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Caitriona Lally
Professor in BioEngineering, Mechanical & Manuf. Eng

Biography

Dr. Caitríona Lally received her BEng (Mechanical Engineering) and MEng (Biomedical Engineering) degrees from University of Limerick and later obtained a PhD from Trinity College Dublin in the area of arterial biomechanics and cardiovascular stenting. In March 2004 she took up a lecturing position in the School of Mechanical & Manufacturing Engineering at Dublin City University, and was appointed senior lecturer in 2014. In 2015, she joined the Department of Mechanical & Manufacturing Engineering in Trinity College Dublin as a Professor in Bioengineering where she continues to carry out research focused on arterial tissue mechanics, vascular imaging, vascular mechanobiology and tissue engineering. She has secured considerable research funding from SFI, Enterprise Ireland and the IRC and was awarded an ERC starting grant in 2014.

Publications and Further Research Outputs

Peer-Reviewed Publications

Shahid, Syed Salman, Christian, Kerskens, Caitriona, Lally, Use of high-resolution micro-diffusion tensor imaging to estimate the ultra-structure of the arterial wall, Bioengineering in Ireland, Belfast, 20-10-2017, 2017 Oral Presentation, 2017 TARA - Full Text

Robert Gaul, Caitríona Lally, Strain Mediated Enzyme Degradation of Arterial Tissue; Implications in Disease and Medical Device Design, Summer Biomechanics, Bioengineering and Biotransport Conference 2017, Arizona, USA, June 2017, 2017 Oral Presentation, 2017 TARA - Full Text

Coupled Finite Element-Agent Based Models for the Simulation of Vascular Growth and Remodeling in, editor(s)Miguel Cerrolaza Sandra J. Shefelbine Diego Garzon-Alvarado , Numerical Methods and Advanced Simulation in Biomechanics and Biological Processes, Elsevier, 2017, pp283 - 298, [David Nolan, Caitriona Lally] Book Chapter, 2017

David Nolan, Assessment of a Clinically Relevant Geometric Measure for Identifying Vulnerable Carotid Plaques, Bioengineering in Ireland, Belfast, 2017 Meeting Abstract, 2017 TARA - Full Text

Robert Gaul, David Nolan, Caitríona Lally, Collagen fibre characterisation in arterial tissue under load using SALS, Journal of the Mechanical Behavior of Biomedical Materials, 75, 2017, p359 - 368 Journal Article, 2017 TARA - Full Text URL

Syed Salman Shahid, Robert Gaul, Christian Kerskens, Vittoria Flamini, Caitríona Lally, Quantifying the ultrastructure of carotid artery using high-resolution micro-diffusion tensor imaging - Comparison of intact vs. open cut tissue , Physics in Medicine and Biology, 2017 Journal Article, 2017 URL TARA - Full Text

David R. Nolan, Caitríona Lally, An Investigation of Damage Mechanisms in Mechanobiological Models of In-Stent Restenosis, Journal of Computational Science, 2017 Journal Article, 2017 TARA - Full Text URL

Syed salman Shahid, Christian Kerskens, Robert Gaul, Caitriona Lally, Quantification of extracellular matrix components in arterial tissue using high-resolution micro diffusion tensor imaging, European Molecular Imaging Meeting, Germany, 5-04-2017, 2017 Poster, 2017 TARA - Full Text

David Nolan; Caitríona Lally, An in-silico investigation into the influence of endothelial denudation on the progression on in-stent restenosis, European Society of Biomechanics, Seville, 2017 Meeting Abstract, 2017 TARA - Full Text

Syed Salman Shahid, Christian Kerskens, Robert Gaul, Vittoria Flamini, Caitriona Lally, Ex-vivo arterial collagen fibre tractography using micro-diffusion tensor imaging, European Society for Magnetic Resonance in Medicine and Biology , Vienna, Austria, 29-09-2017, 2016 Poster, 2016 TARA - Full Text

David Nolan, Caitriona Lally, A Mechanobiological Framework for the Prediction of In-Stent Restenosis; Insights into the role of load induced damage in restenotic growth, The Virtual Physiological Human Conference, Amsterdam, 26/09/2016, edited by Alfons Hoekstra , 2016 Conference Paper, 2016 TARA - Full Text

Robert Gaul, Thomas Sinnott, Caitríona Lally, The automated characterisation of collagen fibre orientation in arteries using small angle light scattering, UK Society for Biomaterials, Belfast, Ireland, 2015 Poster, 2015 TARA - Full Text

Flamini V, Creane A.P, Kerskens C.M, Lally C, Imaging and finite element analysis: A methodology for non-invasive characterization of aortic tissue, Medical Engineering and Physics, 37, (1), 2015, p48 - 54 Journal Article, 2015 DOI URL

McCartney, W.T., Galvin, E., Cummins, C., Lally, C., Mac Donald, B.J., Use of a biodegradable magnesium implant for Osseous fixation in four cases, International Journal of Applied Research in Veterinary Medicine, 13, (3), 2015, p171-174 Journal Article, 2015

Zahedmanesh, H., Van Oosterwyck, H., Lally, C., A multi-scale mechanobiological model of in-stent restenosis: deciphering the role of matrix metalloproteinase and extracellular matrix changes, Computer Methods in Biomechanics and Biomedical Engineering, 17, (8), 2014, p813-828 Journal Article, 2014

Colombo, A., Guha, S., Mackle, J.N., Cahill, P.A., Lally, C., Cyclic strain amplitude dictates the growth response of vascular smooth muscle cells in vitro: Role in in-stent restenosis and inhibition with a sirolimus drug-eluting stent, Biomechanics and Modeling in Mechanobiology, 12, (4), 2013, p671-683 Journal Article, 2013 DOI

Flamini V, Kerskens C, Moerman K, Simms CK and Lally C, Fibre orientation of fresh and frozen porcine aorta determined non-invasively, Medical Engineering and Physics, 35, (6), 2013, 765-776 Journal Article, 2013 DOI

Galvin, E., Morshed, M.M., Cummins, C., Daniels, S., Lally, C., MacDonald, B., Surface modification of absorbable magnesium stents by reactive ion etching, Plasma Chemistry and Plasma Processing, 33, (6), 2013, p1137-1152 Journal Article, 2013 DOI

Campbell, E.M., Cahill, P.A., Lally, C., Investigation of a small-diameter decellularised artery as a potential scaffold for vascular tissue engineering; biomechanical evaluation and preliminary cell seeding, Journal of the Mechanical Behavior of Biomedical Materials, 14, 2012, p130-142 Journal Article, 2012

Zahedmanesh, H., Lally, C., A multiscale mechanobiological modelling framework using agent-based models and finite element analysis: Application to vascular tissue engineering, Biomechanics and Modeling in Mechanobiology, 11, (3-4), 2012, p363-377 Journal Article, 2012

Creane, A., Maher, E., Sultan, S., Hynes, N., Kelly, D.J., Lally, C., A remodelling metric for angular fibre distributions and its application to diseased carotid bifurcations., Biomechanics and Modeling in Mechanobiology, 11, (6), 2012, p869-882 Journal Article, 2012 DOI

Redmond, E.M., Lally, C., Cahill, P.A., Hemodynamic control of vascular smooth muscle function, Muscle, 2, 2012, p1231-1242 Journal Article, 2012

Patient Specific Computational Modeling in Cardiovascular Mechanics in, Patient-Specific Computational Modeling, 2012, pp61-79 , [A Creane, DJ Kelly, C Lally. ] Book Chapter, 2012 DOI

Brackmann, C., Dahlberg, J.-O., Vrana, N.E., Lally, C., Gatenholm, P., Enejder, A., Non-linear microscopy of smooth muscle cells in artificial extracellular matrices made of cellulose, Journal of Biophotonics, 5, (5-6), 2012, p404-414 Journal Article, 2012

Maher E, Early M, Creane A, Lally C, Kelly DJ, Site specific inelasticity of arterial tissue., Journal of biomechanics, 45, (8), 2012, p1393-1399 Journal Article, 2012 DOI TARA - Full Text

Eoghan Maher, Arthur Creane, Caitríona Lally, Daniel J. Kelly, An anisotropic inelastic constitutive model to describe stress softening and permanent deformation in arterial tissue, Journal of the Mechanical Behavior of Biomedical Materials, 12, 2012, p9-19 Journal Article, 2012 URL TARA - Full Text DOI

Maher, E., Creane, A., Sultan, S., Hynes, N., Lally, C. Kelly, D.J., Inelasticity of Human Carotid Atherosclerotic Plaque. , Annals of Biomedical Engineering, 39, (9), 2011, p2445-2455 Journal Article, 2011 DOI

Zahedmanesh, H., MacKle, J.N., Sellborn, A., Drotz, K., Bodin, A., Gatenholm, P., Lally, C., Bacterial cellulose as a potential vascular graft: Mechanical characterization and constitutive model development, Journal of Biomedical Materials Research - Part B Applied Biomaterials, 97 B, (1), 2011, p105-113 Journal Article, 2011

Guha, S., Cullen, J.P., Morrow, D., Colombo, A., Lally, C., Walls, D., Redmond, E.M., Cahill, P.A., Glycogen synthase kinase 3 beta positively regulates Notch signaling in vascular smooth muscle cells: Role in cell proliferation and survival, Basic Research in Cardiology, 106, (5), 2011, p773-785 Journal Article, 2011

Creane, A., Maher, E., Sultan, S., Hynes, N., Kelly, D.J., Lally, C. Nagel, T., Kelly, D.J., Prediction of fibre architecture and adaptation in diseased carotid bifurcations. , Biomechanics and Modeling in Mechanobiology , 10, (6), 2011, p831-843 Journal Article, 2011 DOI

Flamini V, Kerskens C, Moerman K, Simms C and Lally C, Imaging arterial fibres using diffusion tensor imaging - feasibility study & preliminary results, EURASIP Journal on Advances in Signal Processing, 2010, 2010, pArticle ID 904091 Journal Article, 2010 DOI TARA - Full Text

Colombo, A., Zahedmanesh, H., Toner, D.M., Cahill, P.A., Lally, C., A method to develop mock arteries suitable for cell seeding and in-vitro cell culture experiments, Journal of the Mechanical Behavior of Biomedical Materials, 3, (6), 2010, p470-477 Journal Article, 2010

Vittoria Flamini, Christian Kerskens, Kevin Mattheus Moerman, Ciaran Simms and Caitríona Lally , Imaging Arterial Fibres Using Diffusion Tensor Imaging-Feasibility Study and Preliminary Results, EURASIP Journal on Advances in Signal Processing, 2010, (904091), 2010 Journal Article, 2010 TARA - Full Text DOI URL

Boyle CJ, Lennon AB, Early M, Kelly DJ, Lally C, Prendergast PJ, Computational simulation methodologies for mechanobiological modelling: a cell-centred approach to neointima development in stents., Philosophical transactions. Series A, Mathematical, physical, and engineering sciences, 368, (1921), 2010, p2919-35 Journal Article, 2010 DOI URL TARA - Full Text

Creane, A., Maher, E., Sultan, S., Hynes, N., Kelly, D.J., Lally, C. , Finite element modelling of diseased carotid bifurcations generated from in vivo computerised tomographic angiography., Computers in Biology and Medicine, 40, (4), 2010, p419-429 Journal Article, 2010 DOI

Moerman, KM ; Kerskens, CM ; Lally, C ; Flamini, V ; Simms, CK , Evaluation of a Validation Method for MR Imaging-Based Motion Tracking Using Image Simulation, EURASIP Journal on Advances in Signal Processing, 2010, 2010, p942131 Journal Article, 2010 DOI TARA - Full Text

Zahedmanesh, H., Kelly, D.J., Lally, C. , Simulation of a balloon expandable stent in a realistic coronary artery; Determination of the optimum modelling strategy, Journal of Biomechanics, 43, (11), 2010, p2126-2132 Journal Article, 2010 DOI

Michael Early; Catriona Lally; Patrick J. Prendergast; Daniel J. Kelly, Stresses in peripheral arteries following stent placement: a finite element analysis, Computer Methods in Biomechanics and Biomedical Engineering, 12, (1), 2009, p25 - 33 Journal Article, 2009 TARA - Full Text DOI URL

Creane, A., Maher, E., Sultan, S., Hynes, N., Kelly, D.J., Lally, C., Patient specific finite element modelling of the carotid bifurcation, Proceedings of the ASME Summer Bioengineering Conference 2009, SBC2009, (PART A), 2009, p529-530 Journal Article, 2009

Zahedmanesh, H., Gatenholm, P., Lally, C., Bacterial cellulose: A potential vascular graft and tissue engineering scaffold, Proceedings of the ASME Summer Bioengineering Conference 2009, SBC2009, (PART A), 2009, p519-520 Journal Article, 2009

Pericevic, I., Lally, C., Toner, D., Kelly, D.J. , The influence of plaque composition on underlying arterial wall stress during stent expansion: the case for lesion-specific stents, Medical Engineering and Physics , 31, (4), 2009, p428-433 Journal Article, 2009 TARA - Full Text DOI URL

Zahedmanesh, H., Lally, C., Determination of the influence of stent strut thickness using the finite element method: Implications for vascular injury and in-stent restenosis, Medical and Biological Engineering and Computing, 47, (4), 2009, p385-393 Journal Article, 2009

Maher, E., Creane, A., Sultan, S., Hynes, N., Lally, C. Kelly, D.J. , Tensile and compressive properties of fresh human carotid atherosclerotic plaques. , Journal of Biomechanics, 42, (16), 2009, p2760-2767 Journal Article, 2009 TARA - Full Text DOI

Boyle, C.J., Lally, C., Prendergast, P.J, Injury driven biological model of restenotic lesion development predicts the effects of stent geometry on restenosis, Proceedings of the ASME Summer Bioengineering Conference 2009, SBC2009, 11th ASME Summer Bioengineering Conference, SBC2009, Lake Tahoe, edited by 17-21 June , PART B, ASME, 2009, pp1055-1056 Conference Paper, 2009

Maher, E., Creane, A., Sultan, S., Hynes, N., Lally, C., Kelly, D.J., Mechanical characterization of fresh human carotid atherosclerotic plaque, Proceedings of the ASME Summer Bioengineering Conference 2009, SBC2009, (PART B), 2009, p1307-1308 Journal Article, 2009

Flamini, V., Kerskens, C., Lally, C., An anisotropic structural model of the aortic wall based on tensile tests and non-invasive 3D fibre analysis using diffusion tensor imaging, Proceedings of the ASME Summer Bioengineering Conference 2009, SBC2009, (PART A), 2009, p411-412 Journal Article, 2009

Lally, C., Sellborn, A., Bodin, A., Bäckdahl, H., Gatenholm, P., Risberg, B., Mechanical characterization of bacterial cellulose tubes for vascular tissue engineering, 8th World Biomaterials Congress 2008, 2, 2008 Journal Article, 2008

Colombo, A., Cahill, P.A., Lally, C., An analysis of the strain field in biaxial Flexcell membranes for different waveforms and frequencies, Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine, 222, (8), 2008, p1235-1245 Journal Article, 2008

Lally, C., Dolan, F., Prendergast, P.J., Erratum to "Cardiovascular stent design and vessel stresses: A finite element analysis". [Journal of Biomechanics 38 (2005) 1574-1581] (DOI:10.1016/j.jbiomech.2004.07.022), Journal of Biomechanics, 39, (9), 2006 Journal Article, 2006

Lally, C, Dolan, F, Prendergast, PJ, Cardiovascular stent design and blood vessel stress: a finite element analysis, Journal of Biomechanics, 38, (8), 2005, p1574 - 1581 Journal Article, 2005 URL DOI

Lally, C, Reid, AJ, Prendergast, PJ, Elastic behaviour of porcine coronary arteries under uniaxial and equibiaxial tension, Annals of Biomedical Engineering, 32, 2004, p1355 - 1364 Journal Article, 2004

Prendergast, PJ, Lally, C, Daly, S, Lee, TC, Quinn, D, Dolan, F, Analysis of prolapse in cardiovascular stents: a constitutive equation for vascular tissue and finite element modelling, Journal of Biomechanical Engineering , 125, 2003, p692-699 Journal Article, 2003

Non-Peer-Reviewed Publications

Alix Whelan, Robert Gaul, Paul Gunning, Caitriona Lally, Investigation of Collagen Fibre Orientation in Bovine Pericardium, Proceedings of the 23rd Annual Conference of the Section of Bioengineering of the Royal Academy of Medicine in Ireland, Belfast, 20/01/17, 2017 Oral Presentation, 2017 TARA - Full Text

Robert Gaul, Caitríona Lally, Strain mediated enzyme degradation of arterial tissue characterised by small angle light scattering, Proceedings of the 23rd Annual Conference of the Section of Bioengineering of the Royal Academy of Medicine in Ireland., Belfast, Ireland, 2017 Oral Presentation, 2017 TARA - Full Text

Robert Gaul, Caitríona Lally, Load induced changes in collagen fibre architecture in arteries characterised by small angle light scattering, Proceedings of the 22nd Annual Conference of the Section of Bioengineering of the Royal Academy of Medicine in Ireland, Galway, Ireland, 2016 Oral Presentation, 2016 TARA - Full Text

Robert Gaul, Caitríona Lally, The use of small angle light scattering for the characterisation of collagen fibre orientation in arteries, Proceedings of the 21st Annual Conference of the Section of Bioengineering of the Royal Academy of Medicine in Ireland, Kildare, Ireland, 2015 Oral Presentation, 2015 TARA - Full Text

Simulation of in-stent restenosis for the design of cardiovascular stents in, G. Holzpafel & R. Ogden , Mechanics of Biological Tissue, Springer, 2006, pp255 - 267, [Lally, C, Prendergast, PJ] Book Chapter, 2006

Recognition

Representations

Research Committee Member

Awards and Honours

ERC Starting Grant 2014

Senior author on research paper which was awarded 2nd prize for the Engineers Ireland - IMECHE Young Engineers Research Award 2012

Career Start Grant (DCU) 2005

Royal Society of Medicine in Ireland, 1st prize for best student paper 2004

Royal Society of Medicine in Ireland, 2nd prize for best student paper 2002

Bernard Crossland Symposium, 2nd prize for best student paper 2002

Sylvestor O'Halloran Surgical Meeting, 1st prize in poster presentation 2002

Memberships

Member of the Institution of Engineers of Ireland (MIEI) and member of the committee for the Biomedical Division of the IEI (2006-2009) Member of the Royal Academy of Medicine of Ireland (RAMI) and the European Society of Biomechanics. PI in the Trinity Centre for Bioengineering