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Paediatric Haematology

Natural Anticoagulant mechanism (JPEG 22 kB).

Childhood Leukaemia: A study has been completed on the relevance and detection of MRD in childhood ALL. Other investigations include a natural history of GATA1 mutations, bone marrow angioganesis in ALL and the role of E2A-HLF fusion transcripts in ALL.

Work continues on the molecular and cellular basis of the inflammatory/coagulation interface in human disease. A Central relationship between the protein C anticoagulant/cytoprotective pathway and sepsis or systemic inflammatory response sepsis syndrome.


Hochart H, Jenkins PV, Preston RJ, Smith OP, White B, O'Donnell J. Concentration-dependent roles for heparin in modifying lipopolysaccharide-induced activation of mononuclear cells in whole blood. Thromb Haemost. 2008 Mar;99(3):570–5.

Principal Investigators

Principal Investigator Email Telephone
Professor Owen Smith  
Dr James O'Donnell

+353 1 896 2141

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Last updated 21 September 2016 School Web Administrator (Email).