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Dr Juan-Pablo Labrador

 Dr Juan Pablo Labrador

Position: Lecturer in Genetics

  • Contact details: Smurfit Institute of Genetics, Trinity College Dublin
  • Email: jp.labrador@tcd.ie
  • Telephone: 353-01-896-8429

Research Interests

It is estimated that in an adult human there are of the order of hundreds of billions of neurons, each of which establishes specific connections. Surface molecules expressed by each neuron will largely determine how these connections take place. Many transcription factors that control neuronal subtype specification have been identified. However, how do they ultimately control the specification of the vast array of different neurons, and how the expression of surface molecules is regulated in them is unknown. My lab is trying to understand how transcriptional codes specify neuronal identity and regulate the expression of membrane molecules. I employ a number of in vitro and in vivo approaches including high-throughput mRNA profiling, ChIP-chip, ChIP-Seq, primary neuronal culture, confocal laser scanning microscopy and a range of biochemical & molecular techniques. My research group comprises 2 post-doctoral researchers and 2 postgraduate students.

Recent Publications

Labrador JP, O'Keefe D, Yoshikawa S, McKinnon RD, Thomas JB and Bashaw GJ (2005). The homeobox transcription factor even-skipped regulates netrin-receptor expression to control dorsal motor-axon projections in Drosophila. Curr Biol.15: 1413-1419.

Hu H, Li M, Labrador JP, McEwen J, Lai EC, Goodman CS and Bashaw GJ (2005). Cross GTPase-activating protein (CrossGAP)/Vilse links the Roundabout receptor to Rac to regulate midline repulsion.Proc Natl Acad Sci U S A.102: 4613-4618.

Fan X, Labrador JP, Hing H and Bashaw GJ (2003). Slit stimulation recruits Dock and Pak to the roundabout receptor and increases Rac activity to regulate axon repulsion at the CNS midline. Neuron. 40: 113-127.

Ikeda K, Wang LH, Torres R, Zhao H, Olaso E, Eng FJ, Labrador P, Klein R, Lovett D, Yancopoulos GD, Friedman SL and Lin HC (2002). Discoidin domain receptor 2 interacts with Src and Shc following its activation by type I collagen. J Biol Chem. 277:19206-19212.

Olaso E, Labrador JP,Wang L, Ikeda K, Eng FJ, Klein R, Lovett DH, Lin HC and Friedman SL (2002). Discoidin domain receptor 2 regulates fibroblast proliferation and migration through the extracellular matrix in association with transcriptional activation of matrix metalloproteinase-2. J Biol Chem. 277: 3606-3613.

TCIN publications 2007-2009

Research Funding

Science Foundation Ireland, Enterprise Ireland, Deutsche- Forschungsgemeinschaft, Irish Research Council for Science, Engineering and Technology