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Prof Marina Lynch

Professor Marina Lynch

  • Position:Professor of Cellular Neuroscience
  • Contact details: Department of Physiology, Trinity College Institute of Neuroscience, Trinity College Dublin
  • Email: lynchma@tcd.ie
  • Telephone: 353-01-896-8531


Research Interests

My research focuses on investigating the contribution of neuroinflammatory changes in the age-related and amyloid β-induced deterioration in synaptic function in the brain, especially in the hippocampus. A key component of neuroinflammation is activation of microglia and astrocytes and therefore a particular objective is to understand the factors which trigger activation of these cells, with the aim of modulating these changes and restoring synaptic function. Current work includes an evaluation of the role of cell-cell interaction in modulating microglial activation with a special focus on assessing the interaction between CD200 and its receptor. Among the factors which upregulates CD200 expression is the anti-inflammatory cytokine, IL-4 and recent studies have provided evidence that some novel anti-inflammatory agents attenuate age- and amyloid β-induced changes in hippocampus because they exert an effect on IL-4 and CD200 expression. My current research group consists of 6 postdoctoral fellows and 9 PhD students

Recent Publications

Blau CW, Cowley TR, O’Sullivan J, Grehan B, Browne TC, Kelly L, Birch A, Murphy N, Kelly ÁM, Kerskens CM and Lynch MA (2012). The age-related deficit in LTP is associated with changes in perfusion and blood brain barrier permeability.  Neurobiol. Aging.  [Epub ahead of print; PMID: 22071124]

Costello DA, Lyons A, Browne T, Denieffe S, Cox FF, Lynch MA. (2011) Long-term potentiation is impaired in CD200-deficient mice: a role for Toll-like receptor activation. J Biol Chem. 286, 34722-34732

Costello DA, Watson MB, Cowley T, Murphy N, Murphy Royal C, Garlanda C and Lynch MA (2011) IL-1α and HMGB1 mediate hippocampal dysfunction in SIGIRR-deficient mice. J Neuroscience. 31, 3871-3879.

Lyons A, Murphy K, Clarke, R and Lynch MA (2011) Atorvastatin prevents age-related and amyloid-β-induced microglial activation by blocking interferon-γ release from natural killer cells in the brain. J Neuroinflammation, 8, 27

Murphy N, Cowley TR, Richardson JC, Virley D, Upton N, Walter D, Lynch MA (2011) The neuroprotective effect of a specific P2X(7) receptor antagonist, derives from its ability to inhibit assembly of the NLRP3 inflammasome in glial cells.  Brain Pathol. [Epub ahead of print; PMID: 21933216]

TCIN publications 2007-2009

Research Funding

Science Foundation Ireland, Health Research Board, Wellcome Trust


Email: neuroscience@tcd.ie
Last updated 29 February 2012

Associations

In association with:
Ireland's EU Structural Funds Programmes 2007-2013, NDP, European Union Structural Funds and HEA