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Neuropsychiatric Genetics Research Group
Attention-Deficit/Hyperactivity Disorder

Deficits in Attention and Executive function in relation to ADHD genotype

We have previously identified three genes (DAT1, DBH and DRD5) contributing to ADHD in Irish families in a study funded by the Health Research Board. Each of these may influence the liability of the clinical diagnosis of ADHD to a small degree.

However, it is most unlikely that genes map directly to the clinical phenotype of ADHD. It is more likely that individual genes influence individual neuropsychological systems, which in certain combinations, result in the clinical diagnosis. The genetic architecture underlying these 'traits' is likely to be less complicated than for the ADHD clinical diagnosis.

Clear abnormalities in specific neuropsychological measures of attention and executive function are known to exist in ADHD and one of our researchers has been influential in developing new measures of attention that build on recent theoretical advances in understanding the differing attention systems of the brain.

The aim of this study is to measure patterns of attentional and executive dysfunction in a large sample of children diagnosed as suffering from ADHD. This will establish neuropsychological phenotypes to be used as quantitative traits in a genetic association study of gene polymorphisms.

For more information contact:

Prof Michael Gill or Tel. (01) 896 2241
Prof Ian Robertson or Tel. (01) 896 2684
Dr Katherine Johnson or Tel. (01) 896 8403
Dr Wouter Braet or Tel. (01) 896 8403

Last updated 21 September 2016 by School Web Administrator.