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Margaret Lucitt
Assistant Professor, Pharmacology & Therapeutics

Biography

Margaret graduated with a BSc in Biochemistry from University College Cork, followed by a PhD in Cardiovascular Pharmacology at the University of Pennsylvania, Philadelphia, USA. This was followed by a postdoctoral position at the Royal College of Surgeons Ireland where she received a fellowships from the Irish Research Council for Science, Engineering & Technology. Research interests to date include the use of animal models (mouse and zebrafish) specifically looking at atherosclerosis and hypertension to investigate novel therapeutic pathways. The development of clinical diagnostic assays in the cardiovascular area to better assess antiplatelet therapy. Currently a lecturer in the Department of Pharmacology and Therapeutics in the School of Medicine she is involved in teaching pharmacology to dental and medical students through lectures and small group problem based learning. Ongoing research is to establish a strong cardiovascular research group which currently investigates statin effects.

Publications and Further Research Outputs

Peer-Reviewed Publications

Lucitt MB, O'Brien S, Cowman J, Meade G, Basabe-Desmonts L, Somers M, Kent N, Ricco AJ, Kenny D, Assaying the efficacy of dual-antiplatelet therapy: use of a controlled-shear-rate microfluidic device with a well-defined collagen surface to track dynamic platelet adhesion., Analytical and bioanalytical chemistry, 405, (14), 2013, p4823-34 Journal Article, 2013 DOI

O'Brien S, Kent NJ, Lucitt M, Ricco AJ, McAtamney C, Kenny D, Meade G, Effective hydrodynamic shaping of sample streams in a microfluidic parallel-plate flow-assay device: matching whole blood dynamic viscosity., IEEE transactions on bio-medical engineering, 59, (2), 2012, p374-82 Journal Article, 2012

M. Lucitt, S. O'Brien, G. Meade, L. Basabe-Desmonts, M. Somers, T. Ricco, D. Kenny. , Real Time Kinetic Analysis of Platelet Thrombus Formation, Irish Journal of Medical Science, 179, (7), 2010 Journal Article, 2010

Yu Y, Lucitt MB, Stubbe J, Cheng Y, Friis UG, Hansen PB, Jensen BL, Smyth EM, FitzGerald GA, Prostaglandin F2alpha elevates blood pressure and promotes atherosclerosis., Proceedings of the National Academy of Sciences of the United States of America, 106, (19), 2009, p7985-90 Journal Article, 2009

Lucitt MB, Price TS, Pizarro A, Wu W, Yocum AK, Seiler C, Pack MA, Blair IA, Fitzgerald GA, Grosser T, Analysis of the zebrafish proteome during embryonic development., Molecular & cellular proteomics : MCP, 7, (5), 2008, p981-94 Journal Article, 2008

Zhou W, Blackwell TS, Goleniewska K, O'Neal JF, Fitzgerald GA, Lucitt M, Breyer RM, Peebles RS, Prostaglandin I2 analogs inhibit Th1 and Th2 effector cytokine production by CD4 T cells., Journal of leukocyte biology, 81, (3), 2007, p809-17 Journal Article, 2007

Price TS, Lucitt MB, Wu W, Austin DJ, Pizarro A, Yocum AK, Blair IA, FitzGerald GA, Grosser T, EBP, a program for protein identification using multiple tandem mass spectrometry datasets., Molecular & cellular proteomics : MCP, 6, (3), 2007, p527-36 Journal Article, 2007

Egan KM, Wang M, Fries S, Lucitt MB, Zukas AM, Puré E, Lawson JA, FitzGerald GA, Cyclooxygenases, thromboxane, and atherosclerosis: plaque destabilization by cyclooxygenase-2 inhibition combined with thromboxane receptor antagonism., Circulation, 111, (3), 2005, p334-42 Journal Article, 2005

Research Expertise

Description

The research of Dr Lucitt focuses on understanding mechanisms underlying cardiovascular disease, including atherosclerosis and thrombosis. Current emphasis is placed on how statin therapy mediates inflammatory and thrombotic effects outside of their lipid lowering ability in protecting against cardiovascular disease. Studies are carried out looking at inflammatory pathways in macrophage cells which constitutes the primary inflammatory cell in atherosclerotic plaques in blood vessels. Thrombotic effects following statin therapy are also investigated using microfluidic devices as well as standard aggregatory assays for assessment of platelet function. The goal is to identify new strategies to treat the inflammatory components of cardiovascular disease.

Last updated 21 September 2016 oneillm1@tcd.ie (Email).