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Chronic Lymphocytic Leukaemia


New prognostic markers in this disease have been introduced by the Department and are currently used in the evaluating of patients at diagnosis and directing the choice of appropriate therapy. We have active research projects investigating novel agents in the treatment of chronic lymphocytic leukaemia and the role of the tumour microenvironment in disease pathogenesis and progression.

Publications

Langabeer SE, Quinn F, O'Brien D, McElligott AM, Kelly J, Browne PV, Vandenberghe E.  Incidence of the BRAF V600E mutation in chronic lymphocytic leukaemia and prolymphocytic leukaemia. Leuk Res. 2012; 36(4):483-4.

Bacon CL, Daly P, Sheane B, Conneally EC, Browne PV, McCann S, Ni Chongaile M, McDermot R, Hollywood D, Wilson L,  Vandenberghe E. Successful outcome of patients with relapsed/refractory Hodgkin lymphoma treated with high dose chemotherapy at the National adult Bone Marrow Transplant Unit in St James's Hospital. Irish Medical Journal. 102, 1, 26-28. 2009.

McElligott AM, Maginn EN, Greene LM, McGuckin S, Hayat A, Browne PV, Butini S, Campiani G, Catherwood MA, Vandenberghe E, Williams DC, Zisterer DM, Lawler M. The novel tubulin-targeting agent pyrrolo-1,5-benzoxazepine-15 induces apoptosis in poor prognostic subgroups of chronic lymphocytic leukemia. Cancer Res. 2009; 69(21):8366-75.

Amjad Hayat, David O'Brien, Paul O'Rourke, Siobhan McGuckin, Tony Fitzgerald, Eibhlin Conneally, Paul V Browne, Shaun R McCann, Mark P Lawler, Elisabeth Vandenberghe. CD38 expression level and pattern of expression remains a reliable and robust marker of progressive disease in chronic lymphocytic leukemia. Leukemia & Lymphoma. 47 (11): 2371-2379. 2006.

Chronic Lymphocytic Leukaemia MRD analysis by flow cytometry (JPEG 49 kB).

Principal Investigators

Principal Investigator Email Telephone
Elisabeth Vandenberghe vandenbe@tcd.ie + 353 1 410 3546
Paul Browne
pbrowne@stjames.ie +353 1 896 3236
Tony McElligott http://people.tcd.ie/mcelliga +353 1 896 3276

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Last updated 21 September 2016 School Web Administrator (Email).