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Models of Disease

Researchers in TCIN have developed a range of models offering the ability to study the following diseases:

Alzheimer’s disease and cognitive impairment

Stroke, Ischemia and Cell Stress

  • Transgenic models of Alzheimer’s disease
  • Aβ infusion models
  • Aged model
  • Basal forebrain cholinergic lesion model
  • Middle Cerebral Artery Occlusion (MCAO) model
  • Traumatic brain injury
  • Oxygen-glucose deprivation
  • Hypoxia/re-oxygenation
  • Excitotoxicity (glutamate, NMDA, kainate)
  • Oxidative stress
  • Inflammatory stress

Depression

Other disease models:

  • Interferon-α-induced depression
  • Olfactory bulbectomy
  • Chronic mild stress
  • Restraint stress
  • Prion disease: ME7 mouse model
  • Motor neurone disease
  • Macular degeneration and retinitis pigmentosa

Multiple Sclerosis

 
EAE (including relapsing/remitting); mice and rats  

Therapeutic Interventions

Researchers in TCIN use both pharmacological and non-pharmacological interventions to ameliorate pathology in a variety of disease models.

Methodologies for CNS delivery of therapeutics

Non-pharmacological interventions

  • Intrahippocampal and other deep sites
  • Intracerebroventricular
  • Osmotic minipump chronic infusion
  • Electroconvulsive stimulation
  • Deep brain stimulation
  • Exercise protocols
  • Dietary manipulation