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Minimal Residual Disease

MRD sensitivity graph (JPEG 49 kB).

Minimal Residual Disease (MRD) is currently the focus of much research interest. The ability to monitor MRD allows early stratification of patients on the basis of their response to therapy and the early treatment of relapsed disease. Flow cytometry and PCR-based amplification of disease-specific genes are among the techniques employed. Research in this area has been conducted between St James's Hospital and Our Lady's Hospital for Sick Children, Crumlin. For more information visit the Institute of Molecular Medicine.

Principal Investigators

Principal Investigators Email Telephone
Dr Paul Browne pbrowne@stjames.ie +353 1 416 2166
Dr Owen Smith owen.smith@olhsc.ie  
Dr Aengus O'Marcaigh omarcaia@tcd.ie +353 1 455 8111
Professor Mark Lawlor mlawler@stjames.ie +353 1 896 2093

Recent Publications

Ryan J, Quinn F, Meunier A, Boublikova L, Crampe M, Tewari P, O'Marcaigh A, Stallings R, Neat M, O'Meara A, Breatnach F, McCann S, Browne P, Smith O, Lawler M. Minimal residual disease detection in childhood acute lymphoblastic leukaemia patients at multiple time-points reveals high levels of concordance between molecular and immunophenotypic approaches. Br J Haematol. 2009; 144(1):107-15.

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Last updated 21 September 2016 School Web Administrator (Email).