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Orla Sheils
Professor, Histopathology

Biography

Professor Orla Sheils is: . Director of the Trinity Translational Medicine Institute (TTMI), . Professor in Molecular Pathology and . Director of Medical Ethics at the School of Medicine, Trinity College Dublin. She has a PhD in Molecular Pathology from Trinity College Dublin and a MA in Medical Law and Ethics from Kings College London. The underlying theme of her research is to understand the causes and molecular basis of the development of disease, with particular reference to cancer, and to apply this knowledge to improving disease prevention, detection, diagnosis, and treatment. She has a particular interest in developing novel molecular diagnostics. Translational research is the common theme throughout Prof Sheils' research, linking identification of disease processes with targets for early disease detection or classification. She has been an independent investigator since 2001 and has supervised 24 students to PhD level. Her department currently has 6 students pursuing the degree of PhD by research. She works closely with industry bringing novel technologies and applications to the translational research setting.

Publications and Further Research Outputs

Peer-Reviewed Publications

Emma R Dorris, Gordon Blackshields, Gary Sommerville, Mohsen Alhashemi, Andrew Dias, Victoria McEneaney, Paul Smyth, John J O'Leary, Orla Sheils, Pluripotency markers are differentially induced by MEK inhibition in thyroid and melanoma BRAFV600E cell lines, Cancer biology & therapy, 17, (5), 2016, p526 - 542 Journal Article, 2016 DOI

Leahy TR, McManus R, Doherty DG, Grealy R, Coulter T, Smyth P, Blackshields G, Sheils O, Carr MJ, Purandare N, Geary M, Hodemaekers HM, Janssen R, Bont L, Slattery D, Ryan T, Interleukin-15 is associated with disease severity in viral bronchiolitis., The European respiratory journal, 47, (1), 2016, p212-22 Journal Article, 2016 DOI

Chion A, O'Sullivan JM, Drakeford C, Bergsson G, Dalton N, Aguila S, Ward S, Fallon PG, Brophy TM, Preston RJ, Brady L, Sheils O, Laffan M, McKinnon TA, O'Donnell JS., N-linked glycans within the A2 domain of von Willebrand factor modulate macrophage-mediated clearance., Blood, 128, (15), 2016, p1959-1968 Journal Article, 2016 DOI

Aherne, S.T., Smyth, P., Freeley, M., Smith, L., Spillane, C., O'Leary, J., Sheils, O., Altered expression of MIR-222 and MIR-25 influences diverse gene expression changes in transformed normal and anaplastic thyroid cells, and impacts on MEK and TRAIL protein expression, International Journal of Molecular Medicine, 38, (2), 2016, p433-445 Journal Article, 2016 DOI

O'Sullivan J., O'Sullivan J., Aguila S., Aguila S., McRae E., Ward S., Ward S., Rawley O., Fallon P., Brophy T., Brophy T., Preston R., Preston R., Brady L., Sheils O., Chion A., Chion A., O'Donnell J., O'Donnell J., O'Donnell J., N-linked glycan truncation causes enhanced clearance of plasma-derived von Willebrand factor, Journal of Thrombosis and Haemostasis, 14, (12), 2016, p2446-2457 Journal Article, 2016 DOI

Sadlier, C., Lynam, A., O'Dea, S., Delamere, S., Quinlan, M., Clarke, S., Sheils, O., Bergin, C., HPV vaccine acceptability in HIV-infected and HIV negative men who have sex with men (MSM) in Ireland, Human Vaccines and Immunotherapeutics, 12, (6), 2016, p1536-1541 Journal Article, 2016

Sadlier, C., Sheils, O., Bergin, C., Response to letter: limitations of human papillomavirus DNA testing in measuring previous exposure and vaccine protection, HIV Medicine, 17, (7), 2016, p557-558 Journal Article, 2016

Sheane, B.J., Smyth, P., Scott, K., Aziz, R., Buckley, M., Lodge, E., Kiely, N., Kingston, M., McGovern, E., Healy, M., Walsh, J.B., Sheils, O., Cunnane, G., An Association between MicroRNA-21 Expression and Vitamin D Deficiency in Coronary Artery Disease, MicroRNA (Sh"riqah, United Arab Emirates), 4, (1), 2015, p57-63 Journal Article, 2015

Tops, B.B.J., Normanno, N., Kurth, H., Amato, E., Mafficini, A., Rieber, N., Le Corre, D., Rachiglio, A.M., Reiman, A., Sheils, O., Noppen, C., Lacroix, L., Cree, I.A., Scarpa, A., Ligtenberg, M.J.L., Laurent-Puig, P., Development of a semi-conductor sequencing-based panel for genotyping of colon and lung cancer by the Onconetwork consortium, BMC Cancer, 15, (1), 2015 Journal Article, 2015

Cooke, N.M., Spillane, C.D., Sheils, O., O'Leary, J., Kenny, D., Aspirin and P2Y12 inhibition attenuate platelet-induced ovarian cancer cell invasion, BMC Cancer, 15, (1), 2015, p627- Journal Article, 2015 TARA - Full Text DOI

Czilwik, G., Messinger, T., Strohmeier, O., Wadle, S., Von Stetten, F., Paust, N., Roth, G., Zengerle, R., Saarinen, P., Niittymäki, J., McAllister, K., Sheils, O., O'Leary, J., Mark, D., Rapid and fully automated bacterial pathogen detection on a centrifugal-microfluidic LabDisk using highly sensitive nested PCR with integrated sample preparation, Lab on a Chip - Miniaturisation for Chemistry and Biology, 15, (18), 2015, p3749-3759 Journal Article, 2015

Khan AR, Amu S, Saunders SP, Hams E, Blackshields G, Leonard MO, Weaver CT, Sparwasser T, Sheils O, Fallon PG., Ligation of TLR7 on CD19(+) CD1d(hi) B cells suppresses allergic lung inflammation via regulatory T cells., European Journal of Immunology, 2015 Journal Article, 2015 DOI TARA - Full Text

Gallagher, M.F., Salley, Y., Spillane, C.D., Ffrench, B., Baruni, S.E., Blacksheilds, G., Smyth, P., Martin, C., Sheils, O., Watson, W., O'Leary, J.J., Enhanced regulation of cell cycle and suppression of osteoblast differentiation molecular signatures by prostate cancer stem-like holoclones, Journal of Clinical Pathology, 68, (9), 2015, p692-702 Journal Article, 2015 DOI

McEvoy, L.M., O'Toole, S.A., Spillane, C.D., Martin, C.M., Gallagher, M.F., Stordal, B., Blackshields, G., Sheils, O., O'Leary, J.J., Identifying novel hypoxia-associated markers of chemoresistance in ovarian cancer, BMC Cancer, 15, (1), 2015, p547- Journal Article, 2015 DOI TARA - Full Text

Sadlier C, Rowley D, Morley D, Surah S, O'Dea S, Delamere S, O'Leary J, Smyth P, Clarke S, Sheils O, Bergin C, Prevalence of human papillomavirus in men who have sex with men in the era of an effective vaccine; a call to act., HIV medicine, 15, (8), 2014, p499-504 Journal Article, 2014 DOI TARA - Full Text

Human papillomavirus DNA and mRNA prevalence and association with cervical cytological abnormalities in the Irish HIV population. Loy A, McInerney J, Pilkington L, Keegan H, Delamere S, Martin CM, She, (2014), 25258395p, Int J STD AIDS, [eds.] Journal, 2014

Loy A, McInerney J, Pilkington L, Keegan H, Delamere S, Martin CM, Sheils O, O'Leary JJ, Mulcahy F., Human papillomavirus DNA and mRNA prevalence and association with cervical cytological abnormalities in the Irish HIV population., International Journal of Sexually Transmitted Diseases and AIDS, 2014 Journal Article, 2014

Prevalence of human papillomavirus in men who have sex with men in the era of an effective vaccine; a call to act. Sadlier C, Rowley D, Morley D, Surah S, O'Dea S, Delamere S, O'Leary J, Smyth P, Clar, 15, 8, (2014), doi: 10.1111/hiv.12150p, British HIV Association, [eds.] Journal, 2014

Vencken SF, Sethupathy P, Blackshields G, Spillane C, Elbaruni S, Sheils O, Gallagher MF, O'Leary JJ, An integrated analysis of the SOX2 microRNA response program in human pluripotent and nullipotent stem cell lines., BMC genomics, 15, 2014, p711 Journal Article, 2014 TARA - Full Text DOI

Doyle Brendan, Lee Clarence C, Harkins Timothy T, Petraroli Rosella, Smyth Paul, Sheahan Kieran, O†Leary John J, Sheils Orla, Comparing ion torrent with pyrosequencing and Sanger sequencing for the detection of TP53 mutations in colorectal cancer , 5 , (Suppl 1 ), 2014, ppA32 - Meeting Abstract, 2014

d'Adhemar CJ, Spillane CD, Gallagher MF, Bates M, Costello KM, Barry-O'Crowley J, Haley K, Kernan N, Murphy C, Smyth PC, O'Byrne K, Pennington S, Cooke AA, Ffrench B, Martin CM, O'Donnell D, Hennessy B, Stordal B, Finn S, McCann A, Gleeson N, D'Arcy T, Flood B, O'Neill LA, Sheils O, O'Toole S, O'Leary JJ, The MyD88+ phenotype is an adverse prognostic factor in epithelial ovarian cancer., PloS one, 9, (6), 2014, pe100816 Journal Article, 2014 TARA - Full Text DOI

Czilwik, G., Messinger, T., Strohmeier, O., Von Stetten, F., Zengerle, R., Saarinen, P., Niittymäki, J., McAllister, K., Sheils, O., Drexler, J., Mark, D., Fully integrated PCR detection of pathogens for fast diagnosis of neonatal sepsis on labdisk, 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014, 2014, p2528-2529 Journal Article, 2014

Sadlier, C., Rowley, D., Higgins, D., Sheils, O., Bergin, C., Human papillomavirus (HPV) and the usefulness of the HPV vaccine for men who have sex with men, Journal of Infectious Diseases, 210, (10), 2014 Journal Article, 2014

Tjalma WA, Fiander A, Reich O, Powell N, Nowakowski AM, Kirschner B, Koiss R, O'Leary J, Joura EA, Rosenlund M, Colau B, Schledermann D, Kukk K, Damaskou V, Repanti M, Vladareanu R, Kolomiets L, Savicheva A, Shipitsyna E, Ordi J, Molijn A, Quint W, Raillard A, Rosillon D, De Souza SC, Jenkins D, Holl K; HERACLES/SCALE Study Group., Differences in human papillomavirus type distribution in high-grade cervical intraepithelial neoplasia and invasive cervical cancer in Europe., International Journal of Cancer, 132, (4), 2013, p854 - 867 Journal Article, 2013 DOI

Smyth, C.M., Akasheh, N., Woods, S., Kay, E., Morgan, R.K., Thornton, M.A., O'Grady, A., Cummins, R., Sheils, O., Smyth, P., Gleich, G.J., Murray, F.M., Costello, R.W., Activated Eosinophils in Association with Enteric Nerves in Inflammatory Bowel Disease, PLoS ONE, 8, (5), 2013 Journal Article, 2013 DOI

Laios A, Mohamed BM, Kelly L, Flavin R, Finn S, McEvoy L, Gallagher M, Martin C, Sheils O, Ring M, Davies A, Lawson M, Gleeson N, D'Arcy T, d'Adhemar C, Norris L, Langhe R, Saadeh FA, O'Leary JJ, O'Toole SA, Pre-Treatment of Platinum Resistant Ovarian Cancer Cells with an MMP-9/MMP-2 Inhibitor Prior to Cisplatin Enhances Cytotoxicity as Determined by High Content Screening., International journal of molecular sciences, 14, (1), 2013, p2085-103 Journal Article, 2013 TARA - Full Text DOI

Lynam-Lennon N, Reynolds JV, Marignol L, Sheils OM, Pidgeon GP, Maher SG, MicroRNA-31 modulates tumour sensitivity to radiation in oesophageal adenocarcinoma., Journal of molecular medicine (Berlin, Germany), 2012 Journal Article, 2012 DOI

Kirby, D., Kijanka, G., Siegrist, J., Burger, R., Sheils, O., O'Leary, J., Ducrée, J., Immunomagnetic purification of cancer cells from whole blood on a centrifugal microfluidic platform, Proceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012, 2012, p1126-1128 Journal Article, 2012

Gallagher MF, Heffron CC, Laios A, O'Toole SA, Ffrench B, Smyth PC, Flavin RJ, Elbaruni SA, Spillane CD, Martin CM, Shelis OM, O'Leary JJ. , Suppression of Cancer Stemness p21-regulating mRNA and microRNA Signatures in Recurrent Ovarian Cancer Patient Samples. , Journal of Ovarian Research, 5, (1), 2012, p2- Journal Article, 2012 DOI

Kirby, D., Siegrist, J., Kijanka, G., Zavattoni, L., Sheils, O., O'Leary, J., Burger, R., Ducrée, J., Centrifugo-magnetophoretic particle separation, Microfluidics and Nanofluidics, 13, (6), 2012, p899-908 Journal Article, 2012

Furlong F, Fitzpatrick P, O'Toole S, Phelan S, McGrogan B, Maguire A, O'Grady A, Gallagher M, Prencipe M, McGoldrick A, McGettigan P, Brennan D, Sheils O, Martin C, W Kay E, O'Leary J, McCann A, Low MAD2 expression levels associate with reduced progression-free survival in patients with high-grade serous epithelial ovarian cancer., The Journal of pathology, 226, (5), 2012, p746-55 Journal Article, 2012

Murphy MA, O'Connell DJ, O'Kane SL, O'Brien JK, O'Toole S, Martin C, Sheils O, O'Leary JJ, Cahill DJ, Epitope presentation is an important determinant of the utility of antigens identified from protein arrays in the development of autoantibody diagnostic assays, Journal of Proteomics, 75, (15), 2012, p4668 - 4675 Journal Article, 2012 TARA - Full Text

Dorris ER, Smyth P, O'Leary JJ, Sheils O, MIR141 Expression Differentiates Hashimoto Thyroiditis from PTC and Benign Thyrocytes in Irish Archival Thyroid Tissues., Frontiers in endocrinology, 3, 2012, p102 Journal Article, 2012

Flavin R, Finn SP, Choueiri TK, Ingoldsby H, Ring M, Barrett C, Rogers M, Smyth P, O'Regan E, Gaffney E, O'Leary JJ, Loda M, Signoretti S, Sheils O, RET protein expression in papillary renal cell carcinoma., Urologic oncology, 30, (6), 2012, p900-5 Journal Article, 2012

Burger, R., Kurzbuch, D., Gorkin, R., Sheils, O., O'Leary, J., Glynn, M., Kijanka, G., Ducrée, J., Laser-based manipulation and fluorescent detection of individual, centrifugally arrayed bioparticles, Proceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012, 2012, p1666-1668 Journal Article, 2012

Egan, K, Crowley, D, Smyth, P, O'Toole, S, Spillane, C, Martin, C, Gallagher, M, Canney, A, Norris, L, Conlon, N, McEvoy, L, Ffrench, B, Stordal, B, Keegan, H, Finn, S, McEneaney, V, Laios, A, Ducree, J, Dunne, E, Smith, L, Berndt, M, Sheils, O, Kenny, D, O'Leary, J, Platelet Adhesion and Degranulation Induce Pro-Survival and Pro-Angiogenic Signalling in Ovarian Cancer Cells, PLOS ONE, 6, 2011 Journal Article, 2011

O'Hurley G, Perry AS, O'Grady A, Loftus B, Smyth P, O'Leary JJ, Sheils O, Fitzpatrick JM, Hewitt SM, Lawler M, Kay EW, The role of secreted frizzled-related protein 2 expression in prostate cancer., Histopathology, 59, (6), 2011, p1240-1248 Journal Article, 2011 DOI

Astbury K, McEvoy L, Brian H, Spillane C, Sheils O, Martin C, O'Leary JJ, MYBL2 (B-MYB) in cervical cancer: putative biomarker., International journal of gynecological cancer : official journal of the International Gynecological Cancer Society, 21, (2), 2011, p206-12 Journal Article, 2011 DOI

Yusof A, Keegan H, Spillane CD, Sheils OM, Martin CM, O'Leary JJ, Zengerle R, Koltay P, Inkjet-like printing of single-cells., Lab on a chip, 11, (14), 2011, p2447-54 Journal Article, 2011

O'Hurley, G, Perry, AS, O'Grady, A, Loftus, B, Smyth, P, O'Leary, JJ, Sheils, O, Fitzpatrick, JM, Hewitt, SM, Lawler, M, Kay, EW, The role of secreted frizzled-related protein 2 expression in prostate cancer, HISTOPATHOLOGY, 59, 2011 Journal Article, 2011

Karl Egan., Darragh Crowley., Paul Smyth, Sharon O'Toole, Cathy Spillane, Cara Martin, Michael Gallagher, Aoife Canney, Lucy Norris, Niamh Conlon, Lynda McEvoy2, Brendan Ffrench2, Britta Stordal, Helen Keegan, Stephen Finn, Victoria McEneaney, Alex Laios, Jens Ducre, Eimear Dunne, Leila Smith, Michael Berndt, Orla Sheils, Dermot Kenny, John O'Leary, Platelet Adhesion and Degranulation Induce Pro-Survival and Pro-Angiogenic Signalling in Ovarian Cancer Cells, PLoS ONE, 6, (10, e26125), 2011 Journal Article, 2011 TARA - Full Text

O'Hurley, G., Perry, A.S., O'Grady, A., Loftus, B., Smyth, P., O'Leary, J.J., Sheils, O., Fitzpatrick, J.M., Hewitt, S.M., Lawler, M., Kay, E.W., The role of secreted frizzled-related protein 2 expression in prostate cancer, Histopathology, 59, (6), 2011, p1240-1248 Journal Article, 2011 DOI

Egan, K., Crowley, D., Smyth, P., O'Toole, S., Spillane, C., Martin, C., Gallagher, M., Canney, A., Norris, L., Conlon, N., McEvoy, L., Ffrench, B., Stordal, B., Keegan, H., Finn, S., McEneaney, V., Laios, A., Ducrée, J., Dunne, E., Smith, L., Berndt, M., Sheils, O., Kenny, D., O'Leary, J., Platelet adhesion and degranulation induce pro-survival and pro-angiogenic signalling in ovarian cancer cells, PLoS ONE, 6, (10), 2011 Journal Article, 2011 DOI

Cantwell-Dorris ER, O'Leary JJ, Sheils OM, BRAFV600E: implications for carcinogenesis and molecular therapy., Molecular cancer therapeutics, 10, (3), 2011, p385-94 Journal Article, 2011

Burger, R., Kijanka, G., Sheils, O., O'Leary, J., Ducrée, J., Arrayed capture, assaying and binary counting of cells in a stopped-flow sedimentation mode, 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011, 1, 2011, p538-540 Journal Article, 2011

O'Hurley, G., O'Grady, A., Smyth, P., Byrne, J., O'Leary, J.J., Sheils, O., Watson, R.W.G., Kay, E.W., Evaluation of Zinc-α-2-glycoprotein and proteasome subunit β-type 6 expression in prostate cancer using tissue microarray technology, Applied Immunohistochemistry and Molecular Morphology, 18, (6), 2010, p512-517 Journal Article, 2010 DOI

Mocanu E, Shattock R, Barton D, Rogers M, Conroy R, Sheils O, Collins C, Martin C, Harrison R, O'Leary J, All azoospermic males should be screened for cystic fibrosis mutations before intracytoplasmic sperm injection., Fertility and sterility, 2010 Journal Article, 2010 DOI

O'Hurley, G, O'Grady, A, Smyth, P, Byrne, J, O'Leary, JJ, Sheils, O, Watson, RWG, Kay, EW, Evaluation of Zinc-alpha-2-Glycoprotein and Proteasome Subunit beta-Type 6 Expression in Prostate Cancer Using Tissue Microarray Technology, APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY, 18, 2010 Journal Article, 2010

Mocanu, E., Shattock, R., Barton, D., Rogers, M., Conroy, R., Sheils, O., Collins, C., Martin, C., Harrison, R., O'Leary, J., All azoospermic males should be screened for cystic fibrosis mutations before intracytoplasmic sperm injection, Fertility and Sterility, 94, (6), 2010, p2448-2450 Journal Article, 2010 DOI

Nucera, C., Eeckhoute, J., Finn, S., Carroll, J.S., Ligon, A.H., Priolo, C., Fadda, G., Toner, M., Sheils, O., Attard, M., Pontecorvi, A., Nose, V., Loda, M., Brown, M., FOXA1 is a potential oncogene in anaplastic thyroid carcinoma, Clinical Cancer Research, 15, (11), 2009, p3680-3689 Journal Article, 2009 DOI

Martin, C.M., Astbury, K., McEvoy, L., O'Toole, S., Sheils, O., O'Leary, J.J., Gene expression profiling in cervical cancer: identification of novel markers for disease diagnosis and therapy., Methods in molecular biology (Clifton, N.J.), 511, 2009, p333-359 Journal Article, 2009 DOI

Nucera C, Eeckhoute J, Finn S, Carroll JS, Ligon AH, Priolo C, Fadda G, Toner M, Sheils O, Attard M, Pontecorvi A, Nose V, Loda M, Brown M., FOXA1 is a potential oncogene in anaplastic thyroid carcinoma, Clinical Cancer Research, 15, (11), 2009, p3680-3689 Journal Article, 2009 TARA - Full Text

Maher, S.G., Gillham, C.M., Duggan, S.P., Smyth, P.C., Miller, N., Muldoon, C., O'Byrne, K.J., Sheils, O.M., Hollywood, D., Reynolds, J.V., Gene expression analysis of diagnostic biopsies predicts pathological response to neoadjuvant chemoradiotherapy of esophageal cancer, Annals of Surgery, 250, (5), 2009, p729-736 Journal Article, 2009 DOI

Flavin, R.J., Smyth, P.C., Laios, A., O'Toole, S.A., Barrett, C., Finn, S.P., Russell, S., (...), O'Leary, J.J. , Potentially important microRNA cluster on chromosome 17p13.1 in primary peritoneal carcinoma, Modern Pathology , 22, (2), 2009, p197-205 Journal Article, 2009 DOI

Flavin R, Smyth P, Barrett C, Russell S, Wen H, Wei J, Laios A, O'Toole S, Ring M, Denning K, Li J, Aherne S, Sammarae D, Aziz NA, Alhadi A, Finn SP, Loda M, B S, Sheils O, O'Leary JJ, miR-29b expression is associated with disease-free survival in patients with ovarian serous carcinoma., International journal of gynecological cancer : official journal of the International Gynecological Cancer Society, 19, (4), 2009, p641-7 Journal Article, 2009 DOI

Flavin, R., Jackl, G., Finn, S., Smyth, P., Ring, M., O'Regan, E., Cahill, S., Unger, K., Denning, K., Li, J., Aherne, S., Tallini, G., Gaffney, E., O'Leary, J.J., Zitzelsberger, H., Sheils, O., RET/PTC rearrangement occurring in primary peritoneal carcinoma, International Journal of Surgical Pathology, 17, (3), 2009, p187-197 Journal Article, 2009 DOI

Gallagher MF, Flavin RJ, Elbaruni SA, McInerney JK, Smyth PC, Salley YM, Vencken SF, O'Toole SA, Laios A, Lee MY, Denning K, Li J, Aherne ST, Lao KQ, Martin CM, Sheils OM, O'Leary JJ, Regulation of microRNA biosynthesis and expression in 2102Ep embryonal carcinoma stem cells is mirrored in ovarian serous adenocarcinoma patients., Journal of ovarian research, 2, 2009, p19 Journal Article, 2009 TARA - Full Text DOI

Flavin R, Jackl G, Finn S, Smyth P, Ring M, O'Regan E, Cahill S, Unger K, Denning K, Jinghuan Li Aherne S, Tallini G, Gaffney E, O'Leary JJ, Zitzelsberger H, Sheils O, RET/PTC rearrangement occurring in primary peritoneal carcinoma., International journal of surgical pathology, 17, (3), 2009, p187-97 Journal Article, 2009 DOI

Gallagher, M.F., Flavin, R.J., Elbaruni, S.A., McInerney, J.K., Smyth, P.C., Salley, Y.M., Vencken, S.F., O'Toole, S.A., Laios, A., Lee, M.Y., Denning, K., Li, J., Aherne, S.T., Lao, K.Q., Martin, C.M., Sheils, O.M., O'Leary, J.J., Regulation of microRNA biosynthesis and expression in 2102Ep embryonal carcinoma stem cells is mirrored in ovarian serous adenocarcinoma patients, Journal of Ovarian Research, 2, (1), 2009 Journal Article, 2009 DOI

Stephen G. Maher, Charles M. Gillham, Shane P. Duggan, Paul C. Smyth, Nicola Miller, Cian Muldoon, Kenneth J. O'Byrne, Orla M. Sheils, Donal Hollywood, John V. Reynolds, Gene expression analysis of diagnostic biopsies predicts pathological response to neoadjuvant chemoradiotherapy of esophageal cancer., Annals of surgery, 250, (5), 2009, p729-37 Journal Article, 2009 DOI

Denning K, Smyth P, Cahill S, Li J, Flavin R, Aherne S, O' Leary JJ, Sheils O, ret/PTC-1 expression alters the immunoprofile of thyroid follicular cells., Molecular cancer, 7, 2008, p44 Journal Article, 2008 DOI

Hornig, M., Briese, T., Buie, T., Bauman, M.L., Lauwers, G., Siemetzki, U., Hummel, K., (...), Lipkin, W.I. , Lack of association between measles virus vaccine and autism with enteropathy: A case-control study , PLoS ONE, 3, (9), 2008, part. no. e3140 Journal Article, 2008 DOI

O'Regan EM, Toner ME, Finn SP, Fan CY, Ring M, Hagmar B, Timon C, Smyth P, Cahill S, Flavin R, Sheils OM, O'Leary JJ, p16(INK4A) genetic and epigenetic profiles differ in relation to age and site in head and neck squamous cell carcinomas., Human pathology, 39, (3), 2008, p452-8 Journal Article, 2008 DOI

Li J, Smyth P, Cahill S, Denning K, Flavin R, Aherne S, Pirotta M, Guenther SM, O'Leary JJ, Sheils O, Improved RNA quality and TaqMan Pre-amplification method (PreAmp) to enhance expression analysis from formalin fixed paraffin embedded (FFPE) materials., BMC biotechnology, 8, 2008, p10 Journal Article, 2008 DOI

Flavin RJ, Smyth PC, Finn SP, Laios A, O'Toole SA, Barrett C, Ring M, Denning KM, Li J, Aherne ST, Aziz NA, Alhadi A, Sheppard BL, Loda M, Martin C, Sheils OM, O'Leary JJ, Altered eIF6 and Dicer expression is associated with clinicopathological features in ovarian serous carcinoma patients., Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 21, (6), 2008, p676-84 Journal Article, 2008 DOI

Laios, A., O'Toole, S., Flavin, R., Martin, C., Kelly, L., Ring, M., Finn, S.P., (...), O'Leary, J. , Potential role of miR-9 and miR-223 in recurrent ovarian cancer , Molecular Cancer, 7, 2008, part. no. 35 Journal Article, 2008 TARA - Full Text DOI

Laios, A., O'Toole, S.A., Flavin, R., Martin, C., Ring, M., Gleeson, N., D'Arcy, T., (...), O' Leary, J.J. , An integrative model for recurrence in ovarian cancer , Molecular Cancer, 7, 2008, part. no. 8 Journal Article, 2008 DOI

Aherne ST, Smyth PC, Flavin RJ, Russell SM, Denning KM, Li JH, Guenther SM, O'Leary JJ, Sheils OM., Geographical mapping of a multifocal thyroid tumour using genetic alteration analysis & miRNA profiling., Molecular Cancer, 7, 2008, particle no, 89 Journal Article, 2008 DOI

Flavin R, Smyth P, Crotty P, Finn S, Cahill S, Denning K, Jinghuan Li O'Regan E, O'Leary J, Sheils O, BRAF T1799A mutation occurring in a case of malignant struma ovarii., International journal of surgical pathology, 15, (2), 2007, p116-20 Journal Article, 2007 DOI

SA O'Toole, A Laios, B Sheppard, N Gleeson, T D'Arcy, E McGuinness, M Ring, E Gaffney, C Martin, R Flavin, D Cahill, D O'Connell, J O'Brien, O Sheils, JJ O'Leary, miRNA Signatures in Primary Versus Recurrent Ovarian Cancers, USCAP 96th Annual Meeting, San Diego, CA, March, 2007 Conference Paper, 2007

A Laios, SA O'Toole, B Sheppard, N Gleeson, T D'Arcy, E McGuinness, M Ring, R Flavin, C Martin, J O'Brien, D O'Connell, O Sheils, D Cahill, E Gaffney, JJ O'Leary, Recurrence in Ovarian Cancer; a Transcriptomic Approach, USCAP 96th Annual Meeting, San Diego, CA, March, 2007 Conference Paper, 2007

Denning KM, Smyth PC, Cahill SF, Finn SP, Conlon E, Li J, Flavin RJ, Aherne ST, Guenther SM, Ferlinz A, O'Leary JJ, Sheils OM, A molecular expression signature distinguishing follicular lesions in thyroid carcinoma using preamplification RT-PCR in archival samples., Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 20, (10), 2007, p1095-102 Journal Article, 2007 DOI

Murphy AJ, Hughes CA, Lannigan G, Sheils O, O'Leary J, Loftus B, Heterogeneous expression of alpha-methylacyl-CoA racemase in prostatic cancer correlates with Gleason score, Histopathology, 50, (2), 2007, p243 - 251 Journal Article, 2007 DOI

Murphy, A.J., Hughes, C.A., Barrett, C., Magee, H., Loftus, B., O'Leary, J.J., Sheils, O., Low-level TOP2A amplification in prostate cancer is associated with HER2 duplication, androgen resistance, and decreased survival, Cancer Research, 67, (6), 2007, p2893-2898 Journal Article, 2007

O'Toole SA, Sheppard BL, Laios A, O'Leary JJ, McGuinness EP, D'Arcy T,Bonnar J, Potential predictors of chemotherapy response in ovarian cancer--how do we define chemosensitivity?, Gynecol Oncol., 104, (2), 2007, p345 - 351 Journal Article, 2007 DOI

P Smyth, S Cahill, K Denning, J Li, SP Finn, S Guenther, R Henfrey, JJ O'Leary, O Sheils, MicroRNA Profiling of Papillary Thyroid Carcinoma Cell Lines, USCAP 96th Annual Meeting, San Diego, CA,, March, 2007 Conference Paper, 2007

Crowley A, Martin C, Fitzpatrick P, Sheils O, O'Herlihy C, O'Leary JJ, Byrne BM, Free fetal DNA is not increased before 20 weeks in intrauterine growth, Prenat Diagn., 27, (2), 2007, p174 - 179 Journal Article, 2007 DOI

Li J, Smyth P, Flavin R, Cahill S, Denning K, Aherne S, Guenther SM, O'Leary JJ, Sheils O, Comparison of miRNA expression patterns using total RNA extracted from matched samples of formalin-fixed paraffin-embedded (FFPE) cells and snap frozen cells., BMC biotechnology, 7, 2007, p36 Journal Article, 2007 DOI

K Denning, P Smyth, S Cahill, S Finn, E Conlon, JH Li, R Flavin, S Guenther, A Ferlinz, JJ O'Leary, O Sheils, Molecular Markers of Follicular Variant Papillary Thyroid Carcinoma (FVPTC) and Follicular Adenoma, USCAP 96th Annual Meeting, San Diego, CA, March, 2007 Conference Paper, 2007

J Li, P Smyth, S Cahill, K Denning, R Flavin, S Guenther, J O'Leary, O Sheils, Extraction and Amplification Methods To Enhance Expression Analysis from Formalin Fixed Paraffin Embedded (FFPE) Tissues, USCAP 96th Annual Meeting, San Diego, CA, March, 2007 Conference Paper, 2007

CM Martin, K Astbury, C Becker, R Henfrey, J Sherlock, S Guenther, O Sheils, JJ O'Leary, MicroRNA Signatures in Cervical Cancer: Suggests Hierarchical miRNA Control of Gene Expression, USCAP 96th Annual Meeting, San Diego, CA, March, 2007 Conference Paper, 2007

CCBB Heffron, MF Gallagher, S Guenther, R Henfrey, J Sherlock, O Sheils, C Martin, J O'Leary, Regulation of Cancer Stemness: Understanding Self-Renewal and Early Differentiation in Cancer Stem Cells, USCAP 96th Annual Meeting, San Diego, CA, March, 2007 Conference Paper, 2007

M Ring, S Crowther, C Martin, K Astbury, O Sheils, M Griffin, E Gaffney, D Gibbons, JJ O'Leary, Significant Dysregulation of DNA Replication License and Replisome Proteins in Villoglandular Carcinomas of the Cervix Indicates Possible Aggressive Biological Behaviour, USCAP 96th Annual Meeting, San Diego, CA, March, 2007 Conference Paper, 2007

Finn SP, Smyth P, Cahill S, Streck C, O'regan EM, Flavin R, Sherlock J,Howells D, Henfrey R, Cullen M, Toner M, Timon C, O'leary JJ, Sheils OM, Expression microarray analysis of papillary thyroid carcinoma and benign thyroid tissue: emphasis on the follicular variant and potential markers of malignancy, Virchows Arch, 450, (3), 2007, p249 - 260 Journal Article, 2007 DOI

M Ring, S Crowther, C Martin, K Astbury, O Sheils, M Griffin, E Gaffney, D Gibbons, JJ O'Leary, Significant Dysregulation of DNA Replication License and Replisome Proteins in Villoglandular Carcinomas of the Cervix Indicates Possible Aggressive Biological Behaviour, Significant Dysregulation of DNA Replication License and Replisome Proteins in Villoglandular Carcinomas of the Cervix Indicates Possible Aggressive Biological Behaviour, San Diego, CA, March, 2007 Conference Paper, 2007

Crowley, A., Martin, C., Fitzpatrick, P., Sheils, O., O'Herlihy, C., O'Leary, J.J., Byrne, B.M., Free fetal DNA is not increased before 20 weeks in intrauterine growth restriction or pre-eclampsia, Prenatal Diagnosis, 27, (2), 2007, p174-179 Journal Article, 2007

Murphy AJ, Hughes CA, Barrett C, Magee H, Loftus B, O'Leary JJ, Sheils O, Low Level TOP2A Amplification in Prostate Cancer is associated with HER2 Duplication, Androgen Resistance and Decreased Survival, Cancer Research , 67, (6), 2007, p2893 - 2898 Journal Article, 2007 DOI

Cahill S, Smyth P, Denning K, Flavin R, Li J, Potratz A, Guenther SM, Henfrey R, O'Leary JJ, Sheils O, Effect of BRAFV600E mutation on transcription and post-transcriptional regulation in a papillary thyroid carcinoma model., Molecular cancer, 6, 2007, p21 Journal Article, 2007 DOI

Heffron, C.C.B.B., Gallagher, M.F., Guenther, S., Sherlock, J., Henfrey, R., Martin, C., Sheils, O., O'Leary, J.J. , Global mRNA analysis to determine a transcriptome profile of cancer stemness in a mouse model , Anticancer Research, 27, (3A), 2007, p1319-1324 Journal Article, 2007 URL

RJ Flavin, S O'Toole, P Smyth, A Laois, S Cahill, J Li, K Denning, C Martin, S Finn, B Shepherd, K Lao, O Sheils, JJ O'Leary, MicroRNA Gene Expression Profiling in Human Ovarian and Primary Peritoneal Serous Carcinomas, USCAP 96th Annual Meeting, San Diego, CA, March, 2007 Conference Paper, 2007

O'Toole SA, Dunn E, Sheppard BL, Klocker H, Bektic J, Smyth P, Martin C, Sheils O, O'Leary JJ, Genome-wide analysis of deoxyribonucleic acid in endometrial cancer using comparative genomic hybridization microarrays, International Journal of Gynecological Cancer , 16, (2), 2006, p834 - 842 Journal Article, 2006 DOI

EM O'Regan, CY Fan, ME Toner, M Ring, SP Finn, C Timon, P Smyth, S Cahill, O Sheils, JJ O'Leary, Genetic And Epigenetic Alteration Profiles For p16 In Head And Neck Squamous Cell Carcinoma In Young Adults, Nature, USCAP 2006 Annual Meeting, Atlanta, USA, Feb, 86, (Suppl 1), 2006 Conference Paper, 2006

Sheils O, 7. Effect of Ret/PTC 1 rearrangement on Transcription and Post-transcriptional Regulation in a Papillary Thyroid Carcinoma Model, Molecular Cancer, 5, (70), 2006 Journal Article, 2006 DOI

Cahill S, Smyth P, Finn SP, Denning K, Flavin R, O'Regan EM, Li J, Potratz A, Guenther SM, Henfrey R, O'Leary JJ, Sheils O, Effect of ret/PTC 1 rearrangement on transcription and post-transcriptional regulation in a papillary thyroid carcinoma model., Molecular cancer, 5, 2006, p70 Journal Article, 2006 DOI

Leahy M, Farah N, Bolger N, O'Leary JJ, Turner MJ, Should cervical smears be taken at a postnatal visit?, Irish Medical Journal, 99, (8), 2006, p244 - 245 Journal Article, 2006

O'Regan EM, Timon C, Sheils O, Codd M, O'Leary JJ, Toner M, Squamous cell carcinoma of the head and neck in young Irish adults, British Journal of Oral and Maxillofacial Surgery , 44, (3), 2006, p203 - 206 Journal Article, 2006 DOI

Logan C, O'Leary JJ, O'Sullivan N, Real-time reverse transcription-PCR for detection of rotavirus and adenovirus as causative agents of acute viral gastroenteritis in children, J Clin Microbiol., 44, (9), 2006, p3189 - 3195 Journal Article, 2006 DOI

P Smyth, S Finn, S Cahill, C Streck, E O'Regan, M Toner, R Henfry, J Sherlock, D Howells, C Timon, M Cullen, J O'Leary, O Sheils, Genome wide expression microarray analysis of papillary thyroid carcinoma and benign thyroid tissue: emphasis on the follicular variant and potential markers of malignancy, Centenary Meeting of the Pathological Society of Great Britain and Ireland, Manchester, July, 2006 Conference Paper, 2006

Sheils O., Expanding Applications of Diagnostic Tools, Translational Medicine Product Note- Genetic Engineering News, 26, (16), 2006, p50 - 51 Journal Article, 2006

SA O'Toole, A Laios, BL Sheppard, NC Gleeson, T D'Arcy, EPJ McGuinness, J Bonnar, O Sheils and JJ O'Leary, Potential predictors of chemotherapy response in ovarian cancer how do we define chemosensitivity?, Laboratory Investigation, United States and Canadian Society of Pathology, Nature, Atlanta, USA, 86, (Suppl 1), 2006, pp190A Meeting Abstract, 2006

Martin CM, Astbury K, O'Leary JJ, Molecular profiling of cervical neoplasia, Expert Review of Molecular Diagnostics , 6, (2), 2006, p217 - 229 Journal Article, 2006 DOI

K Astbury, C Martin, M Ring, O Sheils, J O'Leary, Identification of cell cycle regulatory molecules as biomarkers in cervical cancer by gene expression profiling, Centenary Meeting of the Pathological Society of Great Britain and Ireland, Manchester, July, 2006 Conference Paper, 2006

CM Martin, K Astbury, R Henfrey, O Sheils, M Gallagher, C Heffron, C Logan, SA O'Toole, JJ O'Leary, miRNA expression signatures in cervical cancer, Journal of RNAi and Gene Silencing, RNAi2006: Advances in RNA Interference Research, St Anne's College, Oxford, United Kingdom, March, 2, (2), 2006 Conference Paper, 2006

K. Astbury, C.Martin, O.Sheils, JJ O'Leary, Detection of Cyclin A and B Overexpression in Cervical Cancer Using Gene Expression Profiling and TaqMan PCR, Irish Association for Cancer Research, Galway, Ireland, March, 2006 Conference Paper, 2006

S Cahill, P Smyth, K. Denning , J H Lee , S P Finn, E O'Regan, M. Gallagher , M Toner, C Streck, R Henfrey, J Sherlock, J J O'Leary and O M Sheils, Expression microarray analysis of thyroid carcinoma cell lines harboring BRAF, Irish Association for Cancer Research, Galway, Ireland, March, 2006 Conference Paper, 2006

C.Martin, K. Astbury, O.Sheils, JJ O'Leary, MicroRNA Signatures in Cervical Cancer, Irish Association for Cancer Research, Galway, Ireland, March, 2006 Conference Paper, 2006

Laios A, O'Toole SA, Sheppard BL, Gleeson NC, D'Arcy T, McGuinness EPJ, Ring M, Sheils O, O'Leary JJ., Signalling pathways implicated in the recurrence of ovarian cancer, Irish Association for Cancer Research, Galway, Ireland, March, 2006 Conference Paper, 2006

Astbury, K., Martin, C.M., Ring, M., Pilkington, L., Bolger, N., Sheils, O.M., O'Leary, J.J. , Future molecular aspects of cervical cytology , Current Diagnostic Pathology, 12, (2), 2006, p104-113 Journal Article, 2006 DOI

A Laios, SA O'Toole, BL Sheppard, NC Gleeson, T D'Arcy, E PJ McGuinness, M Ring, O Sheils and JJ O'Leary, Molecular profiling of primary versus recurrent ovarian serous papillary adenocarcinomas. , Laboratory Investigation, United States and Canadian Society of Pathology, Nature, USCAP 2006 Annual Meeting, Atlanta, USA, Feb, 86, (Suppl 1), 2006, pp185A Conference Paper, 2006

S Cahill, P Smyth, K Denning, R Flavin, JH Li, SP Finn, EM O'Regan, R Henfrey, J Sherlock, JJ O'Leary, OM Sheils, mircoRNA profiling of papillary thyroid carcinoma cell lines, Centenary Meeting of the Pathological Society of Great Britain and Ireland, Manchester, July, 2006 Conference Paper, 2006

O'Regan EM, Toner ME, Smyth PC, Finn SP, Timon C, Cahill S, Flavin R, O'Leary JJ, Sheils O, Distinct array comparative genomic hybridization profiles in oral squamous cell carcinoma occurring in young patients., Head & neck, 28, (4), 2006, p330-8 Journal Article, 2006 DOI

SP Finn, PC Smyth, S Cahill, C Streck, EM O'Regan, ME Toner, C Timon, J Sherlock, R Henfry, JJ O'Leary, OM Sheils, Narrow Repertoire Of Gene Expression Including Aberrant Expression Of MHC Type 2 Molecules Distinguishes FPTC From Classic Morphology PTC And Benign Thyroid Tissue, Nature, USCAP 2006 Annual Meeting, Atlanta, USA, Feb, 86, (Suppl 1), 2006 Conference Paper, 2006

AJ Murphy, CA Hughes, C Barrett, H Magee, B Loftus, J O'Leary, O Sheils, TOP2A amplification in prostate cancer is associated with HER -2 amplification, Androgen resistance abd decreased survival, Centenary Meeting of the Pathological Society of Great Britain and Ireland, Manchester, July, 2006 Conference Paper, 2006

A. Lynch, M Ring, O Sheils, C Martin, J O'Leary, The NOD2/CARD12 3020insC polymorphism is not associated with gastrointestinal disease in autistic patients, Centenary Meeting of the Pathological Society of Great Britain and Ireland, Manchester, July, 2006 Conference Paper, 2006

CM Martin, K Astbury, O Sheils, JJ O'Leary, miRNA expression signatures in cervical cancer, Centenary Meeting of the Pathological Society of Great Britain and Ireland, Manchester, July, 2006 Conference Paper, 2006

K Astbury, C Martin, M Ring, O Sheils, J O'Leary, Identification of cell cycle regulatory molecules as biomarkers in cervical cancer by gene expression profiling, Centenary Meeting of the Pathological Society of Great Britain and Ireland, Manchester, July, 2006 Conference Paper, 2006

RJ Flavin, P Smyth Sp Finn, S Cahill, EM O'Regan, M Ring, J O'Leary, O Sheils, BRAF (T1799A) mutations are not expressed in non-papillary thyroid lesions, Centenary Meeting of the Pathological Society of Great Britain and Ireland, Manchester, July, 2006 Conference Paper, 2006

Laios A, O'Toole SA, Sheppard BL, Gleeson NC, D'Arcy T, McGuinness EPJ, Ring M, Sheils O, Smyth P, O'Leary JJ., Recurrent ovarian cancer cDNA signatures, Centenary Meeting of the Pathological Society of Great Britain and Ireland, Manchester, July, 2006 Conference Paper, 2006

Sheils Orla, Expanding applications of diagnostic tools-Isolating papillary thyroid cancer biomarkers , GENETIC ENGINEERING NEWS , 26 , (16 ), 2006, p50 - 51 Journal Article, 2006

S Cahill, P Smyth, K Denning, JH Li, SP Finn, E O'Regan, M Gallagher, M toner, C Streck, R Henfrey, J Sherlock, JJ O'Leary, OM Sheils, Expression microarray analysis of thyroid carcinoma cell lines harbouring BRAF V600E mutation, Centenary Meeting of the Pathological Society of Great Britain and Ireland, Manchester, July, 2006 Conference Paper, 2006

P Smyth, SP Finn, S Cahill, E O'Regan, M Toner, C Streck, R Henfrey, J Sherlock, JJ O'Leary, OM Sheils, cDNA Microarray Analysis Of Thyroid Carcinoma Cell Lines Harboring ret/PTC Oncogenes And BRAF V600E Mutations, Nature, USCAP 2006 Annual Meeting, Atlanta, USA, Feb, 86, (Suppl 1), 2006 Conference Paper, 2006

Finn S, Smyth P, Cahill S, Streck C, O'Regan E, Toner M, Timon C, O'Leary JJ, Sheils O, Expression microarray analysis of papillary thyroid carcinoma and benign thyroid tissue: Emphasis on the follicular variant and potential biomarkers of malignancy, Irish Association for Cancer Research, Galway, Ireland, March, 2006 Conference Paper, 2006

Hughes C, Murphy A, Martin C, Fox E, Ring M, Sheils O, Loftus B, O'Leary J, Topoisomerase II-alpha expression increases with increasing Gleason score and with hormone insensitivity in prostate carcinoma, Journal of Clinical Pathology, 59, (7), 2006, p721 - 724 Journal Article, 2006 DOI

Laser capture microdissection in, editor(s)Crocker, J. Burnett, D. , The Science of Laboratory Diagnosis, John Wiley & Sons, Ltd., 2005, pp489 - 493, [Sheils, O., Smyth, P., O'Regan, E.M.,Finn, S., Flavin, R., O'Leary, J.J.] Book Chapter, 2005

EM O'Regan, OM Sheils, NC Murphy, M Ring, ME Toner, SP Finn, PC Smyth, S Cahill, JJ O'Leary, Absence of p16 Gene (CDKN2A) Deletions in HNSCC Occurring in Young Adults, USCAP 2005 Annual Meeting, San Antonio, Texas, 2005 Conference Paper, 2005

O'Toole SA, Sheppard BL, D'Arcy T, Mc Guinness EPJ, Gleeson NC, Bonnar J, Sheils O, O'Leary JJ., Angiogenesis in Ovarian Cancer does not predict response to chemotherapy, Irish Association for Cancer Research, Kilkenny, Ireland, March, 2005 Conference Paper, 2005

Mocanu EV, Adala S, O'Leary JJ, Womb with a view, Human Fertility (Camb)., 8, (1), 2005, p35 - 40 Journal Article, 2005 DOI

O'Toole SA, Sheppard BL, Sheils O, O'Leary JJ, Spengler B, Christoffel V, Analysis of DNA in endometrial cancer cells treated with phyto-estrogenic compounds using comparative genomic hybridisation microarrays, Planta Medica, 71, (5), 2005, p435 - 439 Journal Article, 2005 DOI

Murphy N, Ring M, Heffron CC, King B, Killalea AG, Hughes C, Martin CM,McGuinness E, Sheils O, O'Leary JJ, p16INK4A, CDC6, and MCM5: predictive biomarkers in cervical preinvasive, Journal of Clinical Pathology, 58, (5), 2005, p525 - 534 Journal Article, 2005 DOI

Murphy AM, Sheils OM, McDonald GS, Kelleher DP., Detection of a Tyrosine Phosphatase LAR on Intestinal Epithelial Cells and Intraepithelial Lymphocytes in the Human Duodenum., Mediators of Inflammation, 1, 2005, p23 - 30 Journal Article, 2005 DOI TARA - Full Text

CGH array analysis of human tissues in, editor(s)Crocker, J. Burnett, D. , The Science of Laboratory Diagnosis, John Wiley & Sons, Ltd., 2005, pp523 - 528, [O'Regan, E, Martin, C.M., Finn, S, Smyth, P., Flavin, R., O'Leary, J.J. Sheils, O.] Book Chapter, 2005

O'Toole SA, Laios A, Sheppard BL, Gleeson NC, D'Arcy T, Mc Guinness EPJ, Bonnar J, Sheils O, O'Leary JJ, Potential Predictors of Chemotherapy Response in Ovarian Cancer, Irish gynaecological oncology society, Belfast, 2005 Conference Paper, 2005

DNA Sequencing in, editor(s)Crocker, J. Burnett, D. , The Science of Laboratory Diagnosis, John Wiley & Sons, Ltd., 2005, pp531 - 539, [Martin, C.M., Picton, S.J. Sheils, O., O'Leary, J.J.] Book Chapter, 2005

In-cell PCR in, editor(s)Crocker, J. Burnett, D. , The Science of Laboratory Diagnosis, John Wiley & Sons, Ltd., 2005, pp505 - 513, [O'Leary, J.J., Martin, C.M., Sheils, O.] Book Chapter, 2005

Hughes C, Murphy A, Martin C, Sheils O, O'Leary J, Molecular pathology of prostate cancer, Journal of Clinical Pathology, 58, (7), 2005, p673 - 684 Journal Article, 2005 DOI

Real Time PCR gene analysis in, editor(s)Crocker, J. Burnett, D. , The Science of Laboratory Diagnosis, John Wiley & Sons, Ltd., 2005, pp495 - 504, [Martin, C.M., Sheils, O, O'Leary, J.J.] Book Chapter, 2005

O'Toole S, Laios A, Sheppard B, Smyth P, O'Regan E, Sheils O, O'Leary J., Expression profiling of endometrial stromal cells treated with estradiol and phytoestrogens, 20th European Congress of Pathology, Paris, Sept, 2005 Conference Paper, 2005

O'Toole SA, Dunn E, Sheppard BL, Sheils O, O'Leary JJ, Wuttke W,, Oestrogen regulated gene expression in normal and malignant endometrial tissue, Maturitas, 51, (2), 2005, p187 - 198 Journal Article, 2005 DOI

O'Toole SA, Sheppard BL, D'Arcy T, Mc Guinness EPJ, Gleeson NC, Bonnar J, Sheils O, O'Leary JJ., Multidrug resistance gene only plays a role in some ovarian cancers, Irish Association for Cancer Research, Kilkenny, Ireland, March, 2005 Conference Paper, 2005

Crocker John, Burnett David, The Science of laboratory diagnosis , John Wiley & Sons , 2005 Book, 2005

Smyth P, Finn S, Cahill S, O'Regan E, Flavin R, O'Leary JJ, Sheils O, ret/PTC and BRAF act as distinct molecular, time-dependant triggers in a sporadic Irish cohort of papillary thyroid carcinoma, International Journal of Surgical Pathology, 13, (1), 2005, p1 - 8 Journal Article, 2005 DOI

O'Toole SA, Laios A, Sheppard BL, Gleeson NC, D'Arcy T, Mc Guinness EPJ, Bonnar J, Sheils O, O'Leary JJ, Angiogenesis markers in ovarian cancer act as prognostic markers but not indicators of chemotherapy response, Pathological Society of Great Britain and Ireland, Newcastle, UK, July, 2005 Conference Paper, 2005

High density SNP and cDNA array analysis in, editor(s)Crocker, J. Burnett, D. , The Science of Laboratory Diagnosis, John Wiley & Sons, Ltd., 2005, pp515 - 521, [Sheils, O., Smyth, P., Sherlock, J., Martin, C.M., Finn, S., O'Regan, E.M., O'Leary, J.J.] Book Chapter, 2005

Murphy N, Ring M, Heffron CC, King B, Killalea AG, Hughes C, Martin CM, McGuinness E, Sheils O, O'Leary JJ. , p16INK4A, CDC6, and MCM5: predictive biomarkers in cervical preinvasive neoplasia and cervical cancer. , Journal of Clinical Patholology, 58, (5), 2005, p525 - 534 Journal Article, 2005

Sheils O, Molecular classification and biomarker discovery in papillary thyroid carcinoma., Expert Review of Molecular Diagnostics, 5, (6), 2005, p927 - 946 Journal Article, 2005 DOI

A Laios, SA O'Toole, B Sheppard, N Gleeson, T D'Arcy, E PJ McGuinness, M Ring, O Sheils and JJ O'Leary, Transcriptome profiling of primary and recurrent ovarian cancers, Junior Obstetrics and Gynaecology Society, Dublin, Nov, 2005 Conference Paper, 2005

CA Hughes, A Murphy, C Martin, O Sheils, B Loftus, J O'Leary, Topoisomerase 11-alpha expression correlates with Gleason Score in prostate carcinoma, Pathological Society of Great Britain and Ireland, Newcastle, UK, July, 2005 Conference Paper, 2005

Murphy, N., Ring, M., Heffron, C.C.B.B., Martin, C.M., McGuinness, E., Sheils, O., O'Leary, J.J., Quantitation of CDC6 and MCM5 mRNA in cervical intraepithelial neoplasia and invasive squamous cell carcinoma of the cervix, Modern Pathology , 18, (6), 2005, p844-849 Journal Article, 2005 DOI

Molecular markers in cervical dyskaryosis in, editor(s)Davies P.O.,Prendiville W , The Clinican's HPV handbook (vol 1), Parthenon Medical Publishing, 2005, pp73 - 88, [Murphy, N., Ring, M., Sheils, O., O'Leary, J.J.] Book Chapter, 2005

AJ Murphy, CA Hughes, O Sheils, JJ O'Leary, B Loftus, Variable Expression of a-Methylacyl-CoA Racemase in Benign Prostatic Hyperplasia and Prostate Cancer, USCAP 2005 Annual Meeting, San Antonio, Texas, 2005 Conference Paper, 2005

CCBB Heffron, N Murphy, M Ring, C Martin, O Sheils, J O'Leary, A novel combination of biomarkers for cervical glandular neoplasia, Pathological Society of Great Britain and Ireland, Newcastle, UK, July, 2005 Conference Paper, 2005

CM Martin, L Pilkington, O Sheils, S Murch, AJ Wakefield, JJ OLeary, Cytokine mRNA Expression Analysis in Children with Lymphonodular Hyperplasia and Autistic Spectrum Disorders, USCAP 2004 Annual Meeting, Vancouver, 2004 Conference Paper, 2004

SA O'Toole, E Dunn, BL Sheppard, O Sheils, JJ O' Leary, W Wuttke, D. Seidlova-Wuttke, Oestrogen regulated gene expression in normal and malignant endometrial tissue, 5th International Symposium on Women's Health and Menopause, Florence, Italy, Apr, 2004 Conference Paper, 2004

S. P. Finn, P. Smyth, E. O'Regan, S. Cahill, R. Flavin, J. O'Leary and O. Sheils, Array comparative genomic hybridisation analysis of gamma-irradiated human thyrocytes, Virchows Arch, 445, (4), 2004, p396-404 Journal Article, 2004 DOI

SA O'Toole, BL Sheppard, P Smyth, C Martin, O Sheils, JJ O'Leary, B Spengler, V Christoffel, Genome wide analysis of DNA in endometrial cells treated with phytoestrogens using comparative genomic hybridisation microarrays, 5th International Symposium on Women's Health and Menopause, Florence, Italy, Apr, 2004 Conference Paper, 2004

SP Finn, P Smyth, EM ORegan, R Flavin, JJ OLeary, OM Sheils, Array Comparative Genomic Hybridization Analysis of -Irradiated Human Thyrocytes, USCAP 2004 Annual Meeting, Vancouver, 2004 Conference Paper, 2004

P Smyth, S Finn, R Flavin, S Cahill, E O'Regan, JJ O'Leary, O Sheils, Trends in ret/PTC oncogene and T1796A B-Raf mutation detection in Irish thyroid neoplasms, Irish Association for Cancer Research, 2004 Conference Paper, 2004

RJ Flavin, SP Finn, P Symth, EM ORegan, E Gaffney, JJ OLeary, OM Sheils, Induction of ret/PTC-3 Chimera by -Irradiation of Immortalized Human Thyrocytes, USCAP 2004 Annual Meeting, Vancouver, 2004 Conference Paper, 2004

Murphy, N., Heffron, C.C.B.B., King, B., Ganuguapati, U.G., Ring, M., McGuinness, E., Sheils, O., O'Leary, J.J., P16INK4A positivity in benign, premalignant and malignant cervical glandular lesions: A potential diagnostic problem, Virchows Archiv, 445, (6), 2004, p610-615 Journal Article, 2004

EV Mocanu, R Shattock, D Barton, M Rogers, O Sheils, JJ OLeary, RF Harrison, Cystic Fibrosis Carriage and Male Subfertility - A Concern, USCAP 2004 Annual Meeting, Vancouver, 2004 Conference Paper, 2004

CC Heffron, N Murphy, B King, UG Ganuguapathi, M Ring, O Sheils, JJ O Leary, p16INK4A Positivity in Benign, Premalignant and Malignant Cervical Glandular Lesions: A Potential Diagnostic Problem, USCAP 2004 Annual Meeting, Vancouver, 2004 Conference Paper, 2004

O'Toole SA, Dunn E, Sheppard BL, Klocker H, Bektic J, Smyth P, Martin C, Sheils O, O'Leary JJ., Genome wide analysis of DNA in endometrial cancer using comparative genomic hybridisation microarrays, Irish gynaecological oncology society, Cork, Ireland,, 2004 Conference Paper, 2004

N. Murphy, C. C. Heffron, B. King, U. G. Ganuguapati, M. Ring, E. McGuinness, O. Sheils and J. J. O'Leary, P16(INK4A) positivity in benign, premalignant and malignant cervical glandular lesions: a potential diagnostic problem, Virchows Archiv, 445, (6), 2004, p610-615 Journal Article, 2004 DOI

SA O'Toole, E Dunn, BL Sheppard, P Smyth, C Martin, O Sheils, JJ O'Leary, J. Bektic, H. Klocker, Genome wide analysis of DNA in endometrial cancer using comparative genomic hybridisation microarrays, 5th International Symposium on Women's Health and Menopause, Florence, Italy, Apr, 2004 Conference Paper, 2004

SA O'Toole, E Dunn, BL Sheppard, O Sheils, JJ O' Leary, W Wuttke, D. Seidlova-Wuttke, Oestrogen regulated gene expression in normal and malignant endometrial tissue, Irish gynaecological oncology society, Cork, Ireland, 2004 Conference Paper, 2004

Murphy, N., Heffron, C.C.B.B., King, B., Ganuguapati, U.G., Ring, M., McGuinness, E., Sheils, O., O'Leary, J.J., P16INK4A positivity in benign, premalignant and malignant cervical glandular lesions: A potential diagnostic problem, Virchows Archiv, 445, (6), 2004, p610-615 Journal Article, 2004

RJ Flavin, SP Finn, P Symth, EM ORegan, E Gaffney, JJ OLeary, OM Sheils, ret-PTC-1: A Novel Chimeric Transcript Occurring in Ovarian Serous Surface Carcinomas: Preliminary Results, USCAP 2004 Annual Meeting, Vancouver, 2004 Conference Paper, 2004

EM ORegan, PA Smyth, SP Finn, OM Sheils, RJ Flavin, JJ OLeary, ME Toner, Microarray Comparative Genomic Hybridisation Analysis of Head and Neck Squamous Cell Carcinomas Occurring in Young Patients, USCAP 2004 Annual Meeting, Vancouver, 2004 Conference Paper, 2004

S. P. Finn, P. Smyth, J. O'Leary, E. C. Sweeney and O. Sheils, Ret/PTC chimeric transcripts in an Irish cohort of sporadic papillary thyroid carcinoma, Journal of Clinical Endocrinology and Metabolism, 88, (2), 2003, p938-941 Journal Article, 2003 DOI

Blots, dots, amplification and sequencing in, Molecular Biology and Pathology of Paediatric Cancer 2003, Oxford University Press, 2003, pp56 - 73, [O'Leary JJ, Cullinane C, Sheils O.] Book Chapter, 2003

The in-situ polymerase chain reaction in, editor(s)Crocker J, Murray PG. , Molecular Biology in Cellular Pathology, Wiley & Sons, 2003, pp233 - 249, [O'Leary JJ, Martin CM, Sheils O.] Book Chapter, 2003

P. Smyth, S. Finn, J. O'Leary and O. Sheils, Real-time analysis of beta- and gamma-catenin mRNA expression in ret/PTC-1 activated and nonactivated thyroid tissues, Diagnostic Molecular Pathology, 12, (1), 2003, p44-49 Journal Article, 2003 DOI

Sheils, O.M., Finn, S., O'Leary, J.J., Quality-control issues for PCR-based assays in the molecular laboratory , 9, (3), 2003, p165-172 Journal Article, 2003 DOI

Sheils, O., Finn, S., O'Leary, J., Nucleic acid microarrays: An overview, 9, (3), 2003, pPages 155-158 Journal Article, 2003 DOI

E.M. O'Regan, P. Smyth, S.P. Finn, O. Sheils, J.J. O'Leary, M. Toner, Investigating the molecular evidence for the histogenesis of osteoclastoma like anaplastic thyroid carcinoma, 19th European Congress of Pathology, Ljubljana, Slovenia, 2003 Conference Paper, 2003

E.M. O'Regan, P. Smyth, S.P. Finn, O. Sheils, J.J. O'Leary, M. Toner, Osteoclastoma like anaplastic thyroid carcinoma: molecular evidence of its histogenesis, Second Joint Meeting of the British Division of the International Academy of Pathology and the Pathological Society of Great Britain and Ireland, Bristol, 2003 Conference Paper, 2003

Crocker John, Murray Paul G, Molecular biology in cellular pathology , 2003, - Miscellaneous, 2003

TaqMan technology and real-time polymerase chain reaction in, editor(s)Crocker J., Murray PG. , Molecular Biology in Cellular Pathology, Wiley & Sons, 2003, pp251 - 268, [O'Leary JJ, Sheils O, Martin C, Crowley A.] Book Chapter, 2003

O'Leary, J.J., Potential viral pathogenic mechanism for new variant inflammatory bowel disease [1] , 2003, - 248 Miscellaneous, 2003 DOI

C. Martin, R. Hickey, O. Sheils, A.J. Wakefield, S. Murch, J.J. O'Leary, Cytokine Expression Analysis in Autistic Enterocolitis, Second Joint Meeting of the British Division of the International Academy of Pathology and the Pathological Society of Great Britain and Ireland, Bristol, 2003 Conference Paper, 2003

O'Toole SA, Sheppard BL, Sheils O, Smyth P, Martin C, O'Leary JJ, Spengler B, Christoffel V, Genome wide analysis of DNA sequence copy number in endometrial cells treated with phytoserms using comparative genomic hybridisation microarray, Irish Association for Cancer Research, Kilkenny, Ireland, Apr, 2003 Conference Paper, 2003

Silva, P. Smyth, C. Martin, O. Sheils, J.J. O'Leary, Common endothelial cell genetic events occur during HHV8 transformation: evidence from primary transformed endothelial and co-hybrid transformed culture model systems, Second Joint Meeting of the British Division of the International Academy of Pathology and the Pathological Society of Great Britain and Ireland, Bristol, 2003 Conference Paper, 2003

C. Martin, O.Sheils, A.J. Wakefield, S. Murch, J.J. O'Leary, Gene Expression Profiling in Inflammatory Bowel Disease, Second Joint Meeting of the British Division of the International Academy of Pathology and the Pathological Society of Great Britain and Ireland, Bristol, 2003 Conference Paper, 2003

N. Murphy, C. Long, F. Mulcahy, E. McGuinness, M. Griffin, C.M. Martin, O. Sheils, J.J. O'Leary, Absolute quantitation of cdc 6 and mcm 5 mRNA in cervical intraepithelial neoplasia and invasive squamous cell carcinoma of the cervix, Second Joint Meeting of the British Division of the International Academy of Pathology and the Pathological Society of Great Britain and Ireland, Bristol, 2003 Conference Paper, 2003

A.Crowley, C. Martin, O Sheils, C. O'Herlihy, JJ O'Leary, B. Byrne, The Dynamics of Fetal trafficking in Pregnancy, Second Joint Meeting of the British Division of the International Academy of Pathology and the Pathological Society of Great Britain and Ireland, Bristol, 2003 Conference Paper, 2003

A. Crowley, C. O'Herlihy, O. Sheils, J.J. O'Leary, B. Byrne, Fetal trafficking in first trimester of pregnancy - a marker of Itrauterine Growth restriction?, Second Joint Meeting of the British Division of the International Academy of Pathology and the Pathological Society of Great Britain and Ireland, Bristol, 2003 Conference Paper, 2003

N. Murphy, M. Ring, A. G. Killalea, V. Uhlmann, M. O'Donovan, F. Mulcahy, M. Turner, E. McGuinness, M. Griffin, C. Martin, O. Sheils and J. J. O'Leary, p16INK4A as a marker for cervical dyskaryosis: CIN and cGIN in cervical biopsies and ThinPrep smears, Journal of Clinical Pathology, 56, (1), 2003, p56-63 Journal Article, 2003 DOI URL

S.P. Finn, P. Smyth, E.C. Sweeney, J.J. O'Leary, O.M. Sheils, Ret/PTC chimeric transcripts in sporadic papillary thyroid carcinoma: Correlation with tumour morphology, XXIVth International Congress of the International Academy of Pathology (IAP), Amsterdam, 2002 Conference Paper, 2002

ODONOVAN, M, EXPRESSION PROFILING OF KAPOSI'S SARCOMA REVEALS DYSREGULATION OF IMMUNOMODULATORY, PRO-INFLAMMATORY, CONNECTIVE TISSUE AND VASCULAR/HAEMATOLOGICAL RELATED GENES, unknown, 2002, 198, ISI Web of Science, 2002, pp10A - 10A Meeting Abstract, 2002

Sheils, O., Smyth, P., Finn, S., Sweeney, E.C., O'Leary, J.J., Nikiforov, Y., RET/PTC rearrangements in Hashimoto's thyroiditis (multiple letters), International Journal of Surgical Pathology, 10, (2), 2002, p167-169 Journal Article, 2002

M O'Donovan, I Silva, OM Sheils, JJ O'Leary, Expression Profiling of Kaposi's Sarcoma, 91st annual meeting USCAP, Chicago, IL, 2002 Conference Paper, 2002

A Cotter, CM Martin, O Sheils, SF Daly, JJ O'Leary, Increased maternal fetal trafficking in early pregnancy is associated with an increased risk of pre-eclampsia, Annual Meeting of the Pathological Society of Great Britain and Ireland, Dublin, 2002 Conference Paper, 2002

SMYTH, P, ANALYSIS OF BETA-CATENIN EXPRESSION IN THYROID NEOPLASIA, unknown, 2002, 198, ISI Web of Science, 2002, pp49A - 49A Meeting Abstract, 2002

HUGHES, C, DEVELOPMENT OF A DETAILED MOLECULAR PROFILE FOR PROSTATE CANCER, unknown, 2002, 198, ISI Web of Science, 2002, pp21A - 21A Meeting Abstract, 2002

SHEILS, O, DEVELOPMENT OF AN 'ALLELIC DISCRIMINATION' TYPE ASSAY TO DIFFERENTIATE BETWEEN THE STRAIN ORIGINS OF MEASLES VIRUS DETECTED IN INTESTINAL TISSUE OF CHILDREN WITH ILEOCOLONIC LYMPHONODULAR HYPERPLASIA AND CONCOMITANT DEVELOPMENTAL DISORDER, unknown, 2002, 198, ISI Web of Science, 2002, pp5A - 5A Meeting Abstract, 2002

SMYTH, P, E-CADHERIN EXPRESSION IS REDUCED IN REVPTC-1 BUT NOT REVPTC-3 ACTIVATED THYROID NEOPLASMS, unknown, 2002, 198, ISI Web of Science, 2002, pp11A - 11A Meeting Abstract, 2002

OM Sheils, N Murphy, A Killalea, JJ O'Leary, p16 (INK4A) as a Marker of Cervical Dyskaryosis in Cytopathology, 91st annual meeting USCAP, Chicago, IL, 2002 Conference Paper, 2002

O. Sheils, P. Smyth, S. Finn, E. C. Sweeney and J. J. O'Leary, RET/PTC rearrangements in Hashimoto's thyroiditis, International Journal of Surgical Pathology, 10, (2), 2002, p167-8; author reply 168-9 Journal Article, 2002 DOI

SILVA, I, GENOME WIDE EVALUATION OF A HHV 8 VIRALLY TRANSFORMED CO-HYBRID CELL CULTURE MODEL SYSTEM, unknown, 2002, 198, ISI Web of Science, 2002, pp27A - 27A Meeting Abstract, 2002

COTTER, A, INCREASED MATERNAL FETAL CELL TRAFFICKING IN EARLY PREGANCY IS ASSOCIATED WITH AN INCREASED RISK OF PRE-ECLAMPSIA, unknown, 2002, 198, ISI Web of Science, 2002, pp8A - 8A Meeting Abstract, 2002

FINN, SP, RET/PTC-3 CORRELATES WITH FOLLICULAR/SOLID MORPHOLOGY IN "SPORADIC" PAPILLARY THYROID CARCINOMA, unknown, 2002, 198, ISI Web of Science, 2002, pp50A - 50A Meeting Abstract, 2002

SHEILS, OM, IN-VITRO AND IN-VIVO EVIDENCE OF AN ASSOCIATION BETWEEN RET/PTC EXPRESSION AND CELL ADHESIVENESS AND MORPHOLOGY IN THYROID NEOPLASIA, unknown, 2002, 82, ISI Web of Science, 2002, pp120A - 120A Meeting Abstract, 2002

V. Uhlmann, C. M. Martin, O. Sheils, L. Pilkington, I. Silva, A. Killalea, S. B. Murch, J. Walker-Smith, M. Thomson, A. J. Wakefield and J. J. O'Leary, Potential viral pathogenic mechanism for new variant inflammatory bowel disease, Molecular pathology, 55, (2), 2002, p84-90 Journal Article, 2002 DOI URL

MURPHY, D, CYTOKINE PROFILE ANALYSIS IN MULTIPLE SCLEROSIS, unknown, 2002, 198, ISI Web of Science, 2002, pp52A - 52A Meeting Abstract, 2002

CROWLEY, A, QUANTIFICATION OF FETAL DNA IN THE PERIPHERAL BLOOD OF WOMEN WITH PRE-ECLAMPSIA IN SOUTH AFRICA AND IRELAND - A USEFUL MARKER OF DISEASE SEVERITY?, unknown, 2002, 198, ISI Web of Science, 2002, pp22A - 22A Meeting Abstract, 2002

ODONOVAN, M, MOLECULAR ANALYSIS OF PRIMARY EFFUSION LYMPHOMA, unknown, 2002, 15, ISI Web of Science, 2002, pp257A - 257A Meeting Abstract, 2002

SHEILS, OM, IN-VITRO AND IN-VIVO EVIDENCE OF AN ASSOCIATION BETWEEN RET/PTC EXPRESSION AND CELL ADHESIVENESS AND MORPHOLOGY IN THYROID NEOPLASIA, unknown, 2002, 15, ISI Web of Science, 2002, pp120A - 120A Meeting Abstract, 2002

MURPHY, N, P16INK4A, CDC6, MCM5 AND HPV STATUS: PREDICTIVE BIOMARKERS OF CERVICAL PRE-NEOPLASIA?, unknown, 2002, 198, ISI Web of Science, 2002, pp16A - 16A Meeting Abstract, 2002

ODONOVAN, M, MOLECULAR ANALYSIS OF PRIMARY EFFUSION LYMPHOMA USING MFISH AND CGH ANALYSIS: DEMONSTRATES COMMON MOLECULAR-GENETIC PATHWAYS, unknown, 2002, 198, ISI Web of Science, 2002, pp13A - 13A Meeting Abstract, 2002

Sheils, O., Smyth, P., Finn, S., Sweeney, E.C., O'Leary, J.J., Nikiforov, Y., RET/PTC rearrangements in Hashimoto's thyroiditis (multiple letters), International Journal of Surgical Pathology, 10, (2), 2002, p167-169 Journal Article, 2002

COTTER, A, INCREASED MATERNAL FETAL CELL TRAFFICKING AND RH "D" GENE IMMUNIZATION IN PRE-ECLAMPSIA, unknown, 2002, 198, ISI Web of Science, 2002, pp2A - 2A Meeting Abstract, 2002

ODONOVAN, M, EXPRESSION PROFILING OF KAPOSI'S SARCOMA, unknown, 2002, 82, ISI Web of Science, 2002, pp307A - 307A Meeting Abstract, 2002

SHEILS, O, RET/PTC REARRANGEMENTS IN HASHIMOTO'S THYROIDITIS, 2002, - Miscellaneous, 2002

MARTIN, CM, POTENTIAL VIRAL PATHOGENIC MECHANISM FOR NOW VARIANT INFLAMMATORY BOWEL DISEASE, unknown, 2002, 198, ISI Web of Science, 2002, pp37A - 37A Meeting Abstract, 2002

OM Sheils, P Smyth, S Finn, C Martin, JJ O'Leary, In-Vitro and In-Vivo Evidence of an Association between ret/PTC Expression and Cell Adhesiveness and Morphology in Thyroid Neoplasia, 91st annual meeting USCAP, Chicago, IL, 2002 Conference Paper, 2002

SHEILS, OM, P16 (INK4A) AS A MARKER OF CERVICAL DYSKARYOSIS IN CYTOPATHOLOGY, unknown, 2002, 82, ISI Web of Science, 2002, pp86A - 86A Meeting Abstract, 2002

C. M. Martin, V. Uhlmann, A. Killalea, O. Sheils and J. J. O'Leary, Detection of measles virus in children with ileo-colonic lymphoid nodular hyperplasia, enterocolitis and developmental disorder, Molecular psychiatry, 7 Suppl 2, 2002, pS47-s48 Journal Article, 2002 DOI

SKINNER, J, NOVEL METHODOLOGY FOR THE ANALYSIS OF FOETAL DNA IN MATERNAL VENOUS BLOOD AND DETECTION OF ABNORMALITIES IN CHROMOSOMES 13,16, 18 AND 21 IN FIRST TRIMESTER MISCARRIAGE., unknown, 2001, 193, ISI Web of Science, 2001, pp49A - 49A Meeting Abstract, 2001

SHEILS, OM, THE USE OF LASER CAPTURE MICRODISSECTION TO PRODUCE HOMOGENOUS CELL POPULATIONS FROM ARCHIVAL MATERIAL FOR RT-TAQMAN ANALYSIS., unknown, 2001, 193, ISI Web of Science, 2001, pp48A - 48A Meeting Abstract, 2001

P. Smyth, O. Sheils, S. Finn, C. Martin, J. O'Leary and E. C. Sweeney, Real-time quantitative analysis of E-cadherin expression in ret/PTC-1-activated thyroid neoplasms, International Journal of Surgical Pathology , 9, (4), 2001, p265-272 Journal Article, 2001 URL

MURPHY, N, IMMUNOCYTOCHEMICAL ANALYSIS OF P16 PROTEIN EXPRESSION IN CERVICAL CANCER AND CERVICAL INTRAEPITHELIAL NEOPLASIA., unknown, 2001, 195, ISI Web of Science, 2001, pp2A - 2A Meeting Abstract, 2001

M. O'Donovan, I. Silva, V. Uhlmann, N. Bermingham, K. Luttich, C. Martin, O. Sheils, A. Killalea, C. Kenny, S. Pileri and J. J. O'Leary, Expression profile of human herpesvirus 8 (HHV-8) in pyothorax associated lymphoma and in effusion lymphoma, Molecular pathology, 54, (2), 2001, p80-85 Journal Article, 2001 DOI URL

SMYTH, P, E-CADHERIN EXPRESSION IN RET/PTC-1 ACTIVATED THYROID NEOPLASMS, DETECTED BY TAQMAN RT-PCR., unknown, 2001, 195, ISI Web of Science, 2001, pp37A - 37A Meeting Abstract, 2001

ODONOVAN, M, GENOME WIDE EVALUATION OF KAPOSI'S SARCOMA DERIVED PRIMARY SPINDLE CELL CULTURES AND HHV 8 TRANSFORMED ENDOTHELIAL CELLS., unknown, 2000, 190, ISI Web of Science, 2000, pp7A - 7A Meeting Abstract, 2000

O Sheils , V Uhlmann , K Luttich , M O'Donovan , N Bermingham , D Howell , S Picton, E Sweeney, JJ O'Leary JJ, Demonstration of ret/PTC-1 chimeric transcripts in a Papillary Thyroid Cancer Cell Line using in-situ RT-TaqMan PCR, Pathological Society of Great Britain and Ireland - Winter Meeting, 2000 Conference Paper, 2000

J. J. O'Leary, M. Kennedy, K. Luttich, V. Uhlmann, I. Silva, J. Russell, O. Sheils, M. Ring, M. Sweeney, C. Kenny, N. Bermingham, C. Martin, M. O'Donovan, D. Howells, S. Picton and S. B. Lucas, Localisation of HHV-8 in AIDS related lymphadenopathy, Molecular Pathology, 53, (1), 2000, p43-47 Journal Article, 2000 URL DOI

O. M. Sheils, J. O'Eary J, V. Uhlmann, K. Lattich and E. C. Sweeney, ret/PTC-1 Activation in Hashimoto Thyroiditis, International Journal of Surgical Pathology, 8, (3), 2000, p185-189 Journal Article, 2000 DOI

O Sheils , V Uhlmann , K Luttich , M O'Donovan , N Bermingham , D Howell , S Picton , E Sweeney , JJ O'Leary, Assessment of ret/PTC-1 expression in Papillary Thyroid Carcinoma, Pathological Society of Great Britain and Ireland - Winter Meeting, 2000 Conference Paper, 2000

V. Uhlmann, M. Prasad, I. Silva, K. Luettich, L. Grande, L. Alonso, M. Thisted, K. J. Pluzek, J. Gorst, M. Ring, M. Sweeney, C. Kenny, C. Martin, J. Russell, N. Bermingham, M. O'Donovan, O. Sheils and J. J. O'Leary, Improved in situ detection method for telomeric tandem repeats in metaphase spreads and interphase nuclei, Molecular pathology, 53, (1), 2000, p48-50 Journal Article, 2000 URL DOI

SHEILS, O, DEMONSTRATION OF RET/PTC-1 CHIMERIC TRANSCRIPTS IN A PAPILLARY THYROID CANCER CELL LINE USING IN-SITU RT-TAQMAN PCR, unknown, 2000, 190, ISI Web of Science, 2000, pp49A - 49A Meeting Abstract, 2000

O Sheils , V Uhlmann , K Luttich , M O'Donovan, N Bermingham , D Howell , S Picton , E Sweeney E, JJ O'Leary, Demonstration of ret/PTC-1 chimeric transcripts in a Papillary Thyroid Cancer Cell Line using in-situ RT-TaqMan PCR, United States and Canadian Academy of Pathology - 89th Annual Meeting, 2000 Conference Paper, 2000

O Sheils , V Uhlmann , K Luttich , M O'Donovan , N Bermingham , D Howell , S Picton , E Sweeney , JJ O'Leary, Demonstration of ret/PTC-1 chimeric transcripts in a Papillary Thyroid Cancer Cell Line using in-situ RT-TaqMan PCR, IAP annual meeting, Nagoya, Japan, 2000 Conference Paper, 2000

SHEILS, OM, DETECTION OF RET/PTC-1 ACTIVATION IN HASHIMOTO THYROIDITIS USING LASER CAPTURE MICRODISSECTION AND TAQMAN RT-PCR., unknown, 2000, 78, ISI Web of Science, 2000, ppB33 - B33 Meeting Abstract, 2000

SHEILS, O, RET/PTC-1 ACTIVATION IN HASHIMOTO'S THYROIDITIS, unknown, 2000, 190, ISI Web of Science, 2000, pp25A - 25A Meeting Abstract, 2000

O. M. Sheils, J. J. O'Leary and E. C. Sweeney, Assessment of ret/PTC-1 rearrangements in neoplastic thyroid tissue using TaqMan RT-PCR, The Journal of Pathology, 192, (1), 2000, p32-36 Journal Article, 2000 URL DOI

BERMINGHAM, N, HHV8 VIRAL SEQUENCES AND TRANSCRIPTS IN CD34+CELLS AND DENDRITIC CELLS ISOLATED FROM MYELOMA PATIENTS, unknown, 2000, 190, ISI Web of Science, 2000, pp33A - 33A Meeting Abstract, 2000

O Sheils , V Uhlmann, K Luttich, M O'Donovan , N Bermingham , D Howell , S Picton , JJ O'Leary, E Sweeney, ret/PTC-1 activation in Hashimoto Thyroiditis, Pathological Society of Great Britain and Ireland - Winter Meeting, 2000 Conference Paper, 2000

O Sheils , V Uhlmann , JJ O'Leary, EC Sweeney, Detection of ret/PTC-1 activation in Hashimoto thyroiditis using Laser Capture Microdissection and TaqMan RT-PCR, EU High Level Scientific Conference- Microdissection and its Downstream Tools, Bonn, 2000 Conference Paper, 2000

UHLMANN, V, MEASLES VIRUS (MV) IN REACTIVE LYMPHO-NODULAR HYPERPLASIA AND ILEO-COLITIS OF CHILDREN, unknown, 2000, 190, ISI Web of Science, 2000, pp33A - 33A Meeting Abstract, 2000

Sheils, O.M., O'Leary, J.J., Sweeney, E.C., Differentiation of multicentric origin from intra-organ metastatic spread of hepatocellular carcinomas by comparative genomic hybridization, Journal of Pathology, 192, (1), 2000, p43-51 Journal Article, 2000 DOI

J. O'Leary, M. Kennedy, D. Howells, I. Silva, V. Uhlmann, K. Luttich, S. Biddolph, S. Lucas, J. Russell, N. Bermingham, M. O'Donovan, M. Ring, C. Kenny, M. Sweeney, O. Sheils, C. Martin, S. Picton and K. Gatter, Cellular localisation of HHV-8 in Castleman's disease: is there a link with lymph node vascularity?, Journal of Clinical Pathology - Molecular Pathology, 53, (2), 2000, p69-76 Journal Article, 2000 DOI URL

SHEILS, O, ASSESSMENT OF RET/PTC-L EXPRESSION IN PAPILLARY THYROID CARCINOMA, unknown, 2000, 190, ISI Web of Science, 2000, pp7A - 7A Meeting Abstract, 2000

O Sheils , V Uhlmann , K Luttich , M O'Donovan , N Bermingham , D Howell , S Picton , E Sweeney , JJ O'Leary, Demonstration of ret/PTC-1 chimeric transcripts in a Papillary Thyroid Cancer Cell Line using in-situ RT-TaqMan PCR, IAP annual meeting, Nagoya, Japan, 2000 Conference Paper, 2000

UHLMANN, V, NOVEL IN-CELL AMPLIFICATION FOR THE DETECTION OF DNA AND RNA IN TISSUE SECTIONS, unknown, 2000, 190, ISI Web of Science, 2000, pp34A - 34A Meeting Abstract, 2000

JJ O'Leary, M O'Donovan, N Bermingham, I Silva, K Luttich, D Howells, S Picton, V Uhlmann, M Ring, M Sweeney, C Kenny, J Russell, O Sheils, S Lucas, Identification of Human Herpes Virus 8 (HHV8) and characterisation of a novel polymorphism in HIV affected women, Pathological Society of Great Britain and Ireland - Winter Meeting, 2000 Conference Paper, 2000

OLEARY, JJ, IDENTIFICATION OF HUMAN HERPES VIRUS 8 (HHV8) CHARACTERISATION OF A NOVEL POLYMORPHISM IN AFFECTED WOMEN WITH CIN, unknown, 2000, 190, ISI Web of Science, 2000, pp29A - 29A Meeting Abstract, 2000

EC Sweeney, O Sheils, Expression of TSH receptor in archival thyroid carcinomas using 5' Nuclease Assay (TaqMan), 17th European Congress of Pathology, 1999 Conference Paper, 1999

Sheils OM, Sweeney EC. , TSH receptor status of thyroid neoplasms--TaqMan RT-PCR analysis of archival material., Journal of Pathology, May; 188, (1), 1999, p87-92 Journal Article, 1999 DOI

O Sheils, J O'Leary, EC Sweeney, Assessment of ret/PTC-1 Expression in Papillary Thyroid Carcinoma using TaqMan RT-PCR, 17th European Congress of Pathology, 1999 Conference Paper, 1999

OM Sheils, EC Sweeney, Differential expression of TSH receptor in archival thyroid carcinomas using 5' Nuclease Assay (TaqMan)., BACR/IACR, 1999 Conference Paper, 1999

O Sheils, JJ O'Leary, EC Sweeney, Detection of ret/PTC-1 activation in Papillary Thyroid Carcinoma using TaqMan RT-PCR, IACR meeting, 1999 Conference Paper, 1999

Burnett David, Crocker John, The science of laboratory diagnosis , CRC Press , 1999 Book, 1999

OM Sheils, EC Sweeney, Differential expression of TSH receptor in archival thyroid carcinomas using 5' Nuclease Assay (TaqMan), BACR/IACR, 1998 Conference Paper, 1998

SHEILS, OM, DIFFERENTIAL EXPRESSION OF TSH RECEPTOR IN ARCHIVAL THYROID CARCINOMAS USING 5 ' NUCLEASE ASSAY (TAQMAN), unknown, 1998, 78, ISI Web of Science, 1998, pp60 - 60 Meeting Abstract, 1998

D. S. O'Briain, O. Sheils, S. McElwaine, S. R. McCann and M. Lawler, Sorting out mix-ups. The provenance of tissue sections may be confirmed by PCR using microsatellite markers, American Journal of Clinical Pathology, 106, (6), 1996, p758-64 Journal Article, 1996

Mabruk MJ, Flint SR, Coleman DC, Shiels O, Toner M, Atkins GJ., A rapid microwave-in situ hybridization method for the definitive diagnosis of oral hairy leukoplakia: comparison with immunohistochemistry., Journal of Oral Pathology & Medicine, 25, (4), 1996, p170-176 Journal Article, 1996 DOI

Balluz IM, Farrell MA, Kay E, Staunton MJ, Keating JN, Sheils O, Cosby SL, Mabruk MJ, Sheahan BJ, Atkins GJ., Colocalisation of human immunodeficiency virus and human cytomegalovirus infection in brain autopsy tissue from AIDS patients., Ir J Med Sci. , Apr-Jun;165, (2), 1996, p133-138 Journal Article, 1996 DOI

OBRIAIN, DS, HIGH GRADE ENTEROPATHY ASSOCIATED T CELL LYMPHOMA (EATL), A DISTINCT FORM OF T CELL LYMPHOMA, unknown, 1996, 74, ISI Web of Science, 1996, pp691 - 691 Meeting Abstract, 1996

OBRIAIN, DS, THE PROVENANCE OF TISSUE-SECTIONS MAY BE CONFIRMED BY PCR USING MICROSATELLITE MARKERS, unknown, 1995, 72, ISI Web of Science, 1995, ppA167 - A167 Meeting Abstract, 1995

MB McDermott, RA McDermott, O Sheils, M Mabruk, PA Daly, DS O'Briain, Epstein Barr Virus in lymphomas of the upper aerodigestive tract : A study of 56 cases with clinical follow up, United States and Canadian Academy of Pathology Meeting, 1995 Conference Paper, 1995

MCDERMOTT, M, EPSTEIN-BARR-VIRUS IS INFREQUENTLY ASSOCIATED WITH NON-HODGKINS-LYMPHOMAS ARISING IN WALDEYERS RING, unknown, 1995, 72, ISI Web of Science, 1995, ppA103 - A103 Meeting Abstract, 1995

O. Sheils, C. Kilgallen, EC Sweeney, Cell proliferation and p53 expression in Anaplastic Thyroid Carcinoma, IACR meeting, 1995 Conference Paper, 1995

Mabruk MJ, Flint SR, Toner M, Leonard N, Sheils O, Coleman DC, Atkins GJ., Detection of Epstein-Barr virus DNA in tongue tissues from AIDS autopsies without clinical evidence of oral hairy leukoplakia., Journal of Oral Pathology and Medicine, 24, (3), 1995, p109-112 Journal Article, 1995 DOI

Kelleher D, Murphy A, Sheils O, Long A, McDevitt J., Tyrosine phosphorylation in the human duodenum., Gut. , 36, (1), 1995, p34-38 Journal Article, 1995 TARA - Full Text DOI

McDermott MB, O'Briain DS, Shiels OM, Daly PA., Malignant lymphoma of the epididymis. A case report of bilateral involvement by a follicular large cell lymphoma., Cancer, 75, (8), 1995, p2174-2179 Journal Article, 1995 DOI

(ed.), Irish association for cancer research - Proceedings of the 1993 IACR Annual Scientific Meeting held April 2-3, 1993 in Kilkenny, 163, (7), 1994, 341-354 p Proceedings of a Conference, 1994

MCMAHON, JN, ALTERED CELL-PROLIFERATION IN LEIOMYOSARCOMA IS NOT ASSOCIATED WITH MUTATIONS IN P53 EXONS 5-8, unknown, 1994, 70, ISI Web of Science, 1994, ppA8 - A8 Meeting Abstract, 1994

Lawler M, Humphries P, O'Farrelly C, Hoey H, Sheils O, Jeffers M, O'Briain DS, Kelleher D., Adenovirus 12 E1A gene detection by polymerase chain reaction in both the normal and coeliac duodenum., Gut. , 35, (9), 1994, p1226-1232 Journal Article, 1994 DOI TARA - Full Text

O Sheils, M McDermott, DS O'Briain, Lineage Promiscuity in Malignant Lymphomas, IACR meeting, 1994 Conference Paper, 1994

(ed.), Irish association for cancer research - Proceedings of the 1993 IACR Annual Scientific Meeting held April 2-3, 1993 in Kilkenny, 163, (7), 1994, 341-354 p Proceedings of a Conference, 1994

N Leonard, M Toner, M Mabruk, O Sheils, SR Flint, Autopsy findings in the tongues of 16 patients with AIDS, IAOP/BSOP meeting, 1994 Conference Paper, 1994

J McMahon, O Sheils, D Grehan, H Lane, E Gaffney, An assessment of Proliferating Cell Nuclear Antigen (PCNA) and p53 Immunoreactivity in Synovial Sarcoma, IACR meeting, 1994 Conference Paper, 1994

MCMAHON, JN, LARGE GROWTH FRACTION IN SYNOVIAL SARCOMA IS NOT ASSOCIATED WITH ACCUMULATION OF MUTANT P53-PROTEIN, unknown, 1993, 68, ISI Web of Science, 1993, ppA8 - A8 Meeting Abstract, 1993

(ed.), Irish society of gastroenterology: Proceedings Of Meeting Held, 161, (3), 1992, 81-97 p Proceedings of a Conference, 1992

Sheils O., Comparison between PCR and immunohistochemistry as methods for the detection of HPV in paraffin embedded tissues, World Congress of Med. Lab. Science, 1992 Conference Paper, 1992

(ed.), Irish society of gastroenterology: Proceedings Of Meeting Held, 161, (3), 1992, 81-97 p Proceedings of a Conference, 1992

Quinn DG, Fennell JS, Sheils O, Gaffney EF, Feighery CF., Effect of cyclosporin on immune complex deposition in murine glomerulonephritis., Immunology. , 72, (2), 1991, p550-554 Journal Article, 1991

GALLAGHER, RB, IMMUNOLOGICAL INVOLVEMENT OF BRUNNER GLANDS IN CELIAC-DISEASE, unknown, 1989, 30, ISI Web of Science, 1989, ppA1451 - A1452 Meeting Abstract, 1989

Gallagher RB, Kelly CP, Neville S, Sheils O, Weir DG, Feighery CF., Complement activation within the coeliac small intestine is localised to Brunner's glands., Gut. , Nov; 30, (11), 1989, p1568-1573 Journal Article, 1989 DOI

Non-Peer-Reviewed Publications

N Murphy, M Ring, A Killalea, F Mulcahy, E McGuinness, M Griffin, C Martin, O Sheils, JJ O'Leary, p16ink4a, cdc 6, mcm 5 and HPV status: predictive biomarkers of cervical pre-neoplasia?, Annual Meeting of the Pathological Society of Great Britain and Ireland, Dublin, 2002 Conference Paper, 2002

I Silva, M O'Donovan, N Murphy, O Sheils, SB Lucas, JJ O'Leary, Genome wide evaluation of a HHV8 virally transformed co-hybrid cell culture model system, Annual Meeting of the Pathological Society of Great Britain and Ireland, Dublin, 2002 Conference Paper, 2002

C Hughes, C Martin, O Sheils, B Loftus, JJ O'Leary, Development of a detailed molecular profile for prostate cancer, Annual Meeting of the Pathological Society of Great Britain and Ireland, Dublin, 2002 Conference Paper, 2002

M O'Donovan, I Silva, C Martin, O Sheils, JJ O'Leary, Molecular Analysis of Primary Effusion Lymphoma using mFISH and CGH analysis demonstrates common molecular genetic pathways, Annual Meeting of the Pathological Society of Great Britain and Ireland, Dublin, 2002 Conference Paper, 2002

D Murphy, V Uhlmann, C Martin, O Sheils, J O'Leary, Cytokine Profile analysis in multiple sclerosis, Annual Meeting of the Pathological Society of Great Britain and Ireland, Dublin, 2002 Conference Paper, 2002

O Sheils, P Smyth, C Martin, JJ O'Leary, Developmant of an allelic discrimination type assay to differentiate between the strain origins of measles virus detected in intestinal tissue of children with ileocolonic lymphonodular hyperplasia and concomitant developmental disorder, Annual Meeting of the Pathological Society of Great Britain and Ireland, Dublin, 2002 Conference Paper, 2002

P Smyth, S Finn, JJ O'Leary, O Sheils, E-cadherin expression is reduced in ret/PTC-1 but not ret/PTC-3 activated thyroid neoplasms, neoplasms., Dublin, 2002 Conference Paper, 2002

P.S. Smyth, S.P. Finn, J.J. O'Leary, O.M. Sheils, E-cadherin expression in ret/PTC activated Thyroid Neoplasms detected by Taqman RT-PCR, XXIVth International Congress of the International Academy of Pathology (IAP), Amsterdam, 2002 Conference Paper, 2002

SP Finn, P Smyth, E Sweeney, JJ O'Leary, O Sheils, Ret/PTC-3 correlates with follicular/solid morphology in "sporadic" papillary thyroid carcinoma, Annual Meeting of the Pathological Society of Great Britain and Ireland, Dublin, 2002 Conference Paper, 2002

CM Martin, V Uhlmann, O Sheils, L Pilkington, I Silva, A Killalea, J Walker Smith, SB Murch, M Thompson, A Wakefield, JJ O'Leary, Potential viral pathogenic mechanism for new variant inflammatory bowel disease, Annual Meeting of the Pathological Society of Great Britain and Ireland, Dublin, 2002 Conference Paper, 2002

A Crowley, JJ O'Leary, O Sheils, C Martin, F Taulo, J Anthony, C O'Herlihy, BM Byrne, Quantification of fetal DNA in the peripheral blood of women with pre-eclampsia in South Africa and Ireland -a useful marker of disease severity, Annual Meeting of the Pathological Society of Great Britain and Ireland, Dublin, 2002 Conference Paper, 2002

M O'Donovan, I Silva, OM Sheils, JJ O'Leary, Molecular Analysis of Primary Effusion Lymphoma, 91st annual meeting USCAP, Chicago, IL, 2002 Conference Paper, 2002

M O'Donovan, I Silva, C. Martin, SB Lucas, OM Sheils, JJ O'Leary, Expression Profiling of Kaposi's Sarcoma reveals dysregulation of immunomodulatory, pro-inflammatory, connective tissue and vascular/haematological related genes, Annual Meeting of the Pathological Society of Great Britain and Ireland, Dublin, 2002 Conference Paper, 2002

P Smyth S Finn, JJ O'Leary, O Sheils, Analysis of -catenin expression in thyroid neoplasia, Annual Meeting of the Pathological Society of Great Britain and Ireland, Dublin, 2002 Conference Paper, 2002

MO'Donovan, N Bermingham , I Silva, K Luttich, D Howells, S Picton, V Uhlmann, M Ring, M Sweeney, C Kenny, J Russell, O Sheils, S Lucas, JJ O'Leary, Genome wide evaluation of Kaposi's sarcoma derived primary spindle cell cultures and HHV8 transformed endothelial cells, Pathological Society of Great Britain and Ireland - Winter Meeting, 2000 Conference Paper, 2000

V Uhlmann, O Sheils, M O'Donovan, N Bermingham, M Ring, JJ O'Leary, Measles virus (MV) in reactive lympho-nodular hyperplasia and ileo-colitis of children, Pathological Society of Great Britain and Ireland - Winter Meeting, 2000 Conference Paper, 2000

N Bermingham, M O'Donovan, I Silva , K Luttich, S Picton, V Uhlmann, M Ring, M Sweeney, C Kenny, J Russell, R Lemoli R, O Sheils, JJ O'Leary, HHV8 viral sequences and transcripts in CSD34+ cells and dendritic cells isolated from myeloma patients, Pathological Society of Great Britain and Ireland - Winter Meeting, 2000 Conference Paper, 2000

V Uhlmann, K Luttich, M O'Donovan, N Bermingham, I Silva, D Howells, S Picton, M Ring, M Sweeney, C Kenny, J Russell, O Sheils, JJ O'Leary, Novel in-cell amplification for the detection of DNA and RNA in tissue sections, Pathological Society of Great Britain and Ireland - Winter Meeting, 2000 Conference Paper, 2000

DS O'Briain, O Sheils, M Lawler, The provenance of tissue sections may be confirmed by PCR using microsatellite markers, United States and Canadian Academy of Pathology Meeting, 1995 Conference Paper, 1995

R McManus, J McMahon, J Stephens, O Sheils, N Parfrey, E Gaffney, P Daly, Loss of heterozygosity and p53 mutations in female patients with multiple cancers, IACR meeting, 1995 Conference Paper, 1995

J McMahon, J Stephens, N Parfrey, O Sheils, E Gaffney, Altered Cell Proliferation in leiomyosarcoma is not associated with mutations in p53 exons 5-8, IACR meeting, 1994 Conference Paper, 1994

Research Expertise

Description

My research is of international consequence and of consequence to individual patients. I have developed a significant programme concerned with molecular diagnostics and prognostics. I have made seminal discoveries in the areas of thyroid and cervical pathobiology. I have procured grants worth >€35M, I have published >120 peer reviewed journal articles and presented my work on the international stage. I am a leader in multidisciplinary molecular pathology. I have championed a niche area facilitating interaction between basic science, translational research, clinical service provision and biotechnology. The significance and transformational value of my work resides in my international recognition, industry disruptive research and benefit to cancer patients quality of life. I am Director of and a Principal Investigator in the Trinity Translational Medicine Institute and a PI in Biomedical Diagnostics Institute at DCU. I work closely with several biotech companies and have procured European Reference Lab status from ThermoFisher. This industry recognition of my research ensures we have pre-commercial launch access to novel chemistries and we act as a beta test site for new technology platforms and analysis kits. My research focuses on elucidating the underlying mechanisms of human disease with a focus on cancer and metastasis of solid tumors. This work is translated into novel assays for better diagnosis and prognostication of patients' disease. I have made seminal discoveries into the pathobiology of cancers including thyroid and cervix, which have resulted in major changes to the way patients are treated. I am a founder member of several international consortia working to establish novel sequencing technologies as routine diagnostic testing regimens in clinical laboratories. My research has been published in international journals at the highest levels and has been incorporated into fundamental pathology textbooks. My research continues to enhance TCD's reputation as an international force in cancer research. The international significance of my research is recognized by invitations to deliver plenary and keynote addresses at leading conferences in Pathology and Human Genetics. Additional transformational significance has seen Trinity College affiliated St James's Hospital become Ireland's first accredited Cancer Diagnostics Laboratory. My position within the Department of Histopathology means that I have an understanding of the diagnostic and prognostic deficiencies within current clinical practice and many of the research innovations made under my supervision have been geared towards enhanced service delivery. Thus there is a spectrum of research in which I am involved from basic science to more translational research with direct application in the clinical setting. My work in early cancer diagnostics and theranostics is recognised globally and has made tangible differences in the way patients are managed. The translation of basic research to clinically relevant assays has had an industry disruptive and transformative influence on molecular diagnostics. I have positioned myself for leadership by building an infrastructure within and outwith of TCD that is unique to the College ecosystem and from which TCD continues to make a real difference in people's lives who are affected by cancer. My translational research positions us to lead cancer related diagnostics in Ireland and beyond. This research will form the bedrock of service provision and interdisciplinary innovation that are central to the aspirations of the newly proposed Cancer Institute at the SJH site. In Summary, my research has led to discoveries highlighting pivotal mutations in cancers and directly influencing improved treatment of patients. In essence my research has been the difference between life or death for many patients.

Projects

  • Title
    • Current Projects
  • Summary
    • Irish Cancer Society Prostate Cancer Research Consortium 2011-2016 Work Package 3: Integrated mRNA and miRNA signatures Sheils O- [coPI] . Merck Serono Validation of k-ras testing in colorectal samples Sheils O [PI] €5000 2011-12 . Amgen Validation of KRAS detection in colorectal samples Sheils O [PI] €5000 2011-12 . BDI 2 CSET (Onc 1 project) SFI Sheils O [co-investigator] Total €19.2M TCD component €991K 2010-1015 . EU 7th FP grant (FP7-HEALTH-2007-A) Sheils O [co-investigator] 'Automatic Cancer Screening Based on real-time PCR' "AutoCast" Total €4,188,503.00 TCD component €682K 2010-2013 . EU 7th FP grant (FP7-HEALTH-2007-A) Sheils O [co-investigator] Project number 257073 PASCA-Platform for Advanced Single Cell-Manipulation and Analysis Total €3,000,000 TCD component €700K 2010-2013 . EU 7th FP grant (FP7-HEALTH-2010-Cp-FP) Sheils O [PI] Project Number: 258759-2 Fast Automated Multiplex Analysis of Neonatal Sepsis Markers on a Centrifugal Microfluidic Platform 'ASCMicroPlat' Total €2,452,517 TCD component €686K 2011-2015 . The Irish Cancer Society [2008-2012] . Sheils O [co-PI] 'Hsa-miR-141 and hsa-miR-223 are central to Ovarian Serous Carcinoma Pathogenesis through regulation of JAG1 and SMARCD1 proteins' Role: Co-Principal Investigator . The Emer Casey Foundation [2008-2012] Sheils O [co-investigator] ' The role of hypoxia in chemoresistance in ovarian cancer' Role: Co-Investigator . The Emer Casey Foundation [2008-2012] Sheils O [co-investigator] 'Discovering novel signatures of early ovarian cancer' Role: Co-Investigator . Health Research Board [2004-2012] Sheils O [co-P.I.] 'PhD training site grant' Role: Co-Principal Investigator . HRB_HRA/2012/82 Sheils O [co-investigator] 2012 - 2015, Title: "Understanding the role of cancer stem-like cells in resistance to radiation using a clinically-relevant model of radioresistance in oesophageal adenocarcinoma". €291,357.
  • Title
    • Molecular Pathology of Thyroid Disease
  • Summary
    • Current research being undertaken by our group aspires to elucidate the relationship between ret/PTC-1 activation and its associated morphological patterns, by investigating the link between ret/PTC-1 activation and expression of cell adhesion molecules such as E-Cadherin, and the catenin family of proteins. An associated project is underway to characterise ret/PTC3 positive papillary thyroid carcinomas and correlate the findings with disease manifestation. The focus of the proposed study is to broaden the scope of the current research, by using genome wide analysis of diagnostic cohorts of thyroid tumours, to attempt to integrate morphologic and molecular biological findings as suggested by Rosai et al. This would culminate in the establishment of functional genomics of diagnostic cohorts. . It will comprehensively determine levels of expression of gene targets across a spectrum of thyroid disease - from normal, through autoimmune thyroiditis to papillary thyroid carcinoma and its variants (Follicular variant, Tall cell variant, Columnar cell variant, Hurthle cell papillary carcinoma) using comparative genomic hybridisation (CGH) and micro-array technology.
  • Funding Agency
    • CRI, HRB, Applied Biosystems
  • Date From
    • 2000
  • Date To
    • 2010
  • Title
    • Head and Neck Oncology
  • Summary
    • Investigators: Dr. Esther O'Regan (PhD Candidate) Dr. Mary Toner Prof. Conrad Timon Dr. Orla Sheils Prof. John O'Leary Head and neck squamous cell carcinoma (HNSCC) is an aggressive epithelial malignancy that is the sixth most common neoplasm in the world today. This tumour usually afflicts middle to older-aged individuals with a history of tobacco and alcohol use. However recent evidence suggests that there is an increased incidence of HNSCC in individuals in patients under the age of 40, who have not been chronic users of tobacco and alcohol. Genome wide evaluation of tumours is possible. Our group plans to determine the molecular genetic alterations associated with HNSCC in young people, and compare it to those in an older population. Rather than compare the commonly altered chromosomal regions in typical HNSCC, with the same regions in HNSCC affecting a younger population, we plan to perform a genome wide analysis of HNSCC in a cohort of young individuals, in order to identify potential candidate genes that may be significant in the tumorigenesis occurring in this young population. The hypothesis is that HNSCC in young patients (without significant risk factors) is a distinct disease.
  • Funding Agency
    • CRI
  • Date From
    • 2002
  • Date To
    • 2006
  • Title
    • Molecular Markers in Cervical Cancer
  • Summary
    • Recently, our group in the Department of Histopathology has identified a novel set of molecular markers for use in cervical screening programmes. The markers include HPV type, load and integration status, cdc6 and mcm5 expression, telomerase expression and telomeric stabilization/lengthening. Preliminary data suggests that cdc6 and mcm5 (proteins involved in DNA replication) selectively mark dyskaryotic cells in smears and tissue biopsies. The ability to isolate individual dyskaryotic cells from CIN/cGIN and malignant cells from squamous and glandular carcinomas can now be achieved using LCM technology. The above investigators will attempt to identify the mechanism of cdc6 and mcm5 localisation in the nuclei of dyskaryotic cells, and in tandem will examine the influence of HPV infection, telomerase expression and telomeric lengthening/stabilization on such localization phenomena. The experiments will involve geographical isolation and CGH array analysis of cells in CIN 1,2,3,cGIN and invasive squamous and glandular carcinomas of the cervix.
  • Funding Agency
    • HRB, CRI, Applied Biosystems
  • Title
    • Molecular Profiling in Prostate Cancer
  • Summary
    • The purpose of this project is to study the genetic profile of pre-invasive prostatic neoplasia and subsequent stages of prostatic carcinoma in order to identify genetic discriminators of disease progression. This knowledge could form the basis for the development of new treatment strategies. Prostate cancer is a major world-wide problem, and is the second commonest cancer in men in Ireland. The number of newly diagnosed cases has increased in men of all ages. Prostate cancer has a high mortality rate, and accounts for almost 500 deaths in Ireland annually. The number of deaths is increasing by 3.5% per annum. The rising mortality rate may be due to a number of factors, including undertreatment. One of the major problems and challenges in prostate carcinoma is to predict the outcome of individual patients. Diagnosis of prostatic carcinoma is usually made on prostate biopsy, performed for a raised PSA. In addition, prostatic carcinoma may be diagnosed incidentally in transurethreal prostatic resection (TURP) specimens, performed for benign prostatic disease. Such tumours appear to be biologically more indolent compared with clinically suspected prostate cancers, and this may be due due a different genetic profile. There is no laboratory test currently available which will predict progression of disease. Knowledge of genetic changes underlying initiation, development and progression of prostate carcinoma is limited, and no specific genetic event has yet been identified. We hypothesise that demonstration of chromosomal gains and losses using CGH micro-array technology may identify genetic markers for disease progression.
  • Funding Agency
    • AMNCH trust, Applied Biosystems
  • Title
    • Assessment of Viral Pathogens in IBD
  • Summary
    • The investigators are examining a range of viral pathogens which may play a role in the pathogenesis of inflammatory bowel disease. Preliminary evidence suggests that paramyxoviruses may selectively localize to dendritic antigen presenting cells in the mucosa of the gut, thereby establishing foci of inflammation and altering antigen presentation from mucosa to gut endothelium. It is intended to delineate the precise location of GI infection and to examine the alteration in cytokine cascade of large and small bowel mucosa in patients with Crohn's Disease, Ulcerative Colitis and 'new variant IBD' which is associated with autism.. Intestinal dysfunction in autism is poorly understood. Recently, one centre in the UK has described enterocolitis in children with developmental disorder. Ileocolonic lymphoid nodular hyperplasia (LNH) appears to be a consistent feature of this 'new variant IBD'. In addition to LNH, mild to moderate colitis that lacks the specific histopathological diagnostic features of either Crohn's Disease or Ulcerative Colitis is found. However, these observations require confirmation and expansion. CD8(+) density, gd T cell and intraepithelial lymphocyte (IEL) numbers are increased in children with this 'new variant IBD' as compared to patients with Crohn's Disease, isolated LNH (not related to autism) and normal controls. In addition, gut enterocytic epithelium is HLA DR negative, suggesting predominantly a T(H)2 immune response in the mucosa of affected children, leading to impaired intestinal permeability. In this study, we intend to establish the prevalence of gastrointestinal dysfunction/ abnormalities in patients with autistic spectrum disorder using a combined endoscopic, immunological, biochemical and molecular biological approach, which will characterise the functional immunology and pathobiology of gastrointestinal abnormalities in autistic patients, and highlight any discrepancies between enterocolitis in autistic spectrum disorder and conventional inflammatory bowel disease.

Keywords

Autoimmunity; Bioinformatics; Biomedical ethics; Cancer genetics and cell biology including metastasis; Cervical cancer; Commercialisation of scientific research; Diagnostics; Endocrine function and disease; Environmental Carcinogenesis; Foetal, maternal and neonatal physiology; Gene transcription in human cancer; Gynaecology oncology; HASHIMOTO THYROIDITIS; Immunochemistry and immunogenetics; Inflammatory bowel disease; Intra and intercellular signalling; Medical Law; Medical Sciences, Research; Membrane and protein trafficking; Oncogenes, apoptosis and tumour development; Oral diseases and Oral medicine; Oral pathology; Pathophysiology; Prostate cancer; Quantitative and molecular genetics; Regulatory methods of gene expression; RET ONCOGENE ACTIVATION; RNA processing, stability and degradation; Role of oestrogens in age related urogenital diseases; SIGNAL TRANSDUCTION; TAQMAN RT-PCR; Thyroid Cancer; Tumour immunology and immunotherapy; TYROSINE PHOSPHORYLATION; Virology and viral pathogenesis

Recognition

Representations

Member of the Advisory Committee - Societal Challenge 1, Health & Demographic Change. European Commission 2013

Board Member - European Institute of Women's Health 2017

Associate Editor Irish Journal of Medical Science 2017

National workgroup on Bio-banking 2012

Member, MMI Cancer Principal Investigators, Trans-institutional grouping of Principal Investigators leading research on Cancer themes 2010

Associate Editor BMC Cancer 2010

Member, Core Technology PI's, DMMC Principal Investigators leading the development of core technology platforms. 2006

Wellcome Trust - Reviewer 2005

Reviewer for South African Medical Research Council 2004

Scientific Advisor - I act in an advisory capacity for ThermoFisher, offering insight into planning and development of molecular diagnostic tools, ensuring the internationally renowned profiles of the Discipline of Histopathology and of College are maintained and positioning us to have early access to novel products and have input into their construction. 2010

Reviewer for Hong Kong Earmarked Research Grants (ERG) [administered by the Research Grants Council (RGC) ] 2005

Member of Editorial Board of Journal of Endocrine Pathology 2009

Advisor to the National Council with expertise in Medical Teaching -USI Academic Affairs Advisory Panel. 2015

Reviewer for journals including: Oncogene, Nature Biotechnology, Nature Medicine, Journal of Clinical Endocrinology and Metabolism, Molecular Cancer, Molecular Endocrinology, Journal of Pathology, Modern Pathology, International Journal of Surgical Pathology, DU Law Review 2003

Awards and Honours

FTCD 2009

Provost's Teaching Award 2012

MA jure oficii 2007

Memberships

Member of the Pathological Society of Great Britain and Ireland 2001 – present

Member of Medico-legal Society of Ireland 2006 – present

Fellow of the Royal College of Pathologists 2007 – present

Fellow of the Institute of Biomedical Sciences 2016 – present


Last updated 21 September 2016 Paul Smyth (Email).