as a potential candidate for treating this devastating childhood illness.

 

 

Physiology Friday!

14th October 2016, 12-5pm, Trinity Biomedical Sciences Institute

Physiology Friday Flyer

Click image to download PDF that you can print and distribute.

 

Head of Discipline - Professor Kumlesh Dev 

Following from the recent election process, Professor Kumlesh Dev has been elected as the Head of Discipline of Physiology for a three year period effective immediately. The academic, technical, and administrative staff would also like to thank Professor Áine Kelly for all her work as Head of Discipline over the last six years.

 

 

 

Human Health and Disease student wins Undergraduate Awards at two International Conferences 

SS Human Health and Disease BSc student David O’Driscoll has won two prestigious Undergraduate Awards for his research project at the British Association of Psychopharmacology meeting in Brighton (17th July 2016 - 20th July 2016) and the Physiological Society meeting at the Convention Centre Dublin (29 July 2016 - 31 July 2016).

His project was entitled “An investigation of human plasma protein biomarkers in Burning Mouth Syndrome” and was carried out under the supervision of Dr. Eric Downer (Asst. Prof. and Director of Human Health and Disease BSc), Dr. Massimiliano Bianchi (Adjunct Asst. Prof. and General Manager and Scientific Director of Transpharmation Ireland, Transpharmation Ltd) and Dr. Jack Prenderville (Senior Scientist, Transpharmation Ireland, Transpharmation Ltd).

 

 

 

Dr. Eric Downer awarded Dean’s Award for Innovation in Teaching

Dr. Downer, has teamed up with Dr. John Dingliana and Dr. Jean Fletcher to develop a novel teaching aid for incorporation into the Human Health and Disease BSc programme.

Embryology is a core subject undertaken by Health Science students, with the aim to bring together core knowledge in Cell Biology, Anatomy and Physiology to describe the developmental process from fertilization to birth. For the 2015-16 academic year student feedback indicated difficulty visualising key embryological concepts in 2D, particularly embryonic folding/flexion and cell layer migration during gastrulation.

This project will develop an interactive audio-visual animation that will be implemented into the Junior Freshman curriculum for teaching embryology and will be assessed via pre- and post- animation surveys to determine if the audio-visual aid improves student learning in embryology. Furthermore, the collation of questionnaire data associated with the animation will be conducted as part of a research project. Overall, this will explore how the animation can be used to supplement student education beyond the traditional classroom. This project will act as the first steps to develop a prospective pilot animation, which will be introduced in 2016-17, and will act as a platform to develop/implement new audio-visual teaching tools into degree programmes throughout the School/Faculty, including Medicine, Nursing and Occupational Therapy.

Full details here:

http://www.healthsciences.tcd.ie/awards/innovation-in-teaching-winners.php

 

 

Dr. Eric Downer's research profiled in "MS Research"

From Exercise to Cannabinoids

Dr. Downer's research is featured on page 8 of Issue 1 of MS Research in the linked PDF

 

 

RAMI 2016

Congratulations to Dr. Sinéad Ryan, Department of Physiology, School of Medicine, who was awarded the Barcroft Early Career Award at the 2016 meeting of the Biomedical Sciences Section of the Royal Academy of Medicine in Ireland, held on June 23rd in UCC.

Sinéad researches the cellular mechanisms underlying the neuroprotective effects of exercise in a model of Alzheimer’s Disease and works in Dr Áine Kelly’s laboratory.


Sinéad is pictured receiving the Barcroft Medal from Prof. Ken O’Halloran, UCC, click for larger version.

 

Human Health and Disease Results 2016

Congratulations to the Human Health and Disease Senior Sophister class of 2016 who recently received their results.
HHD Results
Click for larger version.

 

Human Health and Disease BSc Career Event

Dr. Jean Fletcher and Dr. Eric Downer hosted a career evening for the Human Health and Disease BSc in the Knowledge Exchange, TBSI, on March 10th. The event was attended by the current Senior Freshman, Junior and Senior Sophister Human Health and Disease classes.

Dr. Fletcher and Dr. Downer welcomed the return of nine Human Health and Disease alumni to share their experiences of life after their undergraduate years in the BSc programme. All nine graduates provided excellent insight into their chosen careers paths in scientific research, industry and medicine.

 

 

Trinity College launches new free online course:
“Exercise Prescription for the Prevention and Treatment of Disease”

"Exercise Prescription for the Prevention and Treatment of Disease", Trinity’s newest free Massive Open Online Course (MOOC), run in partnership with FutureLearn, begins on the 18th of April 2016.

This two week free online course from Trinity College Dublin will explore the evidence behind exercise prescription, and how it has evolved as a tool for preventing and treating disease. Geared towards healthcare professionals, the course details how physiological adaptations to exercise can translate to improved health outcomes, and will help enhance confidence in exercise prescription as a treatment.

Assistant Professor of Physiotherapy Dr Cuisle Forde explains, Not that long ago bed rest was prescribed to patients with cardiovascular and respiratory disease, and exercise was considered by many health professionals as something to be avoided. Today, exercise is an integral part of patient treatment”.

The free online course will address the role of exercise in the treatment of a variety of clinical populations including people with cardiovascular disease, mental health problems, paediatric conditions and cancer. 
Available to anyone with internet access across multiple devices including desktops, tablets and smartphones, the two-week innovative course will enable healthcare professionals anywhere to experience a Trinity education. Throughout the course there will be an opportunity to engage with researchers, healthcare professionals and exercise prescription experts from the discipline of Physiotherapy and the Department of Physiology at Trinity College Dublin.

Head of Physiology Dr Aine Kelly says "One of the best things about this course is that it is accessible to health care professionals who feel they need to increase their working knowledge and awareness of the latest research in exercise prescription for patient populations."

This course is designed for healthcare professionals who wish to broaden their understanding of exercise prescription and physical activity as a tool to prevent and treat disease, but no previous experience or qualifications are required.

Register for this free online course which starts on the 18th of April here: https://www.futurelearn.com/courses/exercise-prescription/1/

Trinity College School of Medicine is an international leader in postgraduate education with a strong research focus. This course will give learners a taster of the Online Postgraduate Certificate in Clinical Exercise. Applications are now open for this course, with details available here: http://www.medicine.tcd.ie/physiotherapy/postgraduate/online/

For more information on online education, including postgraduate courses, at Trinity College Dublin click here https://www.tcd.ie/OnlineEducation/

 

 

MS Ireland - Research Explored

FREE event Thursday, 19th November @ 6.30pm, Trinity Biomedical Sciences Building, Pearse Street, Dublin 2

As part of the event Dr. Eric Downer, Dept of Physiology, Trinity College Dublin will present:
"From Exercise to Cannabis, exploring therapeutic avenues in MS"

Details and registration link can be found here:

http://www.ms-society.ie/research/blogs/1924

 

Dept. Physiology taking part in Discover Research Dublin 2015

Friday 25th September

Prof. Marina Lynch, Dr. Eric Downer and Dr. Aedín Minogue, Department of Physiology, will participate in the Discover Research Dublin 2015 Event on Friday 25th September. On this evening, members of the general public are invited to the TCD campus to meet scientists and hear about their research.

This year the Discover Research Dublin themes are Human, Tech, World and Society.
During the evening, Dr. Minogue will present, along with Neurosoc, the ‘Brain Games for Kids’ event, running experiments, activities, and games for primary school children to learn about how the brain works. Prof. Lynch and Dr. Downer will participate in the ‘Meet the Researchers’ event, explaining how research is advancing our understanding of the brain in health and disease. Both events are taking place in the Trinity College Institute of Neuroscience.

The Discover Research Dublin website has full details of all events but a PDF of "Brain" themed events is available to download here

 

GL Brown Prize Lecture
Trinity College Dublin

07th October 2015

Professor Mike Tipton, University of Portsmouth, will give the GL Brown Prize Lecture - Extreme Threats in Trinity College Dublin in the Paccar Theatre, Science Gallery, The Naughton Institute, Pearse Street, Dublin 2 on Wednesday 7th October, from 6pm to 7pm. Download a PDF version of the poster if you would like to print a copy.

GL Brown Prize Lecture

For more information please contact events@physoc.org or see the Physiological Society website.

For publication in Experimental Physiology.

Physiology Sophister Vivas 2015

Physiology Graduates 2015

Congratulations to Physiology Senior Sophister class of 2015 who recently received their results.

The class comprised:

Sharaan Azam, Jessica Comerford, Ossian Corish, Conor Davis, Paul Gallagher, Maria Kavanagh, Hannah Kenny Boyd, Phoebe Lyons, Michelle Mc Donald, Eadaoin Mc Namara, Robert Milling, Lora Jo Minogue, Aisling O’Grady, Victoria Potterton, Ruth Scott, Danai Stefanaki, Shanice Vallely, Ngoc Anh Vu,

 

Human Health and Disease 2015

Human Health and Disease Graduates 2015

Congratulations to the Human Health and Disease Senior Sophistors class of 2015 who recently received their results.

Pictured is Dr. Sarah Harney, Human Health and Disease Course Coordinator for 2015.

 

 

Diploma in Exercise Physiology 2015

Diploma in Exercise Physiology Graduates 2015

Congratulations to the Diploma in Exercise Physiology 2015 who recently received their results.

Pictured are external examiner Prof. Niall Moyna, Course Coordinator Dr. Mikel Egana, and Mr Bernard Donne.

 

 

Innovation Academy Graduations 2015

innovation academy grad

Congratulations to Physiology PhD students who received their Postgraduate Certificate in Innovation & Entrepreneurship from the Minister of Education, Jan O'Sullivan T.D, at a special ceremony hosted by the Department of Education on 29th February 2015.
This programme is available free to all PhD student through the Innovation Academy (www.innovationacademy.ie)

L-R, Catherine O'Sullivan, Eimear O'Neill, Steven Fagan, Michael McDonald, Rosin McManus, Justin Yssel (Pharmacy)

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Last updated 3 July 2017 Physiology (Email).