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Martin Hegner
Professor, Physics
Professor, CRANN

Biography

Prof. Hegner studied Life Sciences at the Swiss Federal Institute of Technology, Zurich in 1984 (CH). He received his Diplom ("master of science") degree in Cellular Biochemistry, Molecular Biology, Immunology and Toxicology in 1989 and he completed his PhD thesis in 1994 with work in the field of 'Protein Translocation across Membranes' and 'Biological Scanning Probe Microscopy' at the Swiss Federal Institute of Technology, Institute for Biochemistry in Zurich. In 1994-96 he had a post-doctoral position at the Institute of Physics in Basel in the laboratory of Prof. H.-J. Güntherodt, a pioneer in the field of scanning probe microscopy. Thereafter ('96-'99) he joined the world leading group of C. Bustamante at the Howard Hughes Medical Institute in Eugene, OR and then at University of California at Berkeley, CA as a research associate to acquire know-ho in the field of single molecule manipulation with optical tweezers. In 1999 he joined the Institute of Physics at University of Basel (Switzerland) as group and project leader for biological nanoscale science within the newly founded Swiss National Centre of Competence 'Nanoscale Science'. Until today he introduced several novel approaches to investigate molecular interactions with nanomechanical tools. In 2001 he received his 'venia docendi' in Experimental Physics at the University of Basel, Switzerland and in 2007 he joined the Physics faculty of the University of Dublin, Trinity College Dublin Ireland. He was appointed as Professor and pursues his interdisciplinary research in the Centre of Research on Adaptive Nanostructures and Nanodevices (CRANN) in the field of Nanobiotechnology.

Publications and Further Research Outputs

Peer-Reviewed Publications

Padovani, F., Duffy, J., Hegner, M., Microrheological Coagulation Assay Exploiting Micromechanical Resonators, Analytical Chemistry, 89, 2017, p751 - 758 Journal Article, 2017 URL DOI

Wruck, F., Katranidis, A., Nierhaus, K.H., Büldt, G., Hegner, M., Translation and folding of single proteins in real-time, Proc. Natl. Acad. Sci. USA, 114, (22), 2017, pE4399 - E4407 Journal Article, 2017 DOI

Jadhav V.S, BrÃŒggemann D, Wruck F, Hegner M, Single-molecule mechanics of protein-labelled DNA handles, Beilstein Journal of Nanotechnology, 7, (1), 2016, p138 - 148 Journal Article, 2016 URL DOI

Walther, M.,Fleming, P.M., Padovani, F., Hegner, M., An optimized measurement chamber for cantilever array measurements in liquid incorporating an automated sample handling system, EPJ Techniques and Instrumentation, 2, (7), 2015 Journal Article, 2015 DOI TARA - Full Text

Winters S, Berner N.C, Mishra R, DÃŒmbgen K.C, Backes C, Hegner M, Hirsch A, Duesberg G.S, On-surface derivatisation of aromatic molecules on graphene: the importance of packing density, Chemical Communications, 51, (94), 2015, p16778 - 16781 Journal Article, 2015 DOI URL

Mishra, Rohit , Hegner, Martin , Effect of non-specific species competition from total RNA on the static mode hybridization response of nanomechanical assays of oligonucleotides, Nanotechnology, 25, (22), 2014, p225501- Journal Article, 2014 DOI

Maloney, N., Lukacs, G., Jensen, J., Hegner, M. , Nanomechanical sensors for single microbial cell growth monitoring, Nanoscale, 6, (14), 2014, p8242-8249 Journal Article, 2014 DOI

Maloney, N., Lukacs, G., Ball, S.L., Hegner, M. , Device for filamentous fungi growth monitoring using the multimodal frequency response of cantilevers., The Review of scientific instruments, 85, (1), 2014, p015003 Journal Article, 2014 TARA - Full Text DOI

Jensen, J., Maloney, N., Hegner, M., A multi-mode platform for cantilever arrays operated in liquid, Sensors and Actuators B: Chemical, 183, 2013, p388 - 394 Journal Article, 2013 DOI

Optical Tweezers in, editor(s)Bhushan, Bharat , Encyclopedia of Nanotechnology, New York, Springer, 2012, pp1981 - 1991, [Hegner, M., Bruggemann, D., Skoko, D.] Book Chapter, 2012

Jensen, J., Farina, M., Zuccheri, G., Grange, W. and Hegner, M., Quantitative, Label-Free Detection of the Aggregation of alpha-Synuclein Using Microcantilever Arrays Operated in a Liquid Environment , Journal of Sensors, 2012, 2012, pArticle number 874086 Journal Article, 2012 TARA - Full Text DOI

Ronan Daly, Shishir Kumar, Gyongyi Lukacs, Kangho Lee, Anne Weidlich, Martin Hegner, and Georg S. Duesberg, Cell Proliferation Tracking Using Graphene Sensor Arrays, Journal of Sensors, 2012, 2012, p219485-219492 Journal Article, 2012 TARA - Full Text DOI

G. Lukacs, N. Maloney, and M. Hegner, Ink-Jet Printing: Perfect Tool for Cantilever Array Sensor Preparation for Microbial Growth Detection, Journal of Sensors, 2012, 2012, p561256-561263 Journal Article, 2012 TARA - Full Text DOI

Maloney, N., Lukacs, G., Nugaeva, N., Grange, W., Ramseyer, J. P., Jensen, J., Hegner, M., Fibre Optic Readout of Microcantilever Arrays for Fast Microorganism Growth Detection, Journal of Sensors, 2012, 2012, Art. no 405281 Journal Article, 2012 DOI TARA - Full Text

Jensen, J. and Hegner, M., Predictions of the Compressible Fluid Model and its Comparison to Experimental Measurements of Q Factors and Flexural Resonance Frequencies for Microcantilevers, Journal of Sensors, 2012, 2012, p258381- Journal Article, 2012 DOI TARA - Full Text

Rohit Mishra, Wilfried Grange, and Martin Hegner, Rapid and Reliable Calibration of Laser Beam Deflection System for Microcantilever-Based Sensor Setups, Journal of Sensors, 2012, (617386), 2012, p6 Journal Article, 2012 URL DOI TARA - Full Text

Noy, P., Steiner, R., Voelkle, J., Hegner, M. and Fattinger, Ch, Instrument for Label-Free Detection of Noncoding RNAs Journal of Sensors,, Journal of Sensors, 2012, 2012, p208079- Journal Article, 2012 DOI TARA - Full Text

Hegner, M., Tenje, M., Jeon, S., Nanomechanical sensing, Journal of Sensors , 2012, pArticle number 346062 Journal Article, 2012 TARA - Full Text DOI

Katranidis, A., Grange, W., Schlesinger, R.,Choli-Papadopoulou, T., Bruggemann, D., Hegner, M., Buldt, G, Force measurements of the disruption of the nascent polypeptide chain from the ribosome by optical tweezers, FEBS Letters, 585, 2011, p1859 - 1863 Journal Article, 2011

Park, K. K., Lee, H., Kupnik, M., Oralkan, O., Ramseyer, J. P., Lang, H. P., Hegner, M., Gerber, C., Khuri-Yakub, B., Capacitive micromachined ultrasonic transducer (CMUT) as a chemical sensor for DMMP detection, Sensors and Actuators B-Chemical, 160, 2011, p1120-1127 Journal Article, 2011

Haas, P.,Then, P., Wild, A., Grange, W., Zorman, S., Hegner, M., Calame, M., Aebi, U., Flammer, J., Hecht, B., Fast Quantitative Single-Molecule Detection at Ultra low Concentrations, Analytical Chemistry, 82, (14), 2010, p6299 - 6302 Journal Article, 2010

Nanomechanical Cantilever Array Sensors in, editor(s)Bushan , Springer Handbook of Nanotechnology, New York, Springer, 2010, pp427 - 452, [Hans Peter Lang, Martin Hegner, Christoph Gerber] Book Chapter, 2010

Braun, T., Ghatkesar, M.K., Backmann, N., Grange, W., Boulanger, P., Letelier, L., Lnag, H.P., Bietsch, A., Gerber, C., Hegner, M., Quantitative, time-resolved measurement of membrane protein-ligand interactionsusing microcantilever array sensors., Nature Nanotechnology, 4, 2009, p179-185 Journal Article, 2009 DOI

Huber, F., Lang, H. P., Hegner, M., Despont, M., Drechsler, U., Gerber, Ch., Analyzing refractive index changes and differential bending in microcantilever arrays, Review of Scientific Instruments, 79, (8), 2008, p086110 Journal Article, 2008 TARA - Full Text DOI

Ghatkesar, M. K., Lang, H. P., Gerber, C., Hegner, M., Braun, T. , Comprehenisive characterization of molecular interactions based on nanomechanics, PLoS ONE, 3, (11), 2008, pe3610 Journal Article, 2008 DOI TARA - Full Text

Grange, W., Haas, P., Wild, A., Lieb, M.A., Calame, M., Hegner, M., Hecht, B. , Detection of transient events in the presence of background noise, Journal of Physical Chemistry B, 112, (23), 2008, p7140-7144 Journal Article, 2008 DOI

Ghatkesar, M. K., Rakhmatullina, E., Lang, H. P., Gerber, Ch., Hegner, M., Braun, T. , Multi-parameter microcantilever sensor for comprehensive characterization of Newtonian fluids, Sensors and Actuators B: Chemical, 135, (1), 2008, p133-138 Journal Article, 2008 DOI

Grange, W., Duckely, M., Husale, S., Jacob,S., Engel, A., Hegner, M., VirE2: A Unique ssDNA Compacting Molecular Machine, PLoS Biology, 6, (2), 2008, p343-351 Journal Article, 2008 TARA - Full Text DOI

Husale, S., Grange,W., Karle, M.,Bürgi, S., Hegner, M., Interaction of cationic surfactants with DNA: a single-molecule study, Nucleic Acids Research, 36, (5), 2008, p1443-1449 Journal Article, 2008 TARA - Full Text DOI

Ghatkesar, M.K., Braun, T., Barwich, V., Ramseyer, J.P., Gerber, C., Hegner, M., Lang, H.P., Resonating modes of vibrating microcantilevers in liquid, Applied Physics Letters, 92, (4), 2008, p043106 Journal Article, 2008 TARA - Full Text DOI

Dorrestijn, M., Bietsch, A., Açikalin, T., Raman, A., Hegner, M., Meyer, E. and Ch. Gerber , Chladni Figures Revisited based on Nanomechanics, Physical Review Letters, 98, (2), 2007, p026102 Journal Article, 2007 TARA - Full Text DOI

Watari, M., Galbraith, J. Lang, H.P., Sousa, M., Hegner, M., Gerber, Ch., Horton, M.A. and McKendry, R.A. , Investigating the Molecular Mechanisms of In-plane Mechanochemistry on Cantilever Arrays, Journal of American Chemistry Society, 129, (3), 2007, p601-609 Journal Article, 2007 DOI

Ghatkesar, MK; Barwich, V; Braun, T, Ramseyer, J.P., Gerber, C., Hegner, M., Lang, H.P., Drechsler, U., Despont, M., Higher modes of vibration increase mass sensitivity in nanomechanical microcantilevers, Nanotechnology, 18, (44), 2007, p445502 Journal Article, 2007 DOI

Braun, T., Huber, F., Ghatkesar, M.K., Backmann, N., Lang, H.P., Gerber, C., Hegner, M. , Processing of kinetic microarray signals, Sensors and Actuators B: Chemical, 128, (1), 2007, p75-82 Journal Article, 2007 DOI

Park, K.K., Lee, H,J.,Yaralioglu, G.G., Ergun, A.S., Oralkan, O., Kupnik, M., Quate, C.F., Khuri-Yakub, B.T., Braun, T., Ramseyer, J.P., Lang, H.P., Hegner, M., Gerber, Ch., Gimzewski, J.K. , Capacitive micromachined ultrasonic transducers for chemical detection in nitrogen, Applied Physics Letters, 91, 2007, p094102 Journal Article, 2007 TARA - Full Text DOI

Nugaeva, N., Gfeller, K., Backmann, N., Lang, H.P., Güntherodt, H.J., Hegner, M., An antibody-sensitized microfabricated cantilever for the growth detection of Aspergillus niger spores , Microscopy and Microanalysis, 13, (1), 2007, p13-17 Journal Article, 2007 DOI

Zhang, J., Lang, H. P., Bietsch, A., Huber, F., Certa, U., Güntherodt, H.-J., Hegner, M. Gerber, Ch., Rapid and label-free nanomechanical detection of biomarker transcripts in human RNA, Nature Nanotechnology, 1, 2006, p214-220 Journal Article, 2006 DOI

Braun, T., Backmann, N., Bietsch, A., Engel, A., Lang, H.P., Gerber, Ch., Hegner, M., Conformational change of bacteriorhodopsin quantitatively monitored by microcantilever sensors, Biophysics Journal, 90, (8), 2006, p2970-2977 Journal Article, 2006 DOI

Microfabricated Cantilever Array Sensors for (Bio-) Chemical Detection in, editor(s)B. Bhushan, H. Fuchs , Applied Scanning Probe Methods IV - Industrial Applications, Springer Verlag (Berlin, New York, Heidelberg), Applied Scanning Probe Methods IV - Industrial Applications, 2006, pp183-213 , [H.P. Lang, Hegner M. and Gerber Ch.] Book Chapter, 2006

Gerber, Ch. Hegner, M., Meyer, E. , Special issue featuring papers from ICN&T 2006, Nanotechnology, 18, (4), 2006, p040201 Journal Article, 2006 DOI

Nanomechanical Cantilever Array Sensors in, editor(s) , Springer Handbook of Nanotechnology, Berlin, New York, Heidelberg, Springer Verlag , 2006, pp443-450 , [H.P. Lang, Hegner M. and Gerber Ch.] Book Chapter, 2006

Shahgaldian P., Pieles U, Hegner M. , Enantioselective recognition of phenylalanine by a chiral amphiphilic macrocycle at the air-water interface: A copper-mediated mechanism, Langmuir , 21, (14), 2005, p6503-6507 Journal Article, 2005 DOI

Backmann, N., , Zahnd, Ch., Huber, F., Bietsch, A., Plückthun, A., Lang, H.P., Güntherodt, H.J., Hegner, M., Gerber, Ch., A label-free immunosensor array using single-chain antibody fragments, Proceedings of the National Academy of Science USA, 102, (4), 2005, p14587-14592 Journal Article, 2005 DOI

Bertoncini, P., Schoenauer, R., Agarkova, I., Hegner, M., Perriard, J.-C., Güntherodt, H.-J. , Study of the Mechanical Properties of Myomesin Proteins Using Dynamic Force, Journal of Molecular Biology, 348, (5), 2005, p1127-1137 Journal Article, 2005 DOI

Schoenauer, R., Bertoncini, P., Machaidze, G., Aebi, U., Perriard, J.C., Hegner, M., Agarkova, I. , Myomesin is a molecular spring with adaptable elasticity , Journal of Molecular Biology, 49, (2), 2005, p367-379 Journal Article, 2005 DOI

Gfeller, K.Y, Nugaeva, N., Hegner, M. , Rapid biosensor for the detection of selective growth of Escherichia coli, Applied and Environmental Microbiology, 71, (5), 2005, p2626-2631 Journal Article, 2005 DOI

Nugaeva, N., Gfeller, K.Y., Backmann, N., Lang, H.P., Düggelin, M., Hegner, M. , Micromechanical cantilever array sensors for selective fungal immobilization and fast growth detection, Biosensors and Bioelectronics, 21, (6), 2005, p849-856 Journal Article, 2005 DOI

Gfeller, K., Nugaeva, N., Hegner, M., Micromechanical oscillators as rapid biosensors for the detection of active growth of Escherichia coli, Biosensors and Bioelectronics, 21, (3), 2005, p528-533 Journal Article, 2005 DOI

Braun, T., Barwich, V., Ghatkesar, M.K., Bredekamp, A.H., Gerber, Ch., Hegner, M., Lang, H.P., Mass sensors for biomolecular detection in physiological environment, Physical Review E, 72, 2005, p031907 Journal Article, 2005 TARA - Full Text DOI

Shahgaldian, P., Hegner, M., Pieles, U., A cyclodextrin Self-Assembled Monolayer (SAM) based surface plasmon resonance (SPR) sensor for enantioselective analysis of thyroxine, Journal of Inclusion Phenomena and Macrocyclic Chemistry, 53, 2005, p35-39 Journal Article, 2005 DOI

Huber, F., Hegner, M., Gerber, Ch.,Güntherodt, H.J., Lang, H.P., Label free analysis of transcription factors using microcantilever arrays, Biosensors and Bioelectronics, 21, (8), 2005, p1599 - 1605 Journal Article, 2005 DOI

Lang, H.P., Hegner, M., Gerber, Ch. , Cantilever array sensors, Materials today, 8, (4), 2005, 30-36 Journal Article, 2005 DOI

Ghatkesar M. K., Barwich, V., Braun, T., Bredekamp, A.H., Drechsler, U., Despont, M., Lang, H. P., Hegner, M., Gerber Ch., RealTime Mass Sensing by Nanomechanical Resonatorsin Fluid, Proceedings of IEEE Sensors, 2, 2004, p1060 - 1063 Journal Article, 2004 TARA - Full Text DOI

Bietsch, A., Zhang, J.Y., Hegner, M., Lang, H.P., Gerber, Ch., Rapid functionalization of cantilever array sensors by inkjet printing, Nanotechnology , 15, (8), 2004, p873-880. Journal Article, 2004 DOI

Atomic Force Microscopy & Laser Tweezers. Physics meets Biology in, editor(s)Gompper, G., Kaupp, U.B., Dhont, J.K.G., Richter, D. Winkler, R.G. , Matter and Materials, Jülich , Forschungszentrum Jülich, 2004, pp19 , [Engel, A. & Hegner, M.] Book Chapter, 2004

Schwarzenbach, M.S., Reimann, P., Thommen, V., Hegner, M., Mumenthaler, M., Schwob, J., Güntherodt, H.J. , Topological structure and chemical composition of inner surfaces of borosilicate vials, PDA Journal of Pharmaceutical Science and Technology, 58, (3), 2004, p169-175 Journal Article, 2004 URL

Hegner, M., The Basel NanoBio-Network , Chimia, 58, (11), 2004, 788 - 791 Journal Article, 2004

Bietsch, A., Hegner, M., Lang, H.P., Gerber, C., Inkjet deposition of alkanethiolate monolayers and DNA oligonucleotides on gold: Evaluation of spot uniformity by wet etching, Langmuir, 20, (12), 2004, p5119-5122 Journal Article, 2004 DOI

Arntz, Y., Seelig, J.E., Zhang, J., Lang, H.P., Hunziker, P., Ramseyer, J.P., Meyer, E., Hegner, M., and Gerber, Ch., A label-free protein assay based on a nanomechanical cantilever array, Nanotechnology, 14, 2003, p86-90 Journal Article, 2003 DOI

Hegner, M. and Grange, W., Mechanics and imaging of single DNA molecules, Journal of Muscle Research and Cell Motility, 23, (5-6), 2003, p367-375 Journal Article, 2003 DOI

Research Expertise

Projects

  • Title
    • Nanomechanical detection of noncoding RNA for diagnosis in biological fluids
  • Summary
    • MicroRNAs act at the molecular scale and influence the regulation of cellular processes. We have identified specific expression patterns of miRNA relevant to cancer, and infectious diseases and adverse drug effects. We will integrate novel label-free technologies across multiple disciplines to create smart diagnostic systems that significantly improve the identification and prognosis of diseases. Nanomechanical sensing can selectively analyse these molecules in complex biological fluids and offers previously unexplored non-invasive, rapid and more sensitive diagnosis, monitoring and prognosis of diseases than current biopsy-based sample collection involving sequencing, amplification and labelling of biomarkers.
  • Funding Agency
    • Science Foundation Ireland
  • Date From
    • 10-2016
  • Date To
    • 09-2020
  • Title
    • Nanomechanics of molecular motors and cantilever array bio-diagnostic devices
  • Summary
    • Nanobiotechnology provides unprecedented insights into biological processes (e.g. observing a single molecular-motor at work). In addition, advances in nanotechnology allow new devices to be designed that will result in the next generation of fast, sensitive diagnostics approaches applicable to broad ranges of human diseases. These improvements necessitate new methodologies for isolation and detection of minute physiological quantities of biomarker molecules at previously unachievable levels of sensitivity, multi-parameter analysis, speed and reliability. The proposed projects hinge on effective interdisciplinary collaborations. The 'Nanobio' group at CRANN forms a nucleus of interdisciplinary researchers from the areas of physics, biophysics, surface chemistry, biochemistry, molecular biology and cell biology. The application is divided on two major sections, the first describing state-of-the-art-single biomolecule manipulations with optical tweezers and the second describing the utilization of label-free cantilever array sensors devices for basic science and applied diagnostics.
  • Funding Agency
    • Science Foundation Ireland
  • Date From
    • 04-2010
  • Date To
    • 03-2015
  • Title
    • Nanoremedies
  • Funding Agency
    • HEA
  • Date From
    • 03-2011
  • Date To
    • 12-2015
  • Title
    • ncRNA diagnostics
  • Funding Agency
    • Hoffmann-la-Roche Ltd.
  • Date From
    • 01-2011
  • Date To
    • 12-2015
  • Title
    • Nanomechanical Thrombosis Diagnostic
  • Funding Agency
    • Science Foundation Ireland
  • Date From
    • 02-2012
  • Date To
    • 12-2015
  • Title
    • Lab on a chip for nanomechnical assays
  • Funding Agency
    • EI
  • Date From
    • 02-2013
  • Date To
    • 03-2014
  • Title
    • Fast Microbial Growth Detection
  • Funding Agency
    • Science Foundation Ireland
  • Date From
    • 03-2009
  • Date To
    • 12-2013
  • Title
    • H2020 Coordination
  • Funding Agency
    • EI
  • Date From
    • 01-2014
  • Date To
    • 12-2014
  • Title
    • Nanomechanical Sensing
  • Funding Agency
    • Science Foundation Ireland
  • Date From
    • 01-2008
  • Date To
    • 12-2012
  • Title
    • ncRNA diagnostics
  • Funding Agency
    • Science Foundation Ireland
  • Date From
    • 01-2016
  • Date To
    • 12-2017

Keywords

Applied physics; Biochemistry; Bioengineering; Biomarker; BIOMOLECULES; Biophysics; BIOSENSOR; Biosensors; Diagnostics; Imaging, image processing; Molecular Biology; Molecular Biophysics; Molecular markers and recognition; Multisensory technology, multi sensing; Nano Biotechnology; NANOBIOTECHNOLOGY; Nanomedicine; Nanotechnology; Nuclei acids, polynucleotides, protein synthesis; Optical Tweezers; Optics; Physics; Positioning and guidance systems; Quality, quality control, traceability; Scanning Probe Microscopy; Sensory science, sensors and instrumentation; Surface and interface physics; Surface chemistry; Surface Funtionalisation

Recognition

Awards and Honours

Panel Member Volkswagen Research Foundation 2013

Editor in chief EPJ - TI (Springer) 2013

Fellow TCD 2011

Associate Editor; BMC J. Nanobiotech 2008

Stoke's Award - Science Foundation Ireland 11/2007

Wissenschaftspreis des Kanton Basel Stadt 2004 12/2004

Member NCCR Nanoscale Science; University of Basel 07/2001

ELTEM Regio lecturer position in Nanoscale Science 07/2001

Treubel Stiftung Habilitations fellowship 09/1999

Human Frontier Science Program fellowship 07/1997

Swiss National Science Foundation fellowship for advanced researcher 06/1996

CIBA Geigy fellowship 11/1995

GSE award for diploma work in biochemistry at ETH 11/1989

Memberships

Biophysical Society USA 1997 – present