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Myeloma

New treatment regiments for the treatment of this disease are underway in association with autologous transplantation. These new treatments include thalidomide, thalidomide analogues and proteasome inhibitors. Our research focuses on molecular epidemiology of myeloma and investigation of novel treatment strategies.

Publications

Tewari P, Ryan AW, Hayden PJ, Catherwood M, Drain S, Staines A, Grant T, Nieters A, Becker N, de Sanjose S, Foretova L, Maynardie M, Cocco P, Boffetta P, Brennan P, Chanock S, Lawler M, Browne PV. Genetic variation at the 8q24 locus confers risk to multiple myeloma. Br J Haematol. 2012; 156(1):133-6.

Maginn EN, Browne PV, Hayden P, Vandenberghe E, MacDonagh B, Evans P, Goodyer M, Tewari P, Campiani G, Butini S, Williams DC, Zisterer DM, Lawler MP, McElligott AM. PBOX-15, a novel microtubule targeting agent, induces apoptosis, upregulates death receptors, and potentiates TRAIL-mediated apoptosis in multiple myeloma cells. Br J Cancer. 2011; 104(2):281-9.

Tewari P, Kenny E, Staines A, Chanock S, Browne P, Lawler M. Genetic variants in XRRC5 may predict development of venous thrombotic events in myeloma patients on thalidomide. Blood. 2009; 113(22):5691-2.

Principal Investigators

Principal Investigator Email Telephone
Dr Paul Browne pbrowne@stjames.ie +353 1 416 2166
Dr P. Hayden http://people.tcd.ie/haydenp  

Dr Tony McElligott

http://people.tcd.ie/mcelliga +353 1 896 3276

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Last updated 21 September 2016 School Web Administrator (Email).