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The influence of Vγ9Vδ2 T cells on antigen presentation and antibody production

Andreea Petrasca/Derek Doherty

The nature of an adaptive immune response is determined by antigen-presenting cells (APC), which drive T cell differentiation.  Vγ9Vδ2 T cells are innate T cells that can drive maturation of dendritic cells (DC) into APC.  Since antigen presentation is an essential prerequisite for the initiation of adaptive immune responses, Vγ9Vδ2 T cells play a central role in initiating and regulating adaptive immunity and are therefore potential targets for the treatment of disease.  We are investigating if Vγ9Vδ2 T cells can selectively instruct DC to mature into tolerogenic or immunogenic APC, or into immunogenic APC that drive distinct adaptive immune responses. We will also test if Vγ9Vδ2 T cells influence antigen presentation by B cells and explore Vγ9Vδ2 T cells themselves as APC. The results may identify better adjuvants for DC-based therapies and vaccines.  This research project is funded by Science Foundation Ireland.

 

andreea-lab andreea

The left picture shows a flow cytometry plots of circulating mononuclear cells with the Vγ9Vδ2 T cells circled.  The right picture is of Andreea Petrasca.


Last updated 21 September 2016 Immunology (Email).