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The influence of invariant natural killer T cells and mucosal-associated invariant T cells on B cell maturation in patients with common variable immunodeficiency

Serena Arduini /Conleth Feighery/ Derek Doherty

This project focuses on Common Variable Immunodeficiency (CVID), a disease in which B cells fail to fully mature into plasma cells and produce antibodies; this exposes patients to recurrent infections, considered the hallmark of the disease. Patients are also affected by an imbalance in their immune systems detectable as numerical abnormalities in subsets of B cells and T cells, including innate populations such as MAIT cells and iNKT cells. These abnormalities are frequently associated with the development of other pathologies such as autoimmune disease, neoplasias or granulomatosis. Serena is using the techniques of cell culture and flow cytometry to examine the numbers and functions of a variety of cells involved in innate and adaptive immunity in a cohort of CVID patients from St. James’s hospital.

serena-lab serena

The left picture shows a flow cytometry plot used to determine the stage of maturation of a B cells.  The right hand photo is of Serena.

 

 


Last updated 21 September 2016 Immunology (Email).