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SINGLE MOLECULE MANIPULATION AND BIOSENSING USING OPTICAL TWEEZER AND MEMS DIAGNOSTIC TECHNOLOGY - BIOANALYTICS @ MOLECULAR LEVEL

Welcome to the bioanalytics laboratory at Trinity College Dublin. As the leader of this group I welcome you to visit our website, correspond with members of our group and discuss your technical interests with us. Our laboratory is focusing on bioanalytics at molecular – and system level. We explore the dynamics and kinetics of interacting biomolecules, the mechanics of protein imported to mitochondria membranes, the kinetics of molecular motors under external strain and the nanomechanical action at ribosomal complexes during translation. We develop and utilize state of the art combined force – and optical spectroscopy tweezers instruments for single biomolecule analysis. We design in-vitro diagnostic MEMS platforms based on microfluidic liquid systems and tailor made bio-engineered nano-mechanical biosensors. Our current research focus is on quantitative diagnostic assays in drug monitoring (miRNA diagnostic and siRNA pharmakokinetics), proteomics, microbio (environmental and clinical) and heamostasis assays. Most of our developed devices and assays awill be used in translational science in collaboration with hospitals (St. James Hospital, Dublin and Lund University, SWE) and health institutes (Swiss Tropical Institute, Basel).

A team of 5 researchers (Physics, Molecular Biology, Bioengineering, Nanoscale Science) under the guidance of Martin Hegner is currently developing the next generation of in vitro-diagnostic nano-mechanical assays. With several national and international collaborations we are involved in a multi-disciplinary team effort with the goal of developing specialized devices and assays for a rich variety of applications. We are committed to changing the world through discoveries and development of new technologies. Our efforts begin where the imaginative mind meets the experienced. We are excited about what future technology can offer society.