Prof. T. J. Foster - Research Page

Research Activities – Professor J. Geoghegan

STAPHYLOCOCCAL PATHOGENESIS

Joan Geoghegan, B.A., Ph.D.

J Geoghegan

Research Interests

Staphylococcal Pathogenesis

Our research focuses on the Gram-positive human pathogen Staphylococcus aureus . We study the molecular basis of the interaction of S. aureus with the host. In particular, we are interested in how bacterial surface proteins interact with host cells and components of the human innate immune system. These protein-protein interactions are of importance during colonisation of the nares and skin and during the establishment of invasive infection.
We are also interested in identifying novel targets for antimicrobial therapy. The ability of staphylococci to correctly display surface components is of crucial importance during the establishment of infection. A greater understanding of protein translocation and surface display in S. aureus will facilitate identification of novel targets for the treatment and prevention of infection.

Postgraduate Researchers:
Mr Dara O'Halloran ohallodp@tcd.ie
Ms Orla Fleury fleuryo@tcd.ie
Ms Leanne Hays hayslm@tcd.ie