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Prof Celia Holland, Trinity College Dublin

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Professor Celia Holland

 

image Celia HollandProfessor Celia Holland BA (TCD), PhD (Cantab), FTCD, MRIA
Professor in Parasitology

Address Department of Zoology,
School of Natural Sciences,
Trinity College, Dublin 2

Email cholland@tcd.ie

Tel +353 1 8961096

Research gate profile

 

Research interests

I am a parasitologist with a particular interest in the relative contributions of host exposure and susceptibility to parasite intensity from an epidemiological standpoint. This encompasses nutritional, immunological, genetic and behavioural characteristics of the host and aspects of its environment. I have chosen to study these mechanisms in a number of parasite species, in both humans and other animals, in the field and the laboratory.

My particular focus has been on the soil-transmitted nematode Ascaris, which is an important human parasite in the tropics and is also economically significant in pigs and Toxocara canis, which infects dogs but is also a zoonotic infection in humans with a cosmopolitan distribution in both temperate and tropical regions. Both infections are classic neglected diseases that contribute to many unanswered questions!

Selected recent publications

 

Medley, G. F., Turner, H. C., Baggaley, R.F. Holland, C.V. and Hollingsworth, T.D. (2016). The role of more sensitive helminth diagnostics in mass drug administration campaigns: elimination and health impacts. In: Basáñez, M.G., Anderson, R.M., (Eds.), Mathematical Models for Neglected Tropical Diseases: Essential Tools for Control and Elimination, Part B, pp. 343–392.


Deslyper, G., Colgan, T.J., Cooper, A.J.R., Holland, C.V. and Carolan, J. (2016). A proteomic investigation of hepatic resistance to Ascaris in a murine model. PLOS Neglected Tropical Diseases 10(8): e0004837.

Loxton, K. C., Lawton, C., Stafford, P. and Holland, C.V. (2016). Reduced helminth parasitism in the introduced bank vole (Myodes glareolus): more parasites lost than gained.  International Journal of Parasitology Parasites and Wildlife 5 (2) 175-183.

Holland, C.V. (2015). Knowledge gaps in the epidemiology of Toxocara: the enigma remains. ParasitologySpecial Issue on One Health. Published online 16 December 2.

Fan, C-K., Holland, C.V., Loxton, K. And Barghouth, U. (2015). Cerebral toxocariasis: silent progression to neurogenerative disorders? Clinical Microbiology Reviews 28 (3), 663-686.

Hamilton, C.M., Yoshida, A., Pinelli, E. and Holland, C.V. (2014). Toxocariasis in Helminth infections and their impact on global public health. Editor F. Bruschi, F. pp 425 – 460. Springer, Vienna.

Holland, C. (2013) (Editor). Ascaris the neglected parasite. Elsevier. 439 pp. ***Click here to see a recent review of this book published in Parasites & Vectors***

Holland, C.V., Behnke, J.M.B. and Dold, C. (2013). Larval ascariasis: impact, significance and model organisms. In “Ascaris the neglected parasite” (Editor Holland, C) pp 108-119. Elsevier.

Abanyie, F.A., McCracken, C., Kirwan, P., Molloy, S.F., Asaolu, S.O., Holland, C.V., Gutman, J. and Lamb, T.J. (2013). Ascaris co-infection does not alter malaria-induced anaemia in a cohort of Nigerian preschool children. Malaria Journal 12:1.

Molloy, S.F., Tanner, C.J., Kirwan, P., Asaolu, S.O., Smith, H.V., Nichols R.A.B., Connelly, L. and Holland, C.V. (2011). Cryptosporidium infection in Nigerian children: Risk factors with species identification. Epidemiology and Infection 139 (6) 946-954.

Kirwan, P., Jackson, A.L., Asaolu, S.O., Abiona, T.C., Bruce, M.C., Ranford-Cartwright, L., O'Neill, S.M. and Holland, C.V. (2010). Impact of repeated four-monthly anthelmintic treatment on Plasmodium infection in preschool children: a double-blind placebo-controlled randomized trial. BMC Infectious Diseases 10, 277.

Molloy, S.F., Smith, H.V., Kirwan, P., Nichols, R.B., Asaolu, S.O., Connelly, L. and Holland, C.V. (2010). Evidence of a high diversity of Cryptosporidium species, genotypes and subtypes in a pediatric population in Nigeria. American Journal of Tropical Medicine and Hygiene 82(4), 608-613.

Dold, C., Cassidy, J.P., Stafford, P., Behnke, J.M. and Holland, C.V. (2010). Genetic influence on the kinetics and associated pathology of early stage (intestinal-hepatic) migration of Ascaris suum in mice. Parasitology 137, 173-185.

Smith, H., Holland, C., Taylor, M.R.H., Magnaval, J-F., Schantz, P. and Maizels, R. (2009). How common is human toxocariasis? Towards standardising our knowledge. Trends in Parasitology 25, 4, 182-188.

Holland, C. (2009). Predisposition to ascariasis: patterns, mechanisms and implications. Parasitology (Centenary volume) 136, 1537-1547.

Kirwan, P., Asaolu, S.O., Molloy, S.F., Abiona, T.C., Jackson, A.L. and Holland, C. (2009). Patterns of soil transmitted helminth infection and impact of four monthly anthelmintic treatment in preschool children from semi-urban communities in Nigeria: a double blind placebo-controlled randomized trial. BMC Infectious diseases 9, 2009, 20.

Roddie, G., Stafford, P., Holland, C. and Wolfe, A. (2008). Contamination of dog hair with the eggs of Toxocara canis. Veterinary Parasitology 152, 85-93.

Holland, C. and Smith, H. (2006). (Editors). Toxocara the enigmatic parasite. CABI publishing. 301pp.

Lewis, R., Stafford, P., Behnke, J.M. and Holland, C. (2006). The development of a mouse model to explore resistance and susceptibility to early Ascaris suum infection. Parasitology 132, 289-300.

>>full list of publications>>

 

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Teaching

Medical Parasitology (Senior Sophister Medicine)
Parasitology (Z03030) (Junior Sophister Zoology and Functional Biology)
Experimental Design and Analysis (Part 1 and 2)(ZO3070) (Junior Sophister Zoology, Functional Biology, Plant Science and Environmental Science)
Tutorials (JS Functional Biology)
Advances in Parasitology (ZO4401) (Senior Sophister Zoology and Functional Biology)
Zoology and Society (ZO4040) (Senior Sophister Zoology)
Contribution to Module in Parasite Immunology, MSc in Immunology

 


Last updated 25 August 2017 by SHASSETT@tcd.ie.