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Imaging and Cognition

Imaging


Genetic influences on schizophrenia and subcortical volumes: large-scale proof of concept

Franke B, et al.
Nature Neuroscience, 2016

A useful guide to the state of the field in 2015 showing that landmark discoveries in schizophrenia are beginning to be replicated in other psychiatric disorders.



Common genetic variants influence human subcortical brain structures

Hibar DP, et al.
Nature, 2015

In this large collaborative study we show that common risk variants aggregate in biological pathways and that these pathways are shared between schizophrenia, bipolar disorder and depression.



Effects of MIR137 on fronto-amygdala functional connectivity
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Mothersill O, et al.
Neuroimage, 2014

In the largest reported genome-wide association study (GWAS) of schizophrenia we identify associations spanning 108 loci: 83 of these were new findings



Effects of a novel schizophrenia risk variant at CNNM2 on brain structure and attributional style

Rose EJ, et al.
British Journal of Psychiatry, 2014

In one of the first published schizophrenia whole exome studies we report an excess of mutations involving genes that regulate transcription including CHD8, MECP2 and HUWE1.



Psychosis susceptibility gene ZNF804A and cognitive performance in schizophrenia

Walters JT, et al.
Archives of General Psychiatry, 2010

We find evidence that a rare duplication at this gene, likely inherited from a single founder, increases risk of schizophrenia and bipolar disorder in Ireland and other populations.


Cognition


Computerized working-memory focused cognitive remediation therapy for psychosis: a preliminary study

Hargreaves A, et al.
Nature Neuroscience, 20150

In this large collaborative study we show that common risk variants aggregate in biological pathways and that these pathways are shared between schizophrenia, bipolar disorder and depression.



Variability in working memory performance explained by epistasis vs polygenic scores in the ZNF804A pathway

Nicodemus KK, et al.
JAMA Psychiatry, 2014

In the largest reported genome-wide association study (GWAS) of schizophrenia we identify associations spanning 108 loci: 83 of these were new findings.
 



Effects of ZNF804A on auditory P300 response in schizophrenia
 
 

O'Donoghue T, et al.
Translational Psychiatry, 2014

In one of the first published schizophrenia whole exome studies we report an excess of mutations involving genes that regulate transcription including CHD8, MECP2 and HUWE1.



Mood congruent psychotic symptoms and specific cognitive deficits in carriers of the schizophrenia risk variant at MIR-137

Cummings E, et al.
Neuroscience Letters, 2013

We find evidence that a rare duplication at this gene, likely inherited from a single founder, increases risk of schizophrenia and bipolar disorder in Ireland and other populations.



ZNF804A and social cognition in patients with schizophrenia and healthy controls

Hargreaves A, et al.
Molecular Psychiatry, 2012

In our first major sequencing project loss of function variants were over-represented in Neurexin and Neuroligin Interacting Protein genes: neatly mirroring the finding from our earlier pathway analysis of SNP data.



Last updated 23 November 2016 by School Web Administrator.